检索结果-南通市图书馆

Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming

引用

Cell Regeneration 2020年第1期9卷 180-189页

作者： Mengdan Zhang Qian Li Tingting Yang Fei Meng Xiaowei Lai Lining Liang Changpeng Li Hao Sun Jiaqi Sun Hui Zheng CAS Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences#190 Kaiyuan Ave.Science CityGuangzhou 510530Huangpu DistrictChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510700China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou 510530China University of chinese academy of sciences Beijing 100049China Guangzhou Medical University Guangzhou 511436China Institutes for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

Retinoic acid(RA)and 2-phospho-L-ascorbic acid trisodium salt(AscPNa)promote the reprogramming of mouse embryonic fibroblasts to induced pluripotent stem *** the current studies,the lower abilities of RA and AscPNa to promote reprogramming in the presence of each other suggested that they may share downstream pathways at least *** hypothesis was further supported by the RNA-seq analysis which demonstrated a high-level overlap between RA-activated and AscPNa activated genes during *** addition,RA upregulated Glut1/3,facilitated the membrane transportation of dehydroascorbic acid,the oxidized form of L-ascorbic acid,and subsequently maintained intracellular L-ascorbic acid at higher level and for longer *** the other hand,AscPNa facilitated the mesenchymal-epithelial transition during reprogramming,downregulated key mesenchymal transcriptional factors like Zeb1 and Twist1,subsequently suppressed the expression of Cyp26a1/b1 which mediates the metabolism of RA,and sustained the intracellular level of ***,the different abilities of RA and AscPNa to induce mesenchymal-epithelial transition,pluripotency,and neuronal differentiation explain their complex contribution to reprogramming when used individually or in ***,the current studies identified a positive feedback between RA and AscPNa,or possibility between vitamin A and C,and further explored their contributions to reprogramming.

关键词： Reprogramming L-ascorbic acid Retinoic acid Positive feedback Mesenchymal-epithelial transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation

引用

Cell Regeneration 2021年第1期10卷 64-75页

作者： Jiaqi Sun Junzheng Yang Xiaoli Miao Horace HLoh Duanqing Pei Hui Zheng Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) #188 Kaiyuan Ave.Science CityHuangpu DistrictGuangzhou 510700China CAS Key Laboratory of Regenerative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou 510530China Institutes for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China School of Life Science Westlake UniversityHangzhou 310024China

Background:Epigenetic modifications,namely non-coding RNAs,DNA methylation,and histone modifications such as methylation,phosphorylation,acetylation,ubiquitylation,and sumoylation play a significant role in brain *** methyltransferases,methyl-CpG binding proteins,and ten-eleven translocation proteins facilitate the maintenance,interpretation,and removal of DNA methylation,*** forms of methylation,including 5-methylcytosine,5-hydroxymethylcytosine,and other oxidized forms,have been detected by recently developed sequencing *** evidence suggests that the diversity of DNA methylation patterns in the brain plays a key role in fine-tuning and coordinating gene expression in the development,plasticity,and disorders of the mammalian central nervous *** stem cells(NSCs),originating from the neuroepithelium,generate neurons and glial cells in the central nervous system and contribute to brain plasticity in the adult mammalian *** body:Here,we summarized recent research in proteins responsible for the establishment,maintenance,interpretation,and removal of DNA methylation and those involved in the regulation of the proliferation and differentiation of *** addition,we discussed the interactions of chemicals with epigenetic pathways to regulate NSCs as well as the connections between proteins involved in DNA methylation and human ***:Understanding the interplay between DNA methylation and NSCs in a broad biological context can facilitate the related studies and reduce potential misunderstanding.

关键词： DNA methylation Neural stem cells DNA methyltransferases Methyl-CpG binding proteins Ten-eleven translocations Vitamin C

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：