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A systematic review of phytochemicals from Chinese herbal medicines for non-coding RNAs-mediated cancer prevention and treatment:From molecular mechanisms to potential clinical applications

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Medicine in Novel technology and Devices 2022年第4期16卷 364-379页

作者： Wenjuan Zhai Yu Hu Ying Zhang Guiyu Zhang Haipeng Chen Xuanjing Tan Yuting Zheng Wenhui Gao Yijie Wei Jinjun Wu Guangdong Provincial key Laboratory of Translational Cancer Research of Chinese Medicines Joint International Research Laboratory of Translational Cancer Research of Chinese MedicinesInternational Institute for Translational Chinese MedicineSchool of Pharmaceutical SciencesGuangzhou University of Chinese MedicineGuangzhouGuangdong510006China Affiliated Cancer Hospital&Institute of Guangzhou Medical University GuangzhouGuangdong510095China

Worldwide,cancer is a growing epidemic that results in large social and economic *** advances in current diagnosis and treatment,most of the prognosis in cancer patients remains *** is urgent to find alternative therapies with effective cancer prevention and *** herbal medicines(CHMs)have been increasingly used worldwide for cancer prevention and treatment due to their privileged *** are useful in the suppression of various types of cancers through different mechanisms of ***-coding RNAs(ncRNAs),including microRNAs,long non-coding RNAs and circular RNAs,are closely involved in the cancer progression and *** of ncRNAs in tumor cells may be a useful pharmacological strategy for the cancer prevention and *** evidence exists that various phytochemicals from CHMs exert potent anticarcinogenic effects by regulating ncRNAs-related targets and signaling ***,the purpose of this paper is to conclude the current understanding of phytochemicals from CHMs in ncRNAs-mediated cancer suppression and the molecular *** review will help to provide beneficial clues related to the clinical use of CHMs in the cancer prevention and treatment and further promote new drug discovery against cancer.

关键词： Chinese herbal medicines Phytochemicals Non-coding RNAs Cancer prevention and treatment

An efficient protocol for studying human pluripotent stem cell-derived myotube senescence

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Biophysics Reports 2023年第5期9卷 232-240页

作者： Qian Zhao Ying Jing Shuai Ma Weiqi Zhang Jing Qu Si Wang Guang-Hui Liu Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Aging Translational Medicine Center International Center for Aging and Cancer Beijing Municipal Geriatric Medical Research Center Xuanwu Hospital Capital Medical University State key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine Institute for Stem Cell and Regeneration CAS University of Chinese Academy of sciences CAS key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics and China National Center for Bioinformation Chinese Academy of Sciences Sino-Danish College University of Chinese Academy of Sciences Sino-Danish Center for Education and Research State key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences

Sarcopenia, an age-related skeletal muscle condition characterized by a progressive decline in muscle mass and function, is linked to increased vulnerability, a higher likelihood of falls, and higher mortality rates in older individuals. A comprehensive understanding of the intricate mechanisms driving skeletal muscle aging is of great significance in both scientific and clinical fields. Consequently, myotube models that facilitate studying regulatory mechanisms underlying skeletal muscle aging are important tools required to advance intervention strategies against skeletal muscle aging and associated ***, we provide a detailed protocol to generate human pluripotent stem cells-derived myotubes and describe their applications in aging studies, as well as a troubleshooting for potential problems. Overall,this protocol serves as a valuable methodological reference for exploring the role and mechanism of genes involved in skeletal muscle aging.

关键词： Human pluripotent stem cell Myotube Senescence Differentiation In vitro

Comparison of Micro-morphological Characteristics of Four Triticeae Species in Gramineae

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Agricultural science & technology 2008年第6期9卷 97-101页

作者：张燕林小虎周印富秦素平张珊珊王秋涛河北科技师范学院河北秦皇岛066004 河北省保定职业技术学院河北保定071000

[Objective] This study was to investigate the difference in microscopic features of pollen grain and stoma of four triticeae species, as well as the relationship between the sizes of pollen grain and stoma, and the chromosome ploidy. [Method] Comparison of the micro-morphological characteristics of pollen grain and leaf epiderm among diaploid Thinopyrum elongatum, Elytrigia intermedia, hexaploid Triticum aestivum and octoploid Tritielytrigia types were carried out by observation under scanning electronic microscope(SEM). [Result] There were some differences among the four species in the micro-morphology, the size, the surface protuberance, the germ pore of pollen grain and the leaf epidermal stoma, in which diploid Thinopyrum elongatum was obviously different from the other three. Diploid, hexaploid and octoploid species of triticeae had remarkable differences in micro-morphological characteristics of pollen grain and stoma. However, some differences between hexaploid species and octoploid species were not significant. [Conclusion] Some microscopic characteristics of pollen grain and stoma could be used as the evidence to identify diaploid, hexaploid and octoploid spieces whose chromosome ploidy are hugely different.

关键词： Triticeae Microscopic characteristics Scanning electronic microscope (SEM)

肾周脂肪的产热活性促进肾透明细胞癌的进展并影响肿瘤治疗效果

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中华医学杂志 2021年第46期101卷 3832-3832页

作者：杨濛(编译) 张宗勤(编译) Wei G Sun HL Dong K 海军军医大学第二附属医院泌尿外科不详

肾细胞癌(RCC)是一种常见的致命恶性肿瘤,占所有成人癌症的2%以上,根据组织学和细胞遗传学特征,80%的肾细胞癌被细分为透明细胞肾细胞癌(ccRCC)。肾周脂肪组织(PAT)是一种位于肾筋膜和肾包膜之间的白色脂肪组织(WAT)。在肿瘤发生过程中,... 详细信息

肾细胞癌(RCC)是一种常见的致命恶性肿瘤,占所有成人癌症的2%以上,根据组织学和细胞遗传学特征,80%的肾细胞癌被细分为透明细胞肾细胞癌(ccRCC)。肾周脂肪组织(PAT)是一种位于肾筋膜和肾包膜之间的白色脂肪组织(WAT)。在肿瘤发生过程中,ccRCC细胞可穿透肾包膜并进入PAT,与肾癌预后不良相关。然而,ccRCC和PAT之间的相互作用还没有得到很好的研究。研究者通过对ccRCC细胞和PAT之间双向通信的深入探究发现,ccRCC细胞通过旁分泌模式分泌甲状旁腺激素相关蛋白(PTHrP)激活PKA途径驱动邻近的PAT褐变,使褐色变的肾周脂肪细胞代谢增强并释放大量的代谢产物,其中过量的乳酸被释放到肿瘤微环境中,从而促进ccRCC的生长、侵袭和转移,构成了一种新的促进ccRCC肿瘤生长的可能机制。该研究提示肾癌手术中切除邻近脂肪组织可能会阻止褐色脂肪细胞的代谢产物流动,从而改善手术后的预后。

关键词：肾透明细胞癌肿瘤微环境肾包膜肾细胞癌肾周脂肪甲状旁腺激素相关蛋白分泌模式肾筋膜

Wuzi Yanzong prescription(五子衍宗丸)from Traditional Chinese Medicine for male infertility:a narrative review

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Journal of Traditional Chinese Medicine 2023年第2期43卷 416-428页

作者： CHEN Zhimin AO Mingyue LIAO Yujiao YU Lingying YANG Zhuo HU Lin LI Wenbing HU Changjiang GAO Yongxiang Department of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Department of Pharmacy Chengdu Women’s&Children’s Central HospitalChengdu 610074China Institute of Qinghai-tibetan Plateau Southwest Minzu UniversityChengdu 610041China

Wuzi Yanzong prescription(WYP),as a classical prescription for male infertility with kidney essence deficiency,is composed of Gouqizi(Fructus Lycii),Tusizi(Semen Cuscutae),Wuweizi(Fructus Schisandrae Chinensis),Fupenzi(Fructus Rubi Chingii)and Cheqianzi(Semen Plantaginis).It has been used for hundreds of years in the treatment of male infertility,known as“the first prescription of ancient and modern seeds”,with convincing clinical *** present,more than 100 chemical compounds have been isolated from WYP,including polysaccharide,fatty acids,flavonoids,phenylpropanoids,organic acids,alkaloids,terpenoids,*** and clinical studies show that WYP has an obvious effect on reproductive system diseases,especially male infertility,which has a very wide application *** also has effects on the nervous system,inhibiting liver injury,lowering blood sugar and blood lipid,anti-aging,improving immunity,resisting hypoxia and fatigue *** study reviewed the chemical constituents,quality control,pharmacology,and clinical application of *** is no doubt about the clinical value of WYP,but its quality control system is not perfect,pharmacological mechanism is not fully explained,and clinical applications need to be ***,the follow-up researches should proceed from the theory of Traditional Chinese Medicine(TCM)and clinical applications,further explain the theoretical connotation,reveal the mechanism of action,and provide the basis for the secondary development of classic famous *** addition,WYP is mostly used in combination with western medicines besides being used *** it can improve the efficacy and reduce side effects will also be a meaningful research direction in the future.

关键词： quality control pharmacology clinical applications chemical constituents Wuzi Yanzong prescription review

Effects of Storage Methods and Time on Content of Nutrients in Biogas Slurry of Straw

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Agricultural science & technology 2014年第11期15卷 1995-1997页

作者：边文范张柏松王艳芹马征田叶徐长英郑福丽郭洪海山东省农业科学院农业资源与环境研究所山东济南250100

To study the effects of different storage methods and time on content of nutrients in biogas slurry of straw, two storage methods were carried out on biogas slurry between open storage and airtight storage conditions at normal atmospheric temperature. The contents of N, P, K, and organic matter in biogas slurry of straw were determined in different storage times. The results showed that： during the pro-cess of biogas slurry storage, little change occurred in the content of the organic matter while the total content of N, P, K significantly declined; up to 50 days, the total content of N, P, K reduced to nearly 80%-90%. Because the contents of N, P, K in biogas slurry reduced less in airtight storage conditions so that a better re-sult was found on airtight storage methods than open storage methods in fertilizer field of biogas slurry of straw.

关键词： Biogas slurry of straw Storage method Time Content of nutrients

Self-consistent Sources and Conservation Laws for Sup er-Geng Equation Hierarchy

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Chinese Quarterly Journal of Mathematics 2016年第2期31卷 201-210页

作者： WEI Han-yu CUI Zhong-yuan XIA Tie-cheng College of Mathematics and Statistics Zhoukou Normal University Zhoukou 466001 China Col-lege of Computer science and technology Zhoukou Normal University Zhoukou 466001 China De-partment of Mathematics Shanghai University Shanghai 200444 China

Based on the matrix Lie super algebra and supertrace identity, the integrable super-Geng hierarchy with self-consistent is established. Furthermore, we establish the infinitely many conservation laws for the integrabl... 详细信息

关键词： supertrace identity self-consistent sources conservation laws super-Geng hierarchy

艾拉片对重复束缚应激所致勃起功能障碍小鼠的治疗作用（英文）

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Journal of Chinese Pharmaceutical sciences 2021年第11期30卷 883-894页

作者：高泽宇陈君阿依努尔·热合曼孙懿吴涛希尔艾力·吐尔逊蒲小平阿吉艾克拜尔·艾萨赵欣北京大学药学院天然药物及仿生药物国家重点实验室北京大学药学院分子与细胞药理学系中国科学院新疆理化技术研究所干旱区植物资源与化学重点实验室中国科学院大学新疆医科大学维吾尔医学院

艾拉片是由经典维医方药Majun Mupakhi Ela优化提取制备得到的。该方一直用于阳痿的治疗,但艾拉片的具体适应证和治疗机制尚不清楚。本研究拟探讨艾拉片对重复束缚应激所致勃起功能障碍(ED)小鼠的保护作用及其可能机制。每天将小鼠置于... 详细信息

艾拉片是由经典维医方药Majun Mupakhi Ela优化提取制备得到的。该方一直用于阳痿的治疗,但艾拉片的具体适应证和治疗机制尚不清楚。本研究拟探讨艾拉片对重复束缚应激所致勃起功能障碍(ED)小鼠的保护作用及其可能机制。每天将小鼠置于束缚盒中连续14天,并在束缚前1小时给予艾拉片。第14日晚进行交配实验。此后,收集血液、睾丸和阴茎样本,测定血清睾酮水平,HE染色观察睾丸组织形态,免疫印迹法检测磷酸二脂酶5(PDE5)在海绵体中的表达变化情况。结果表明,艾拉片能显著缩短性唤起时间,增加性接触次数,维持睾丸组织的正常形态,提高血清睾酮水平,降低阴茎海绵体PDE5的表达。综上,艾拉片对重复束缚应激小鼠的性能力具有保护作用,其机制与保护睾丸组织形态、维持睾酮水平及抑制阴茎PDE5表达有关。

关键词：艾拉片勃起功能障碍重复束缚应激

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焦虑障碍青少年的反应抑制性的探讨(英文)

教育生物学杂志 2013年第2期1卷 95-105页

作者：张劲松王新程文红刘漪上海交通大学医学院附属新华医院儿童与青少年保健科临床心理科上海市环境与儿童健康重点实验室上海200092 上海交通大学医学院上海市精神卫生中心上海200030

目的探讨13~16岁患焦虑障碍(anxiety disorders,ANX)的青少年有关刺激反应的调控机制,采用Go/NoGo任务。方法记录和分析事件相关电位(event-related potentials,ERP)的N2和P3成分,进行多元方差分析、t检验和相关分析。结果在完成Go任务... 详细信息

目的探讨13~16岁患焦虑障碍(anxiety disorders,ANX)的青少年有关刺激反应的调控机制,采用Go/NoGo任务。方法记录和分析事件相关电位(event-related potentials,ERP)的N2和P3成分,进行多元方差分析、t检验和相关分析。结果在完成Go任务和NoGo任务中,NoGo-N2潜伏期长于Go-N2潜伏期[F(1,26)=4.61,P0.05]。NoGo-P3潜伏州比Go-P3潜伏期长[F(1,26)=8.98,P0.05]。ANX组的P3比对照组的P3小,NoGo任务的组间效应有显著性[F(1,26)=4.24,P=0.05],提示在对刺激的评价和做决定时,焦虑障碍患者可能有缺陷,尤其在脑的额-中部和中部区域。此外,用儿童焦虑量表(SCARD)评估,Pearson’s相关系数进行分析,焦虑的严重程度与P3波幅呈负相关性(除外NoGo-Fz),焦虑较高。结论在冲突监测和反应抑制中,除对外刺激反应时间较长,ANX青少年没有明显的缺陷,而是在评估和做决定的过程中有明显缺陷。此外,对于焦虑。

关键词：事件相关电位(ERPs) 焦虑障碍青少年 Go/NoGo N2 P3