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Novel Cathelicidins with Potent Antimicrobial,Biofilm Inhibitory,and Anti-inflammatory Activities from the Frog Fejervarya multistriata

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Asian Herpetological Research 2017年第3期18卷 199-212页

作者： Aili WANG Yan CHEN Haining YU Yipeng WANG Weifang University of science and Technology Department of Pharmaceutical sciences College of Pharmaceutical SciencesSoochow University Department of Bioscience and Biotechnology Dalian University of Technology

Antimicrobial peptides（AMPs）,a class of gene-encoded peptides,are the first line of immune system to defense microbial invasions in multicellular *** are an important family of AMPs that have been identified exclusively in ***,up to now,cathelicidins from amphibians are poorly *** the present study,we reported the identification and characterization of two novel cathelicidins（FM-CATH1 and FMCATH2） from the frog Fejervarya *** c DNA sequences encoding FM-CATHs were successfully cloned from the constructed lung c DNA library of *** of the c DNA sequences encoding FM-CATHs are 447 bp in length,and the deduced mature peptides of FM-CATHs are composed of 34 *** analysis indicated that FM-CATH1 and FM-CATH2 mainly assume amphipathic alpha-helical *** and bacterial killing kinetic analysis indicated that both FM-CATH1 and FM-CATH2 possess potent,broad-spectrum and rapid antimicrobial *** cytoplasmic membrane permeabilization analysis indicated that FM-CATH1 and FMCATH2 kill bacteria by inducing the permeabilization of bacterial *** direct antimicrobial activities,FM-CATHs also exhibited significant inhibitory effect on the formation of bacterial biofilms at low concentrations below 1×***,FM-CATH1 and FM-CATH2 exhibited potent anti-inflammatory activities by inhibiting LPS-induced transcription and production of pro-inflammatory cytokines TNF-α,IL-1β,and IL-6 in mouse peritoneal ***,FM-CATHs showed relatively low cytotoxic activity against mammalian normal and tumor cell lines,and low hemolytic activity against human *** summary,the identification of FM-CATHs provides novel clues for our understanding of the roles of cathelicidins in amphibian immune *** potent antimicrobial,biofilm inhibitory,anti-inflammatory activities,and low cytotoxicity of FM-CATHs imply their great potential in novel

关键词： cathelicidin Fejervarya multistriata FM-CATHs antimicrobial peptide bacterial biofilm antiinflammatory

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Current Clinical Research of Acute Kidney Injury in China

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Chinese Medical Journal 2015年第9期128卷 1268-1271页

作者： Bi-Cheng Liu Ri-Ning Tang Zhi-Hong Liu Department of Nephrology Institute of Nephrology Zhongda Hospital Southeast University School of Medicine Nanjing Jiangsu 210009 China Department of Nephrology Institute of Nephrology Jinling Hospital Nanjing University Nanjing Jiangsu 210002 China

INTRODUCTION Acute kidney injury （AKI） is a common clinical syndrome characterized by an abrupt decline of renal function and has been recognized as a major healthcare problem affecting millions of patients *** is strongly associated with increased resource utilization,mortality,and risk for the development of chronic kidney disease （CKD）.[1-3]

关键词： Acute Kidney Injury China Epidemiology

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工业纯铝等通道球形转角膨胀挤压变形的力学与摩擦学性能

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稀有金属材料与工程 2021年第3期50卷 733-739页

作者：张翔王晓溪耿彦波陈波徐国王峰江苏徐工工程机械研究院有限公司江苏徐州221004 徐州工程学院机电工程学院江苏徐州221018 高端工程机械智能制造国家重点实验室江苏徐州221004

对传统等通道转角挤压工艺(equal channel angular extrusion,ECAE)进行改进,提出一种新型剧烈塑性变形法(severe plastic deformation,SPD)——等通道球形转角膨胀挤压(equal channel angular expansion extrusion with spherical cavity,ECAEE-SC)。该工艺通过耦合镦-剪-挤等多种变形效应,可在单道次挤压下实现坯料内部较大的塑性应变累积,进而获得理想的晶粒细化与性能提升效果。在室温条件下采用ECAEE-SC工艺对工业纯铝(Al-1060)进行单道次挤压,并与相同条件下的2道次ECAE处理变形结果进行对比。采用EBSD、SEM等测试手段,研究了工业纯铝经ECAEE-SC变形晶粒特征与磨损表面形貌,并测试了变形材料显微硬度、拉伸性能与摩擦学性能。结果表明,在ECAEE-SC工艺剧烈塑性应变诱导下,工业纯铝经单道次挤压变形后晶粒显著细化,呈典型的剪切条带状特征。与初始退火态相比,变形材料显微硬度与抗拉伸强度分别提升了92.6%和91.8%,且性能提升效果明显优于2道次ECAE变形。同时,ECAEE-SC工艺有效提高了工业纯铝的耐磨性能,工业纯铝变形后表面磨痕宽度最小,磨痕深度最浅,其磨损机理以磨粒磨损为主导。

关键词：剧烈塑性变形力学性能纯铝摩擦学性能磨损机理

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Mei’s symmetry theorem for time scales nonshifted mechanical systems

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Theoretical & Applied Mechanics Letters 2021年第5期11卷 246-251页

作者： Yi Zhang College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011China

We focus on Mei symmetry for time scales nonshifted mechanical systems within Lagrangian framework and its resulting new conserved ***,the dynamic equations of time scales nonshifted holonomic systems and time scales nonshifted nonholonomic systems are derived from the generalized Hamilton’s ***,the definitions of Mei symmetry on time scales are given and its criterions are ***,Mei’s symmetry theorems for time scales nonshifted holonomic conservative systems,time scales nonshifted holonomic nonconservative systems and time scales nonshifted nonholonomic systems are established and proved,and new conserved quantities of above systems are *** are illustrated with two examples.

关键词： Mei’s symmetry theorem Nonholonomic system Nonconservative system Time scales Nonshifted calculus of variation

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Quantitative trait loci analysis for rice seed vigor during the germination stage

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2010年第12期11卷 958-964页

作者： Zhou-fei WANG Jian-fei WANG Yong-mei BAO Fu-hua WANG Hong-sheng ZHANG State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Nanjing 210095 China Institute of Crop science Henan Academy of Agricultural Sciences Zhengzhou 450002 China

Seed vigor is an important characteristic of seed quality,and rice cultivars with strong seed vigor are desirable in direct-sowing rice production for optimum stand *** the present study,the quantitative trait loci (QTLs) of three traits for rice seed vigor during the germination stage,including germination rate,final germination percentage,and germination index,were investigated using one recombinant inbred line (RIL) population derived from a cross between japonica Daguandao and indica IR28,and using the multiple interval mapping (MIM) *** results show that indica rice presented stronger seed vigor during the germination stage than japonica rice.A total of ten QTLs,and at least five novel alleles,were detected to control rice seed vigor,and the amount of variation (R2) explained by an individual QTL ranged from 7.5% to 68.5%,with three major QTLs with R2>20%.Most of the QTLs detected here are likely to coincide with QTLs for seed weight,seed size,or seed dormancy,suggesting that the rice seed vigor might be correlated with seed weight,seed size,and seed *** least five QTLs are novel alleles with no previous reports of seed vigor genes in rice,and those major or minor QTLs could be used to significantly improve the seed vigor by marker-assisted selection (MAS) in rice.

关键词： Rice Recombinant inbred line (RIL) population Seed vigor Quantitative trait locus (QTL) Germination

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Air entrainment of hydraulic jump aeration basin

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Journal of Hydrodynamics 2018年第5期30卷 962-965页

作者： Jian-hua Wu Yu Zhou Fei Ma College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

In order to avoid the cavitation damage and the decrease of the energy dissipation of the stepped spillways with a large unit discharge, the air entrainments of the hydraulic jump aeration basin （HJAB） are theoretically and experimentally investigated for the hydraulic-jump-stepped spillway developed by the authors. It is shown that the submerged degree of the hydraulic jump and the air concentration in the measuring section are all functions of the dimensionless discharge, the length and the end sill height of the H JAB. The submerged degree odecreases with the increase of the dimensionless discharge or the dimensionless length of the H JAB, but increases with the increase of the dimensionless height of the end sill of the HJAB. The flow regimes near the critical hydraulic jump, namely, at or= 1.0, have the best effect of the air entrainment for the flow at the measuring section and then that of the stepped spillway.

关键词： Air entrainment hydraulic jump hydraulic jump aeration basin stepped spillway submerged degree

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Analysis on life model of large sensor networks

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science China(Information sciences) 2013年第4期56卷 40-49页

作者： ZHU XiaoRong WANG Yong ZHU HongBo Wireless Comminication Key Lab of jiangsu province Nanjing University of Posts and Telecommunications Department of science PLA University of Science and Technology

A large sensor network needs multiple base stations(BSs) to collect data *** design effort often aims at maximizing the network *** lifetime of a network depends on,besides battery capacity,factors such as node density,sampling period and the partitioning of the network for the multiple base *** this paper,we propose a stochastic approach to finding the lifetime of large sensor networks with multiple BSs and randomly scattered *** begin by partitioning the network into regions by the Voronoi diagram method,one for each base *** then propose a method to find the minimum transmission range needed for guaranteeing network *** nodes connected,we derive the traffic rate of nodes at specific distance from the base *** on the traffic rate and energy consumption model,the lifetime distribution of a region is *** the results of individual regions,the network lifetime distribution is *** studies are presented and verified by computer simulation.

关键词： sensor networks lifetime distribution multiple base stations

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Approximate solving method of shock for nonlinear disturbed coupled Schrdinger system

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Applied Mathematics and Mechanics(English Edition) 2012年第12期33卷 1583-1594页

作者：姚静荪欧阳成陈丽华莫嘉琪 Department of Mathematics Anhui Normal University Faculty of science Huzhou Teacher College Department of Mathematics and Computer science Fuqing Branch of Fujian Normal University

A class of nonlinear disturbed coupled SchrSdinger systems is studied. The specific technique is used to relate the exact and approximate solutions. The correspond- ing typical coupled system is considered. An exact shock travelling solution is obtained by a mapping method. The travelling asymptotic solutions of the disturbed coupled SchrSdinger system are then found with an approximate method.

关键词： SchrSdinger system solitary wave asymptotic solution

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Effect of fretting amplitudes on fretting wear behavior of steel wires in coal mines

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Mining science and Technology 2010年第6期20卷 803-808页

作者： SHEN Yan, ZHANG Dekun, GE Shirong School of Materials science and Engineering, China University of Mining & Technology, Xuzhou 221116, China School of Materials science and Engineering China University of Mining & Technology Xuzhou 221116 China

Given that fretting wear causes failure in steel wires, we carried out tangential fretting wear tests of steel wires on a self-made fretting wear test rig under contact loads of 9 and 29 N and fretting amplitudes ranging from 5 to 180 μm. We observed morphologies of fretted steel wire surfaces on an S-3000N scanning electron microscope in order to analyze fretting wear mecha-nisms. The results show that the fretting regime of steel wires transforms from partial slip regime into mixed fretting regime and gross slip regime with an increase in fretting amplitudes under a given contact load. In partial slip regime, the friction coefficient has a relatively low value. Four stages can be defined in mixed fretting and gross slip regimes. The fretting wear of steel wires in-creases obviously with increases in fretting amplitudes. Fretting scars present a typical morphology of annularity, showing slight damage in partial slip regime. However, wear clearly increases in mixed fretting regime where wear mechanism is a combination of plastic deformation, abrasive wear and oxidative wear. In gross slip regime, more severe degradation is present than in the other regimes. The main fretting wear mechanisms of steel wires are abrasive wear, surface fatigue and friction oxidation.

关键词： steel wires fretting wear fretting amplitude fretting regime wear mechanism

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Indirect Adaptive Fuzzy and Impulsive Control of Nonlinear Systems

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International Journal of Automation and computing 2010年第4期7卷 484-491页

作者： Hai-Bo Jiang School of Mathematics Yancheng Teachers University Yancheng 224002 PRC

The problem of indirect adaptive fuzzy and impulsive control for a class of nonlinear systems is investigated. Based on the approximation capability of fuzzy systems, a novel adaptive fuzzy and impulsive control strategy with supervisory controller is developed. With the help of a supervisory controller, global stability of the resulting closed-loop system is established in the sense that all signals involved are uniformly bounded. Furthermore, the adaptive compensation term of the upper bound function of the sum of residual and approximation error is adopted to reduce the effects of modeling error. By the generalized Barbalat＇s lemma, the tracking error between the output of the system and the reference signal is proved to be convergent to zero Asymptotically. Simulation results illustrate the effectiveness of the proposed approach.

关键词： Fuzzy control adaptive control impulsive control generalized Barbalat's lemma.

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