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Influence of seasonal migration on evolution of insecticide resistance in Plutella xylostella

Insect Science 2022年第2期29卷 496-504页

作者： Menglun Wang Bin Zhu Lei Zhang Yutao Xiao Pei Liang Kongming Wu Department of Entomology China Agricultural UniversityBeijing100193 China Guangdong laboratory for lingnan modern agriculture Guangzhou510642 China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen518120 China

The diamondback moth,Plutella xylostella(L.),is one of the most destructive migratory pest species of cruciferous vegetables worldwide and has developed resistance to most of the insecticides used for its *** migration regularity,migratory behavior,and relationship between flight and reproduction of *** have been widely ***,the effect of migration on insecticide resistance in this pest is still *** this study,the effect of migration on *** resistance to seven insecticides was investigated using populations across the Bohai Sea that were collected in the early and late seasons during 2017–*** bioassay results showed that the early season populations of *** from south China possessed much higher resistance to insecticides because of intensive insecticide application;alternatively,the late season populations migrated from northeast China,where the insecticides were only used occasionally,showed much lower insecticide *** genome re-sequencing results revealed that,among the eight mutations involved in insecticide resistance,the frequencies of two acetylcholinesterase mutations(A298S and G324A)responsible for organophosphorus insecticide resistance were significantly decreased in the late season *** results indicated that *** migration between tropical and temperate regions significantly delayed the development of insecticide *** findings illustrated the effect of regional migration on the evolution of insecticide resistance in ***,and provided foundational information for further research on the relationship between migration and insecticide resistance development in other insects.

关键词： Bohai Sea insecticide resistance migration Plutella xylostella

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Melatonin shapes bacterial clearance function of porcine macrophages during enterotoxigenic Escherichia coli infection

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Animal Nutrition 2022年第4期11卷 242-251页

作者： Lingfei Du Bingnan Liu Ziyi Han Yaoyao Xia Miaomiao Wu Shaojuan Liu Guangdong laboratory of lingnan modern agriculture College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Animal Nutritional Genome and Germplasm Innovation Research Center College of Animal Science and TechnologyHunan Agricultural UniversityChangshaChina

Due to the immature gastrointestinal immune system,weaning piglets are highly susceptible to pathogens,e.g.,enterotoxigenic Escherichia coli(ETEC).Generally,pathogens activate the immune cells(e.g.,macrophages)and shape intracellular metabolism(including amino acid metabolism);nevertheless,the metabolic cues of tryptophan(especially melatonin pathway)in directing porcine macrophage function during ETEC infection remain ***,this study aimed to investigate the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage *** macrophages(3D4/21 cells)were infected with ETEC,and the change of serotonin pathway was analysed by reverse transcription PCR and metabolomic *** effect of melatonin on porcine macrophage function was also studied with proteomic *** order to investigate the effect of melatonin on bacterial clearance function of porcine macrophages during ETEC infection,methods such as bacterial counting,reverse transcription PCR and western blotting were used to detect the corresponding *** results showed that ETEC infection blocked melatonin production in porcine macrophages(P<0.05)which is largely associated with the heat-stable enterotoxin b(STb)of ETEC(P<0.05).Interestingly,melatonin altered porcine macrophage functions,including bacteriostatic and bactericidal activities based on proteomic *** addition,melatonin pretreatment significantly reduced extracellular lactate dehydrogenase(LDH)activity(P<0.05),indicating that melatonin also attenuated ETEC-triggered macrophage ***,melatonin pretreatment resulted in the decrease of viable ETEC in 3D4/21 cells(P<0.05),suggesting that melatonin enhances bacterial clearance of porcine *** results suggest that melatonin is particularly important in shaping porcine macrophage function during ETEC infection.

关键词： Porcine macrophage Melatonin Enterotoxigenic Escherichia coli Serotonin pathway

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Photoinduced Cu^(+)/Cu^(2+)interconversion for enhancing energy conversion and storage performances of CuO based Li-ion battery

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Journal of Energy Chemistry 2023年第4期79卷 83-91页

作者： Qiuman Zhang Meng Wei Qianwen Dong Qiongzhi Gao Xin Cai Shengsen Zhang Teng Yuan Feng Peng Yueping Fang Siyuan Yang Key laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 51006GuangdongChina

Pursuing appropriate photo-active Li-ion storage materials and understanding their basic energy storage/conversion principle are pretty crucial for the rapidly developing photoassisted Li-ion batteries(PA-LIBs).Copper oxide(CuO)is one of the most popular candidates in both LIBs and *** CuO based PA-LIBs have never been reported ***,one-dimensional(1D)CuO nanowire arrays in situ grown on a three-dimensional(3D)copper foam support were employed as dualfunctional photoanode for both‘solar-to-electricity’and‘electricity-to-chemical’energy conversion in the *** is found that light energy can be indeed stored and converted into electrical energy through the assembled CuO based *** external power source,the photo conversion efficiency of CuO based photocell reaches about 0.34%.Impressively,at a high current density of 4000 m A g^(-1),photoassisted discharge and charge specific capacity of CuO based PA-LIBs respectively receive 64.01%and 60.35%enhancement compared with the net electric charging and discharging *** investigation reveals that photogenerated charges from CuO promote the interconversion between Cu^(2+)and Cu^(+)during the discharging/charging process,thus forcing the lithium storage reaction more completely and increasing the specific capacity of the *** work can provide a general principle for the development of other high-efficient semiconductor-based PA-LIBs.

关键词： Li-ion batteries Energy conversion and storage Photo rechargeable Electrochemistry Copper oxide

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A Rigid Nanoplatform for Precise and Responsive Treatment of Intracellular Multidrug-Resistant Bacteria

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Engineering 2022年第8期8卷 57-66页

作者： Shaoqi Qu Xiaoyong Huang Xiangbin Song Yifan Wu Xiaowei Ma Jianzhong Shen Kui Zhu National Center for Veterinary Drug Safety Evaluation College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong laboratory for lingnan modern Agricultur

Antibiotic treatment failure against life-threatening bacterial pathogens is typically caused by the rapid emergence and dissemination of antibiotic *** current lack of antibiotic discovery and development urgently calls for new strategies to combat multidrug-resistant(MDR)bacteria,especially those that survive in host *** nanoparticles are promising intracellular drug delivery systems whose advantages include their high biocompatibility and tunable surface *** by the fact that the rigidity of nanoparticles potentiates their cellular uptake,rigidity-functionalized nanoparticles(RFNs)coated with bacteria-responsive phospholipids were fabricated to boost endocytosis,resulting in the increased accumulation of intracellular *** delivery and high antibacterial efficacy were demonstrated by the clearing of 99%of MDR bacteria in 4 h using methicillin-resistant Staphylococcus aureus(MRSA)and pathogenic Bacillus cereus as *** addition,the subcellular distribution of the RFNs was modulated by altering the phospholipid composition on the surface,thereby adjusting the electrostatic effects and reprograming the intracellular behavior of the RFNs by causing them to accurately target ***,the RFNs showed high efficacy against MRSA-associated infections in animal models of wound healing and *** findings provide a controllable rigidity-regulated delivery platform with responsive properties for precisely reprograming the accumulation of cytosolic antibiotics,shedding light on precision antimicrobial therapeutics against intracellular bacterial pathogens in the future.

关键词： Antibiotic Bacteria Mesoporous silica Phospholipid Rigidity

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Phenylalanine diminishes M1 macrophage inflammation

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Science China(Life Sciences) 2023年第12期66卷 2862-2876页

作者： Qingzhuo Zhang Siyuan Chen Yan Guo Fang He Jian Fu Wenkai Ren Guangdong laboratory of lingnan modern agriculture National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and Technology Southwest UniversityChongqing 400715China

Emerging evidence suggests that amino acids dictate the effector functions of immune cells;however, whether and how phenylalanine(Phe) orchestrates the polarization of macrophages is not understood. Here, we determined that Phe attenuated lipopolysaccharide(LPS) and P. multocida serotype A strain CQ2(PmCQ2) infection-induced inflammation in vivo. Furthermore, we demonstrated that Phe inhibited the production of interleukin(IL)-1β and tumor necrosis factor(TNF)-α in proinflammatory(M1) macrophages. Phe reprogrammed the transcriptomic and metabolic profiles and enhanced oxidative phosphorylation in M1 macrophages, which reduced the activation of caspase-1. Notably, the valine-succinyl-CoA axis played a critical role in Phe-mediated inhibition of IL-1β production in M1 macrophages. Taken together, our findings suggest that manipulating the valine-succinyl-CoA axis provides a potential target for preventing and/or treating macrophage-related diseases.

关键词： IL-1β macrophage phenylalanine succinyl-CoA valine

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Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs

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Animal Nutrition 2022年第4期11卷 190-200页

作者： Bingnan Liu Dongming Yu Jing Sun Xiaoyan Wu Zhongquan Xin Baichuan Deng Lijuan Fan Jian Fu Liangpeng Ge Wenkai Ren State Key laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory of Lingnan Modern AgricultureNational Engineering Research Center for Breeding Swine IndustryGuangdong Provincial Key Laboratory of Animal Nutrition ControlCollege of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Chongqing Academy of Animal Sciences ChongqingChina

Intestinal microbes are closely associated with host health,depending on metabolic crosstalk between the microbiota and *** metabolism is one of the best examples of metabolic crosstalk between intestinal microbiota and host;however,our understanding about the influence of intestinal microbiota on host tryptophan metabolism is ***,we established germ-free(GF)pig models to systemically explore the influence of intestinal microbiota on tryptophan *** GF pigs were kept in GF conditions throughout the experiment(GF group).Six GF pigs were transplanted with fecal microbiota from donor sows to act as control *** with control pigs,the GF pigs had remarkable alterations in tryptophan *** differential metabolites(P<0.05)were mainly found in the liver,circulation system and large ***,the alteration of metabolites in tryptophan metabolism varied among organs,especially for the serotonin *** GF pigs,tryptophan and kynurenine in the large intestine and 5-hydroxytryptophan in most organs were increased(P<0.05),while metabolites in the indole pathway in most organs were decreased(P<0.05).Collectively,our study reveals changes in tryptophan metabolism in GF pigs,highlighting the critical role of gut microbes in shaping host tryptophan metabolism.

关键词： Germ-free pig Gut microbiota Tryptophan Indole Kynurenine

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Arbuscular mycorrhizal fungi inoculation and exogenous indole-3-acetic acid application induce antioxidant defense response to alleviate cadmium toxicity in Broussonetia papyrifera

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Pedosphere 2024年第2期34卷 447-459页

作者： Xue LI Jingwei LIANG Hongjian WEI Yuxuan KUANG Hui CHEN Ming TANG Wentao HU State Key laboratory of Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern AgricultureGuangdong Key Laboratory for Innovative Development and Utilization of Forest Plant GermplasmCollege of Forestry and Landscape ArchitectureSouth China Agricultural UniversityGuangzhou 510642China

Cadmium(Cd)contamination in soil poses a huge threat to plants even at low concentrations;Broussonetia papyrifera has great potential in remediation of soil heavy metal ***,whether exogenous indole-3-acetic acid(IAA)application and arbuscular mycorrhizal fungi(AMF)have synergistic effects on Cd tolerance of *** remains *** investigate the effects of AMF inoculation and IAA application on the tolerance of *** to Cd stress,two experiments were conducted:the first to investigate the effect of AMF(Rhizophagus irregularis)inoculation on the tolerance of *** to Cd stress and the second to investigate the combined effects of AMF inoculation and IAA application on the tolerance of *** to Cd *** including endogenous hormone concentration,antioxidant defense response,malondialdehyde(MDA)content,and gene expression related to antioxidant enzyme system and hormone were *** results indicated that AMF alleviated Cd toxicity of *** by reducing MDA content and improving antioxidant enzyme activities and Cd absorption ***,the combination of AMF inoculation and IAA application had a synergetic effect on the tolerance of *** to Cd stress through upregulating BpAUX1 and BpAUX2,which might contribute to root growth and root xylem synthesis,and by upregulating BpSOD2 and BpPOD34 to enhance the antioxidant enzyme *** work provides a new insight into the application of IAA in the remediation of soil Cd pollution by mycorrhizal plants.

关键词： enzyme activity geneexpression heavy metal phytoremediation remediation Rhizophagus irregularis soil cadmium pollution stress tolerance

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Selective recognition of PTRE1 transcripts mediated by protein-protein interaction between the m^(6)A reader ECT2 and PTRE1

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Plant Communications 2024年第11期5卷 144-156页

作者： Li Yang Bo Wang Duanmu Zhao Xuechun Li Yifei Qin Ning Ouyang Zhili Xiao Zhibing Zhang Gad Galili Jiayang Li Hadas Peled-Zehavi Jian Wu Guangdong laboratory for lingnan modern agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesKey Laboratory of Plant Molecular Breeding of Guangdong ProvinceCollege of AgricultureSouth China Agricultural UniversityGuangzhou 510642China Key laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 76100Israel State Key laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China These authors contributed equally to this article

N^(6)-methyladenosine (m^(6)A) is a prevalent internal post-transcriptional modification in eukaryotic RNAs executed by m^(6)A-binding proteins known as “readers.” Our previous research demonstrated that the Arabidopsis m^(6)A reader ECT2 positively regulates transcript levels of the proteasome regulator PTRE1 and several 20S proteasome subunits, thereby enhancing 26S proteasome activity. However, mechanism underlying the selective recognition of m^(6)A targets by readers, such as ECT2, remains elusive. In this study, we further demonstrate that ECT2 physically interacts with PTRE1 and several 20S proteasome subunits. This interaction, which occurs on the ribosome, involves the N terminus of PTRE1, suggesting that ECT2 might bind to the nascent PTRE1 polypeptide. Deleting ECT2’s protein interaction domain impairs its mRNA-binding ability, whereas mutations in the m^(6)A-RNA-binding site do not affect protein-protein interactions. Moreover, introducing a novel protein-binding domain into ECT2 increases transcript levels of proteins interacting with this domain. Our findings indicate that interaction with the PTRE1 protein enhances ECT2’s binding to PTRE1 m^(6)A mRNAs during translation, thereby regulating PTRE1 mRNA levels.

关键词： ECT2 20S proteasome m^(6)A RNA protein interaction Arabidopsis

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Research progress on anti-stress nutrition strategies in swine

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Animal Nutrition 2023年第2期13卷 342-360页

作者： Leli Wang Chuni Wang Yao Peng Yiru Zhang Yuxin Liu Yan Liu Yulong Yin Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjinChina Hunan Provincial Key laboratory of Animal Intestinal Function and Regulation College of Life SciencesHunan Normal UniversityChangshaChina Institute of Subtropical agriculture Chinese Academy of SciencesChangshaChina

In swine production,stress is a common encounter that leads to serious bacterial infection and adverse effects on growth *** antibiotics have been frequently used to control pathogen spread,sustained negative impacts from antibiotics have been found to affect intestinal integrity and the immune *** nutritional strategies have shown potential to counteract stress and replace antibiotics,including functional amino acids,low protein diet,plant extracts,organic acids,prebiotics,probiotics,minerals and *** additives relieve the stress response in swine via different mechanisms and signal transduction *** on the overview of signaling pathways and stress models,this review highlights the potential of nutritional strategies in swine for preventing or treating stress-related health *** wider application in the pig industry,the dose ranges measured require for further validation in different physiological contexts and *** the future,micro-fluid devices and novel stress models are expected to enhance the efficiency of screening for new anti-stress candidates.

关键词： Nutritional strategy Anti-stress Swine Antibiotic

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Dihydroartemisinin inhibits plasmid transfer in drug-resistant Escherichia coli via limiting energy supply

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Zoological Research 2023年第5期44卷 894-904页

作者： Xue-Yang Wang Huang-Wei Song Tian Yi Ying-Bo Shen Chong-Shan Dai Cheng-Tao Sun De-Jun Liu Jian-Zhong Shen Cong-Ming Wu Yang Wang National Key laboratory of Veterinary Public Health Security College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong laboratory for lingnan modern agriculture GuangzhouGuangdong 510642China

Conjugative transfer of antibiotic resistance genes(ARGs)by plasmids is an important route for ARG *** increasing number of antibiotic and nonantibiotic compounds have been reported to aid the spread of ARGs,highlighting potential challenges for controlling this type of horizontal *** of conjugation inhibitors that block or delay the transfer of ARG-bearing plasmids is a promising strategy to control the propagation of antibiotic *** such inhibitors are rare,they typically exhibit relatively high toxicity and low efficacy in vivo and their mechanisms of action are inadequately ***,we studied the effects of dihydroartemisinin(DHA),an artemisinin derivative used to treat malaria,on *** inhibited the conjugation of the IncI2 and IncX4 plasmids carrying the mobile colistin resistance gene(mcr-1)by more than 160-fold in vitro in Escherichia coli,and more than two-fold(IncI2 plasmid)in vivo in a mouse *** also suppressed the transfer of the IncX3 plasmid carrying the carbapenem resistance gene bla_(NDM-5)by more than twofold in *** of intracellular adenosine triphosphate(ATP)and proton motive force(PMF),in combination with transcriptomic and metabolomic analyses,revealed that DHA impaired the function of the electron transport chain(ETC)by inhibiting the tricarboxylic acid(TCA)cycle pathway,thereby disrupting PMF and limiting the availability of intracellular ATP for plasmid conjugative ***,expression levels of genes related to conjugation and pilus generation were significantly down-regulated during DHA exposure,indicating that the transfer apparatus for conjugation may be *** findings provide new insights into the control of antibiotic resistance and the potential use of DHA.

关键词： Dihydroartemisinin Plasmid mcr-1 bla_(NDM-5) Conjugation inhibitors TCA cycle

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