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Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 246-261页

作者： Ai-Yu Nie Zhong-Hui Xiao Jia-Li Deng Na Li Li-Yuan Hao Sheng-Hao Li Xiao-Yu Hu College of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Infection Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are *** cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune *** a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in ***,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor *** To investigate the dual-regulation mechanism of cGAS-STING in *** This review was conducted according to the PRISMA *** study conducted a comprehensive search for articles related to HCC on PubMed and Web of science *** rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC *** All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 *** removing duplicates,remaining 964 records were ***,55 articles met the inclusion criteria and were included in this *** Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its *** cGAS-STING pathway activation will result in a suppressive tumor microenvironment.

关键词： Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology

Deep-sea oil and gas plow-type cable broadband wide-azimuth 3D seismic acquisition and imaging

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science China Earth sciences 2025年第3期68卷 683-701页

作者： Yunfei YE Li-Yun FU Lijun MI Chuncai CHEN Zhenhua JIAO Hanming GU Yu WU China national Offshore Oil Corporation Research Institute Co. Ltd. national Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) China Oilfield Services Limited School of Geophysics and Space Information China University of Geosciences (Wuhan) Sinopec Geophysical Research Institute Co. Ltd.

In recent years, significant advancements have been made in deep-sea broadband seismic acquisition and its support data processing technologies. Compared with traditional constant-depth flat-cable acquisition, variable-depth cable acquisition significantly differentiates frequency notches and enhances information complementarity between traces, effectively broadening the frequency band of acquired seismic data. Based on the international slanted cable technology, China has independently developed a plow-type cable seismic acquisition and imaging system: a combination of slanted and deep-deployed flat cables,along with a deghosting processing technique. This innovation optimizes the segmented depth variation of cables, further improving low-frequency response and broadening the high-frequency range. This paper extends the 2D technology into three dimensions, establishing an integrated technology system for deep-sea broadband, wide-azimuth seismic acquisition and imaging, consisting of three-ship and six-source acquisition equipments, 3D plow-type cable mat, blended acquisition design with rolling dual-random sources, and wavenumber-domain 3D deghosting techniques. Applications to two tectonic zones in the South China Sea demonstrate that the frequency band of seismic data is expanded from three octaves(8–85 Hz) by conventional acquisition and imaging methods to five octaves(2–130 Hz), significantly improving the data quality and imaging precision of deep structures. This advancement effectively supports the researches of fundamental geology, hydrocarbon accumulation,reservoir prediction, and fluid identification in deep-water basins. The successful deployment of these technologies has advanced China's deep-sea oil and gas exploration and has been generalized to more than ten international deep-sea oilfields.

关键词： Deep-sea oil and gas Broadband wide-azimuth 3D plow-type cable deployment Three-ship six-source blended acquisition Deghosting

Uncovering the oxidation mechanism of sphalerite(ZnS)in the absence and presence of water:A first-principles investigation

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International Journal of Mining science and technology 2025年第1期35卷 149-157页

作者： Yuanjia Luo Wei Sun Haisheng Han Jian Peng Feng Jiang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

Herein,a first-principles investigation was innovatively conducted to research the surface oxidation of ZnS-like sphalerite in the absence and presence of H_(2)O .The findings showed that single O_(2) was preferred to be dissociated adsorption on sphalerite surface by generating SAO and Zn AO bonds,and the S atom on the surface was the most energy-supported site for O_(2) adsorption,on which a≡Zn-O-S-O-Zn≡structure will be ***,dissociated adsorption of single H_(2)O will not *** was preferred to be adsorbed on the top Zn atom on sphalerite surface in molecular form through Zn-O ***,sphalerite oxidation can occur as if O_(2) was present regardless of the presence of H_(2)O ,and when H_(2)O and O_(2) coexisted,the formation of sulfur oxide(SO_(2) )needed a lower energy barrier and it was easier to form on sphalerite surface than that only O_(2) *** the absence of H_(2)O ,when SO_(2) was generated,further oxidation of which would form neutral zinc *** the presence of H_(2)O ,the formation of SO_(2) on sphalerite surface was easier and the rate of further oxidation to form sulfate was also ***,the occurrence of sphalerite oxidation was accelerated.

关键词： First-principles Oxidation Sphalerite H_(2)O Lower energy barrier

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Experimental study of dual nano-network, high-temperature resistant aerogel material as an integration of thermal management functions

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Journal of Energy Chemistry 2025年第1期100卷 157-170页

作者： Yueyue Xiao Tianke Mao Zun Zhao Yuelei Pan Heping Zhang Xudong Cheng State Key Laboratory of Fire science University of Science and Technology of ChinaHefei 230026AnhuiChina

Thermal management system is highly desirable to guarantee the performance and thermal safety of lithium-ion batteries,but it reduces the energy density of battery modules and even is unable to provide highly effective ***,a thermal management function integrated material is presented based on high-temperature resistant aerogel and phase change material and is applied at both charge–discharge process and thermal runaway *** this sandwich structure Paraffin@SiC nanowire/Aerogel sheet (denoted as PA@SAS) system,SiC nanowires endow the middle aerogel sheet (SAS) a dual nano-network *** enhanced mechanical properties of SAS were studied by compressive tests and dynamic mechanical ***,the thermal conductivity of SAS at 600°C is only 0.042 W/(m K).The surface phase change material layers facilitate temperature uniformity of batteries (surface temperature difference less than 1.82°C) through latent ***,a large-format battery module with four 58 Ah LiNi0.5Co0.2Mn0.3O2LIBs was ***@SAS successfully prevents thermal runaway propagation,yielding a temperature gap of 602°C through the 2 mm-thick cross ***@SAS also exhibits excellent performance in other safety issues such as temperature rise rate,flame heat flux,*** lightweight property and effective insulation performance achieves significant safety enhancement with mass and volume energy density reduction of only 0.79%and 5.4%,*** originality of the present research stems from the micro and macro structure design of the proposed thermal management material and the combination of intrinsic advantages of every *** work provides a reliable design of achieving the integration of thermal management functions into an aerogel composite and improves the thermal safety of lithium-ion batteries.

关键词： Thermal management Lithium-ionbatteries Aerogel High temperature thermal insulation

Short-TermWind Power Forecast Based on STL-IAOA-iTransformer Algorithm:A Case Study in Northwest China

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Energy Engineering 2025年第2期122卷 405-430页

作者： Zhaowei Yang Bo Yang Wenqi Liu Miwei Li Jiarong Wang Lin Jiang Yiyan Sang Zhenning Pan Faculty of science Kunming University of Science and TechnologyKunming650500China Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming650500China Department of Electrical Engineering and Electronics University of LiverpoolLiverpoolL693GJUK College of Electrical Engineering Shanghai University of Electric PowerShanghai200090China School of Electric Power Engineering South China University of TechnologyGuangzhou510640China

Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart *** numerous studies have employed various methods to forecast wind power,there remains a research gap in leveraging swarm intelligence algorithms to optimize the hyperparameters of the Transformer model for wind power *** improve the accuracy of short-term wind power forecast,this paper proposes a hybrid short-term wind power forecast approach named STL-IAOA-iTransformer,which is based on seasonal and trend decomposition using LOESS(STL)and iTransformer model optimized by improved arithmetic optimization algorithm(IAOA).First,to fully extract the power data features,STL is used to decompose the original data into components with less redundant *** extracted components as well as the weather data are then input into iTransformer for short-term wind power *** final predicted short-term wind power curve is obtained by combining the predicted *** improve the model accuracy,IAOA is employed to optimize the hyperparameters of *** proposed approach is validated using real-generation data from different seasons and different power stations inNorthwest China,and ablation experiments have been ***,to validate the superiority of the proposed approach under different wind characteristics,real power generation data fromsouthwestChina are utilized for *** results with the other six state-of-the-art prediction models in experiments show that the proposed model well fits the true value of generation series and achieves high prediction accuracy.

关键词： Short-termwind power forecast improved arithmetic optimization algorithm iTransformer algorithm SimuNPS

Optimization of lithium extraction solar pond in Zabuye Salt Lake: Theoretical calculation combined with field experiments

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China Geology 2025年第1期8卷 26-38页

作者： Tao Ding Zhen Nie Qian Wu Jiang-jiang Yu Ling-zhong Bu Yun-sheng Wang En-yuan Xing Mian-ping Zheng Yu-bin Li MNR Key Laboratory of Saline Lake Resources and Environments Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China College of Engineering Tibet UniversityLhasa 850000China

This research optimized the structure of lithium extraction solar ponds to enhance the crystallization rate and yield of Li_(2)CO_(3).Using the response surface methodology in Design-Expert 10.0.3,the authors conducted experiments to investigate the influence of four factors related to solar pond structure on the crystallization of Li_(2)CO_(3) and their pairwise *** Fluid Dynamics(CFD)simulations of the flow field within the solar pond were performed using COMSOL Multiphysics software to compare temperature distributions before and after *** results indicate that the optimal structure for lithium extraction from the Zabuye Salt Lake solar ponds includes UCZ(Upper Convective Zone)thickness of 53.63 cm,an LCZ(Lower Convective Zone)direct heating temperature of 57.39℃,a CO32−concentration of 32.21 g/L,and an added soda ash concentration of 6.52 g/*** this optimized pathway,the Li_(2)CO_(3) precipitation increased by 7.34% compared to the initial solar pond process,with a 33.33% improvement in lithium carbonate crystallization *** study demonstrates the feasibility of optimizing lithium extraction solar pond structures,offering a new approach for constructing such ponds in salt *** provides valuable guidance for the efficient extraction of lithium resources from carbonate-type salt lake brines.

关键词： Salt lake Solar pond Lithium extraction Crystallization rate Box-Behnken Computational fluid dynamics Response surface Zabuye salt lake Mineral exploration engineering

AvERF73 positively regulates waterlogging tolerance in kiwifruit by participating in hypoxia response and mevalonate pathway

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Horticultural Plant Journal 2025年第1期11卷 162-174页

作者： Danfeng Bai Yunpeng Zhong Shichao Gu Xiujuan Qi Leiming Sun Miaomiao Lin Ran Wang Yukuo Li Chungen Hu Jinbao Fang national Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crop Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China Key Laboratory of Horticultural Plant Biology College of Horticulture&Forestry Sciences of Huazhong Agricultural UniversityWuhanHubei 430070China

Waterlogging stress is one of the greatest environmental threats to kiwifruit growth and ***-VII proteins have been demonstrated to play pivotal roles in regulating plant tolerance to ***,the genome-wide role of ERF-VII in kiwifruit waterlogging stress tolerance remains ***,we report the function and regulatory network of an ERF-VII transcription factor located to the nucleus,Av ERF73,in kiwifruit waterlogging *** of Av ERF73 in Arabidopsis thaliana and *** *** enhanced waterlogging tolerance in transgenic ***,we performed transcriptome analysis(RNA-seq)and DNA affinity purification sequencing(DAP-seq)to explore the regulatory mechanism of Av ***-seq coupled with DAP-seq showed that Av ERF73 might directly activate Ac NAC022 involved in the“cellular response to hypoxia”process and Ac HMGS1 involved in the mevalonate pathway to respond to waterlogging,which were also confirmed by a dual-luciferase reporter *** on our results,we propose a putative working model for controlling waterlogging tolerance by Av ERF73 in kiwifruit.

关键词： Actinidia ERF-VII Waterlogging stress RNA-seq DAP-seq

Advances on ALV-J in China over the past two decades

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Journal of Integrative Agriculture 2025年第2期24卷 429-440页

作者： Wenrui Fan Yuntong Chen Mengmeng Yu Yongzhen Liu Yulong Gao Avian Immunosuppressive Diseases Division State Key Laboratory for Animal Disease Control and PreventinonHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose Yangzhou University

Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999, spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens. ALV-J typically induces myeloid leukosis in infected chickens, but also induces a high proportion of hemangiomas in infected layer chickens, posing a serious threat to poultry breeds in China. As a retrovirus, the genome of ALV-J has undergone significant mutations, which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J. Over the last two decades, the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry. Specialized detection assays have been developed to combat ALV-J infections in China. Additionally, ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections. This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.

关键词： subgroup J avian leucosis epidemiology molecular variation pathogenicity prevention and control