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Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

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Cellular & Molecular Immunology 2023年第8期20卷 955-968页

作者： Manuel M.Vicente Inês Alves Ângela Fernandes Ana M.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja Münster-Kühnel Afonso R.M.Almeida Sarina Ravens Gabriel A.Rabinovich Manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical sciences Abel Salazar(ICBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of Medicine University of PortoPortoPortugal Nephrology Department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of Clinical Biochemistry Hannover Medical SchoolHannoverGermany Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales(FCEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1CreMgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1CreMgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation

Structural Reliability Analysis of Ship Hulls Accounting for Collision or Grounding Damage

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Journal of Marine science and Application 2020年第4期19卷 717-733页

作者： Branka BužančićPrimorac Joško Parunov C.Guedes Soares Faculty of Electrical Engineering Mechanical Engineering and Naval ArchitectureUniversity of SplitSplitCroatia Faculty of Mechanical Engineering and Naval Architecture University of ZagrebZagrebCroatia Centre of Marine technology and Ocean Engineering(CENTEC)Instituto Superior Técnico Universidade de LisboaLisbonPortugal

Classical structural reliability analysis of intact ship hulls is extended to the case of ships with collision or grounding *** water load distribution and residual bending moment capacity are included as random variables in the limit state *** probability density functions of these random variables are defined based on random damage parameters given by the Marine Environment Protection Committee of the International Maritime Organization,while the proposed reliability formulation is consistent with international recommendations and thus may be valuable in the development of rules for accidental limit *** methodology is applied on an example of an Aframax oil *** proposed approach captures in a rational way complex interaction of different pertinent variables influencing safety of damaged ship structure.

关键词： Ship structures Hull girder Collision and grounding Damaged oil tanker Residual strength Uncertainty modelling Structural reliability

Numerical Analysis of Stress Concentration in Non-uniformly Corroded Small-Scale Specimens

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Journal of Marine science and Application 2021年第1期20卷 1-9页

作者： J.Kodvanj Y.Garbatov C.Guedes Soares J.Parunov Faculty of Mechanical Engineering and Naval Architecture University of ZagrebZagrebCroatia Centre for Marine technology and Ocean Engineering(CENTEC) Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais1049-001 LisbonPortugal

A numerical evaluation of stress concentrations of corroded plate surfaces of small-scale corroded steel specimens is compared with the experimentally estimated *** specimens were cut from a steel box girder,which was initially corroded in real seawater *** surface of all corroded specimens was analysed applying photogrammetry techniques,and a statistical description of an idealised corroded surface of each specimen was *** lives of specimens are determined from the fatigue *** on experimentally obtained fatigue lives,the stress concentration factors are calculated concerning the ideally smooth *** correlation between the statistical parameters of the corroded specimen surfaces and the estimated stress concentration factors is *** corroded surfaces,converted in graphical format,are then used for the finite element modelling in ABAQUS software,and stress concentration factors are estimated from the finite element results.A convergence study is performed to determine the appropriate finite element mesh *** between experimentally obtained and numerically estimated stress concentration factors is performed as well as correlation analysis between actual and finite element predicted crack locations.

关键词： Fatigue life Fatigue tests Corrosion Stress concentration factors Finite element method

Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated

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World Journal of Cardiology 2016年第10期8卷 575-583页

作者： Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro Research Centre in Sports sciences Health and Human DevelopmentCIDESDUniversity Institute of Maia Research Center in Physical Activity Health and LeisureCIAFELFaculty of SportUniversity of Porto School of Health sciences and Institute of Biomedicine iB iM EDUniversity of Aveiro

Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease.

关键词： Physical activity Primary prevention Secondary prevention Cardiovascular disease Health care evaluation mechanisms

Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 714-719页

作者： Marta Oliveira Policarpo Ademar Sales Junior Maria Joao Rodrigues Marina DellaGreca Luisa Barreira Silvane Maria Fonseca Murta Alvaro Jose Romanha Luisa Custodio Center of Marine sciences (CCMAR) University of AlgarveCampus de Gambelas 8005-139 FaroPortugal Centro de Pesquisas Rene Rachou FIOCRUZ Belo HorizonteMinas GeraisBrazil Dipartimento di Chimica Organica e Biochimica Universita` Federico Ⅱ Complesso Universitario Monte Sant'AngeloVia Cintia 4I-80126NapoliItaly

Objective:To evaluate the in vitro anti-Trypanosoma cruzi（***） activity of organic extracts prepared from halophyte species collected in the southern coast of Portugal（Algarve）,and chemically characterize the most active ***:Acetone,dichloromethane and methanol extracts were prepared from 31 halophyte species and tested in vitro against trypomastigotes and intracellular amastigotes of the Tulahuen strain of *** most active extract was fractionated by preparative HPLC-DAD,affording 11 *** most selective fraction was fully characterized by ***:From 94 samples tested,one was active,namely the root dichloromethane extract of Juncus acutus(IC50 < 20 μg/mL).This extract was fractionated by HPLC,affording 11 fractions,one of them containing only a pure compound（juncunol）,and tested for anti-parasitic *** 8(IC50 = 4.1 μg/mL) was the most active,and was further characterized by *** major compounds were phenanthrenes,9,10-dihydrophenanthrenes and ***:Our results suggest that the compounds identified in fraction 8 are likely responsible for the observed anti parasitic *** research is in progress aiming to isolate and identify the specific active *** the best of our knowledge,this is the first report on the in vitro anti *** activity of halophyte species.

关键词： Chagas disease Halophytes Trypanosoma cruzi Phenanthrenes Juncunol

Inverse Eigenvalue Problems and Their Associated Approximation Problems for Matrices with J-（Skew） Centrosymmetry

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Inverse Eigenvalue Problems and Their Associated Approximati...

A Novel Approach to Measuring Spatiotemporal Changes in Social Vulnerability at the Local Level in Portugal

第三届最优化与系统生物学国际研讨会

作者： Zhong-Yun Liu You-Cai Duan Yun-Feng Lai Yu-Lin Zhang School of Math. Changsha University of Science & Technology Dept.of Math. University of MinhoCampus de Gualtar4710-057 BragaPortugal

＜正＞The inverse problems play an important role in MEG reconstructions[3,4,5,6,7].In this paper,a partially described inverse eigenvalue problem and an associated optimal approximation problem for J-centrosymmetric matrices are considered *** is shown under which conditions the inverse eigenproblem has a *** expression of its general solution is given. In case a solution of the inverse eigenproblem exists,the optimal approximation problem can be *** formula of its unique solution is ***,the case for /-skew centrosymmetric matrices is considered.

关键词： J-centrosymmetric matrices J-skew centrosymmetric Inverse eigenvalue problem optimal approximation

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International Journal of Disaster Risk science 2022年第6期13卷 842-861页

作者： Pedro Pinto Santos JoséLuís Zêzere Susana Pereira Jorge Rocha Alexandre Oliveira Tavares Centre for Geographical Studies Institute of Geography and Spatial PlanningTERRAUniversity of Lisbon(CEG-IGOT-ULisboa)1600-276 LisboaLAPortugal Centre for Social Studies Earth Science DepartmentScience and Technology FacultyUniversity of Coimbra(CES/DCT-FCT-UCoimbra)3000-995 CoimbraPortugal

Social vulnerability,as one of the risk components,partially explains the magnitude of the impacts observed after a *** this study,a spatiotemporally comparable assessment of social vulnerability and its drivers was conducted in Portugal,at the civil parish level,for three census *** first challenging step consisted of the selection of meaningful and consistent variables over *** were normalized using the Adjusted Mazziotta-Pareto Index(AMPI)to obtain comparable adimensional-normalized values.A joint principal component analysis(PCA)was applied,resulting in a robust set of variables,interpretable from the point of view of their self-grouping around vulnerability drivers.A separate PCA for each census was also conducted,which proved to be useful in analyzing changes in the composition and type of drivers,although only the joint PCA allows the monitoring of spatiotemporal changes in social vulnerability scores and drivers from 1991 to 2011.A general improvement in social vulnerability was observed for *** two main drivers are the economic condition(PC1),and aging and depopulation(PC2).The remaining drivers highlighted are uprooting and internal mobility,and daily *** data proved their value in the territorial,social,and demographic characterization of the country,to support medium-and long-term disaster risk reduction measures.

关键词： AMPI normalization Portugal Social vulnerability Spatiotemporal changes

Application of a Computational Tool to Study the Influence of Worn Wheels on Railway Vehicle Dynamics

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Journal of Software Engineering and Applications 2012年第2期5卷 51-61页

作者： Joao Pombo IDMEC Instituto Superior TécnicoTechnical University of LisbonLisbonPortugal.

The search for fast, reliable and cost effective means of transport that presents better energy efficiency and less impact on the environment has resulted in renewed interest and rapid development in railway technology. To improve its efficiency and competitiveness, modern trains are required to travel faster, with high levels of safety and comfort and with reduced Life Cycle Costs (LCC). These increasing demands for vehicle requirements imposed by railway operators and infrastructure companies include maintaining the top operational speeds of trainsets during their life cycle, having low LCC and being track friendly. This is a key issue in vehicle design and in train operation since it has a significant impact on the safety and comfort of railway systems and on the maintenance costs of vehicles and infrastructures. The purpose of this work is to analyze how the wear progression on the wheelsets affects the dynamic behavior of railways vehicles and its interaction with the track. For this purpose a vehicle, assembled with new and worn wheels, is studied in realistic operation scenarios. The influence of the wheel profile wear on the vehicle dynamic response is assessed here based on several indicators used by the railway industry. The running stability of the railway vehicles is also emphasized in this study.

关键词： Wear Prediction Software Steel Wheel Profile Vehicle-Track Interaction Wheel-Rail Contact Forces

Pre-fire aboveground biomass, estimated from LiDAR, spectral and field inventory data, as a major driver of burn severity in maritime pine (Pinus pinaster) ecosystems

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Forest Ecosystems 2022年第2期9卷 234-246页

作者： Jose Manuel Fernandez-Guisuraga Susana Suarez-Seoane Paulo MFernandes Victor Fernandez-Garcia Alfonso Fernandez-Manso Carmen Quintano Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversity of Leon24071LeonSpain Centro de Investigacao e de Tecnologias Agroambientais e Biologicas Universidade de Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Department of Organisms and Systems Biology(Ecology Unit)and Research Unit of Biodiversity(IMIB UO-CSIC-PA)University of OviedoOviedoMieresSpain Agrarian science and Engineering Department School of Agricultural and Forestry EngineeringUniversity of Leon24400PonferradaSpain Electronic technology Department School of Industrial EngineeringUniversity of Valladolid47011ValladolidSpain Sustainable Forest Management Research Institute University of Valladolid-Spanish National Institute for Agriculture and Food Research and Technology(INIA)34004PalenciaSpain

Background:The characterization of surface and canopy fuel loadings in fire-prone pine ecosystems is critical for understanding fire behavior and anticipating the most harmful ecological effects of ***,the joint consideration of both overstory and understory strata in burn severity assessments is often *** aim of this work was to assess the role of total,overstory and understory pre-fire aboveground biomass(AGB),estimated by means of airborne Light Detection and Ranging(LiDAR)and Landsat data,as drivers of burn severity in a megafire occurred in a pine ecosystem dominated by Pinus pinaster *** the western Mediterranean ***:Total and overstory AGB were more accurately estimated(R^(2) equal to 0.72 and 0.68,respectively)from LiDAR and spectral data than understory AGB(R^(2)=0.26).Density and height percentile LiDAR metrics for several strata were found to be important predictors of *** severity responded markedly and non-linearly to total(R^(2)=0.60)and overstory(R ^(2)=0.53)AGB,whereas the relationship with understory AGB was weaker(R ^(2)=0.21).Nevertheless,the overstory plus understory AGB contribution led to the highest ability to predict burn severity(RMSE=122.46 in dNBR scale),instead of the joint consideration as total AGB(RMSE=158.41).Conclusions:This study novelty evaluated the potential of pre-fire AGB,as a vegetation biophysical property derived from LiDAR,spectral and field plot inventory data,for predicting burn severity,separating the contri-bution of the fuel loads in the understory and overstory strata in Pinus pinaster *** evidenced relationships between burn severity and pre-fire AGB distribution in Pinus pinaster stands would allow the implementation of threshold criteria to support decision making in fuel treatments designed to minimize crown fire hazard.

关键词： Aboveground biomass Burn severity Landsat LiDAR Pinus pinaster