检索结果-南通市图书馆

Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy

Nano Research 2023年第8期16卷 11125-11138页

作者： Dao Shi Nan Wang Jie Zhang Xi Hu Qiyue Wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong UniversityShanghai 200240China Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmaceutics Jiaxing Key Laboratory for Photonanomedicine and Experimental TherapeuticsCollege of MedicineJiaxing UniversityJiaxing 314001China World Laureates Association(WLA)Laboratories Shanghai 201203China School of Pharmacy Anhui University of Chinese MedicineHefei 230012China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously preventing tumor metastasis and recurrence by activating the host antitumor immune ***-responsive dynamic nanoassemblies(TDNs)have evolved from being a mere curiosity to a promising platform for high-performance ***,the dynamic nano-bio interaction between TDNs and tumor microenvironment remains poorly understood,which shall be critical for precise control of TDNs assembling/disassembling behavior and superior PIT *** deepen the understanding of the structure–function relationship of TDNs,this review introduces the rational design,nano-bio interactions,and controllable functionalities of cutting-edge TDNs for enhanced ***,the synergetic mechanism between TDNs-based PIT and immunomodulatory agents-mediated immunomodulation is particularly ***,the challenges and future perspectives in this emerging field are assessed.

关键词： photoimmunotherapy tumor-responsive dynamic nanoassemblies immunosuppressive tumor microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low-temperature and high-voltage planar micro-supercapacitors based on anti-freezing hybrid gel electrolyte

引用

Journal of Energy Chemistry 2022年第9期31卷 195-202,I0006页

作者： Manning Chen Xiaoyu Shi Xiaolei Wang Hanqing Liu Sen Wang Caixia Meng Yu Liu Liangzhu Zhang Yuanyuan Zhu Zhong-Shuai Wu College of Chemistry and Environment Shenyang University of TechnologyShenyang 110870LiaoningChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023LiaoningChina

Micro-supercapacitors(MSCs)are considered as highly competitive power sources for miniaturized ***,narrow voltage window and poor anti-freezing properties of MSCs in conventional aqueous electrolytes lead to low energy density and limited environmental ***,we report the construction of low-temperature and high-energy-density MSCs based on anti-freezing hybrid gel electrolytes(HGE)through introducing ethylene glycol(EG)additives into aqueous LiCl *** EG partially destroys hydrogen bond network among water molecules,the HGE exhibits maximum electrochemical stability window of 2.7 V and superior anti-freezing features with a glass transition temperature of-62.8℃.Further,the optimized MSCs using activated carbon microelectrodes possess impressive volumetric capacitance of 28.9 F cm^(-3)and energy density of 10.3 mWh cm^(-3)in the voltage of 1.6 V,2.6 times higher than MSCs tested in 1.2 ***,the MSCs display 68.3%capacitance retention even at-30℃ compared to the value at 25℃,and ultra-long cyclability with 85.7%of initial capacitance after 15,000 times,indicating extraordinary low-temperature ***,our devices offer favorable flexibility and modular ***,this work provides a general strategy of realizing flexible,safe and anti-freezing microscale power sources,holding great potential towards subzero-temperature microelectronic applications.

关键词： Hybrid gel electrolyte Micro-supercapacitors Low temperature high voltage Graphene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

引用

Signal Transduction and Targeted Therapy 2023年第5期8卷 2363-2383页

作者： Lei Chen Wenjing Zhang Dan Chen Quan Yang Siwen Sun Zhenwei Dai Zhengzheng Li Xuemei Liang Chaoqun Chen Yuexia Jiao Lili Zhi Lianmei Zhao Jinrui Zhang Xuefeng Liu Jinyao Zhao Man Li Yang Wang Yangfan Qi Institute of Cancer Stem Cells and the Second Affiliated Hospital of dalian Medical University Dalian Medical UniversityDalian116044China Department of Pathology the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Department of Oncology the Second Affiliated Hospital of Dalian Medical UniversityDalian116023China Department of Thoracic Surgery the First Affiliated Hospital of Dalian Medical UniversityDalian116011China Research Center the Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China

Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct ***,the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely *** we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma(ESCC)cells by dictating the activity of LKB1,a critical governor of cancer *** level of RBM4 was specifically elevated in ESCC compared to normal tissues,and RBM4 overexpression promoted the malignant ***4 contributed to overcome H-RAS-or doxorubicin-induced senescence,while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR ***,RBM4 competitively bound LKB1 to disrupt the LKB1/STRAD/MO25 heterotrimeric complex,subsequently recruiting the E3 ligase TRIM26 to LKB1,promoting LKB1 ubiquitination and degradation in ***,such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine ***,the ESCC patients with high RBM4 and low LKB1 have significantly worse overall survival than those with low RBM4 and high *** RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839,providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics.

关键词： LKB1 ESCC protective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research Progress of Tip Winglet Technology in Compressor

引用

Journal of Thermal Science 2021年第1期30卷 18-31页

作者： ZHONG Jingjun WU Wanyang HAN Shaobing Merchant Marine College Shanghai Maritime UniversityShanghai 201306China Naval Architecture and Ocean Engineering College Dalian Maritime UniversityDalian 116026China

In the present study,the research progress of tip winglets that control tip clearance leakage flow in compressors is ***,the effects of tip leakage flow on the aerodynamic performance of the compressor are ***,the development of tip winglet technology is ***,a series of studies on compressor tip winglet technology are ***,the effects of tip winglets on the aerodynamic performance of rectangular cascades of low-speed and high-subsonic compressors,subsonic compressor rotor and transonic compressor rotor are discussed,respectively,and the control effect of tip winglet technology combined with tip groove design on tip leakage is ***,the subsequent development direction and research prospect of compressor tip winglet technology are presented.

关键词： blade tip winglet compressor tip leakage flow tip leakage vortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Cryorolling on the Precipitation of Cu–Ni–Si Alloys: An In Situ X-ray Diffraction Study

引用

Acta Metallurgica Sinica(English Letters) 2018年第10期31卷 1089-1097页

作者： Wei Wang Zong-Ning Chen En-Yu Guo Hui-Jun Kang Yi Liu Cun-Lei Zou Ren-Geng Li Guo-Mao Yin Tong-Min Wang Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences

The effect of cryorolling on the precipitation process of deformed Cu-Ni-Si alloys was investigated through in situ synchrotron X-ray diffraction technique. The results demonstrate that the precipitation process is significantly accelerated by cryorolling. Cryorolling produces higher dislocation density, which provides more heterogeneous nucleation sites for Ni2Si precipitates, hence promotes precipitation. In the early stage of aging, the enhanced nucleation of precipitates accelerates the depletion of supersaturation, and finer precipitates are obtained. In addition, recrystallization is promoted as a result of high stored energy in the cryorolled Cu-Ni-Si alloys, which facilitates the formation of discontinuous precipitation in the late stage of aging.

关键词： Copper alloy Cryogenic Rolling Aging precipitation Synchrotron radiation X-ray diffraction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

AC Line Filter Electrochemical Capacitors:Materials,Morphology,and Configuration

引用

Energy & Environmental Materials 2022年第4期5卷 1060-1083页

作者： Haichao Tang Yang Tian Zhongshuai Wu Yujia Zeng Yang Wang Yang Hou Zhizhen Ye Jianguo Lu State Key Laboratory of Silicon Materials Key Laboratory for Biomedical Engineering of Ministry of EducationSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023China dalian National Laboratory for Clean Energy Chinese Academy of Sciences457 Zhongshan RoadDalian 116023China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Wenzhou Key Laboratory of Novel Optoelectronic and Nano Materials Institute of WenzhouZhejiang UniversityWenzhou 325036China

Recently,more and more supercapacitors(SCs)have been developed as AC line filter capacitors,which are generally named AC line filter electrochemical capacitors(FECs).Compared to traditional bulky aluminum electrolytic capacitors(AECs),FECs have higher capacity and lower space occupancy,which makes them a strong ***,different from the common SCs for energy storage,it is necessary to consider the frequency response of the SCs for AC line filtering,where the contradiction between frequency response and specific capacitance is a *** researchers have proposed different solutions from the perspective of materials,morphology,and configuration for this *** on the above background,in this review,we briefly introduce the principle and parameters of AC line filter electrochemical *** systematically summarize the state-of-the-art progresses of FECs and discuss their possible application and development in the *** development of FECs can greatly promote the planarization,integration,and miniaturization of filter capacitors,and provide a new solution for the utilization of green and unstable energy.

关键词： AC line filtering fast response filter electrochemical capacitors specific capacitance supercapacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Grain nucleation and growth behavior of a Sn-Pb alloy affected by direct current： An in situ investigation

引用

Journal of Materials Science & Technology 2017年第10期33卷 1134-1140页

作者： Fenfen Yang Zongning Chen Fei Cao Rong Fan Huijun Kang Wanxia Huang Qingxi Yuan Tiqiao Xiao Yanan Fu Tongmin Wang Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Dalian 116024 China School of Chemical Engineering Dalian University of Technology Dalian 116024 China School of Automotive Engineering Dalian University of Technology Dalian 116024 China Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201204 China

In situ synchrotron X-ray radiography was used to study the effect of direct current（DC） on the grain nucleation and growth of Sn-50 wt.%Pb alloy. The results showed that applying DC adequately during solidification could effectively enhance the grain nucleation and inhibit its growth. Imaging of comparative experiments with varying DC intensity indicated that the final grain size, determined by the competition between grain nucleation and growth, was sensitively dependent on the DC intensity. It was found that the average grain size was decreased from 1632 to 567 μm with DC density of 1.5 A/mm^2 compared to the case without DC. Beyond this value, raising the current density may cause a significant decrease in the nucleation rate, and thus lead to a coarsening of the grain structure.

关键词： Sn-Pb alloy Synchrotron X-ray radiography Solidification Microstructure Electric current

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of addition of minor amounts of Sb and Gd on hot tearing susceptibility of Mg-5Al-3Ca alloy

引用

Journal of Magnesium and Alloys 2023年第2期11卷 694-705页

作者： Xudong Du Feng Wang Zhi Wang Le Zhou Zheng Liu Pingli Mao School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870P R China Key Laboratory of Magnesium Alloys and the Processing technology of Liaoning Province Shenyang 110870P R China

The effects of addition of minor amount of(0.5 wt.%) antimony(Sb) or gadolinium(Gd) and combined addition of Sb and Gd(0.5 wt.%,respectively) on the hot tearing susceptibility(HTS) of Mg-5Al-3Ca alloy were investigated experimentally using a “T-shaped” hot tearing measuring system. Various solidification parameters of the alloys were measured and calculated through thermal analysis experiments. The microstructure, grain size, and morphology of the crack zone were characterized by scanning electron microscopy and electron backscatter diffraction, and the crystal phases of the alloys were analyzed by X-ray diffraction and energy-dispersive X-ray spectroscopy. The results showed that the addition of 0.5 wt.% Gd resulted in the increase in the vulnerable temperature range(Tv) and reduced the eutectic structure content that could participate in feeding, thereby improving the HTS of the alloy. However, addition of 0.5 wt.% Sb or combined addition of Gd and Sb(0.5 wt.%, respectively) to the Mg-5Al-3Ca alloy shortened the Tvand improved the skeleton strength of the alloy, thereby reducing HTS. Moreover, significantly refined structure of Mg-5Al-3Ca-0.5Gd-0.5Sb alloy improved the feeding ability of the eutectic structure, thus the alloy exhibited the lowest HTS.

关键词： Hot tearing susceptibility Mg-5Al-3Ca alloy Thermal analysis Microstructure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinetic Resolution of 2-Substituted 1,2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation

引用

Chinese Journal of Chemistry 2021年第6期39卷 1606-1610页

作者： Baohua Cai Qingjing Yang Ling Meng Jun(Joelle)Wang Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518055China Department of Chemistry Hong Kong Baptist UniversityKowloonHong KongChina

A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via Rh-catalyzed asymmetric hydroarylation has been described for the first time.A variety of arylboronic acids coupled with 2-substituted 1,2-dihydroquinolines under mild reaction *** transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines as well as the recovered chiral 2-aryl-dihydroquinolines were obtained with high yields and excellent enantioselectivities(86%-99% ee,s factor up to 1057).

关键词： Kinetic resolution Hydroarylation Tetrahydroquinoline Asymmetric catalysis Transition metal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrahigh-rate and high-frequency MXene micro-supercapacitors for kHz AC line-filtering

引用

Journal of Energy Chemistry 2022年第6期31卷 1-8,I0001页

作者： Xin Feng Sen Wang Pratteek Das Xiaoyu Shi Shuanghao Zheng Feng Zhou Jing Ning Dong Wang Jincheng Zhang Yue Hao Zhong-Shuai Wu Guangzhou Wide Bandgap Semiconductor innovation Center Xidian UniversityXi’an 710071ShaanxiChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023LiaoningChina State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology Xidian UniversityXi’an 710071ShaanxiChina Shaanxi Joint Key Laboratory of Graphene Xidian UniversityXi’an 710071ShaanxiChina Xidian-Wuhu Research Institute Wuhu 241000AnhuiChina

Harnessing energy from the environment promotes the rapid development of micro-power generators and relevant power management modules of alternating current (AC) line-filtering to obtain a stabilized direct current (DC) output for storage and use. Micro-supercapacitors (MSCs) with miniaturized volume and high-frequency response are regarded as a critical component in filtering circuits for microscale power conversion. Here, we reported the fabrication of the wafer-sized planar MSCs (M-MSCs) based on 2D Ti_(2)C_(2)T_(6) MXene using a photolithography technique. The M-MSCs exhibited an areal capacitance of 153 μF cm^(-2) and a frequency characteristic (f_(0)) of 5.6 k Hz in aqueous electrolyte. Moreover, by employing suitable ionic liquid as electrolyte, the voltage window was expanded to 2 V and the f_(0) could be pushed to 6.6 k Hz relying on the electrical double-layer mechanism and lower adsorption energy while maintaining quasi-rectangular cyclic voltammogram curves at 5000 V s^(-1). Furthermore, the integrated MSCs pack was constructed and exhibited excellent rectifying ability by filtering various highfrequency 5000 Hz AC signals with different waveforms into stable DC outputs. Such ultrahigh-rate and high-voltage M-MSCs module for k Hz AC line-filtering would be potentially integrated with customizable electronics to realize on-chip rectifiers in high-density integrated circuit.

关键词： MXene Micro-supercapacitors Ionic liquid Photolithography AC line-filtering Energy storage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：