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Neuroscience Bulletin 2020年第11期36卷 1242-1258页

作者： James Morgan Mariana Alves Giorgia Conte Aida Menendez-Mendez Laura de Diego-Garcia Gioacchino de Leo Edward Beamer Jonathon Smith Annette Nicke Tobias Engel Department of Physiology and Medical Physics Royal College of Surgeons in IrelandDublin D02 YN77Ireland FutureNeuro Science Foundation Ireland Research Centre for Chronic and Rare Neurological DiseasesRoyal College of Surgeons in IrelandDublin D02 YN77Ireland Walther Straub Institute of Pharmacology and Toxicology Faculty of MedicineLudwig-Maximilians-Universitat Miinchen80336 MunichGermany

Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the *** increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly demonstrated,the cell type-specific expression of P2X7 and its expression in extra-hippocampal brain structures remains incompletely *** this study,P2X7 expression was visualized by using a transgenic mouse model overexpressing P2X7 fused to the fluorescent protein *** results showed increased P2X7-EGFP expression after status epilepticus induced by intra-amygdala kainic acid and during epilepsy in different brain regions including the hippocampus,cortex,striatum,thalamus and cerebellum,and this was most evident in microglia and *** of P2X7-EGFP with cell type-specific markers was not detected in neurons or *** data suggest that P2X7 activation is a common pathological hallmark across different brain structures,possibly contributing to brain inflammation and neurodegeneration following acute seizures and during epilepsy.

关键词： Purinergic signaling P2X7 Green fluorescence protein Status epilepticus Epilepsy Cell typespecific expression

Neuromuscular trunk activation patterns in back pain patients during one-handed lifting

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World Journal of Orthopedics 2017年第2期8卷 142-148页

作者： Juliane Mueller Tilman Engel Stephan Kopinski Frank Mayer Steffen Mueller University Outpatient Clinic Sports Medicine and Sports OrthopaedicsUniversity of Potsdam

AIM To analyze neuromuscular activity patterns of the trunk in healthy controls(H) and back pain patients(BPP) during one-handed lifting of light to heavy loads. METHODS After assessment of back pain(graded chronic pain scale according to von Korff) all subjects(n = 43) performed a warm-up(treadmill walking). Next, subjects were instructed to lift 3 × a 20 kg weight placed in front of them(with both hand) onto a table(height: 0.75 m). Subsequently, all subjects lifted with one hand(left-side, 3 repetitions) a weight of 1 kg(light), 10 kg(middle) and 20 kg(heavy) in random order from the ground up onto the table left of them. Trunk muscle activity was assessed with a 12-lead EMG(6 ventral/6 dorsal muscles; 4000 Hz). EMG-RMS(%) was averaged over the 3 repetitions and analyzed for the whole one-handed lifting cycle, then normalized to RMS of the two-handed lifting. Additionally, the mean(normalized) EMG-RMS of four trunk areas [right/left ventral area(VR/VL); right/left dorsal area(DR/DL)] was calculated. Data were analyzed descriptively(mean ± SD) followed by student's t-test comparing H and BPP(α = 0.05). With respect to the unequal distribution of subjects in H and BPP, a matched-group analysis was conducted. Seven healthy controls were gender- and age-matched(group H_(matched)) to the 7 BPP. In addition, task failure was calculated and compared between H/H_(matched) vs BPP using χ~2. RESULTS Seven subjects(3m/4f; 32 ± 7 years; 171 ± 7 cm; 65 ± 11 kg) were assigned to BPP(pain grade ≥ 2) and 36(13m/23f; 28 ± 8 years; 174 ± 10 cm; 71 ± 12 kg) to H(pain grade ≤ 1). H and BPP did not differ significantly in anthropometrics(P > 0.05). All subjects were able to lift the light and middle loads, but 57% of BPP and 22% of H were not able to lift the heavy load(all women). χ~2 analysis revealed statistically significant differences in task failure between H vs BPP(P = 0.03). EMG-RMS ranged from 33% ± 10%/30% ± 9%(DL, 1 kg) to 356% ± 148%/283% ± 80%(VR, 20 kg) in H/BPP with n

关键词： Lifting Core Trunk EMG MISPEX

Observation of the Y(4230)and a new structure in e^(+)e^(-)→K^(+)K^(-)J/Ψ

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Chinese Physics C 2022年第11期46卷 7-21页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina R.Baldini Ferroli I.Balossino 班勇 V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈刚陈和生陈玛丽陈申见 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.Ede Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K.Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 顾旻皓关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich T.Holtmann 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍 Z.Huang T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv Q.Ji 姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李贺 H.Li 李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李紫源梁浩梁昊梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat C.X.Lin 林德旭 T.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 FEMaas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥 Y.Pan A.Pathak A.Pathak M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 S.Plura S.Pogodin R.Poling V.Prasad 齐法制齐航漆红荣祈鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 S.Q.Qu Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

The cross sections of e^(+)e^(-)→K^(+)K^(-)J/Ψat center-of-mass energies from 4.127 to 4.600 GeV are measured based on 15.6 fb-1data collected with the BESⅢ detector operating at the BEPCⅡ storage *** resonant structures are observed in the line shape of the cross *** mass and width of the first structure are measured to be(4225.3±2.3±21.5)MeV and(72.9±6.1±30.8)MeV,*** are consistent with those of the established Y(4230).The second structure is observed for the first time with a statistical significance greater than 8σ,denoted as Y(4500).Its mass and width are determined to be(4484.7±13.3±24.1)MeV and(111.1±30.1±15.2)MeV,*** first presented uncertainties are statistical and the second ones are *** product of the electronic partial width with the decay branching fractionΓ(Y(4230)→e^(+)e^(−))B(Y(4230)→K^(+)K^(−)J/Ψ)is reported.

关键词： Y states charmonium-like states BESⅢ

Opening a window to skin biomarkers for diabetes stage with optoacoustic mesoscopy

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Light(Science & Applications) 2023年第11期12卷 2335-2349页

作者： Hailong He Nikolina-Alexia Fasoula Angelos Karlas Murad Omar Juan Aguirre Jessica Lutz Michael Kallmayer Martin Fuchtenbusch Hans-Henning Eckstein Annette Ziegler Vasilis Ntziachristos Institute of Biological and Medical Imaging Helmholtz Zentrum MunchenNeuherbergGermany Chair of Biological Imaging at the Central Institute for Translational Cancer Research(TranslaTUM) School of MedicineTechnical University of MunichMunichGermany Department for Vascular and Endovascular Surgery Klinikum rechts der IsarTechnical University of Munich(TUM)MunichGermany DZHK(German Centre for Cardiovascular Research) partner site Munich Heart AllianceMunichGermany Diabetes Center at Marienplatz MunichGermany Forschergruppe Diabetes e.V. Helmholtz Zentrum MunchenNeuherbergGermany Institute of Diabetes Research Helmholtz Zentrum MunchenNeuherbergGermany

Being the largest and most accessible organ of the human body,the skin could offer a window to diabetes-related complications on the ***,skin microvasculature is typically assessed by histological analysis,which is not suited for applications to large populations or longitudinal *** introduce ultra-wideband rasterscan optoacoustic mesoscopy(RSOM)for precise,non-invasive assessment of diabetes-related changes in the dermal microvasculature and skin micro-anatomy,resolved with unprecedented sensitivity and detail without the need for contrast *** unique imaging contrast,we explored a possible role for RSOM as an investigational tool in diabetes healthcare and offer the first comprehensive study investigating the relationship between different diabetes complications and microvascular features in *** applied RSOM to scan the pretibial area of 95 participants with diabetes mellitus and 48 age-matched volunteers without diabetes,grouped according to disease complications,and extracted six label-free optoacoustic biomarkers of human skin,including dermal microvasculature density and epidermal parameters,based on a novel image-processing *** then correlated these biomarkers to disease severity and found statistically significant effects on microvasculature parameters as a function of diabetes *** discuss how label-free RSOM biomarkers can lead to a quantitative assessment of the systemic effects of diabetes and its complications,complementing the qualitative assessment allowed by current clinical metrics,possibly leading to a precise scoring system that captures the gradual evolution of the disease.

关键词： diabetes anatomy precise

Enhanced magnetic modulation of light polarization exploiting hybridization with multipolar dark plasmons in magnetoplasmonic nanocavities

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Light(Science & Applications) 2020年第1期9卷 1547-1560页

作者： Alberto Lopez-Ortega Mario Zapata-Herrera Nicolo Maccaferri Matteo Pancaldi Mikel Garcia Andrey Chuvilin Paolo Vavassori CIC nanoGUNE-BRTA Donostia-San SebastianDonostia 20018Spain Department of Physics and Materials Science University of LuxembourgL-1511 LuxembourgLuxembourg Department of Physics Stockholm University10691 StockholmSweden IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain

Enhancing magneto-optical effects is crucial for reducing the size of key photonic devices based on the non-reciprocal propagation of light and to enable active ***,we disclose a currently unexplored approach that exploits hybridization with multipolar dark modes in specially designed magnetoplasmonic nanocavities to achieve a large enhancement of the magneto-optically induced modulation of light *** broken geometrical symmetry of the design enables coupling with free-space light and hybridization of the multipolar dark modes of a plasmonic ring nanoresonator with the dipolar localized plasmon resonance of the ferromagnetic disk placed inside the *** hybridization results in a low-radiant multipolar Fano resonance that drives a strongly enhanced magneto-optically induced localized *** large amplification of the magneto-optical response of the nanocavity is the result of the large magneto-optically induced change in light polarization produced by the strongly enhanced radiant magneto-optical dipole,which is achieved by avoiding the simultaneous enhancement of reemitted light with incident polarization by the multipolar Fano *** partial compensation of the magnetooptically induced polarization change caused by the large re-emission of light with the original polarization is a critical limitation of the magnetoplasmonic designs explored thus far and that is overcome by the approach proposed here.

关键词： polar light enable

Faraday effect measurements of holmium oxide(Ho2O3) ceramics-based magneto-optical materials

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High Power Laser Science and Engineering 2018年第1期6卷 7-12页

作者： David Vojna Ryo Yasuhara Hiroaki Furuse Ondrej Slezak Simon Hutchinson Antonio Lucianetti Tomas Mocek Miroslav Cech Hi LASE Centre Institute of Physics Czech Academy of Sciences Za Radnici 828 Dolni Brezany 252 41 Czech Republic National Institute for Fusion Science National Institutes of Natural Sciences 322-6 Oroshi-cho Toki Gifu 509-5292 Japan Kitami Institute of Technology 165 Koen-cho Kitami Hokkaido Japan Department of Physical Electronics Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PragueBrehova 7 Prague 115 19 Czech Republic

Faraday effect measurements of holmium oxide(Ho_2O_3) ceramics-based magneto-optical materials, highly potential material candidates for high-energy laser Faraday isolators, are presented in this paper. Temperature dependence of the Verdet constant of nondoped Ho_2O_3 ceramics was measured for temperatures 15–305 K at 1.064 μm *** Verdet constant dispersion for wavelengths 0.5–1 μm and 1.064 μm was measured for both nondoped Ho_2O_3 ceramics and Ho_2O_3 ceramics doped with terbium Tb3+(0.2 at. %) and cerium Ce3+(0.1 at. %) ions. The results suggest that the relatively low level of doping of Ho_2O_3 with these ions has no significant boosting impact on the Faraday effect. Therefore, other compositions of Ho_2O_3 ceramics-based magneto-optical materials, as well as various doping concentrations, should be further examined.

关键词： Faraday effect magneto-optics optical materials

Toward room-temperature nanoscale skyrmions in ultrathin films

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npj Computational Materials 2020年第1期6卷 58-68页

作者： Anastasiia SVarentcova Stephan von Malottki Maria N.Potkina Grzegorz Kwiatkowski Stefan Heinze Pavel F.Bessarab ITMO University St.Petersburg 197101Russia Science Institute University of IcelandReykjavík 107Iceland Kavli Institute of Nanoscience Delft University of TechnologyP.O.Box 4056Delft 2600 GAThe Netherlands Institute of Theoretical Physics and Astrophysics University of KielLeibnizstrasse 15Kiel 24098Germany St.Petersburg State University St.Petersburg 198504Russia Peter Grünberg Institute and Institute for Advanced Simulation Forschungszentrum JülichJülich 52425Germany

Breaking the dilemma between small size and room-temperature stability is a necessary prerequisite for skyrmion-based information *** we demonstrate by means of rate theory and an atomistic spin Hamiltonian that the stability of isolated skyrmions in ultrathin ferromagnetic films can be enhanced by the concerted variation of magnetic interactions while keeping the skyrmion size *** predict film systems where the lifetime of sub-10 nm skyrmions can reach years at ambient conditions.

关键词： conditions stability films

Visualizing light-induced dynamic structural transformations of Au clusters-based photocatalyst via in situ TEM

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Nano Research 2021年第8期14卷 2805-2809页

作者： Bo Weng Youhong Jiang Hong-Gang Liao Maarten B.J.Roeffaers Feili Lai Haowei Huang Zichao Tang State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China cMACS Department of Microbial and Molecular SystemsKU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium Department of Chemistry KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium

Ultrasmall gold(Au)clusters have been regarded as one of the prototypes materials for solar energy conversion due to their unique strong molecular-like light absorption ***,the light-induced aggregation of Au clusters into nanoparticles is one of the most important factors that restricts its application in *** Au clusters aggregation has been widely demonstrated,the underlying mechanism for cluster fusion is still unclear due to the lack of experimental ***,we report the direct observation of Au clusters on TiO_(2) nanosheets aggregating when used as visible light photocatalysts for the reduction of *** in situ high-resolution transmission electron microscopy(TEM),the coexistence of two fusion mechanisms of Au clusters on TiO_(2) under ultraviolet-visible(UV-Vis)light irradiation in air is identified,i.e.,the migration and coalescence(MC)and Ostwald ripening(OR).Additionally,the correlation between the photostability of Au clusters and reaction atmospheres has been investigated,among which Au clusters have higher stability in an inert N_(2) atmosphere or vacuum than the oxidizing atmospheres(i.e.,air and O_(2)).These results indicate the inherent stability of Au cluster during photocatalysis,and instability comes from the consuming of ligand *** work not only discloses the underlying mechanism of Au cluster sintering but also provides guidelines for enhancing metal clusters-based photocatalysts stability.

关键词： photocatalysis dynamic structural transformation Au clusters in situ TEM

Collagen Fibers in Crocodile Skin and Teeth:A Morphological Comparison Using Light and Scanning Electron Microscopy

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Journal of Bionic Engineering 2020年第4期17卷 669-676页

作者： Piotr Krzysztof Szewczyk Urszula Stachewicz Metals Engineering and Industrial Computer Science and International Centre of Electron Microscopy for Materials Science AGH University of Science and TechnologyKraków 30-059Al.Mickiewicza 30Poland

Collagen is one of the most versatile tissues of living organisms that comes in many shapes and sizes,providing functions ranging from tissue matrix through,ligament formation up to enabling mineralization in *** detailed light microscopy and Scanning Electron Microscopy(SEM)observations conducted in this study,allowed us to investigate morphology,sizes and crimp patterns of collagen fibers observed in crocodile skin and ***,the microscopy study revealed that although two completely different tissues were investigated,many similarities in their structure based on collagen fibers were *** type I is present in crocodile skin and teeth,showing the flexibility in naturally constructed tissues to obtain various *** crimp size investigation of collagen fibers confirmed experimentally the theoretical 67 nm D-periodicity expected for collagen type *** collagen in teeth provides a matrix for crystal growth and in the skin provides flexibility and is a precursor for corneous ***,these observations of the collagen in the skin and tooth structure in crocodiles play an important role in designing biomimetic materials with similar functions and properties.

关键词： crocodile skin collagen crimp fiber crocodile tooth SEM

Point-of-need molecular processing of biosamples using portable instrumentation to reduce turnaround time

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Biosafety and Health 2020年第3期2卷 177-182页

作者： Manousos E.Kambouris Stavroula Siamoglou Zoe Kordou Aphroditi Milioni Stamatis Vassilakis Stavroula Goudoudaki Stavroula Kritikou Yiannis Manoussopoulos Aristea Velegraki George P.Patrinos Department of Pharmacy University of PatrasRio Patras 26504Greece Department of Microbiology School of MedicineNational and Kapodistrian University of AthensMikras Asias 75Athens 11527Greece Plant Protection Division of Patras Institute of Industrial and Forage PlantsN.E.O&AmerikisPatras 26004Greece United Arab Emirates University College of Medicine and Health SciencesDepartment of PathologyAl-AinUnited Arab Emirates United Arab Emirates University Zayed Center of Health SciencesAl-AinUnited Arab Emirates

Infectious agents,both standard and emerging or engineered,might initiate outbreaks with global impact and/or existential-level threat *** agents might infect human,livestock,exploitable plant cultures or the environment at *** of responding by sampling teams which may also carry out prolonged surveillance,a more effective concept is to pre-process the samples,possibly to nucleic acid extract so as to transport them without biological risks by standard channels,or to process them up to a point and return the results,leaving the samples which only need specialized tests and dedicated *** this context a portable device,allowing multiple routine and crisis-management applications due to its inherent flexibility,is scrutinized against alternatives and possible needs so as to develop a novel standard of surveillance and intervention,meant to facilitate containment by providing faster much more reliable laboratory results at a fraction of older generation mobile nucleic acids *** steps,such as agarose in pills and buffers pre-packaged in expendable syringes with pistons locked by improvised safety features may improve the Complexity Level of the whole system so as to make it appealing to intervention/crisis management personnel,while the instrument proper may double as backup for respective benchtop devices.

关键词： Point-of-Need Biosurveillance Public health Biosecurity-biosafety Portable PCR Portable NGS Quarantine pathogens