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Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo

Nano research 2017年第2期10卷 503-519页

作者： Seongchan Kim Yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim DaI-Hee Min center for RNA research Institute for Basic Sciences (IBS) Department of Chemistry Seoul National University Seou108826 Republic of Korea Department of Energy Engineering and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Institute of Nanobio Convergence Technology Lemonex Inc. Seou108826 Republic of Korea College of Pharmacy Ajou University Worldcuplo 206 Yeongtong-gu Suwon 16499 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot （CD）, and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles （NPs） enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein （GFP） expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy.

关键词： bioimaging carbon dot gene delivery RNA interference targeted cancer therapy

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Impact of exciton fine structure on the energy transfer in magicsized(CdSe)13 clusters

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Nano research 2024年第12期17卷 10669-10676页

作者： Jan Bieniek Woonhyuk Baek Severin Lorenz Franziska Muckel Rachel Fainblat Taeghwan Hyeon Gerd Bacher Werkstoffe der Elektrotechnik and CENIDE University of Duisburg-EssenBismarckstr.81Duisburg 47057Germany School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea center for Nanoparticle research Institute for Basic Science(IBS)Seoul 151-742Republic of Korea Department of Semiconductor Science&Technology Baekje-daeroDeokjin-guJeonju-siJeonbuk State 54896Republic of Korea Electroenergetic Functional Materials(EEFM)&CENIDE University Duisburg-EssenDuisburg 47057Germany

Magic-sized(CdSe)13 clusters(MSCs)represent a material class at the boundary between molecules and quantum dots that exhibit a pronounced and well separated excitonic fine *** characteristic photoluminescence is composed of exciton bandgap emission and a spectrally broad mid-gap emission related to surface ***,we report on a thermally activated energy transfer from fine-structure split exciton states to surface states by using temperature dependent photoluminescence excitation *** demonstrate that the broad mid-gap emission can be suppressed by a targeted Mn-doping of the MSC leading to the characteristic orange luminescence of the^(4)T_(1)→^(6)A_(1)Mn^(2+)*** energy transfer to the Mn^(2+)states is found to be significantly different than the transfer to the surface defect states,as the activation of the dopant emission requires a spin-conserving charge carrier transfer that only dark excitons can provide.

关键词： magic-sized cluster Mn-doping excitonic fine structure surface defects energy transfer

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Two-dimensional Dirac plasmon-polaritons in graphene,3D topological insulator and hybrid systems

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Light(Science & Applications) 2022年第11期11卷 2602-2616页

作者： Chihun In Un Jeong Kim Hyunyong Choi Department of Physics Freie Universitat BerlinBerlin 14195Germany Department of Physical Chemistry Fritz-Haber-lInstitute of the Max-Planck-SocietyBerlin 14195Germany Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Institute of Applied Physics Seoul National UniversitySeoul 08826Republic of Korea Advanced Sensor Laboratory Samsung Advanced Institute of TechnologySuwonGyeonggido 16419Republic of Korea

Collective oscillations of massless particles in two-dimensional(2D)Dirac materials offer an innovative route toward implementing atomically thin devices based on low-energy quasiparticle *** confinement of nearfield distribution on the 2D surface is essential to demonstrate extraordinary optoelectronic functions,providing means to shape the spectral response at the mid-infrared(IR)*** the dynamic polarization from the linear response theory has successfully accounted for a range of experimental observations,a unified perspective was stll elusive,connecting the state-of-the-art developments based on the 2D Dirac ***,we review recent works on graphene and three-dimensional(3D)topological insulator(TI)plasmon-polariton,where the mid-IR and terahertz(THz)radiation experiences prominent confinement into a deep-subwavelength scale in a novel optoelectronic *** presenting general light-matter interactions between 2D Dirac plasmon and subwavelength quasiparticle excitations,we introduce various experimental techniques to couple the plasmonpolaritons with electromagnetic *** and optical controls over the plasmonic excitations reveal the hybridized plasmon modes in graphene and 3D Tl,demonstrating an intense near-field interaction of 2D Dirac plasmon within the highly-compressed *** findings can further be applied to invent optoelectronic biomolecular sensors,atomically thin photodetectors,and laser-driven light sources.

关键词： structure Dirac topological

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Miniaturized multicolor fluorescence imaging system integrated with a PDMS light-guide plate for biomedical investigation

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npj Flexible Electronics 2023年第1期7卷 494-503页

作者： Hyogeun Shin Gun-Wook Yoon Woongsun Choi Donghwan Lee Hoyun Choi Deok Su Jo Nakwon Choi Jun-Bo Yoon Il-Joo Cho Department of Biomedical Sciences College of MedicineKorea UniversitySeoulRepublic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DeajeonRepublic of Korea center for Brain Technology Brain Science InstituteKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Biotechnology research Institute of CHROMACH Co. LtdSuwonRepublic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulRepublic of Korea Department of Anatomy College of MedicineKorea UniversitySeoulRepublic of Korea Noul Co. LtdYonginRepublic of Korea

Miniaturized fluorescence imaging systems are promising platforms that overcome the limited use of conventional microscopes in the biomedical ***,there are physical limitations for multicolor fluorescence imaging in existing miniaturized imaging systems because multiple filters have to be integrated into a small ***,we present a miniaturized multicolor fluorescence imaging system integrated with single polydimethylsiloxane(PDMS)light-guide plate(LGP)for multicolor fluorescence *** PDMS LGP allows guiding the transmitted light from the light source only to the fluorescent samples regardless of the wavelength of the light ***,our system is capable of multicolor fluorescence imaging without multiple filters that block the excitation *** demonstrated the usability of our system in the biomedical field by observing green-and red-labeled cells in the *** proposed system can be used in a wide range of applications for studies that require multicolor fluorescence imaging in the biomedical field.

关键词： structure field system

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Recent advances in electronic devices for monitoring and modulation of brain

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Nano research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon Sun Jun Young-Geun Park Jiuk Jang Jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery

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Integrated NLRP3,AIM2,NLRC4,Pyrin inflammasome activation and assembly drive PANoptosis

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Cellular & Molecular Immunology 2023年第12期20卷 1513-1526页

作者： SuHyeon Oh Jihye Lee Jueun Oh Gyoengju Yu Haesun Ryu Daesik Kim SangJoon Lee Department of Biological Science Ulsan National Institute of Science and Technology(UNIST)UlsanRepublic of Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea

Inflammasomes are important sentinels of innate immune defense;they sense pathogens and induce the cell death of infected cells,playing key roles in inflammation,development,and *** inflammasome sensors detect and respond to specific pathogen-and damage-associated molecular patterns(PAMPs and DAMPs,respectively)by forming a multiprotein complex with the adapters ASC and *** disease,cells are exposed to several PAMPs and DAMPs,leading to the concerted activation of multiple ***,the molecular mechanisms that integrate multiple inflammasome sensors to facilitate optimal host defense remain ***,we discovered that simultaneous inflammasome activation by multiple ligands triggered multiple types of programmed inflammatory cell death,and these effects could not be mimicked by treatment with a pure ligand of any single ***,NLRP3,AIM2,NLRC4,and Pyrin were determined to be members of a large multiprotein complex,along with ASC,caspase-1,caspase-8,and RIPK3,and this complex drove ***,this multiprotein complex was released into the extracellular space and retained as multiple *** extracellular inflammasome particles could induce inflammation after their engulfment by neighboring ***,our findings define a previously unknown regulatory connection and molecular interaction between inflammasome sensors,which drives the assembly of a multiprotein complex that includes multiple inflammasome sensors and cell death *** discovery of critical interactions among NLRP3,AIM2,NLRC4,and Pyrin represents a new paradigm in understanding the functions of these molecules in innate immunity and inflammasome biology as well as identifying new therapeutic targets for NLRP3-,AIM2-,NLRC4-and Pyrin-mediated diseases.

关键词： Multiple Inflammasome Inflammatory Cell Death PANoptosis Excellular ASC PANoptosome

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Nontrivial coupling of light into a defect:the interplay of nonlinearity and topology

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Light(Science & Applications) 2020年第1期9卷 646-655页

作者： Shiqi Xia Dario Jukic Nan Wang Daria Smirnova Lev Smirnov Liqin Tang Daohong Song Alexander Szameit Daniel Leykam Jingjun Xu Zhigang Chen Hrvoje Buljan The MOE Key Laboratory of Weak-Light Nonlinear Photonics TEDA Applied Physics Institute and School of PhysicsNankai UniversityTianjin 300457China Faculty of Civil Engineering University of ZagrebA.Kacica Miosica 2610000 ZagrebCroatia Nonlinear Physics Centre Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia Institute of Applied Physics Russian Academy of ScienceNizhny Novgorod 603950Russia Collaborative Innovation center of Extreme Optics Shanxi UniversityTaiyuan 030006 ShanxiPR China Institut für Physik Universitat RostockAlbert-Einstein-Strasse 2318059 RostockGermany center for Theoretical Physics of Complex Systems Institute for Basic Science(IBS)Daejeon 34126Republic of Korea Basic Science program Korea University of Science and TechnologyDaejeon 34113Republic of Korea Department of Physics and Astronomy San Francisco State UniversitySan FranciscoCA 94132USA Department of Physics Faculty of ScienceUniversity of ZagrebBijenička c.3210000 ZagrebCroatia

The flourishing of topological photonics in the last decade was achieved mainly due to developments in linear topological photonic ***,when nonlinearity is introduced,many intriguing questions *** example,are there universal fingerprints of the underlying topology when modes are coupled by nonlinearity,and what can happen to topological invariants during nonlinear propagation?To explore these questions,we experimentally demonstrate nonlinearity-induced coupling of light into topologically protected edge states using a photonic platform and develop a general theoretical framework for interpreting the mode-coupling dynamics in nonlinear topological *** on laser-written photonic Su-Schrieffer-Heeger lattices,our experiments show the nonlinear coupling of light into a nontrivial edge or interface defect channel that is otherwise not permissible due to topological *** theory explains all the observations ***,we introduce the concepts of inherited and emergent nonlinear topological phenomena as well as a protocol capable of revealing the interplay of nonlinearity and *** concepts are applicable to other nonlinear topological systems,both in higher dimensions and beyond our photonic platform.

关键词： nonlinearity topological coupling

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Quasiparticle interference and impurity resonances on WTe2

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Nano research 2020年第9期13卷 2534-2540页

作者： Hyeokshin Kwon Taehwan Jeong Samudrala Appalakondaiah Youngtek Oh Insu Jeon Hongki Min Seongjun Park Young Jae Song Euyheon Hwang Sungwoo Hwang Samsung Advanced Institute of Technology Samsung Electronics Co.Suwon 16678Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea center for Integrated Nanostructure Physics(CINAP) Institute for Basic Science(IBS)Sungkyunkwan UniversitySuwon 16419Republic of Korea

Using scanning tunneling microscopy/spectroscopy(STM/STS),we examine quasiparticle scattering and interference properties at the surface of ***2,layered transition metal dichalcogenide,is predicted to be a type-ll Weyl *** Weyl fermion states in WTe2 emerge as topologically protected touching points of electron and hole pockets,and Fermi arcs connecting them can be visible in the spectral function on the *** probe the properties of surface states,we have conducted low-temperature STM/STS(at 2.7 K)on the surfaces of WTe2 single *** visualize the surface states of WTe2 with atomic scale *** surface states emerging from the bulk electron pocket have been identified and their connection with the bulk electronic states shows good agreement with *** show the interesting double resonance peaks in the local density of states appearing at localized *** low-energy resonant peak occurs near the Weyl point above the Fermi energy and it may be mixed with the surface state of Weyl points,which makes it difficult to observe the topological nature of the Weyl semimetal WTe2.

关键词： WTe2 Weyl semimetal quasi-particle interference scanning tunneling microscopy/spectroscopy

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