Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited...
详细信息
Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.
Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide(LLO),leading to voltage and cap...
详细信息
Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide(LLO),leading to voltage and capacity ***,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room *** functional theory(DFT) calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry(DEMS) indicates that the CrxB complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li+migration,The voltage and capacity fading of the modified cathode(LLO-CrB) are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface(CEI) composed of balanced organic/inorganic ***,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g-1(with a retention rate of 95.1%).This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.
Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the s...
详细信息
Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.
By regarding the Newton constant GNand cosmological constant Λ as variables, in this paper we study the thermodynamics and phase transition of the Reissner-Nordstr o m anti-de Sitter(RN-Ad S) black hole with a global...
详细信息
By regarding the Newton constant GNand cosmological constant Λ as variables, in this paper we study the thermodynamics and phase transition of the Reissner-Nordstr o m anti-de Sitter(RN-Ad S) black hole with a global monopole within the framework of Ad S/CFT correspondence. We find interesting critical phenomena and phase behavior in the(grand)canonical ensembles of fixed( Q,V,C),( Φ,V,C) and( Q,V,μ). When the other parameters are fixed, the free energy decreases with the global monopole increases. In the( Q,V,C) ensemble,the range of the unstable region decreases with the increase of the global monopole. In the( Φ,V,C) ensemble, when Φ < Φc, the free energy appears as two branches, where the upper and lower branches correspond to low and high entropy, respectively. When( Q,V,μ) is fixed, a new zero-order phase transition occurs in the high-entropy phase and the low-entropy phase at certainμ-dependent temperatures. When μ increases to a certain value, this zero-order phase transition disappears. This certain value is negatively related to the magnitude of the global ***, we find that p-V criticality does not appear with the change of global ***, it is important to note that the CFT states of charged black holes with global monopoles do not correspond to van der Waals fluids. Finally, we find that charged black holes with global monopoles can better reflect thermodynamic phase transitions and critical phenomena under the Ad S/CFT correspondence. By adjusting the change of the global monopole, the thermodynamic phase transition will also change.
In current neural network algorithms for nuclide identification in high-background,poor-resolution detectors,traditional network paradigms including back-propagation networks,convolutional neural networks,recurrent ne...
详细信息
In current neural network algorithms for nuclide identification in high-background,poor-resolution detectors,traditional network paradigms including back-propagation networks,convolutional neural networks,recurrent neural networks,etc.,have been limited in research on γ spectrum analysis because of their inherent mathematical *** is difficult to make progress in terms of training data requirements and prediction *** contrast to traditional network paradigms,network models based on the transformer structure have the characteristics of parallel computing,position encoding,and deep stacking,which have enabled good performance in natural language processing tasks in recent ***,in this paper,a transformer-based neural network (TBNN) model is proposed to achieve nuclide identification for the first ***,the Geant4 program was used to generate the basic single-nuclide energy spectrum through Monte Carlo simulations.A multi-nuclide energy spectrum database was established for neural network training using random matrices of γ-ray energy,activity,and *** on the encoder–decoder structure,a network topology based on the transformer was built,transforming the 1024-channel energy spectrum data into a 32×32 energy spectrum sequence as the model *** experiments and adjustments of model parameters,including the learning rate of the TBNN model,number of attention heads,and number of network stacking layers,the overall recognition rate reached 98.7%.Additionally,this database was used for training AI models such as back-propagation networks,convolutional neural networks,residual networks,and long shortterm memory neural networks,with overall recognition rates of 92.8%,95.3%,96.3%,and 96.6%,*** indicates that the TBNN model exhibited better nuclide identification among these AI models,providing an important reference and theoretical basis for the practical application of transformers in the qualitative and quantitativ
Fine-grained sediments are widely distributed and constitute the most abundant component in sedimentary systems, thus the research on their genesis and distribution is of great significance. In recent years, fine-grai...
详细信息
Fine-grained sediments are widely distributed and constitute the most abundant component in sedimentary systems, thus the research on their genesis and distribution is of great significance. In recent years, fine-grained sediment gravity-flows(FGSGF) have been recognized as an important transportation and depositional mechanism for accumulating thick successions of fine-grained sediments. Through a comprehensive review and synthesis of global research on FGSGF deposition, the characteristics,depositional mechanisms, and distribution patterns of fine-grained sediment gravity-flow deposits(FGSGFD) are discussed, and future research prospects are clarified. In addition to the traditionally recognized low-density turbidity current and muddy debris flow, wave-enhanced gravity flow, lowdensity muddy hyperpycnal flow, and hypopycnal plumes can all form widely distributed FGSGFD. At the same time, the evolution of FGSGF during transportation can result in transitional and hybrid gravityflow deposits. The combination of multiple triggering mechanisms promotes the widespread development of FGSGFD, without temporal and spatial limitations. Different types and concentrations of clay minerals, organic matters, and organo-clay complexes are the keys to controlling the flow transformation of FGSGF from low-concentration turbidity currents to high-concentration muddy debris flows. Further study is needed on the interaction mechanism of FGSGF caused by different initiations, the evolution of FGSGF with the effect of organic-inorganic synergy, and the controlling factors of the distribution patterns of FGSGFD. The study of FGSGFD can shed some new light on the formation of widely developed thin-bedded siltstones within shales. At the same time, these insights may broaden the exploration scope of shale oil and gas, which have important geological significances for unconventional shale oil and gas.
To improve the wettability of hypereutectic Al−60Si alloy and enhance the mechanical properties of the joints,Al−60Si alloy was joined by ultrasonic soldering with Sn-9Zn solder,and a sound joint with in-situ Si parti...
详细信息
To improve the wettability of hypereutectic Al−60Si alloy and enhance the mechanical properties of the joints,Al−60Si alloy was joined by ultrasonic soldering with Sn-9Zn solder,and a sound joint with in-situ Si particle reinforcement was *** oxide film of Al−60Si alloy at the interface was identified by transmission electron microscopy(TEM)analysis as amorphous Al_(2)O_(3).The oxide of Si particles in the base metal was also *** oxide film of Al−60Si alloy was observed to be removed by ultrasonic vibration instead of holding *** particle-reinforced joints(35.7 vol.%)were obtained by increasing the ultrasonication *** maximum shear strength peaked at 99.5 MPa for soldering at 330℃with an ultrasonic vibration time of 50 s.A model of forming of Si particles reinforced joint under the ultrasound was proposed,and ultrasonic vibration was considered to promote the dissolution of Al and migration of Si particles.
To investigate the seasonal characteristics in air pollution in Chengdu,a single particle aerosol mass spectrometry was used to continuously observe atmospheric fine particulate matter during one-month periods in summ...
详细信息
To investigate the seasonal characteristics in air pollution in Chengdu,a single particle aerosol mass spectrometry was used to continuously observe atmospheric fine particulate matter during one-month periods in summer and winter,*** results showed that,apart from O_(3),the concentrations of other pollutants(CO,NO_(2),SO_(2),PM_(2.5)and PM_(10))were significantly higher in winter than in *** single particle aerosols were divided into seven categories:biomass burning(BB),coal combustion(CC),Dust,vehicle emission(VE),K mixedwith nitrate(K-NO_(3)),Kmixed with sulfate and nitrate(K-SN),and K mixedwith sulfate(K-SO_(4))*** highest contributions in both seasons were VE particles(24%).The higher contributions of K-SO_(4)(16%)and K-NO_(3)(10%)particles occurred in summer and winter,respectively,as a result of their different formation mechanisms.S-containing(KSO_(4)and K-SN),VE,and BB particles caused the evolution of pollution in both seasons,and they can be considered as targets for future pollution *** mixing of primary sources particles(VE,Dust,CC,and BB)with secondary components was stronger in winter than in *** summer,as pollution worsens,the mixing of primary sources particles with 62[NO_(3)]−weakened,but themixing with 97[HSO_(4)]−***,in winter,the mixing state of particles did not exhibit an obvious evolution *** potential source areas in summer were mainly distributed in the southern region of sichuan,while in winter,besides the southern region,the contribution of the western region cannot be ignored.
With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright *** regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to t...
详细信息
With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright *** regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry,***,there are very few studies on the combination of the two,and even fewer clinical studies have been reported in *** this review,the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized,and the discussion on the development prospects of this research direction will be ***,the working principles and advantages&disadvantages of several types of 3D printers,as well as the mechanism of stem cells in tissue engineering will be *** review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related *** the future,3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies,catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D ***,these developments will further advance the field of oral tissue engineering.
The Scandinavian (SCA) pattern is an important climate signal in regulating the variability of summer extreme precipitation (SEP) over the eastern slopes of the Tibetan Plateau (ESTP). There is a strong negative corre...
详细信息
The Scandinavian (SCA) pattern is an important climate signal in regulating the variability of summer extreme precipitation (SEP) over the eastern slopes of the Tibetan Plateau (ESTP). There is a strong negative correlation between the SCA pattern and SEP over the ESTP, with a correlation coefficient of -0.57. Moisture budget analysis showed that the dynamic component anomalies of both the zonal and vertical moisture advection induced by the SCA pattern play the dominant roles in extreme precipitation variability over the ESTP. These anomalies are solely linked to variations in zonal wind and vertical velocity. The anomalies of the SCA pattern propagate downstream through Rossby waves, leading to the formation of cyclonic circulations over northern East Asia and the Iranian Plateau. The westerlies on the southern side of these cyclonic circulations play a crucial role in influencing the development of significant anomalous westerlies over the ESTP. The anomalous westerlies bring climatologically moist air from the Tibetan Plateau (TP) to the ESTP, resulting in positive zonal moisture advection anomalies over the area. Furthermore, these anomalous westerlies transport climatologically warm air from the TP to the ESTP, leading to significant warm advection anomalies and vertical upward motion anomalies over the ESTP. The upward motion carries lower-tropospheric moisture upward, resulting in positive vertical moisture advection anomalies over the ESTP. The combination of these positive zonal and vertical moisture advection anomalies eventually leads to excessive SEP. (sic)(sic)(sic)(sic)(sic)(sic)(SCA)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). SCA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)-0.57. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), SCA
暂无评论