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In-Vehicle Network Injection Attacks Detection Based on Feature Selection and Classification

Automotive Innovation 2024年第1期7卷 138-149页

作者： Haojie Ji Liyong Wang Hongmao Qin Yinghui Wang Junjie Zhang Biao Chen Key Laboratory of Modern Measurement and Control technology Ministry of EducationBeijing Information Science and Technology UniversityBeijing 100192China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China School of Transportation science and Engineering Beihang UniversityBeijing 100191China Hefei Innovation research Institute Beihang UniversityHefei 230012China

Detecting abnormal data generated from cyberattacks has emerged as a crucial approach for identifying security threats within in-vehicle *** transmission of information through in-vehicle networks needs to follow specific data for-mats and communication protocols ***,statistical algorithms are employed to learn these variation rules and facilitate the identification of abnormal ***,the effectiveness of anomaly detection outcomes often falls short when confronted with highly deceptive in-vehicle network *** this study,seven representative classification algorithms are selected to detect common in-vehicle network attacks,and a comparative analysis is employed to identify the most suitable and favorable detection *** consideration of the communication protocol characteristics of in-vehicle networks,an optimal convolutional neural network(CNN)detection algorithm is proposed that uses data field characteristics and classifier selection,and its comprehensive performance is *** addition,the concept of Hamming distance between two adjacent packets within the in-vehicle network is introduced,enabling the proposal of an enhanced CNN algorithm that achieves robust detection of challenging-to-identify abnormal *** paper also presents the proposed CNN classifica-tion algorithm that effectively addresses the issue of high false negative rate(FNR)in abnormal data detection based on the timestamp feature of data *** experimental results validate the efficacy of the proposed abnormal data detection algorithm,highlighting its strong detection performance and its potential to provide an effective solution for safeguarding the security of in-vehicle network information.

关键词： Classification algorithm Anomaly detection In-vehicle network Feature extraction Injecting attack

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Impacts of pancreatic exocrine insufficiency on gut microbiota

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Journal of Zhejiang university-science B(Biomedicine & Biotechnology) 2024年第4期25卷 271-279页

作者： Yulin GUO Feng CAO Fei LI Department of General Surgery Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Acute Pancreatitis Clinical Center of Capital Medical university Beijing 100053China

Pancreatic exocrine insufficiency(PEI)can be induced by various kinds of diseases,including chronic pancreatitis,acute pancreatitis,and *** main pathogenetic mechanism of PEI involves the decline of trypsin synthesis,disorder of pancreatic fluid flow,and imbalance of secretion *** studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis,with the abundance of Lactobacillus and Bifidobacterium increasing the most,which could be partially reversed by pancreatic enzyme replacement *** studies have also confirmed the association between PEI and the dysbiosis of gut *** exocrine secretions and changes in duodenal p H as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut *** turn,the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional *** forward,more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.

关键词： Pancreatic exocrine insufficiency Gut microbiota Gut microbiome Pancreatic enzyme replacement therapy

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An accurate diagnostic approach for urothelial carcinomas based on novel dual methylated DNA markers in small-volume urine

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Chinese Medical Journal 2024年第2期137卷 232-234页

作者： Yucai Wu Di Cai Jian Fan Chang Meng Shiming He Zhihua Li Lianghao Zhang Kunlin Yang Aixiang Wang Xinfei Li Yicong Du Shengwei Xiong Mancheng Xia Tingting Li Lanlan Dong YanqingGong Liqun Zhou Xuesong Li Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China National Urological Cancer Center Beijing 100034China Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Peking UniversityBeijing 100034China Wuhan Ammunition Life-tech Company Ltd.WuhanHubei 430200China

Diagnostic methods for urothelial carcinomas(UCs)are often invasive or have suboptimal *** of exfoliated cell DNA or cell-free DNA in urine has shown great promise in the diagnosis of ***,most current studies have focused on bladder cancer(BCa),and only a few high-plex methylated DNA panels based on large-volume urine have been reported to exhibit both high sensitivity and specificity.[1,2]The purpose of this study was to identify universal biomarkers for BCa and upper tract urothelial carcinoma(UTUC)using a small volume of *** developed a dual-target diagnostic panel comprising the novel marker AL021918.2 and the well-known BCa biomarker Vimentin(VIM).This panel can accurately detect UCs using only 1.8 mL of full-voided urine.

关键词： urine bladder diagnosis

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Microphysiological systems for modeling gut-organ interaction

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BIOCELL 2024年第8期48卷 1145-1153页

作者： JONG HWAN SUNG Department of Chemical Engineering Hongik UniversitySeoulKorea

The gut is a digestive organ that absorbs nutrients but also plays a vital role in immune response and defense against external *** complex interaction between the gut microbiota and other organs including the immune system of the host has been known in various contexts,yielding the notion of‘axes’between the gut and other *** the presence of various gut-organ axes has been reported,the lack of adequate in vitro model systems for studying this interaction has restricted a deeper insight into these *** developed microphysiological systems(MPS),also known as organ-on-a-chip,allow researchers to study complex interactions between diverse organs,and here we provide a review of how recently developed gut-on-a-chip systems are used for building models of various diseases that were difficult to study.

关键词： Microfluidics Gut-liver axis Gut-brain axis Microphysiological systems

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Variability and trends of near-surface wind speed over the Tibetan Plateau:The role played by the westerly and Asian monsoon

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Advances in Climate Change research 2024年第3期15卷 525-536页

作者： Gang-Feng ZHANG Cesar AZORIN-MOLINA Deliang CHEN Tim RMCVICAR Jose AGUIJARRO Kai-Qiang DENG Lorenzo MINOLA Jaeyeon LEE Seok-Woo SON Heng MA Pei-Jun SHI State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Engineering Center of Desertification and Blown-Sand Control of Ministry of Education Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Beijing Normal UniversityBeijing 100875China Centro de Investigaciones Sobre Desertificaci'on Consejo Superior de Investigaciones Cientı'ficas(CIDECSIC-UV-Generalitat alenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden CSIRO Environment CanberraACT 2600Australia Australian research Council Centre of Excellence for Climate Extremes CanberraACT 2600Australia State Meteorological Agency Balearic Islands OfficePalma de Mallorca 07015Spain School of Atmospheric sciences Sun Yat-sen UniversityZhuhai 519082China Interuniversity Department of Regional and Urban Studies and Planning(DIST) Politecnico and University of TurinTurin 10125Italy School of Earth and Environmental sciences Seoul National UniversitySeoul 08826South Korea Atmospheric and Oceanic sciences Program Princeton UniversityPrinceton NJ 08544USA Geophysical Fluid Dynamics Laboratory NOAAPrinceton NJ 08544USA

Near-surface wind speed exerts profound impacts on many environmental issues,while the long-term(≥60 years)trend and multidecadal variability in the wind speed and its underlying causes in global high-elevation and mountainous areas(e.g.,Tibetan Plateau)remain largely ***,by examining homogenized wind speed data from 104 meteorological stations over the Tibetan Plateau for 1961-2020 and ERA5 reanalysis datasets,we investigated the variability and long-term trend in the near-surface wind speed and revealed the role played by the westerly and Asian *** results show that the homogenized annual wind speed displays a decreasing trend(-0.091 m s^(−1)per decade,p<0.05),with the strongest in spring(-0.131 m s^(−1)per decade,p<0.05),and the weakest in autumn(-0.071 m s^(−1)per decade,p<0.05).There is a distinct multidecadal variability of wind speed,which manifested in an prominent increase in 1961-1970,a sustained decrease in 1970-2002,and a consistent increase in *** observed decadal variations are likely linked to large-scale atmospheric circulation,and the correlation analysis unveiled a more important role of westerly and East Asian winter monsoon in modulating near-surface wind changes over the Tibetan *** potential physical processes associated with westerly and Asian monsoon changes are in concordance with wind speed change,in terms of overall weakened horizontal air flow(i.e.,geostrophic wind speed),declined vertical thermal and dynamic momentum transfer(i.e.,atmospheric stratification thermal instability and vertical wind shear),and varied Tibetan Plateau *** indicates that to varying degrees these processes may have contributed to the changes in near-surface wind speed over the Tibetan *** study has implications for wind power production and soil wind erosion prevention in the Tibetan Plateau.

关键词： Tibetan Plateau Wind speed Decadal change Atmospheric circulation Physical processes

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Data driven computational design of stable oxygen evolution catalysts by DFT and machine learning:Promising electrocatalysts

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Journal of Energy Chemistry 2024年第4期91卷 645-655页

作者： Hwanyeol Park Yunseok Kim Seulwon Choi Ho Jun Kim Department of Display Materials Engineering Soonchunhyang UniversityAsanChung-nam 31538Republic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang Uni-versityAsanChungnam 31538Republic of Korea Department of Mechanical Engineering Hanyang University ERICA Campus55 Hanyangdaehak-roSangnok-guAnsanGyeonggi-do 15588Republic of Korea

The revolutionary development of machine learning(ML),data science,and analytics,coupled with its application in material science,stands as a significant milestone of the scientific community over the last *** active,stable,and cost-efficient catalysts is crucial for oxygen evolution reaction owing to the significance in a range of electrochemical energy co nversion *** this work,we have demonstrated an efficient approach of high-throughput screening to find stable transition metal oxides under acid condition for high-performance oxygen evolution reaction(OER)catalysts through density functional theory(DFT)calculation and a machine learning algorithm.A methodology utilizing both the Materials project database and DFT calculations was introduced to assess the acid stability under specific reaction *** upon this,OER catalytic activity of acid-stable materials was examined,highlighting potential OER catalysts that meet the required *** identified IrO_(2),Fe(SbO_(3))_(2),Co(SbO_(3))_(2),Ni(SbO_(3))_(2),FeSbO_(4),Fe(SbO_(3))4,MoWO_(6),TiSnO_(4),CoSbO_(4),and Ti(WO_(4))_(2)as promising catalysts,several of which have already been experimentally discovered for their robust OER performance,while others are novel for experimental exploration,thereby broadening the chemical scope for efficient OER *** of the bond length of TM-O and the first ionization energy were used to unveil the OER activity *** the calculated results,guidance has been derived to effectively execute advanced high-throughput screenings for the discovery of catalysts with favorable ***,the intrinsic correlation between catalytic performance and various atomic and structural factors was elucidated using the ML *** these approaches,we not only streamline the choice of the promising electrocatalysts but also offer insights for the design of varied catalyst models and the discovery of superior c

关键词： Transition metal oxides Oxygen evolution reaction High-throughput screening First-principles calculation Machine learning

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Assimilating FY-4A AGRI Radiances with a Channel-Sensitive Cloud Detection Scheme for the Analysis and Forecasting of Multiple Typhoons

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Advances in Atmospheric sciences 2024年第5期41卷 937-958页

作者： Feifei SHEN Aiqing SHU Zhiquan LIU Hong LI Lipeng JIANG Tao ZHANG Dongmei XU Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China China Meteorological Administration Basin Heavy Rainfall Key Laboratory/Hubei Key Laboratory for Heavy Rain Monitoring and Warning research Institute of Heavy RainChina Meteorological AdministrationWuhan 430205China National Center for Atmospheric research Boulder 80307COUSA State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China National Meteorological information Center Beijing 100081China Fujian Key Laboratory of Severe Weather and Key Laboratory of Straits Severe Weather China Meteorological AdministrationFuzhou 350001China

This paper presents an attempt at assimilating clear-sky FY-4A Advanced Geosynchronous Radiation Imager(AGRI)radiances from two water vapor channels for the prediction of three landfalling typhoon events over the West Pacific Ocean using the 3DVar data assimilation(DA)method along with the WRF model.A channel-sensitive cloud detection scheme based on the particle filter(PF)algorithm is developed and examined against a cloud detection scheme using the multivariate and minimum residual(MMR)algorithm and another traditional cloud mask–dependent cloud detection *** show that both channel-sensitive cloud detection schemes are effective,while the PF scheme is able to reserve more pixels than the MMR scheme for the same *** general,the added value of AGRI radiances is confirmed when comparing with the control experiment without AGRI ***,it is found that the analysis fields of the PF experiment are mostly improved in terms of better depicting the typhoon,including the temperature,moisture,and dynamical *** typhoon track forecast skill is improved with AGRI radiance DA,which could be explained by better simulating the upper *** impact of assimilating AGRI radiances on typhoon intensity forecasts is *** the other hand,improved rainfall forecasts from AGRI DA experiments are found along with reduced errors for both the thermodynamic and moisture fields,albeit the improvements are limited.

关键词： FY-4A AGRI radiance particle filter multiple typhoons data assimilation numerical weather prediction

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基于CsPbBr_(3)-MXene纳米结构的高线性度突触光电晶体管用于图像分类和边缘检测

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science China Materials 2024年第7期67卷 2246-2255页

作者：代岩陈耿旭黄伟龙许晨晖刘常飞黄紫玉郭太良陈惠鹏 National&Local United Engineering Laboratory of Flat Panel Display technology Institute of Optoelectronic DisplayCollege of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China Fujian science&technology Innovation Laboratory for Optoelectronic information of China Fuzhou 350100China

人工光突触为克服数据存储和处理中的冯诺依曼瓶颈,提供了一种有效的解决方案.人工光突触通过消除带宽连接密度的权衡和低功耗,展现了其相较于电突触的优势.钙钛矿量子点由于其易于合成和良好的光电性能,在人工光突触中引起了广泛的关注... 详细信息

人工光突触为克服数据存储和处理中的冯诺依曼瓶颈,提供了一种有效的解决方案.人工光突触通过消除带宽连接密度的权衡和低功耗,展现了其相较于电突触的优势.钙钛矿量子点由于其易于合成和良好的光电性能,在人工光突触中引起了广泛的关注.然而,有限的载流子迁移率和非线性性能阻碍了它在神经形态中的应用.本研究提出了一种吸附CsPbBr_(3)的MXene纳米结构(CsPbBr_(3)-MXene),即在MXene纳米片上原位生长CsPbBr_(3)量子点,并将其作为光电突触晶体管的吸光层,CsPbBr_(3)和MXene形成的异质结构增强了光电流的产生.在相同的光脉冲刺激下,与仅含CsPbBr_(3)的突触晶体管相比,CsPbBr_(3)-MXene突触晶体管的兴奋性突触后电流(EPSC)提高了24.6%.经过计算和比较,其线性度有了明显的改善(从4.586到1.099);此外,其对手写数字分类的识别准确率也显著提高(从86.13%到92.05%);边缘检测的F1分数也有所提高(从0.8165到0.9065),更加接近于1.这些提升表明这项工作将有助于神经计算领域的进一步发展.

关键词： in-situ growth CsPbBr_(3)-attached MXene synaptic phototransistor pattern recognition accuracy image preproces-sing

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Stay in touch with the endoplasmic reticulum

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science China(Life sciences) 2024年第2期67卷 230-257页

作者： Sha Sun Gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan G.Zhao Xun Huang Ge Yang Huaqing Cai Jose C.Pastor-Pareja Liang Ge Chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of Cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of Computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain research Center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(MCSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,Golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria Golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

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Solid-phase sintering and vapor-liquid-solid growth of BP@MgO quantum dot crystals with a high piezoelectric response

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Journal of Advanced Ceramics 2022年第11期11卷 1725-1734页

作者： Qingwei LIAO Wei HOU Kexuan LIAO Liyin CHEN Yujun SONG Guowei GAO Lei QIN Key Laboratory of Sensors Beijing Information Science&Technology UniversityBeijing 100192China Key Laboratory of Modern Measurement&Control technology Ministry of EducationBeijing Information Science&Technology UniversityBeijing 100192China Key Laboratory of Photoelectric Testing technology Beijing Information Science&Technology UniversityBeijing 100192China School of Chemical science and Engineering Tongji UniversityShanghai 200092China Harvard John A.Paulson School of Engineering and Applied sciences Harvard UniversityCambridge 02138USA Center of Modern Physics technology School of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Low-dimensional piezoelectric and quantum piezotronics are two important branches of low-dimensional materials,playing a significant role in the advancement of low-dimensional devices,circuits,and ***,we firstly propose a solid-phase sintering and vapor–liquid–solid growth(SS–VLS-like)method of preparing a quantum-sized oxide material,i.e.,black phosphorus(BP)@MgO quantum dot(QD)crystal with a strong piezoelectric ***-sized MgO was obtained by Mg slowly released from MgB_(2) within the confinement of a nanoflake BP *** the slow release of Mg only grows nanometer-sized MgO to hinder the further growth of MgO,we added a heterostructure matrix constraint:nanoflake *** the BP as the matrix confinement,MgO QDs embedded in the BP@MgO QD crystals were *** crystals have a layered two-dimensional(2D)structure with a thickness of 11 nm and are stable in the *** addition,piezoresponse force microscopy(PFM)images show that they have extremely strong *** strong polarity can also be proved by polarization reversal and a simple pressure sensor.

关键词： quantum dots(QDs) piezoelectric black phosphorus(BP) MgO

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