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An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs

Science China(Life Sciences) 2024年第6期67卷 1133-1154页

作者： Yang Zhang Mengyao Wang Zhenguo Li Xuan Yang Keqin Li Ao Xie Fang Dong Shihan Wang Jianbing Yan Jianxiao Liu National key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China key Laboratory of Smart Farming for Agricultural Animals Huazhong Agricultural UniversityWuhan 430070China hubei key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhan 430070China College of Informatics Huazhong Agricultural UniversityWuhan 430070China College of Life Sciences Nankai UniversityTianjin 300071China

Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and directions for understanding complex traits by identifying important single nucleotide *** GWAS summary statistics data related to various complex traits have been gathered *** have shown that GWAS risk loci and expression quantitative trait loci(e QTLs)often have a lot of overlaps,which makes gene expression gradually become an important intermediary to reveal the regulatory role of *** this review,we review three types of gene-trait association detection methods of integrating GWAS summary statistics and e QTLs data,namely colocalization methods,transcriptome-wide association study-oriented approaches,and Mendelian randomization-related *** the theoretical level,we discussed the differences,relationships,advantages,and disadvantages of various algorithms in the three kinds of gene-trait association detection *** further discuss the performance of various methods,we summarize the significant gene sets that influence highdensity lipoprotein,low-density lipoprotein,total cholesterol,and triglyceride reported in 16 *** discuss the performance of various algorithms using the datasets of the four lipid *** advantages and limitations of various algorithms are analyzed based on experimental results,and we suggest directions for follow-up studies on detecting gene-trait associations.

关键词： gene-trait association GWAS eQTL colocalization transcriptome-wide association study(TWAS) Mendelian randomization(MR)

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Universal Encapsulation Adhesive for Lead Sedimentation and Attachable Perovskite Solar Cells with Enhanced Performance

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Energy & Environmental Materials 2024年第3期7卷 303-310页

作者： Xuehao Zhu Haoyu Cai Cong Bai Zhengzhe Wu Wenjian Shen Yiming Xiong Juan Zhao Fuzhi Huang Yibing Cheng Jie Zhong Research Centre for Advanced Thin Film Photovoltaics State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528216China School of Automobile Engineering Wuhan University of TechnologyWuhan 430070China

In this work,a modified polyurethane adhesive(PUA)was prepared to realize a convenient encapsulation strategy for lead sedimentation and attachable perovskite solar cells(A-PSCs).The modified PUA can completely self-heal within 45 min at room temperature with an efficient lead ion-blocking rate of 99.3%.The PUA film can be coated on a metal electrode with slight efficiency improvement from 23.96%to 24.15%.The thermal stability at 65℃and the humidity stability at 55%relative humidity(RH)are superior to the devices encapsulated with *** PUA film has strong adhesion to the flexible substrate and the initial efficiency of the flexible perovskite module(17.2%)encapsulated by PUA remains 92.6%within 1825 *** results suggest that PUA encapsulation is universal for rigid and flexible PSCs with enhanced stability and low lead ***,it was found that flexible PSCs can be well attached to various substrates with PUA,providing a facile route for the A-PSCs in various scenarios without additional encapsulation and installation.

关键词： adhesive attachable device flexible module lead leakage polyurethane

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Comparative Analysis of Noise Margin between Pure SET-SET and Hybrid SET-PMOS Inverters

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Chinese Journal of Electronics 2024年

作者： Fan ZHANG Yi LIU Yibo WANG Minghu WU Sheng HU Youli DONG hubei key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of Technology School of Electrical and Electronic Engineering Hubei University of Technology

Single-electron transistor（SET） is considered as one of the promising candidates for future electronic devices due to its advantages of low power consumption and high integration. The comparative analysis of SETbased inverters, especially the noise margin, is carried out. Pure SET-SET and hybrid SET with p type metal oxide semiconductor（SET-PMOS） inverters are designed for investigation. The effects of SET supply voltage, junction resistance and junction capacitance on noise tolerance and power consumption of inverters are studied. For hybrid SET-PMOS inverters, the noise margin for a logic high（NMH） is less than 60 mV under various conditions, which may become the bottleneck of its application. For pure SET-SET inverters, both NMH and the noise margin for a logic low（NML） could reach 300 mV at a supply voltage of 0.8 V. The minimum power consumption of pure SETSET and hybrid SET-PMOS inverters is 2.85 nW and 58 nW, respectively. The pure SET-SET inverters have greater noise tolerance and lower power consumption, which is more conducive to large-scale integration. When junction capacitance CJ= 0.0273 aF and junction resistance V, the NMH and NML are not significantly affected by the junction resistance and the noise margin fluctuates at 300mV.

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Mixed Alkali-zinc Effects on Thermo-mechanical Properties in Borosilicate Glasses

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1093-1099页

作者： XIAO Guanzhou TAO Yunhang ZHOU Hemin ZHENG Qingshuang QIAO Ang TAO Haizheng State key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan 430070China Wuhan University of Technology Advanced Engineering Technology Research Institute of Zhongshan City Zhongshan 528437China

A series of mixed alkali-zinc borosilicate glasses with various r values(r=molar ratio of[ZnO]/([R^(2)O]+[ZnO]))from 0.00 to 1.00 were fabricated to probe the mixed alkali-zinc effects on thermo-mechanical *** nonlinear evolution of glass transition temperature(T_(g))with the addition of ZnO is ascribed to the competition of two converse factors,i e,the T_(g)depression as one of the colligative properties for a solution,on the one hand,and the enhancement of T_(g)due to the higher field strength of zinc cations compared to that of alkali ***,the nonlinear evolution of elastic moduli and coefficients of thermal expansion with r is attributed to the variance of intermediate-range clusters,which is confirmed by infrared and Raman scattering *** findings are very helpful in tailoring the performance of borosilicate glasses.

关键词： glass transition temperature elastic moduli coefficient of thermal expansion borosilicate glass

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Electronic-scale assessment of high-temperature oxidation mechanisms in a novel Fe-based alloy

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Journal of Iron and Steel Research International 2024年第4期31卷 982-997页

作者： Wei-di Luo Ting-ping Hou Xuan Liang Dong Zhang Heng-fu Lin Yu Li Tian-liang Zhao Cheng-yang Hu Serhii Yershov Kai-ming Wu The State key Laboratory of Refractories and Metallurgy.Wuhan University of Science and Technology.Wuhan 430081 HubeiChina hubei province key Laboratory of Systems Science in Meallurgial Process Wuhan University of Science and Technology.Wuhan 430081.Hubei.China International Research Institute for Steel Technology Wuhan University of Science and Technology.Wuhan 430081.HubeiChina Collaborative Innovation Center for Advanced Steels w uhan University of Science and Technology.Wuhan 430081.HuleiChina

The development of alloys with high antioxidation performance is limited by the ambiguous details of the oxidation ***,based on the structures of internal oxides detected by high-resolution transmission electron microscopy,a hybrid method combining first-principles calculation,climb image nudged elastic band method and quasi-harmonic Debye model has been implemented to explain the oxidation mechanism with an emphasis on the origin of delamination and *** results showed that the delamination of oxides corresponds to the acceleration of diffusion of Cr element caused by lamellar *** reduction in the cracking occurrence at high temperature mainly results from the smaller bulk modulus of ***,the stronger chemical bonds promoted by lamellar structures also correspond to the higher crackingresistance.

关键词： Oxidation Crystal structure Diffusion Cracking-First-principles calculation

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Carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites for catalytic transfer hydrogenation:Balance in the ability of substrates adsorption and conversion

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Nano Research 2024年第5期17卷 3724-3732页

作者： Bowen Wang Nan Zhang Ping Xiao Jian Zhang Sónia A.C.Carabineiro Junjiang Zhu hubei key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de LisboaLargo da Torre2829-516 CaparicaPortugal

Catalytic transfer hydrogenation(CTH)is a green and efficient pathway for selective hydrogenation of unsaturated aldehydes and ***,managing the abilities of solid catalysts to adsorb substrates and to convert them into desired products is a challenging ***,we report the synthesis of carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites(LFPO-8@C)for CTH of benzaldehyde(BzH)into benzyl alcohol(BzOH),using isopropanol(IPA)as hydrogen *** coating with carbon improves the ability to adsorb/transfer reactants from solution to active sites,and the doping of Pd2+at Fe3+site strengthens the ability of LaFeO_(3) to convert BzH into BzOH.A balanced point between them(i.e.,abilities to adsorb BzH and to convert BzH into BzOH)is obtained at LFPO-8@C,which exhibits a BzOH formation rate of 3.88 mmol·gcat^(-1)·h^(-1) at 180℃ for 3 h,which is 1.50 and 2.72 times faster than those of LFPO-8 and LaFeO_(3)@C.A reaction mechanism is proposed,in which the acidic sites(e.g.,Fe^(4+),oxygen vacancy)are used for the activation of C=O bond of BzH and O-H bond of IPA,and the basic sites(e.g.,lattice oxygen)for the activation ofα-H(O-H)bond of IPA.

关键词： LaFe_(0.92)Pd_(0.08)O_(3) porous carbon catalytic transfer hydrogenation isopropanol reaction mechanism

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Nested Saturated Control of Uncertain Complex Cascade Systems Using Mixed Saturation Levels

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1163-1174页

作者： Meng Li Zhigang Zeng Wuhan National Laboratory for Optoelectronics Wuhan 430074 School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

This study addresses the problem of global asymptotic stability for uncertain complex cascade systems composed of multiple integrator systems and non-strict feedforward nonlinear systems. To tackle the complexity inherent in such structures, a novel nested saturated control design is proposed that incorporates both constant saturation levels and state-dependent saturation levels. Specifically, a modified differentiable saturation function is proposed to facilitate the saturation reduction analysis of the uncertain complex cascade systems under the presence of mixed saturation levels. In addition, the design of modified differentiable saturation function will help to construct a hierarchical global convergence strategy to improve the robustness of control design scheme. Through calculation of relevant inequalities, time derivative of boundary surface and simple Lyapunov function,saturation reduction analysis and convergence analysis are carried out, and then a set of explicit parameter conditions are provided to ensure global asymptotic stability in the closed-loop systems. Finally, a simplified system of the mechanical model is presented to validate the effectiveness of the proposed method.

关键词： method saturation differentiable

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Impact of wetting-drying cycles and acidic conditions on the soil aggregate stability of yellow‒brown soil

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Journal of Mountain Science 2024年第6期21卷 2075-2090页

作者： XIA Zhenyao NI Yuanzhen LIU Deyu WANG Di XIAO Hai key Laboratory of Geological Hazards on Three Gorges Reservoir Area Ministry of EducationYichang 443002China College of Civil Engineering&Architecture China Three Gorges UniversityYichang 443002China Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of EducationChina Three Gorges UniversityYichang 443002China

Soil aggregate is the basic structural unit of soil,which is the foundation for supporting ecosystem functions,while its composition and stability is significantly affected by the external *** study was conducted to explore the effect of external environment(wetting-drying cycles and acidic conditions)on the soil aggregate distribution and stability and identify the key soil physicochemical factors that affect the soil aggregate *** yellow‒brown soil from the Three Gorges Reservoir area(TGRA)was used,and 8 wetting-drying conditions(0,1,2,3,4,5,10 and 15 cycles)were simulated under 4 acidic conditions(pH=3,4,5 and 7).The particle size distribution and soil aggregate stability were determined by wet sieving method,the contribution of environmental factors(acid condition,wetting-drying cycle and their combined action)to the soil aggregate stability was clarified and the key soil physicochemical factors that affect the soil aggregate stability under wetting-drying cycles and acidic conditions were determined by using the Pearson’s correlation analysis,Partial least squares path modeling(PLS‒PM)and multiple linear regression *** results indicate that wetting-drying cycles and acidic conditions have significant effects on the stability of soil aggregates,the soil aggregate stability gradually decreases with increasing number of wetting-drying cycles and it obviously decreases with the increase of ***,the combination of wetting-drying cycles and acidic conditions aggravate the reduction in the soil aggregate *** wetting-drying cycles,acidic conditions and their combined effect imposes significant impact on the soil aggregate stability,and the wetting-drying cycles exert the greatest *** soil aggregate stability is significantly correlated with the pH,Ca^(2+),Mg^(2+),maximum disintegration index(MDI)and soil bulk density(SBD).The PLS‒PM and multiple linear regression analysis further reveal that the soil aggre

关键词： Yellow‒brown soil Wetting-drying cycles Acidic conditions Soil aggregate stability Soil disintegration

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Predictive Value of High Mobility Group Box-1 and miR-146b in Septic Shock Patients

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 85-94页

作者： FENG Jun SHAO Shasha LIU Junya PAN Yongjun YIN Huimei WANG Junshuai Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Department of Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Department of Critical Care Medicine Southern University of Science and Technology HospitalShenzhen 518055GuangdongChina Department of Emergency Medicine People's Hospital of Bortala Mongol Autonomous PrefectureBole 833400XinjiangChina

In the face of the elevated incidence and mortality rate of septic shock in the ICU,this retrospective study seeks to investigate the indicative and predictive value of high-mobility group box 1(HMGB1)and miR-146b in patients with septic *** RTPCR was employed in this study to quantify the HMGB1 and miR-146b levels in plasma samples obtained from the patient group and healthy *** investigation involved the comparison between the two groups and tracking changes in the patient group over *** finding revealed that upon admission,the patient group exhibited markedly elevated relative expression levels of HMGB1,which subsequently decreased over ***,the patient group displayed significantly reduced relative expression levels of miR-146b upon admission,which subsequently increased over time compared to the control *** operating characteristic(ROC)curves showed good predictive value for HMGB1 and *** experimental results suggest that HMGB1 and miR-146b serve as valuable and convenient biomarkers for evaluating the severity of septic shock and predicting ***,it is proposed that serum miR-146b may be inducible and potentially exerts a negative regulatory effect on the expression of HMGB1.

关键词： septic shock feedback loop high mobility group box-1 miR-146b disease severity

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A deep learning model based on contrast-enhanced computed tomography for differential diagnosis of gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 376-384页

作者： Fei Xiang Qing-Tao Meng Jing-Jing Deng Jie Wang Xiao-Yuan Liang Xing-Yu Liu Sheng Yan Department of Hepatobiliary Pancreatic Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Radiology Affiliated Chuzhou First People’s HospitalAnhui Medical UniversityChuzhou 239000China

Background:Gallbladder carcinoma(GBC)is highly malignant,and its early diagnosis remains *** study aimed to develop a deep learning model based on contrast-enhanced computed tomography(CT)images to assist radiologists in identifying ***:We retrospectively enrolled 278 patients with gallbladder lesions(>10 mm)who underwent contrast-enhanced CT and cholecystectomy and divided them into the training(n=194)and validation(n=84)*** deep learning model was developed based on ResNet50 *** and clinical models were built based on support vector machine(SVM)*** comprehensively compared the performance of deep learning,radiomics,clinical models,and three ***:Three radiomics features including LoG_3.0 gray-level size zone matrix zone variance,HHL firstorder kurtosis,and LHL gray-level co-occurrence matrix dependence variance were significantly different between benign gallbladder lesions and GBC,and were selected for developing radiomics *** regression analysis revealed that age≥65 years[odds ratios(OR)=4.4,95%confidence interval(CI):2.1-9.1,P37 U/mL(OR=4.0,95%CI:1.6-10.0,P=0.003)were significant clinical risk factors of *** deep learning model achieved the area under the receiver operating characteristic curve(AUC)values of 0.864(95%CI:0.814-0.915)and 0.857(95%CI:0.773-0.942)in the training and validation datasets,which were comparable with radiomics,clinical models and three *** sensitivity of deep learning model was the highest both in the training[90%(95%CI:82%-96%)]and validation[85%(95%CI:68%-95%)]***:The deep learning model may be a useful tool for radiologists to distinguish between GBC and benign gallbladder lesions.

关键词： Gallbladder carcinoma Computed tomography Deep learning Radiomics

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