检索结果-南通市图书馆

PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR V.BATOROV ALISA D.INESHINA TATIANA A.ARISTOVA VERA V.DENISOVA SVETLANA A.SIZIKOVA DARIA S.BATOROVA GALINA Y.USHAKOVA EKATERINA Y.SHEVELA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia V.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparatively assessed with flow cytometry in PD-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negative and positive CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusive regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

Modeling of Leachate Propagation in a Municipal Solid Waste Landfill foundation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第6期20卷 1407-1424页

作者： Nadezhda Zubova Andrey Ivantsov Institute of Continuous Media Mechanics of the Ural Branch Russian Academy of SciencePerm614013Russia

The study deals with the numerical modeling of leachate distribution in the porous medium located under a municipal solid waste disposal landfill(MSWLF).The considered three-layer system is based on geological data obtained from field *** simplicity,the problem is investigated by assuming a two-component ***,the heat produced by landfills due to biological and chemical processes and the thermal diffusion mechanism contributing to pollution transport are taken into *** numerical modeling of the propagation of leachate in the considered layered porous medium is implemented for parameters corresponding to natural soil and for the case where disruption of the porous medium structure is due to cracks formation or *** latter is accompanied by an increase in rock *** this case,the emergence of multi-vortex flow in the layer of high permeability is observed to substantially influence the bottom layers and cause intensification of the leachate *** effects should be taken into account when estimating the parameters and properties of materials required for the construction of solid waste disposal facilities.

关键词： Three-layer porous medium binary mixture diffusion thermal diffusion

SANC Monte Carlo programs for small-angle Bhabha scattering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第4期48卷 14-19页

作者： A.B.Arbuzov S.G.Bondarenko I.R.Boyko L.V.Kalinovskaya A.A.Kampf R.R.Sadykov V.L.Yermolchyk Bogoliubov Laboratory of Theoretical Physics JINRDubna141980 Russia Dzhelepov Laboratory of Nuclear Problems JINRDubna141980 Russia Dubna State University Dubna141982 Russia

Luminosity monitoring at e^(+)e^(−)colliders was investigated using SANC Monte Carlo event generator ReneSANCe and integrator MCSANC for simulation of Bhabha scattering at low *** are presented for center-of-mass energies of the Z boson resonance and at 240 GeV for the conditions of typical luminosity *** is shown that bremsstrahlung events with extremely low electron scattering angles are relevant to match the precision tags of future electron-positron colliders.

关键词： luminosity Bhabha scattering QED Monte Carlo simulation

Olefin Polymerization Behavior of Titanium(IV) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim F.Magomedov Svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia V.Nelyubina Evgenii K.Golubev Maria D.Evseeva Viktor G.Vasil'ev Galina G.Nikiforova Mikhail I.Buzin Vyacheslav S.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(IV) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

Libration-Generated Average Convection in a Rotating Flat Layer with Horizontal Axis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第10期20卷 2235-2249页

作者： Kirill Rysin Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia

The study of average convection in a rotating cavity subjected to modulated rotation is an interesting area for the development of both fundamental and applied *** phenomenon finds application in the field of mass transfer and fluid flow control,relevant examples being crystal growth under reduced gravity and fluid mixing in microfluidic devices for cell *** this study,the averaged flow generated by the oscillating motion of a fluid in a planar layer rotating about a horizontal axis is experimentally *** boundaries of the layer are maintained at constant temperatures,while the lateral cylindrical wall is thermally *** is demonstrated that libration results in intense oscillatory fluid motion,which in turn produces a time-averaged *** the first time,quantitative measures for the instantaneous velocity field are obtained using the Particle Image Velocimetry *** is revealed that the flow has the form of counter-rotating *** vortex circulations sense changes during a libration *** increase in the rotation rate and amplitude of the cavity libration results in an increase in the flow *** heat transfer and time-averaged velocity are examined accordingly as a function of the dimensionless oscillation frequency,and resonant excitation of heat transfer and average oscillation velocity are *** threshold curve for the onset of the averaged convection is identified in the plane of control parameters(dimensionless rotational velocity and pulsation Reynolds number).It is found that an increase in the dimensionless rotational velocity has a stabilizing effect on the onset of convection.

关键词： Rotation libration oscillations mass transfer stability averaged convection

Dynamics of Low-Viscosity Liquids Interface in an Unevenly Rotating Vertical Layer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第4期20卷 693-703页

作者： Victor Kozlov Vladimir Saidakov Nikolai Kozlov Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPerm614990Russia Institut de Mécanique des Fluides de Toulouse Toulouse INPToulouse31400France

The behavior of two immiscible low-viscosity liquids differing in density and viscosity in a vertical flat layer undergoing modulated rotation is experimentally *** layer has a circular axisymmetric *** the absence of modulation of the rotation speed,the interphase boundary has the shape of a short axisymmetric cylinder.A new effect has been discovered,under the influence of rotation speed modulation,the interface takes on a new dynamic equilibrium state.A more viscous liquid covers the end boundaries of the layer in the form of thin films,which have the shape of round spots of almost constant radius;with increasing amplitude of the velocity modulation,the wetting boundary *** is found that upon reaching the critical amplitude of oscillations,the film of a viscous liquid loses stability,and the outer edge of the wetting spot collapses and takes on a feathery *** is shown that this threshold is caused by the development of the Kelvin-Helmholtz oscillatory instability of the *** spreading radius of a spot of light viscous liquid and its stability are studied depending on the rotation rate,amplitude,and frequency of rotation speed *** discovered averaged effects are determined by different oscillatory interaction of fluids with the end-walls of the cell,due to different *** effect of films forming can find application in technological processes to intensify mass transfer at interphase boundaries.

关键词： Rotation oscillations immiscible fluids contact line interface film dynamic equilibrium Nomenclature frot

HIFs in hypoxic regulation of the extracellular matrix:focus on little-known player HIF-3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第5期48卷 677-692页

作者： ALEKSANDRA GORNOSTAEVA LUDMILA BURAVKOVA MARGARITA LOBANOVA ELENA ANDREEVA Institute of Biomedical Problems of the russian Academy of sciences Khoroshevskoye Shosse 76AMoscow123007Russia

The structural and associated molecules of the extracellular matrix(ECM)complex is an important component of the local milieu of cells,both for maintaining their functions and *** is a dynamic structure that is finely tuned to changes in the *** of these factors is hypoxia,which can arise in tissues due to physiological or pathological *** a result of the hypoxic effect,the properties of the ECM are significantly modified,stiffness increases,the balance between degradation and synthesis of structural proteins shifts,and the deposition of biologically active mediators’***-inducible factors(HIFs)contribute significantly to the modification of the properties of the ECM under *** the three HIF isoforms,HIF-1 is the most studied,with numerous identified target genes encoding proteins that participate in all matrisome *** less is known about HIF-2 and *** the context of the effects of hypoxia on the matrisome,HIF-3 isoform is of particular *** the first two isoforms,transiently expressed during the first hours of hypoxia,HIF-3 is activated after around 24 h of exposure to hypoxia and persists for a longer *** addition,its transcription is more pronounced under hypoxia than are HIFs 1 and ***-3,rather than the first two isoforms,is possibly responsible for the changes that occur in matrisome during prolonged hypoxic *** review attempts to summarize the available data on the involvement of HIF-3 in the matrisome modification under hypoxia.

关键词： Hypoxia Hypoxia-inducible factors Matrisome

Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第9期16卷 827-831页

作者： Vera V Voinova Daria V Vasina Anton P Bonartsev Faculty of Biology MV Lomonosov Moscow State UniversityMoscow 119234Russia NF Gamaleya National Research Centre for Epidemiology and Microbiology Ministry of Health of the Russian FederationMoscow 123098Russia

Bibliographic analysis is still very rarely used in experimental basic study *** comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of valuable information for writing reviews and experimental papers in this *** experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectives in this *** is due to the fact that these studies have addressed a great variety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselves and their various products:Sponges,hydrogels,exosomes,and genetic *** a wide variety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be provided by bibliometric ***,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for every basic study manuscripts,primarily for the“Introduction”section,and review.

关键词： Bibliometric analysis Mesenchymal stem cells Wound healing Tissue engineering Dressing Hydrogels Matrix Exosomes

Vibrational Suspension of Two Cylinders in a Rotating Liquid-Filled Cavity with a Time-Varying Rotation Rate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2024年第9期20卷 2127-2137页

作者： Olga Vlasova Laboratory of Vibrational Hydromechanics Perm State Humanitarian Pedagogical UniversityPermSibirskaya614990Russia

The dynamics of rotating hydrodynamic systems containing phase inclusions are interesting due to the related widespread occurrence in nature and *** influence of external force fields on rotating systems can be used to control the dynamics of inclusions of various *** inclusions is of current interest for space *** low gravity,even a slight vibration effect can lead to the appearance of a force acting on phase inclusions near a solid *** vibrations are applied to multiphase hydrodynamic systems,the oscillating body intensively interacts with the fluid and introduces changes in the related flow *** in the fluid flow lead to the appearance of an averaged *** a result,the body is repelled from the cavity boundary and takes a position at a certain distance from *** vibrationally-induced movement of phase inclusions in liquids can be used to improve various technological processes(for example,when degassing and cleaning liquids from solid inclusions,mixing various components,etc.).This study presents a relevant methodology to study the averaged vibrational force acting on a pair of free cylindrical bodies near the oscillating wall of a *** is paid to the region of moderate and low dimensionless frequencies when the size of the inclusion is consistent with the thickness of the Stokes boundary *** dynamics of these bodies is considered in a horizontal cylindrical cavity with a fluid undergoing modulated *** average lift force of a vibrational nature is measured by the method of quasi-stationary suspension of bodies whose density differs from the density of the liquid in a static centrifugal force *** developed technique makes it possible to determine the dependence of the lift force on vibration parameters and the distance from the oscillating boundary at which solid inclusions are *** is shown that in the region of moderate dimensionless frequencies,the averag

关键词： Solid bodies rotational oscillations viscous fluid lift force