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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Effects of different additives on microstructure and properties of Al–Zn–Mg–Cu alloys prepared by laser-directed energy deposition

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Progress in Natural Science:Materials International 2023年第6期33卷 812-824页

作者： Yin Wang Yong Li Wei Yu Chen He Haiyao Wang Guangming Xu Jiadong Li State key Laboratory of Rolling and Automation Northeastern University key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Guangxi Advanced Aluminum Processing Innovation Center Co.LTD Shenyang Institute of Automation Chinese Academy of Sciences

There are always microcracks and pores during the laser additive manufacturing of 7xxx aluminum alloy,which significantly limits its performance improvement and *** work uses additives to suppress defects and improve the alloy’s *** three alloys were prepared by the addition of silicon,TiN,or *** microstructure and mechanical properties were investigated in *** results show that silicon can inhibit the crack generation by reducing the solidification *** grain size is *** can refine the grain and it creates *** addition of both can restrain the defects,refine the grains and obtain good comprehensive ***,the hardness and wear resistance of A3 are slightly lower than A2 due to the brittle phase generated by the addition of *** yield strength,tensile strength,elongation,hardness and wear rate of A3 alloy treated by T6 are 214.8 MPa,262.8 MPa,2.59 %,130.9 HV and 2.24 × 10-3mm3/(N·m).

关键词： Laser additive manufacturing Metal matrix composites Al-Zn-Mg-Cu alloys Microstructure Tensile property Friction property

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Strength and ductility enhancement of twin-roll cast Al-Zn-Mg-Cu alloys with high solidification intervals through a synergistic segregation-controlling strategy

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Journal of Materials Science & Technology 2023年第11期142卷 225-239页

作者： Bing Lu Yong Li Wei Yu Haiyao Wang Yin Wang Zhaodong Wang Guangming Xu State key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Guangxi Advanced Aluminum Processing Innovation Center Co.LTD Nanning 530007China key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

Center segregation and banded intergranular segregation(B-IGS)should be well controlled to improve the mechanical properties of twin-roll cast(TRC)aluminum alloys,especially for alloys with high solid-ification *** the present work,a synergistic grain refinement strategy was designed using an Al-5Ti-B grain refiner and Ti,Zr,and Sc microalloying elements to simultaneously control center seg-regation and B-IGS in TRC Al-Zn-Mg-Cu *** the grain size decreased,center segregation defects were eliminated and transformed into dispersed B-IGS defects;simultaneously,the width and length of the B-IGS were also ***,the macro-distributions of the alloying elements along the thickness direction became more homogeneous due to a weak shear-induced dilation *** well-controlled multiscale segregation improved the uniformity of the alloy macrostructure,accelerated the redissolution of the crystalline phase,dispersed the aggregated residual phase,and refined grains under the T6 ***,the strength and ductility of the alloys under the T6 state were simultaneously improved,and the hardness distribution along the thickness direction became more ***,the underlying mechanisms of segregation evolution and strength and ductility enhancements were *** work provides a novel strategy to effectively control multiscale segregation and produce high-performance aluminum alloys with high solidification intervals by TRC.

关键词： Twin-roll casting Al-Zn-Mg-Cu alloy Center segregation Banded intergranular segregation Mechanical properties Grain refinement

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Classification of weed seeds based on visual images and deep learning

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农业信息处理(英文) 2023年第1期10卷 40-51页

作者： Tongyun Luo Jianye Zhao Yujuan Gu Shuo Zhang Xi Qiao Wen Tian Yangchun Han College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100PR China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120PR China Qingdao China-Agri IOT Science&Technology Co.Ltd. Qingdao 266106PR China Guangzhou Customs Districk Technology Center Guangzhou 510623PR China Jiangyin Customs Jiangyin 214400PR China

Weeds are mainly spread by weed seeds being mixed with agricultural and forestry crop seeds,grain,animal hair,and other plant products,and disturb the growing environment of target plants such as crops and wild native *** accurate and efficient classification of weed seeds is important for the effective management and control of ***,classification remains mainly dependent on destructive sampling-based manual inspection,which has a high cost and rather low *** considered that this problem could be solved using a nondestructive intelligent image recognition ***,on the basis of the establishment of the image acquisition system for weed seeds,images of single weed seeds were rapidly and completely segmented,and a total of 47696 samples of 140 species of weed seeds and foreign materials ***,six popular and novel deep Convolutional Neural Network(CNN)models are compared to identify the best method for intelligently identifying 140 species of weed *** these samples,33600 samples are randomly selected as the training dataset for model training,and the remaining 14096 samples are used as the testing dataset for model *** and GoogLeNet emerged from the quantitative evaluation as the best *** has strong classification accuracy and efficiency(low time consumption),and GoogLeNet has the best classification accuracy.A suitable CNN model for weed seed classification could be selected according to specific identification accuracy requirements and time costs of *** research is beneficial for developing a detection system for weed seeds in various *** resolution of taxonomic issues and problems associated with the identi-fication of these weed seeds may allow for more effective management and control.

关键词： Seed identification Image acquisition system Multi-object classification Convolutional neural network Computer vision

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Structural basis of SARS-CoV-2 3CL^pro and anti-COVID-19 drug discovery from medicinal plants

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Journal of Pharmaceutical Analysis 2020年第4期10卷 313-319页

作者： Muhammad Tahir ul Qamar Safar MAlqahtani Mubarak AAlamri Ling-Ling Chen College of Life Science and Technology Guangxi UniversityNanning530004PR China Hubei key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070PR China Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz University11323AlkarjSaudi Arabia

The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health *** viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of ***,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal *** analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19.

关键词： Coronavirus SARS-CoV-2 COVID-19 Natural products Protein homology modelling Molecular docking Molecular dynamics simulation

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Risk of metabolic abnormalities in osteoarthritis:a new perspective to understand its pathological mechanisms

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Bone research 2023年第4期11卷 679-694页

作者： Guizheng Wei Ke Lu Muhammad Umar Zhenglin Zhu William WLu John RSpeakman Yan Chen Liping Tong Di Chen Department of Bone and Joint Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Faculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Orthopedic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Center for Energy Metabolism and Reproduction Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Although aging has traditionally been viewed as the most important risk factor for osteoarthritis(OA),an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA,particularly in younger *** abnormalities,such as obesity and typeⅡdiabetes,are strongly linked to OA,and they affect both weightbearing and non-weight-bearing joints,thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by *** review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk,including the impact of abnormal glucose and lipid metabolism,the potential pathogenesis and targeted therapeutic strategies.

关键词： metabolism pathogenesis osteoarthritis

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Computer vision technology in agricultural automation--A review

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Information Processing in Agriculture 2020年第1期7卷 1-19页

作者： Hongkun Tian Tianhai Wang Yadong Liu Xi Qiao Yanzhou Li College of Mechanical Engineering Guangxi UniversityNanning 530004P.R.China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China key Laboratory of Integrated Pest Management on Crops in South China Ministry of Agriculture and Rural AreaSouth China Agricultural UniversityGuangzhou 510642P.R.China

Computer vision is a field that involves making a machine “see”.This technology uses a camera and computer instead of the human eye to identify,track and measure targets for further image *** the development of computer vision,such technology has been widely used in the field of agricultural automation and plays a key role in its *** review systematically summarizes and analyzes the technologies and challenges over the past three years and explores future opportunities and prospects to form the latest reference for *** the analyses,it is found that the existing technology can help the development of agricultural automation for small field farming to achieve the advantages of low cost,high efficiency and high ***,there are still major ***,the technology will continue to expand into new application areas in the future,and there will be more technological issues that need to be *** is essential to build large-scale data ***,with the rapid development of agricultural automation,the demand for professionals will continue to ***,the robust performance of related technologies in various complex environments will also face *** analysis and discussion,we believe that in the future,computer vision technology will be combined with intelligent technology such as deep learning technology,be applied to every aspect of agricultural production management based on large-scale datasets,be more widely used to solve the current agricultural problems,and better improve the economic,general and robust performance of agricultural automation systems,thus promoting the development of agricultural automation equipment and systems in a more intelligent direction.

关键词： Computer vision Image processing Agricultural automation Intelligent detection

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MmNet:Identifying Mikania micrantha Kunth in the wild via a deep Convolutional Neural Network

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Journal of Integrative Agriculture 2020年第5期19卷 1292-1300页

作者： QIAO Xi LI Yan-zhou SU Guang-yuan TIAN Hong-kun ZHANG Shuo SUN Zhong-yu YANG Long WAN Fang-hao QIAN Wan-qiang Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120P.R.China key Laboratory of Integrated Pest Management on Crops in South China Ministry of Agriculture and Rural Affairs/South China Agricultural UniversityGuangzhou 510642P.R.China College of Mechanical Engineering Guangxi UniversityNanning 530004P.R.China Shaanxi Agricultural Machinery Appraisal Station Xi’an 710065P.R.China College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100P.R.China Guangzhou Institude of Geography Guangdong Academy of SciencesGuangzhou 510070P.R.China

Mikania micrantha Kunth is an invasive alien weed and known as a plant killer around the *** and rapidly identifying *** in the wild is important for monitoring its growth status,as this helps management officials to take the necessary steps to devise a comprehensive strategy to control the invasive weed in the identified ***,this approach still mainly depends on satellite remote sensing and manual *** cost is high and the accuracy rate and efficiency are *** acquired color images of the monitoring area in the wild environment using an Unmanned Aerial Vehicle(UAV)and proposed a novel network-MmNet-based on a deep Convolutional Neural Network(CNN)to identify *** in the *** network consists of AlexNet Local Response Normalization(LRN),along with the GoogLeNet and continuous convolution of VGG inception *** training and testing,the identification of 400 testing samples by MmNet is very good,with accuracy of 94.50%and time cost of 10.369 ***,in quantitative comparative analysis,the proposed MmNet not only has high accuracy and efficiency but also simple construction and outstanding *** with recently popular CNNs,MmNet is more suitable for the identification of *** in the ***,to meet the challenge of wild environments,more *** images need to be acquired for MmNet *** addition,the classification labels need to be sorted in more ***,this research provides some theoretical and scientific basis for the development of intelligent monitoring and early warning systems for *** and other invasive species.

关键词： Mikania micrantha Kunth invasive alien plant image processing deep learning

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Effects of Dietary Picria felterrae Lour Extracts on Serum Biochemical Indexes and Immune Function of Guangxi Partridge Chickens

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Animal Husbandry and Feed Science 2018年第1期10卷 52-57页

作者： Yang Cui Bi Xianda Hu Tingjun Yang Jian Huang Hongye Tan Honglian Peng Jianbo Luo Wenjuan Li Lu Li Chunjie Liao Yuying Yang Jiahuang College of Animal Science and Technology Guangxi UniversityNanning 530004China Guangxi Institute of Animal Science Nanning 530001China Guangxi Beidouxing Animal Health Pharmaceutical Co. Ltd.Nanning 530003China

[Objective] This trial was to investigate the effect of dietary Picria felterrae Lour extracts on serum biochemical indexes and immune function of Guangxi Partridge chickens. [Method] Totally 500 individuals of 1-day-old Guangxi Partridge chickens were randomly divided into five groups, five replicates each group and 20 chicks each replicate. Groups A, B and C were treatment groups supplemented with 0.70%, 0.35% and0.175% P. felterrae extracts in the basal diet, respectively; group D was a medical control group supplemented with 0.01% colistin sulfate premix in the basal diet; and group E was a control group with basal diet. Serum samples were collected from 10 chickens in each group at 21, 35 and 49 days of age, to analyze the biochemical and immune indexes. [Result] It had no significant impact on serum TP and GLU contents of chickens by adding different levels of P. felterrae extracts in the basal diet（P 〉0.05）. However, at 21 and 35 days of age, the TBILI content of chickens in groups A, B and C were extremely lower or significantly lower than that in group E（ P〈0.01; P〈0.05）. At 35 days of age, the serum AKP activities in groups A, B and C were extremely higher than that in group E（P〈0.01）, and the serum GOT activities at 21 and 35 days of age in group C were significantly higher than that in group E（P〈0.05）. At 49 days of age, the serum Ig G content in groups A, B and C and the IL-2 content in group B and group C were significantly lower or extremely lower than that in group E（ P〈0.05; P〈0.01）; the T-AOC content in group B was significantly higher than that in group E（P〈0.05）; the GSH content in groups A, B and C were significantly higher than that in group E（ P〈0.05）. Adding different levels of P. felterrae extracts in the diet significantly decreased the TBILI content, reduced the Ig G, IL-2 and IL-6 contents, and improved the AKP and GOT activities and the T-AOC and GSH contents of Guangxi Partridge chicken. [Conclusion] Adding 0.35% P. felterrae extracts i

关键词： Picria felterrae Lour extracts Guangxi Partridge chicken Serum biochemical index Immune index Antioxidant ability

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Advances in Studies on Interaction between Selenium and Heavy Metal Cadmium

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Asian Agricultural research 2017年第8期9卷 55-58,61页

作者： Liping PAN Yongxian LIU Yanfei HUANG Mengling NONG Shiyang LU Jinping CHEN Yuying ZHAO Liumei XIONG Xiu LAN Kebing LI Institute of Agricultural Resource and Environment Guangxi Academy of Agricultural SciencesNanning 530007China Guangxi Plant Nutrition Engineering Technology research Center Nanjing 530007China Guangxi University Nanjing 530005China

Selenium is an essential functional element of the human body,and the issue of selenium accompanying heavy metals is receiving much *** paper expounded the form of existence of selenium and cadmium in soil and influencing factors of their bioavailability,and further elaborated the interaction between selenium and *** the basis,it provided references for further studies on the interaction between selenium and cadmium,and provided basis for establishing selenium-enriched barrier technology for crops.

关键词： Selenium Cadmium Interaction

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