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Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases

Neural Regeneration Research 2022年第12期17卷 2623-2631页

作者： Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma Research Center of Neurobiology The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi ProvinceChina Department of Neurology Datong Fifth People’s HospitalDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of *** are also involved in the biological effects of immune cells and glial cells,as well as the development of neurodegenerative disorders such as Alzheimer’s disease,Parkinson’s disease,and multiple *** studies by us and others confirmed that ROCKs inhibitors attenuated the symptoms and progression of experimental models of the abovementioned neurodegenerative diseases by inhibiting neuroinflammation,regulating immune imbalance,repairing the blood-brain barrier,and promoting nerve repair and myelin ***,the first ROCKs inhibitor to be used clinically,has a good therapeutic effect on neurodegenerative *** increases the activity of neural stem cells and mesenchymal stem cells,thus optimizing cell *** review will systematically describe,for the first time,the effects of abnormal activation of ROCKs on T cells,B cells,microglia,astrocytes,oligodendrocytes,and pericytes in neurodegenerative diseases of the central nervous system,summarize the therapeutic potential of fasudil in several experimental models of neurodegenerative diseases,and clarify the possible cellular and molecular mechanisms of ROCKs *** review also proposes that fasudil is a novel potential treatment,especially in combination with cell-based *** from this review add support for further investigation of ROCKs and its inhibitor fasudil for the treatment of neurodegenerative diseases.

关键词： Alzheimer’s disease cell-based therapy central nervous system cells fasudil immunocytes multiple sclerosis Parkinson’s disease pericytes Rho kinase inhibitor Rho-associated kinases

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Nanovoid-confinement and click-activated nanoreactor for synchronous delivery of prodrug pairs and precise photodynamic therapy

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Nano Research 2022年第10期15卷 9264-9273页

作者： Peng Wang Fang Zhou Xia Yin Qingji Xie Guosheng Song Xiao-Bing Zhang Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Key Laboratory of Chemical Biology and Traditional chinese Medicine(Hunan Normal University) Ministry of EducationChangsha 410082China

Bioorthogonal cleavage reaction-triggered prodrug activation by the pretargeted methods can achieve accurate cancer ***,the click and release efficiency of these methods in vivo is limited by the space-time dislocation of bioorthogonal prodrug-trigger pairs within the tumor area,caused by their asynchronous administration and inconsistent accumulation for most delivery *** herein created a nanovoid-confinement and click-activated(NCCA)core–shell nanoreactor by incorporating prodrugs within zeolitic imidazolate framework-90(ZIF-90)as core and coating tetrazine-based covalent organic framework(COF)as *** surface modification of aptamer polymer,the NCCA nanoreactor enabled the sufficient delivery of photodynamic prodrugs within ***,the core of ZIF-90 was decomposed by tumor acidic environment,inducing the high-efficiency activation of photodynamic prodrugs via nanoconfined bioorthogonal reaction with tetrazine-based COF *** a result,such photodynamic agents are efficiently and safely accumulated into tumor and specifically activated for precise photodynamic therapy of cancer cells and tumor bearing mice with minimizing toxic side *** together,such NCCA nanoreactor clearly demonstrates the critical feasibility to realize the synchronous delivery of both prodrugs and triggers for precise treatment,which most of delivery systems are not able to afford.

关键词： nanoreactor covalent organic framework bioorthogonal reaction prodrug photodynamic therapy

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Manipulating mechanical properties of graphene/Al composites by an in-situ synthesized hybrid reinforcement strategy

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Journal of Materials Science & Technology 2022年第28期123卷 13-25页

作者： Lizhuang Yang Bowen Pu Xiang Zhang Junwei Sha Chunnian He Naiqin Zhao School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin UniversityTianjin 300072China

The structural deterioration caused by the relatively weak out-of-plane bending stiffness and the chemically-active edge area of graphene limits its outperformance in strengthening for Al matrix composites(AMCs).Introducing one-dimensional(1D)carbon nanotubes(CNTs)to graphene/metal system is one of the promised strategies to complement the weakness of 2D graphene and make full use of the outstanding intrinsic properties of the both *** date,such synergistic strengthening and toughening mechanisms are largely *** this study,AMCs reinforced by a novel hybrid reinforcement,i.e.,graphene nanosheets decorated with Cu nanoparticles and CNTs(Cu@GNS-CNTs),are fabricated by an in-situ synthesis *** combined contrast experiments validated that the organically integrated reinforcing structure promotes the intrinsic load bearing capacity of GNS and the strain hardening capability of the Al matrix *** a result,the composites achieved excellent tensile strength and uniform elongation with almost no *** strengthening mechanism originated primarily from the hybrid reinforcement exhibits superior load-transfer,fracture inhibition and dislocation storage capability by controlling the interface reaction to construct an effective interface structure without damaging the *** work identifies a promising structural modification strategy for 2D materials and provides mechanistic insights into the synergistic strengthening effect of graphene/CNTs hybrid reinforcement.

关键词： Metal-matrix composites(MMCs) Mechanical properties Graphene Synergistic strengthening Interface

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High-efficiency conjugated-polymer-hosted blue phosphorescent light-emitting diodes

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chinese Science Bulletin 2012年第27期57卷 3639-3643页

作者： NIU QiaoLi ZHANG Yong WANG YongLi WANG Xin HE Miao Institute of Optoelectronic Materials and Technology South China Normal UniversityLED Industrial Service Platform of Guangzhou City Guangzhou 510631China

Highly-efficient blue phosphorescent light-emitting diodes were fabricated based on a conjugated-polymer host by doping bis(2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate(FIrpic) into poly(9,9-dioctylfluorene)(PFO).Previously,conjugated polymers were not considered as potential hosts for blue phosphorescent dyes because of their low-lying triplet energy *** back transfer would occur and lead to poor luminescent efficiency in both photoluminescence(PL) and electroluminescence(EL) ***,by inserting a hole-transporting layer of poly(N-vinylcarbazole)(PVK),the energy back transfer was *** low FIrpic-doping concentrations,PFO emissions were completely quenched;with 8 wt% FIrpic,a maximum luminous efficiency of 11.5 cd/A was achieved.

关键词：共轭聚合物发光二极管磷光蓝色 N-乙烯基咔唑承载能量水平发光效率

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A preliminary study on criteria weights for a library's digital resource selection:From the viewpoints of both users and librarians

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chinese Journal of Library and Information Science 2011年第Z1期4卷 82-96页

作者： Qiong TANG Gang WU Danni LIANG Yingliang ZHANG Mingjun TAN School of Information Management Sun Yat-sen University School of Information Management Wuhan University Wuhan University Library

Through investigating both users' and librarians' perceptions of the relative importance of the major criteria governing the selection of digital resources, we attempted to develop a criterion weight framework for a library's selection of digital resources, which can meet both the users' requirements and the library's goal of developing digital collections. The respective weight of each specific criterion is decided through the Analytic Hierarchy Process(AHP) Method. The findings of this study indicate that, when assigning weights to the selection criteria, it is important to consult the opinions of a wide crosssection of people, especially the views of different users. As a result, the digital resource selection system characterized by the criteria weights can reflect more comprehensively the users' requirements, and meanwhile it enables librarians' more rational selection of digital resources.

关键词： Library digital resources Selection criteria Criteria weights Analytic Hierarchy Process(AHP)

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A New Solution to Detectable Byzantine Agreement Problem

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Communications in Theoretical Physics 2009年第12期52卷 1013-1015页

作者： QIN Su-Juan WEN Qiao-Yan MENG Luo-Ming ZHU Fu-Chen State key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China State Key Laboratory of Integrated Service Networks Xidian University Xi＇an 710071 China National Laboratory for Modern Communications P.O. Box 810 Chengdu 610041 China

We present a new quantum protocol for solving detectable Byzantine agreement problem between threeparties by employing one quantum key distribution *** protocol is suggested by a special four-qubit entangledstate inst... 详细信息

关键词： quantum protocol detectable Byzantine agreement entangled state

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A hierarchical porous carbon membrane from polyacrylonitrile/polyvinylpyrrolidone blending membranes: Preparation,characterization and electrochemical capacitive performance

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Journal of Energy Chemistry 2014年第6期23卷 684-693页

作者： Huili Fan Fen Ran Xuanxuan Zhang Haiming Song Wenxia Jing Kuiwen Shen Lingbin Kong Long Kang School of Materials Science and Engineering Lanzhou University of Technology State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology

Novel hierarchical porous carbon membranes were fabricated through a simple carbonization procedure of well-defined blending polymer membrane precursors containing the source of carbon polyacrylonitrile （PAN） and an additive of polyvinylpyrrolidone （PVP）, which was prepared using phase inversion method. The as-fabricated materials were further used as the active electrode materials for supercapacitors. The effects of PVP concentration in the casting solution on structure feature and electrochemical capacitive performance of the as-prepared carbon membranes were also studied in detail. As the electrode material for supercapacitor, a high specific capacitance of 278.0 F/g could be attained at a current of 5 mA/cm2 and about 92.90% capacity retention could be maintained after 2000 charge/discharge cycles in 2 mol/L KOH solution with a PVP concentration of 0.3 wt% in the casting solution. The facile hierarchical pore structure preparation method and the good electrochemical capacitive performance make the prepared carbon membrane particularly promising for use in supercapacitor.

关键词： porous carbon supercapacitors phase separation electrode materials additive

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Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis

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Journal of Genetics and Genomics 2018年第12期45卷 663-672页

作者： Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen State Key Laboratory of Crop Genetics of Disease Resistance and Disease Control State Key Laboratory of Hybrid RiceKey Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River BasinRice Research InstituteSichuan Agricultural UniversitySichuan 611130 China Department of Plant Pathology University of CaliforniaDavisCA 95616USA Triticeae Research Institute.Sichuan Agricultural University Sichuan 611130China State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental Biology，Chinese Academy of SciencesBeijing 100101China

Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis.

关键词： Blast disease Genome-wide sequence analysis Resistance Rice Transcriptome

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Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin

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chinese Journal of Chemistry 2023年第23期41卷 3333-3338页

作者： Yueming Wu Yuan Chen Haowen Yu Alideertu Dong Runhui Liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237 China Key Laboratory for Ultrafine Materials of ministry of education Frontiers Science Center for Materiobiology and Dynamic Chemistry Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237 China Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityHohhotInner Mongolia010021 China

The intensive use of antibiotics intensifies the development of bacterial resistance,which has become a serious problem ***-resistant Staphylococcus aureus(MRSA)has resulted in significant morbidity and ***,it is an urgent need to develop new antimicrobial drugs and administration ***,we report a dual functional diblock copolymer PLL20-b-PBLG20,which was prepared by superfast and water-insensitive polymerization on N-carboxyanhydrides(NCA)initiated by tetraalkylammonium *** addition to direct antimicrobial activity,PLL20-b-PBLG20 also exerts a synergistic bactericidal effect against MRSA with curcumin,a plant extract with antibacterial ***,PLL20-b-PBLG20 successfully encapsulates curcumin to form nanoparticles via *** combination of dual functional PLL20-b-PBLG20 and curcumin holds promise in combating MRSA infections.

关键词： Amino acid polymer Antimicrobial Synergy Encapsulation MRSA

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Identification of Prorocentrum minimum and Takayama pulchella by fluorescence in situ hybridization through epifluorescence microscopy and flow cytometry

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Acta Oceanologica Sinica 2009年第2期28卷 103-114页

作者： HOU Jianjun LAI Hongyan HUANG Bangqin CHEN Jixin College of Fisheries Huazhong Agricultural University Wuhan 430070 China College of Life Sciences Hubei Normal University Huangshi 435002 China State Key Laboratory of Marine Environmental Science Environmental Science Research Center Xiamen University Xiamen 361005 China Key Laboratory of Freshwater Fish Germplasm Resources and Biotechnology Yangtse River Fisheries Research Institute Jinzhou 434000 China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

Partial rDNA sequences of Prorocentrum minimum and Takayama pulchella were amplified, cloned and sequenced, and these sequence data were deposited in the GenBank. Eight oligonucleotide probes （DNA probes） were designed based on the sequence analysis. The probes were employed to detect and identify P. minimum and T. pulchella in unialgal and mixed algal samples with a fluorescence in situ hybridization method using flow cytometry. Epifluorescence micrographs showed that these specific probes labeled with fluorescein isothiocyanate entered the algal cells and bound to target sequences, and the fluorescence signal resulting from whole-cell hybridization varied from probe to probe. These DNA probes and the hybridization protocol we developed were specific and effective for P. minimum and T. pulchella, without any specific binding to other algal species. The hybridization efficiency of different probes specific to P. minimum was in the order： PM18S02 PM28S02 〉 PM28S01 〉PM18S01, and that of the probes specific to T. pulcheUa was TP18S02 TP28S01 〉 TP28S02 〉TP18S01. The different hybridization efficiency of the DNA probes could also be shown in the fluorescent signals between the labeled and unlabeled cells demonstrated using flow cytometry. The DNA probes PM18S02, PM28S02, TP18S02 and TP28S01, and the protocol, were also useful for the detection of Mgae in natural samples.

关键词： oligonucleotide DNA probes Prorocentrum minimum Takayama pulcheUa fluorescence in situ hybridization flow cytometry

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