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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Achievable dual-strategy to stabilize Li-rich layered oxide interface by a one-step wet chemical reaction towards long oxygen redox reversibility

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Journal of Energy Chemistry 2025年第2期101卷 120-131页

作者： Bin He Yujie Dai Shuai Jiang Dawei Chen Xilong Wang Jie Song Dan Xiao Qian Zhao Yan Meng Wei Feng School of Mechanical Engineering Chengdu University Chongqing Institute of Metrology and Quality Inspection Institute of New Energy and Low-Carbon Technology Sichuan University

Oxygen release and electrolyte decomposition under high voltage endlessly exacerbate interfacial ramifications and structu ral degradation of high energy-density Li-rich layered oxide（LLO）,leading to voltage and capacity ***,the dual-strategy of Cr,B complex coating and local gradient doping is simultaneously achieved on LLO surface by a one-step wet chemical reaction at room *** functional theory（DFT） calculations prove that stable B-O and Cr-O bonds through the local gradient doping can significantly reduce the high-energy O 2p states of interfacial lattice O,which is also effective for the near-surface lattice O,thus greatly stabilizing the LLO surface,Besides,differential electrochemical mass spectrometry（DEMS） indicates that the CrxB complex coating can adequately inhibit oxygen release and prevents the migration or dissolution of transition metal ions,including allowing speedy Li+migration,The voltage and capacity fading of the modified cathode（LLO-CrB） are adequately suppressed,which are benefited from the uniformly dense cathode electrolyte interface（CEI） composed of balanced organic/inorganic ***,the specific capacity of LLO-CrB after 200 cycles at 1C is 209.3 mA h g-1（with a retention rate of 95.1%）.This dual-strategy through a one-step wet chemical reaction is expected to be applied in the design and development of other anionic redox cathode materials.

关键词： Interfacial oxygen Lithium-rich layered oxide cathode Local gradient doping One-step wet chemical reaction Surface coating

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong Huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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Holographic thermodynamics of a charged AdS black hole with a global monopole

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Communications in Theoretical Physics 2025年第2期77卷 148-160页

作者： Hebin Zheng Yunxian Chen Jian Tang School of Physics and Astronomy China West Normal University Department of Physics and Electronic science Aba Teachers College

By regarding the Newton constant GNand cosmological constant Λ as variables, in this paper we study the thermodynamics and phase transition of the Reissner-Nordstr o m anti-de Sitter(RN-Ad S) black hole with a global monopole within the framework of Ad S/CFT correspondence. We find interesting critical phenomena and phase behavior in the(grand)canonical ensembles of fixed( Q,V,C),( Φ,V,C) and( Q,V,μ). When the other parameters are fixed, the free energy decreases with the global monopole increases. In the( Q,V,C) ensemble,the range of the unstable region decreases with the increase of the global monopole. In the( Φ,V,C) ensemble, when Φ < Φc, the free energy appears as two branches, where the upper and lower branches correspond to low and high entropy, respectively. When( Q,V,μ) is fixed, a new zero-order phase transition occurs in the high-entropy phase and the low-entropy phase at certainμ-dependent temperatures. When μ increases to a certain value, this zero-order phase transition disappears. This certain value is negatively related to the magnitude of the global ***, we find that p-V criticality does not appear with the change of global ***, it is important to note that the CFT states of charged black holes with global monopoles do not correspond to van der Waals fluids. Finally, we find that charged black holes with global monopoles can better reflect thermodynamic phase transitions and critical phenomena under the Ad S/CFT correspondence. By adjusting the change of the global monopole, the thermodynamic phase transition will also change.

关键词： black holes AdS-CFT correspondence global monopole

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A nuclide identification method ofγspectrum and model building based on the transformer

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Nuclear science and Techniques 2025年第1期36卷 80-93页

作者： Fei Li Chu-Yang Luo Ying-Zi Wen Sheng Lv Feng Cheng Guo-Qiang Zeng Jian-Feng Jiang Bing-Hai Li College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610000China Applied Nuclear Technology in Geosciences Key Laboratory of sichuan province Chengdu 610000China Department of Physics Universitat Politècnica de CatalunyaBarcelona 08028Spain Airborne Survey and Remote Sensing Center of Nuclear Industry Shijiazhuang 050000China Hebei Key Laboratory of Airborne Detection and Remote Sensing Technology Shijiazhuang 050000China

In current neural network algorithms for nuclide identification in high-background,poor-resolution detectors,traditional network paradigms including back-propagation networks,convolutional neural networks,recurrent neural networks,etc.,have been limited in research on γ spectrum analysis because of their inherent mathematical *** is difficult to make progress in terms of training data requirements and prediction *** contrast to traditional network paradigms,network models based on the transformer structure have the characteristics of parallel computing,position encoding,and deep stacking,which have enabled good performance in natural language processing tasks in recent ***,in this paper,a transformer-based neural network (TBNN) model is proposed to achieve nuclide identification for the first ***,the Geant4 program was used to generate the basic single-nuclide energy spectrum through Monte Carlo simulations.A multi-nuclide energy spectrum database was established for neural network training using random matrices of γ-ray energy,activity,and *** on the encoder–decoder structure,a network topology based on the transformer was built,transforming the 1024-channel energy spectrum data into a 32×32 energy spectrum sequence as the model *** experiments and adjustments of model parameters,including the learning rate of the TBNN model,number of attention heads,and number of network stacking layers,the overall recognition rate reached 98.7%.Additionally,this database was used for training AI models such as back-propagation networks,convolutional neural networks,residual networks,and long shortterm memory neural networks,with overall recognition rates of 92.8%,95.3%,96.3%,and 96.6%,*** indicates that the TBNN model exhibited better nuclide identification among these AI models,providing an important reference and theoretical basis for the practical application of transformers in the qualitative and quantitativ

关键词： Nuclide identification Neural network Transformer

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New progresses of fine-grained sediment gravity-flow deposits and their importance for unconventional shale oil and gas plays

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Petroleum science 2025年第1期22卷 1-15页

作者： Tian Yang Ying-Lin Liu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Chengdu University of Technology) Institute of Sedimentary Geology Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of natural Resources Chengdu University of Technology

Fine-grained sediments are widely distributed and constitute the most abundant component in sedimentary systems, thus the research on their genesis and distribution is of great significance. In recent years, fine-grained sediment gravity-flows(FGSGF) have been recognized as an important transportation and depositional mechanism for accumulating thick successions of fine-grained sediments. Through a comprehensive review and synthesis of global research on FGSGF deposition, the characteristics,depositional mechanisms, and distribution patterns of fine-grained sediment gravity-flow deposits(FGSGFD) are discussed, and future research prospects are clarified. In addition to the traditionally recognized low-density turbidity current and muddy debris flow, wave-enhanced gravity flow, lowdensity muddy hyperpycnal flow, and hypopycnal plumes can all form widely distributed FGSGFD. At the same time, the evolution of FGSGF during transportation can result in transitional and hybrid gravityflow deposits. The combination of multiple triggering mechanisms promotes the widespread development of FGSGFD, without temporal and spatial limitations. Different types and concentrations of clay minerals, organic matters, and organo-clay complexes are the keys to controlling the flow transformation of FGSGF from low-concentration turbidity currents to high-concentration muddy debris flows. Further study is needed on the interaction mechanism of FGSGF caused by different initiations, the evolution of FGSGF with the effect of organic-inorganic synergy, and the controlling factors of the distribution patterns of FGSGFD. The study of FGSGFD can shed some new light on the formation of widely developed thin-bedded siltstones within shales. At the same time, these insights may broaden the exploration scope of shale oil and gas, which have important geological significances for unconventional shale oil and gas.

关键词： Fine-grained sediment gravity-flow Depositional mechanism Transportation and evolution Distribution pattern Shale oil and gas

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In-situ Si particle-reinforced joints of hypereutectic Al−60Si alloys by ultrasonic-assisted soldering

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中国有色金属学报 2025年第1期35卷 77-90页

作者： Yuan-xing LI Xiang-bo ZHENG Chao-zheng ZHAO Zong-tao ZHU Yu-jie BAI Hui CHEN Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

To improve the wettability of hypereutectic Al−60Si alloy and enhance the mechanical properties of the joints,Al−60Si alloy was joined by ultrasonic soldering with Sn-9Zn solder,and a sound joint with in-situ Si particle reinforcement was *** oxide film of Al−60Si alloy at the interface was identified by transmission electron microscopy(TEM)analysis as amorphous Al_(2)O_(3).The oxide of Si particles in the base metal was also *** oxide film of Al−60Si alloy was observed to be removed by ultrasonic vibration instead of holding *** particle-reinforced joints(35.7 vol.%)were obtained by increasing the ultrasonication *** maximum shear strength peaked at 99.5 MPa for soldering at 330℃with an ultrasonic vibration time of 50 s.A model of forming of Si particles reinforced joint under the ultrasound was proposed,and ultrasonic vibration was considered to promote the dissolution of Al and migration of Si particles.

关键词： hypereutectic Al−60Si alloy ultrasonic-assisted soldering Si particle reinforcement Sn−9Zn solder

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Insights into the seasonal characteristics of single particle aerosols in Chengdu based on SPAMS

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Journal of Environmental sciences 2025年第3期149卷 431-443页

作者： Junke Zhang Yunfei Su Chunying Chen Xinyi Fu Yuhan Long Xiaoxue Peng Xiaojuan Huang Gehui Wang Wei Zhang Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China Department of Environmental science&Engineering Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3)Fudan UniversityShanghai 200438China Key Lab of Geographic Information science of the Ministry of Education School of Geographic SciencesEast China Normal UniversityShanghai 200241China sichuan Ecological Environment Monitoring Station Chengdu 610091China

To investigate the seasonal characteristics in air pollution in Chengdu,a single particle aerosol mass spectrometry was used to continuously observe atmospheric fine particulate matter during one-month periods in summer and winter,*** results showed that,apart from O_(3),the concentrations of other pollutants(CO,NO_(2),SO_(2),PM_(2.5)and PM_(10))were significantly higher in winter than in *** single particle aerosols were divided into seven categories:biomass burning(BB),coal combustion(CC),Dust,vehicle emission(VE),K mixedwith nitrate(K-NO_(3)),Kmixed with sulfate and nitrate(K-SN),and K mixedwith sulfate(K-SO_(4))*** highest contributions in both seasons were VE particles(24%).The higher contributions of K-SO_(4)(16%)and K-NO_(3)(10%)particles occurred in summer and winter,respectively,as a result of their different formation mechanisms.S-containing(KSO_(4)and K-SN),VE,and BB particles caused the evolution of pollution in both seasons,and they can be considered as targets for future pollution *** mixing of primary sources particles(VE,Dust,CC,and BB)with secondary components was stronger in winter than in *** summer,as pollution worsens,the mixing of primary sources particles with 62[NO_(3)]−weakened,but themixing with 97[HSO_(4)]−***,in winter,the mixing state of particles did not exhibit an obvious evolution *** potential source areas in summer were mainly distributed in the southern region of sichuan,while in winter,besides the southern region,the contribution of the western region cannot be ignored.

关键词： Single particle aerosols Chemical composition Mixing state Regional transport Seasonal characteristics

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Development and application prospect of stem cell combined with 3D printing technology for oral disease

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BIOCELL 2025年第1期49卷 45-59页

作者： YIXIAN YOU YIHUNG LEE YUSHIN HU YOUHUI XU JOUCHEN CHEN WEI JIANG CHANGHAI LIU ENQIANG CHEN HONG TANG HUA ZHANG DONGBO WU Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu610041China West China College of Stomatology Sichuan UniversityChengdu610041China West China School of Medicine Sichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu610041China

With organ transplantation facing many dilemmas,tissue and organ regeneration as an alternative has bright *** regenerative medicine,Three-dimensional(3D)printing technology and stem cells has been widely applied to the treatment of diseases related to tissue or organ replacement in dentistry,***,there are very few studies on the combination of the two,and even fewer clinical studies have been reported in *** this review,the current oral tissue engineering in vivo and in vitro based on 3D printing and stem cell technology will be summarized,and the discussion on the development prospects of this research direction will be ***,the working principles and advantages&disadvantages of several types of 3D printers,as well as the mechanism of stem cells in tissue engineering will be *** review provides clinicians and researchers with the current state of research and trends in the combination of stem cells and 3D printing technology to treat oral-related *** the future,3D bioprinters are poised for ongoing innovation with the advancement of relevant technologies,catalyzing an increase in clinical studies focused on treating oral diseases using stem cells and 3D ***,these developments will further advance the field of oral tissue engineering.

关键词： Stem cells 3D printing Tissue engineering Oral diseases

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Influence of the Scandinavian Pattern on Summer Extreme Precipitation over the Eastern Slopes of the Tibetan Plateau

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ADVANCES IN ATMOSPHERIC scienceS 2025年第3期42卷 438-452页

作者： Chen, Quanliang Zhang, Ziqi Li, Yang Liao, Yujing Dong, Dandan Chengdu Univ Informat Technol Sch Atmospher Sci Plateau Atmospher & Environm Key Lab Sichuan Prov Chengdu 610225 Peoples R China Shaoxing Yuecheng Meteorol Bur Shaoxing 312000 Peoples R China Zhejiang Inst Meteorol Sci Hangzhou 310008 Peoples R China

The Scandinavian (SCA) pattern is an important climate signal in regulating the variability of summer extreme precipitation (SEP) over the eastern slopes of the Tibetan Plateau (ESTP). There is a strong negative correlation between the SCA pattern and SEP over the ESTP, with a correlation coefficient of -0.57. Moisture budget analysis showed that the dynamic component anomalies of both the zonal and vertical moisture advection induced by the SCA pattern play the dominant roles in extreme precipitation variability over the ESTP. These anomalies are solely linked to variations in zonal wind and vertical velocity. The anomalies of the SCA pattern propagate downstream through Rossby waves, leading to the formation of cyclonic circulations over northern East Asia and the Iranian Plateau. The westerlies on the southern side of these cyclonic circulations play a crucial role in influencing the development of significant anomalous westerlies over the ESTP. The anomalous westerlies bring climatologically moist air from the Tibetan Plateau (TP) to the ESTP, resulting in positive zonal moisture advection anomalies over the area. Furthermore, these anomalous westerlies transport climatologically warm air from the TP to the ESTP, leading to significant warm advection anomalies and vertical upward motion anomalies over the ESTP. The upward motion carries lower-tropospheric moisture upward, resulting in positive vertical moisture advection anomalies over the ESTP. The combination of these positive zonal and vertical moisture advection anomalies eventually leads to excessive SEP. (sic)(sic)(sic)(sic)(sic)(sic)(SCA)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic). SCA(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), (sic)(sic)(sic)(sic)(sic)-0.57. (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic), SCA

关键词： atmospheric circulation extreme precipitation Scandinavian pattern moisture budget (sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic)(sic) (sic)(sic)(sic)(sic)(sic)(sic)

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