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Emerging role of vitamin D_(3)in alleviating intestinal structure injury caused by Aeromonas hydrophila in grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第1期16卷 202-217页

作者： Yao Zhang Xiao-Qiu Zhou Wei-Dan Jiang Pei Wu Yang Liu Hong-Mei Ren Lu Zhang Hai-Feng Mi Ling Tang Cheng-Bo Zhong Lin Feng Animal Nutrition Institute Sichuan Agricultural UniversityChengduChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengduChina Key Laboratory for Animal Disease-Resistant Nutrition of China Ministry of Education Sichuan Agricultural UniversityChengduChina Healthy Aquaculture Key Laboratory of Sichuan Province Tongwei Co.Ltd.ChengduChina Sichuan Animal Science Academy Sichuan Animtech Feed Co.Ltd.ChengduChina

Bacterial pathogens destroy the structural integrity of functional organs in fish,leading to severe challenges in the aquaculture *** D_(3)(VD_(3))prevents bacterial infections and strengthens immune system function via vitamin D receptor(VDR).However,the correlation between VD_(3)/VDR and the structural integrity of functional organs remains *** study aimed to investigate the influence of VD_(3)supplementation on histological characteristics,apoptosis,and tight junction characteristics in fish intestine during pathogen infection.A total of 540 healthy grass carp(257.24±0.63 g)were fed different levels of VD_(3)(15.2,364.3,782.5,1,167.9,1,573.8,and 1,980.1 IU/kg)for 70 ***,fish were challenged with Aeromonas hydrophila,a pathogen that causes intestinal *** present study demonstrated that optimal supplementation with VD_(3)(1)alleviated intestinal structural damage,and inhibited oxidative damage by reducing levels of oxidative stress biomarkers;(2)attenuated excessive apoptosisrelated death receptor and mitochondrial pathway processes in relation to p38 mitogen-activated protein kinase signaling(P<0.05);(3)enhanced tight junction protein expression by inhibiting myosin light chain kinase signaling(P<0.05);and(4)elevated VDR isoform expression in fish intestine(P<0.05).Overall,the results demonstrated that VD_(3)alleviates oxidative injury,apoptosis,and the destruction of tight junction protein under pathogenic infection,thereby strengthening pathogen defenses in the *** finding supports the rationale for VD_(3)intervention as an essential practice in sustainable aquaculture.

关键词： Aeromonas hydrophila Antibacterial property Grass carp(Ctenopharyngodon idella) Intestinal health Vitamin D_(3)

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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp(Ctenopharyngodon idella):in vitro and in vivo studies

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1638-1656页

作者： Piao Zhao Lin Feng Weidan Jiang Pei Wu Yang Liu Hongmei Ren Xiaowan Jin Lu Zhang Haifeng Mi Xiaoqiu Zhou Animal Nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130SichuanChina Key Laboratory of Animal Disease‑Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan ProvinceChengdu 611130SichuanChina Tongwei Co. Ltd.Healthy Aquaculture Key Laboratory of Sichuan ProvinceChengdu 610041SichuanChina

Background Ochratoxin A(OTA),a globally abundant and extremely hazardous pollutant,is a significant source of contamination in aquafeeds and is responsible for severe food *** developmental toxicity of OTA and the potential relieving strategy of natural products remain *** study screened the substance curcumin(Cur),which had the best effect in alleviating OTA inhibition of myoblast proliferation,from 96 natural products and investigated its effect and mechanism in reducing OTA myotoxicity in vivo and in *** A total of 720 healthy juvenile grass carp,with an initial average body weight of 11.06±0.05 g,were randomly assigned into 4 groups:the control group(without OTA and Cur),1.2 mg/kg OTA group,400 mg/kg Cur group,and 1.2 mg/kg OTA+400 mg/kg Cur *** treatment consisted of 3 replicates(180 fish)for 60 *** Firstly,we cultured,purified,and identified myoblasts using the tissue block culture *** preliminary screening and re-screening of 96 substances,we examined cell proliferation-related indicators such as cell viability and ultimately found that Cur had the best ***,Cur could alleviate OTA-inhibited myoblast differentiation and myofibrillar development-related proteins(Myo G and MYHC)in vivo and in vitro and improve the growth performance of grass ***,Cur could also promote the expression of OTA-inhibited protein synthesis-related proteins(S6K1 and TOR),which was related to the activation of the AKT/TOR signaling ***,Cur could downregulate the expression of OTA-enhanced protein degradation-related genes(murf1,foxo3a,and ub),which was related to the inhibition of the Fox O3a signaling *** In summary,our data demonstrated the effectiveness of Cur in alleviating OTA myotoxicity in vivo and in *** study confirms the rapidity,feasibility,and effectiveness of establishing a natural product screening method targeting myoblasts to alleviate fungal toxin toxicity.

关键词： Curcumin Grass carp Myotoxic Ochratoxin A Protein deposition

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Causal reasoning in typical computer vision tasks

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Science China(Technological Sciences) 2024年第1期67卷 105-120页

作者： ZHANG KeXuan SUN QiYu ZHAO ChaoQiang TANG Yang Key Laboratory of Advanced Control and Optimization for Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China national Key Laboratory of Air based Information Perception and Fusion Luoyang 471000China Luoyang Institute of Electro Optical Equipment of Avic Luoyang 471000China

Deep learning has revolutionized the field of artificial *** on the statistical correlations uncovered by deep learning-based methods,computer vision tasks,such as autonomous driving and robotics,are growing *** being the basis of deep learning,such correlation strongly depends on the distribution of the original data and is susceptible to uncontrolled *** the guidance of prior knowledge,statistical correlations alone cannot correctly reflect the essential causal relations and may even introduce spurious *** a result,researchers are now trying to enhance deep learningbased methods with causal *** theory can model the intrinsic causal structure unaffected by data bias and effectively avoids spurious *** paper aims to comprehensively review the existing causal methods in typical vision and visionlanguage tasks such as semantic segmentation,object detection,and image *** advantages of causality and the approaches for building causal paradigms will be *** roadmaps are also proposed,including facilitating the development of causal theory and its application in other complex scenarios and systems.

关键词： causal reasoning computer vision tasks vision-language tasks semantic segmentation object detection

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A survey on blockchain-enabled federated learning and its prospects with digital twin

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Digital Communications and Networks 2024年第2期10卷 248-264页

作者： Kangde Liu Zheng Yan Xueqin Liang Raimo Kantola Chuangyue Hu State Key Lab on Integrated Services Network School of Cyber EngineeringXidian UniversityXi'anChina Department of Communications and Networking Aalto UniversityEspooFinland Yangtze Delta Region Blockchain Technology Research Institute JiaxingChina

Digital Twin(DT)supports real time analysis and provides a reliable simulation platform in the Internet of Things(IoT).The creation and application of DT hinges on amounts of data,which poses pressure on the application of Artificial Intelligence(AI)for DT descriptions and intelligent *** Learning(FL)is a cutting-edge technology that enables geographically dispersed devices to collaboratively train a shared global model locally rather than relying on a data center to perform model ***,DT can benefit by combining with FL,successfully solving the"data island"problem in traditional ***,FL still faces serious challenges,such as enduring single-point failures,suffering from poison attacks,lacking effective incentive *** the successful deployment of DT,we should tackle the issues caused by *** from industry and academia have recognized the potential of introducing Blockchain Technology(BT)into FL to overcome the challenges faced by FL,where BT acting as a distributed and immutable ledger,can store data in a secure,traceable,and trusted ***,to the best of our knowledge,a comprehensive literature review on this topic is still *** this paper,we review existing works about blockchain-enabled FL and visualize their prospects with *** this end,we first propose evaluation requirements with respect to security,faulttolerance,fairness,efficiency,cost-saving,profitability,and support for ***,we classify existing literature according to the functionalities of BT in FL and analyze their advantages and disadvantages based on the proposed evaluation ***,we discuss open problems in the existing literature and the future of DT supported by blockchain-enabled FL,based on which we further propose some directions for future research.

关键词： Digital twin Artificial intelligence Federated learning Blockchain

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Passivity-Based Stabilization for Switched Stochastic Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1307-1309页

作者： Yaowei Sun Jun Zhao School of Automation Zhengzhou University of AeronauticsZhengzhou 450046 Henan Key Laboratory of General Aviation Technology Zhengzhou University of AeronauticsZhengzhou 450046China College of Information Science and Engineering Northeastern UniversityShenyang 110819China

Dear Editor,This letter addresses the passivity-based mean square exponential stabilization problem for switched stochastic nonlinear systems.A concept of generalized small-time norm-observability is presented and an appropriate test condition is also *** pre-given passivity rate and average dwell time,a set of feedback controllers is designed by use of the passivity property.

关键词： property letter stabilization

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WTV2.0:A high-coverage plant volatilomics method with a comprehensive selective ion monitoring acquisition mode

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Molecular Plant 2024年第6期17卷 972-985页

作者： Honglun Yuan Yiding Jiangfang Zhenhuan Liu Rongxiu Su Qiao Li Chuanying Fang Sishu Huang Xianqing Liu Alisdair R.Fernie Jie Luo School of Breeding and Multiplication(Sanya Institute of Breeding and Multiplication)and College of Tropical Agriculture and Forestry Hainan UniversitySanya Hainan 572025China Yazhouwan national Laboratory(YNL) Sanya Hainan 572025China Department of Molecular Physiology Max-Planck-Institute of Molecular Plant PhysiologyAm Mühlenberg 1Potsdam-Golm 14476Germany

Volatilomics is essential for understanding the biological functions and fragrance contributions of plant ***,the annotation coverage achieved using current untargeted and widely targeted volatomics(WTV)methods has been limited by low sensitivity and/or low acquisition ***,we introduce WTV 2.0,which enabled the construction of a high-coverage library containing 2111 plant volatiles,and report the development of a comprehensive selective ion monitoring(cSIM)acquisition method,including the selection of characteristic qualitative ions with the minimal ion number for each compound and an optimized segmentation method,that can acquire the smallest but sufficient number of ions for most plant volatiles,as well as the automatic qualitative and semi-quantitative analysis of cSIM ***,the library and acquisition method we developed can be self-expanded by incorporating compounds not present in the library,utilizing the obtained cSIM *** showed that WTV 2.0 increases the median signal-to-noise ratio by 7.6-fold compared with the untargeted method,doubled the annotation coverage compared with the untargeted and WTV 1.0 methods in tomato fruit,and led to the discovery of menthofuran as a novel flavor compound in passion *** 2.0 is a Python library with a user-friendly interface and is applicable to profiling of volatiles and primary metabolites in any species.

关键词： volatilomics widely targeted methods GC-MS selective ion monitoring plant volatiles

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Contrasting strategies of optimizing carrier concentration in bulk InSe for enhanced thermoelectric performance

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Rare Metals 2024年第9期43卷 4425-4432页

作者： Hao-Nan Shi Shu-Lin Bai Yu-Ping Wang Li-Zhong Su Qian Cao Cheng Chang Li-Dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Huabei Cooling Device Co.Ltd. Hebei 065400China

Indium selenide(InSe),as a wide-bandgap semiconductor,has received extensive attention in the flexible electronics field in recent years due to its exceptional plasticity and promising thermoelectric ***,the low carrier concentration severely limits its thermoelectric performance *** this work,we conducted contrasting strategies that can be employed to increase the carrier concentration of InSe,including bandgap narrowing and heterovalent ***,the carrier concentration initially increases as a result of the reduced bandgap upon Te alloying and then slightly decreases due to the weak electronegativity of *** Br doping realizes high carrier concentration by pushing the Fermi level into the conduction bands and activating the multiple *** the other hand,both Te and Br obviously suppress the thermal conductivity due to the point defect *** contrast,Br doping realizes a higher thermoelectric performance with a maximum ZT of~0.13 at 773 K benefiting from the better optimization of carrier *** work elucidates the strategies for enhancing carrier concentration at anion sites and demonstrates the high efficiency of halogen doping in ***,the carrier concentration of InSe is promising to be further optimized,and future work should focus on employing approaches such as cation doping or secondphase compositing.

关键词： Thermoelectric InSe Carrier concentration Bandgap Heterovalent doping

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A Dietary Source of High Level of Fluoroquinolone Tolerance in mcr-Carrying Gram-Negative Bacteria

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Research 2024年第3期2023卷 105-121页

作者： Tianqi Xu Dan Fang Fulei Li Zhiqiang Wang Yuan Liu Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses College of Veterinary MedicineYangzhou UniversityYangzhou 225009China. Joint International Research Laboratory of Agriculture and Agri-Product Safety the Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China. Institute of Comparative Medicine Yangzhou UniversityYangzhou 225009China.

The emergence of antibiotic tolerance,characterized by the prolonged survival of bacteria following antibiotic exposure,in natural bacterial populations,especially in pathogens carrying antibiotic resistance genes,has been an increasing threat to public ***,the major causes contributing to the formation of antibiotic tolerance and underlying molecular mechanisms are yet poorly ***,we show that potassium sorbate(PS),a widely used food additive,triggers a high level of fluoroquinolone tolerance in bacteria carrying mobile colistin resistance gene *** studies demonstrate that PS treatment results in the accumulation of intracellular fumarate,which activates bacterial two-component system and decreases the expression level of outer membrane protein OmpF,thereby reducing the uptake of *** addition,the supplementation of PS inhibits aerobic respiration,reduces reactive oxygen species production and alleviates DNA damage caused by bactericidal ***,we demonstrate that succinate,an intermediate product of the tricarboxylic acid cycle,overcomes PS-mediated ciprofloxacin *** multiple animal models,ciprofloxacin treatment displays failure outcomes in PS preadministrated animals,including comparable survival and bacterial loads with the vehicle *** together,our works offer novel mechanistic insights into the development of antibiotic tolerance and uncover potential risks associated with PS use.

关键词： overcome thereby additive

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"Win-Win"Scenario of High Energy Density and Long Cycling Life in a Novel Na_(3.9)MnCr_(0.9)Zr_(0.1)(PO_(4))_(3)Cathode

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Energy & Environmental Materials 2024年第1期7卷 83-90页

作者： Yao Wang Yukun Liu Pingge He Junteng Jin Xudong Zhao Qiuyu Shen Jie Li Xuanhui Qu Yongchang Liu Lifang Jiao Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 10083China Department of Chemistry and Biochemistry University of California1156 High StreetSanta CruzCA 95064USA Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

The development of high-energy and long-lifespan NASICON-type cathode materials for sodium-ion batteries has always been a research hotspot but a daunting *** Na_(4)MnCr(PO_(4))_(3)has emerged as one of the most promising high-energy-density cathode materials owing to its three-electron reactions,it still suffers from serious structural distortion upon repetitive charge/discharge processes caused by the Jahn-Teller active Mn^(3+).Herein,the selective substitution of Cr by Zr in Na_(4)MnCr(PO_(4))_(3)was explored to enhance the structural stability,due to the pinning effect of Zr ions and the≈2.9-electron reactions,as-prepared Na_(3.9)MnCr_(0.9)Zr_(0.1)(PO_(4))_(3)/C delivers a high capacity retention of 85.94%over 500 cycles at 5 C and an ultrahigh capacity of 156.4 mAh g^(-1)at 0.1 C,enabling the stable energy output as high as 555.2 Wh kg^(-1).Moreover,during the whole charge/discharge process,a small volume change of only 6.7%was verified by in situ X-ray diffraction,and the reversible reactions of Cr^(3+)/Cr^(4+),Mn^(3+)/Mn^(4+),and Mn^(2+)/Mn^(3+)redox couples were identified via ex situ X-ray photoelectron spectroscopy *** intermittent titration technique tests and density functional theory calculations further demonstrated the fast reaction kinetics of the Na_(3.9)MnCr_(0.9)Zr_(0.1)(PO_(4))_(3)/C *** work offers new opportunities for designing high-energy and high-stability NASICON cathodes by ion doping.

关键词： high energy density mechanism investigation NASICON-type cathodes sodium-ion batteries structure modification

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Computer vision tasks for intelligent aerospace perception: An overview

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Science China(Technological Sciences) 2024年第9期67卷 2727-2748页

作者： CHEN HuiLin SUN QiYu LI FangFei TANG Yang School of Information Science and Engineering East China University of Science and TechnologyShanghai 200237China School of Mathematics East China University of Science and TechnologyShanghai 200237China

Computer vision tasks are crucial for aerospace missions as they help spacecraft to understand and interpret the space environment,such as estimating position and orientation, reconstructing 3D models, and recognizing objects, which have been extensively studied to successfully carry out the missions. However, traditional methods like Kalman filtering, structure from motion, and multi-view stereo are not robust enough to handle harsh conditions, leading to unreliable results. In recent years, deep learning(DL)-based perception technologies have shown great potential and outperformed traditional methods, especially in terms of their robustness to changing environments. To further advance DL-based aerospace perception, various frameworks, datasets,and strategies have been proposed, indicating significant potential for future applications. In this survey, we aim to explore the promising techniques used in perception tasks and emphasize the importance of DL-based aerospace perception. We begin by providing an overview of aerospace perception, including classical space programs developed in recent years, commonly used sensors, and traditional perception methods. Subsequently, we delve into three fundamental perception tasks in aerospace missions: pose estimation, 3D reconstruction, and recognition, as they are basic and crucial for subsequent decision-making and control. Finally, we discuss the limitations and possibilities in current research and provide an outlook on future developments,including the challenges of working with limited datasets, the need for improved algorithms, and the potential benefits of multisource information fusion.

关键词： deep learning perception aerospace missions pose estimation 3D reconstruction recognition

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