检索结果-南通市图书馆

Non-exercise estimated cardiorespiratory fitness and cancer incidence:The nih-AARP diet and health study

运动与健康科学(英文) 2023年第6期12卷 739-746页

作者： Baruch Vainshelboim Jonathan Myers Charles EMatthews Center for Tobacco Research Division of Medical OncologyDepartment of Internal MedicineThe Ohio State UniversityColumbusOH 43214USA Cardiology Division Veterans Affairs Palo Alto Health Care System/Stanford UniversityPalo AltoCA 94304USA Metabolic Epidemiology Branch Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleMD 20850USA

Background Non-exercise estimated cardiorespiratory fitness(NEE-CRF)has been shown to be associated with mortality,although its association with cancer incidence is *** study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and *** The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline(1995–1996)(men(n=238,835)and women(n=163,713))and were followed until December 31,*** exposure variable was NEE-CRF expressed in metabolic ***-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline *** outcomes were total cancer incidence and incidence of prostate,breast,lung,and colorectal *** proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk *** During 13.7±3.2 years of follow-up(mean±SD),64,344 men and 31,315 women developed a new *** every 1-metabolic equivalent higher NEE-CRF,the hazard ratios and 95%confidence intervals(95%CIs)were 0.96(95%CI:0.94–0.97)and 0.88(95%CI:0.84–0.92)of total and colorectal cancer incidence among men,and 0.95(95%CI:0.93–0.97)and 0.94(95%CI:0.91–0.97)of total and breast cancer incidence among women,respectively(all p<0.001).NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in *** These results suggest that higher CRF levels,as assessed by the applied non-exercise estimated method,may provide preventive benefits against the development of cancer,while low CRF could potentially serve as a modifiable cancer risk *** NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complemen

关键词： Aerobic capacity Breast cancer Cancer risk Colorectal cancer VO_(2max)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

美国nih、NSF评审制度研究及对深圳的启示

引用

科研管理 2019年第8期40卷 293-296页

作者：李杏林贡毅南方科技大学科研部

近年来深圳市R&D经费快速增长,用于基础研究资金的投入也逐年增加。本文首先综合分析和研究了美国国立卫生研究院(National Institutes of Health,简称nih)、美国国家科学基金会(National Science Foundation,简称NSF)和国家自然科学基... 详细信息

近年来深圳市R&D经费快速增长,用于基础研究资金的投入也逐年增加。本文首先综合分析和研究了美国国立卫生研究院(National Institutes of Health,简称nih)、美国国家科学基金会(National Science Foundation,简称NSF)和国家自然科学基金委(National Science Foundation of China,简称NSFC)的科技项目评审制度和评价体系,在此基础上,结合深圳市的具体情况,将现行的深圳市科技项目评审制度和评价体系同nih、NSF、NSFC等系统进行比较分析,为改革提供借鉴和参考。随着中国全面深化改革的推进,促进科技发展在社会其他领域尤其是经济领域发挥更大的作用,成为科技体制改革过程中的迫切要求。nih和NSF的项目采取不定期申报的方式,我国现有的科技项目大部分采用集中期申报方式,两国管理机构赋予管理人员的管理权限不同。深圳市随着R&D经费的快速增长,用于基础研究资金的投入也逐年增加,加强科学研究与教育的紧密结合、把卓越管理的理念切实落到实处是亟需解决的问题。本文的研究将通过研究两国的科技资助管理政策,分析管理机构在制度建设、考核的全面性与连续性、科技信息管理等方面的特点,结合深圳市科技评价体系的发展情况,提出进一步完善科技评价制度政策体系,突出科技评价重点指标,加强科技评价的全面性及连续性的建议。以充分发挥科技评价的指导和引导作用。

关键词： nih NSF 科技评价体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fas配体对nih3T3增殖和胶原表达的信号机制研究

引用

中国职业医学 2010年第2期37卷 91-94页

作者：姚三巧 LU Yongju WANG Liying Rojanasakul Anand Iyer Neelam Azad Yon Rojanasakul 华北煤炭医学院劳动卫生与环境卫生学科河北唐山063000 美国西弗吉尼亚大学基础药学院 MorgantownWV26505 USA 美国国立职业安全与卫生研究所 MorgantownWV26505USA 河北省煤矿卫生与安全实验室唐山063000

目的探讨Fas配体(FasL)对小鼠成纤维细胞nih3T3增殖和胶原表达的影响及其信号调控机制。方法采用鼠成纤维细胞系HIN3T3,以FasL为诱导剂,采用抑制剂技术和Western blot技术观察nih3T3的增殖及胶原表达情况,同时探讨磷脂酰肌醇3-激酶(PI3K... 详细信息

目的探讨Fas配体(FasL)对小鼠成纤维细胞nih3T3增殖和胶原表达的影响及其信号调控机制。方法采用鼠成纤维细胞系HIN3T3,以FasL为诱导剂,采用抑制剂技术和Western blot技术观察nih3T3的增殖及胶原表达情况,同时探讨磷脂酰肌醇3-激酶(PI3K)/Akt、有丝分裂原活化蛋白(MAPK)/P38、MAPK/ERK信号通路在nih3T3增殖和胶原表达中的作用。结果研究发现低剂量的FasL可调节3T3的生长,表现为细胞数量和胶原表达水平均随FasL剂量的增加而增加,且存在剂量-效应和时间-效应;MAPK/P38及PI3K/Akt信号通路对nih3T3的增殖具有调控作用,MAPK/P38及MAPK/ERK信号通路可调控nih3T3胶原表达。结论Fas/FasL系统对成纤维细胞增殖和胶原表达起促进作用;FasL主要通过PI3K/Akt、MAPK/P38信号通路对成纤维细胞增殖起调控作用;通过MAPK/P38及MAPK/ERK信号通路调节成纤维细胞的胶原表达。

关键词： Fas配体 nih3T3 增殖 Ⅰ、Ⅲ型胶原信号转导

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial sensitivity to absorption changes for various near-infrared spectroscopy methods:A compendium review

引用

Journal of Innovative Optical Health Sciences 2024年第4期17卷 1-115页

作者： Giles Blaney Angelo Sassaroli Sergio Fantini Department of Biomedical Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

This compendium review focuses on the spatial distribution of sensitivity to localized absorption changes in optically diffuse media,particularly for measurements relevant to near-infrared *** three temporal domains,continuous wave,frequency domain,and time domain,each obtain different optical data types whose changes may be related to effective homogeneous changes in the absorption *** is the relationship between a localized perturbation and the recovered effective homogeneous absorption ***,spatial sensitivity maps representing the perturbation location can be generated for the numerous optical data types in the three temporal *** review first presents a history of the past 30 years of work investigating this sensitivity in optically diffuse *** works are experimental and theoretical,presenting one-,two-,and three-dimensional sensitivity maps for different Near-Infrared Spectroscopy methods,domains,and data *** this history,we present a compendium of sensitivity maps organized by temporal domain and then data *** compendium provides a valuable tool to compare the spatial sensitivity of various measurement methods and parameters in one *** for one to generate these maps are provided in Appendix A,including the *** historical review and comprehensive sensitivity map compendium provides a single source researchers may use to visualize,investigate,compare,and generate sensitivity to localized absorption change maps.

关键词： Diffuse optics diffusion theory Monte Carlo spatial sensitivity absorption perturbations near-infrared spectroscopy continuous-wave frequency-domain time-domain

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

引用

Acta Pharmaceutica Sinica B 2024年第3期14卷 1241-1256页

作者： Pengfei Xu Yue Xi Jong-Won Kim Junjie Zhu Min Zhang Meishu Xu Songrong Ren Da Yang Xiaochao Ma Wen Xie Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Pharmacology&Chemical Biology University of PittsburghPittsburghPA 15261USA

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology.3’-Phosphoadenosine 5’-phosphosulfate(PAPS)synthase 2(PAPSS2)is the primary enzyme to generate the universal sulfonate donor *** involvement of PAPSS2-mediated sulfation in adenomatous polyposis coli(APC)mutation-promoted colonic carcinogenesis has not been ***,we showed that the expression of PAPSS2 was decreased in human colon tumors along with cancer stages,and the lower expression of PAPSS2 was correlated with poor prognosis in advanced colon *** epithelial-specific heterozygous Apc deficient and Papss2-knockout(Apc^(Δgut-Het)Papss2^(Δgut))mice were created,and the phenotypes were compared to the spontaneous intestinal tumorigenesis of Apc^(Δgut-Het)***^(Δgut-Het)Papss2^(Δgutmice) were more sensitive to gut tumorigenesis,which was mechanistically accounted for by the activation of Wnt/β-catenin signaling pathway due to the suppression of chondroitin sulfation and inhibition of the farnesoid X receptor(FXR)-transducin-like enhancer of split 3(TLE3)gene regulatory *** sulfate supplementation in Apc^(Δgut-Het)Papss2^(Δgutmice) alleviated intestinal *** summary,we have uncovered the protective role of PAPSS2-mediated chondroitin sulfation and bile acids-FXR-TLE3 activation in the prevention of gut carcinogenesis via the antagonization of Wnt/β-catenin *** sulfate may be explored as a therapeutic agent for Papss2 deficiency-associated colonic carcinogenesis.

关键词： Colon cancer APC Wnt/b-catenin PAPSS2 Chondroitin sulfate Sulfation Bile acids FXR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RNA modifications in the progression of liver diseases:from fatty liver to cancer

引用

Science China(Life Sciences) 2024年第10期67卷 2105-2119页

作者： Simiao Li Wajahat Z Mehal Xinshou Ouyang Department of Internal Medicine Section of Digestive DiseasesYale University School of MedicineNew Haven CT 06520USA

Non-alcoholic fatty liver disease(NAFLD)has emerged as a prominent global health concern associated with high risk of metabolic syndrome,and has impacted a substantial segment of the *** disease spectrum ranges from simple fatty liver to non-alcoholic steatohepatitis(NASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)and is increasingly becoming a prevalent indication for liver *** existing therapeutic options for NAFLD,NASH,and HCC are limited,underscoring the urgent need for innovative treatment *** into gene expression,particularly RNA modifications such as N6methyladenosine(m^(6)A),hold promising avenues for *** modifications play integral roles in RNA metabolism and cellular functions,encompassing the entire NAFLD-NASH-HCC *** review will encompass recent insights on diverse RNA modifications,including m^(6)A,pseudouridine(Ψ),N^(1)-methyladenosine(m^(1)A),and 5-methylcytidine(m^(5)C)across various RNA *** will uncover their significance in crucial aspects such as steatosis,inflammation,fibrosis,and ***,prospective research directions and therapeutic implications will be explored,advancing our comprehensive understanding of the intricate interconnected nature of these pathological conditions.

关键词： m^(6)A RNA modification NASH NAFLD HCC fatty liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transmission of amyloid-βpathology in humans:a perspective on clinical evidence

引用

Neural Regeneration Research 2024年第2期19卷 390-392页

作者： Celso S.G.Catumbela Rodrigo Morales Department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Transmission of misfolded amyloid-β(Aβ)aggregates between human subjects:Protein misfolding disorders are a family of diseases characterized by the accumulation of misfolded protein *** proteinaceous structures,also known as amyloids,are key drivers of fatal neurodegenerative disorders such as prion diseases,Alzheimer’s disease(AD),Parkinson’s disease,and others.

关键词： amyloid diseases Aβ

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A toast to a zebrafish germ cell induction cocktail

引用

Science China(Life Sciences) 2024年第6期67卷 1314-1315页

作者： Mary C.Mullins Department of Cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGCs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implications for brainstem recovery from studies in primates after sensory loss from arm

引用

Neural Regeneration Research 2024年第3期19卷 479-480页

作者： Jamie L.Reed Hui-Xin Qi Jon H.Kaas Department of Psychology Vanderbilt UniversityNashvilleTNUSA

For decades,researchers have known that when neurons lose their activating inputs,they can atrophy and even *** example,removing sensory nerve inputs from the arm to the spinal cord after amputation or cutting the spinal nerves can shrink the post-synaptic target zones(e.g.,Woods et al.,2000).From touch receptors for the hand and arm,primary nerve afferents enter the spinal cord,and axons travel in the dorsal columns to target the cuneate nucleus(Cu)of the brainstem on the same side of the body(Figure 1).When sensory loss is unilateral,the overwhelming result is for the associated primary target zone to shrink in total size(cross-sectional area),as compared to the size of the opposite side.

关键词： brainstem shrink removing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phase-driven progress in nanophotonic biosensing

引用

Light(Science & Applications) 2024年第5期13卷 798-800页

作者： Isabel Barth Hakho Lee Center for Systems Biology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA

In the continuous pursuit of enhancing the sensitivity of nanophotonic biosensors by leveraging phase phenomena,a recent development involved the engineering of an atomically thin Ge2Sb2Te5 layer on a silver nanofilm ... 详细信息

关键词： silver Ge2Sb2Te5 pursuit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：