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Mannan-decorated STING-activating vaccine carrier for spatial coordinative stimulating antigen-specific immune responses

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Fundamental Research 2025年第1期5卷 183-191页

作者： Liu, Liping Zhao, Jiayu Huang, Zichao Xu, Yudi Chen, Hongyu Qiao, Ruirui Song, Wantong Tang, Zhaohui Davis, Thomas P. Chen, Xuesi Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Science and Technology of China Jilin Biomedical Polymers Engineering Laboratory Australian Institute of Bioengineering and Nanotechnology The University of Queensland

In recent years, the use of nanotechnologies to improve immunotherapy efficiency has attracted increasing interest in preventive and therapeutic cancer vaccine design. However, current nanocarriers are restricted by difficulties in the systematic spatial coordinative transport of antigens, which greatly hampers the immune response efficacy of nanovaccines. Herein, we designed a mannan-decorated stimulator of the interferon genes (STING)-activating vaccine carrier for spatial coordinative stimulation of antigen-specific immune responses and elicitation of robust antitumor immunity. Mannan-decoration as the shell could significantly enhance the lymph node draining ability of the nanovaccines, especially in CD8+ dendritic cells (DCs). Azole molecule end-capped polylactic acid-polyethylenimine (PLA-PEI-4BImi) with innate stimulating activity was applied as the inner core for coordinating antigen-presenting cell activation and antigen cross-presentation. In the in vivo therapy study, single usage of this nanovaccine could achieve a 93% tumor suppression rate in the B16-OVA tumor model, which is superior to the commercialized aluminum adjuvant. This study demonstrates that a rational design of vaccine carriers for solving spatial transmission issues could greatly improve cancer vaccine efficiencies. © 2023

关键词： Biopolymer Cancer immunotherapy Cancer vaccine Drug delivery Nanotechnology

Prediction of energy resolution in the JUNO experiment

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chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Marco Beretta Antonio Bergnoli Daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone Jinfan Chang Yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen Pingping Chen Shaomin Chen Xin Chen Yiming Chen Yixue Chen Yu Chen Zelin Chen Zhangming Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng YuChin Cheng Alexander Chepurnov Alexey Chetverikov Davide Chiesa Pietro Chimenti Yen-Ting Chin Po-Lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Marta Colomer Molla Selma Conforti Di Lorenzo Alberto Coppi Daniele Corti Simon Csakli Chenyang Cui Flavio Dal Corso Olivia Dalager Jaydeep Datta Christophe De La Taille Zhi Deng Ziyan Deng Xiaoyu Ding Xuefeng Ding Yayun Ding Bayu Dirgantara Carsten Dittrich Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Wei Dou Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Katherine Dugas Stefano Dusini Hongyue Duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan Jian Fang Wenxing Fang Dmitry Fedoseev Li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng Gao Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Marco Grassi Maxim Gromov Vasily Gromov Minghao G Yerevan Physics Institute YerevanArmenia Université Libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Millennium Institute for SubAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full JUNO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector JUNO simulation reconstruction

Future sea level rise along the coast of China and adjacent region under 1.5℃ and 2.0℃ global warming

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Advances in Climate Change Research 2020年第3期11卷 227-238页

作者： QU Ying LIU Yonggang Svetlana JEVREJEVA Luke P.JACKSON Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing100871China National Oceanography Center LiverpoolL35DAUK Programme for Economic Modelling Nuffield CollegeOxford UniversityOX1 INFUK

Although future sea level rise along the China coast has been projected by various studies for different representative concentration pathways(RCPs),the projections for different warming thresholds,e.g.1.5℃ and 2.0℃,have not been done specifically for this region,to the best of our *** provide such a projection here based on the climate projections of Coupled Model Intercomparison Project Phase 5(CMIP5).The projections are given for 20 tide-gauge stations along the coast of China,Korea,Japan,and *** land motion(VLM)is also estimated for stations that have tide gauge records and satellite altimetry both covering the period of *** land motion(LLM)is then estimated by subtracting the land motion due to glacial isostatic adjustment(GIA)from *** considering LLM,sea level rise by 2100 at median probability is projected to be 38-49 cm relative to the average sea level over 1986-2005 under warming of 1.5℃,and increase to 46-57 cm when the warming threshold is increased to 2.0℃.The steric component is the main contributor to this increase in sea *** of LLM will not affect the sea level increase between the two warming thresholds,but it will make the local sea level rise by 2100 at certain locations substantially higher(up to 36 cm)or lower(up to 13 cm).

关键词： Sea level rise Coast of China Tide gauge records Vertical land motion Warming of 1.5℃ Warming of 2.0℃

Response of North Pacific and North Atlantic decadal variability to weak global warming

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Advances in Climate Change Research 2018年第2期9卷 95-101页

作者： WU Sheng LIU Zheng-Yu CHENG Jun LI Chun Laboratory for Climate and Ocean-Atmosphere Studies (LaCOAS) and Department of Atmospheric and Oceanic Sciences School of Physics Peking University Beijing 100871 China Atmospheric Science Program Department of Geography Ohio State University Columbus 43210 USA Key Laboratory of Meteorological Disaster Ministry of Education (KLME)/Joint International Research Laboratory of Climate and Environment Chenge (ILCEC) Climate Dynamics Research Center Nunjing University of Information Science and Technology Nunjing 210044 China Physical Oceanography Lab Ocean University of China Qingdao 266100 China

The Pacific Decadal Oscillation （PDO） and the Atlantic Multidecadal Variability （AMV） are the two dominant low-frequency modes in the climate system. This research focused on the response of these two modes under weak global warming. Observational data were derived from the Hadley Center Sea Ice and Sea Surface Temperature dataset （HadISST） and coupled model outputs from the Coupled Model Intercomparison Project Phase 5 （CMIP5）. Changes in PDO and AMV were examined using four models （bcc-csml-1, CCSM4, IPSL-CM5A-LR, and MPI- ESM-LR） with long weak global warming scenarios （RCP2.6）. These models captured the two low-frequency modes in both pre-industrial run and RCP2.6 run. Under weak global warming, the time scales of PDO and AMV significantly decreased while the amplitude only slightly decreased. Interestingly, the standard deviation of the North Pacific sea surface temperature anomaly （SSTA） decreased only in decadal time scale, and that of the North Atlantic SSTA decreased both in interannual and decadal time scales. The coupled system consists of a slow ocean component, which has a decadal time scale, and a fast atmospheric component, which is calculated by subtracting the decadal from the total. Results suggest that under global warming, PDO change is dominated by ocean dynamics, and AMV change is dominated by ocean dynamics and stochastic atmosphere forcing.

关键词： Pacific decadal oscillation Atlantic multidecadal variability RCP2.6

Zircon U-Pb SHRIMP Ages from the Late Paleozoic Turpan-Hami Basin,NW China

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Journal of Earth Science 2014年第5期25卷 924-931页

作者： Xiang Mao Jianghai Li Huatian Zhang The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space SciencesPeking University Institute of Oil and Gas Peking University

Permian volcanic rocks are widely distributed in the Turpan-Hami Basin, which is part of the Central Asian orogenic belt. Here we present SHRIMP zircon data for the rhyolite in Well Baocan 1, one of the deepest wells in the basin. The 283.9±2.7 Ma reported in our study provides the best precise age determination for the Yierxitu Formation, the oldest Permian layer of Hami Depression, one of the three substructural units of the Turpan-Hami Basin, and a potential hydrocarbon reservoir in this basin. Our data refines earlier imprecise 39^Ar-40^Ar ages and shows that the volcanic rocks both inside the Turpan-Hami Basin and along its margin are almost coeval. We delineate a collisional orogenesis, and the new age of 283.9±2.7 Ma may limit the latest time of the collision orogenesis.

关键词： SHRIMP U-Pb zircon geochronology Turpan-Hami Basin Permian Yierxitu Forma-tion Central Asian orogenic belt.

One Pot Synthesis of Cubic Gauche Polymeric Nitrogen

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chinese Physics Letters 2024年第12期41卷 97-106页

作者： Runteng Chen Jun Zhang Zelong Wang Ke Lu Yi Peng Jianfa Zhao Shaomin Feng Changqing Jin Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physics University of Chinese Academy of SciencesBeijing 100190China

The long sought cubic gauche polymeric nitrogen(cg-N)consisting of N-N single bonds has been synthesized by one pot route using sodium azide as a precursor at ambient *** recrystallization process was designed to expose crystal faces with low activation energy that facilitates initiating the polymeric reaction at ambient *** azide was considered as a precursor due to the low energy barrier in transforming double bonded N=N to single bonded *** spectrum measurements detected the emerging vibron peaks at 635 cm^(−1) for the polymerized sodium azide samples,demonstrating the formation of cg-N with N-N single *** from traditional high-pressure technique and recently developed plasma enhanced chemical vapor deposition method,the route achieves the quantitative synthesis of cg-N at ambient *** one pot synthesis of cg-N offers potential for further scaling up production as well as practical applications of polymeric nitrogen based materials as high energy density materials.

关键词： materials azide bonds

New criterion for optimization of solar selective absorber coatings

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chinese Optics Letters 2013年第13期11卷 122-126页

作者：郑礼清周福云刁训刚赵叔晞 School of Physics and Nuclear Energy Engineering Beihang University Beijing 100083 China Dongguan CAMDA New Energy Research Institute Dongguan 523407 China Div. of Solid State Physics Angstr6m Laboratory Uppsala University Sweden

We discuss a merit function F as judgment of photo-thermal conversion efficiency instead of two indepen- dent parameters： solar absorptance α and thermal emittance ε. The merit function F is developed using Essential Macleod software to optimize the photo-thermal conversion efficiency of solar selective coating. Bruggeman and Maxwell-Garnett models are used to calculate the dielectric function of composite cermet film. Mo, W, V, and Pd are used as metallic component as well as infrared （IR） refector materials, and SiO2, A1203, A1N, and TiO2 are used for dielectric component or antireflection （AR） layer materials. The layer structure can be described as substrate （Sub）/IR reflector/ high-metal-volume fraction （HMVF）/ low-metal-volume fraction （LMVF）/AR. Results show that Mo-Al2O3, Mo-AlN, W-SiO2, W-A12O3, V- SiO2, and V-A1203 double-cermet coatings have high conversion efficiency which is greater than 86%. The best among above is Mo-SiO2 with α=0.94, e=0.05 at 450℃, f= 89.9%. Some selective coatings with different layer thicknesses have been successfully optimized for different solar irradiations （air mass （AM0）, AM1.5D, and AM1.5G spectra） and different operating temperatures （300, 450, and 600 ℃）, respectively. However, the optical constants for calculation are from the software, most datum are measured for bulk materials. Therefore. results are more useful to indicate the trend than the exact values.

关键词： Silica

Synthesis and Characterization of a Water-stable Metal-organic Framework Based on Mixed Ligands

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chinese Journal of Structural Chemistry 2016年第12期35卷 1929-1935页

作者：张磊吴小园卢灿忠陈文哲 College of Materials Science and Engineering Fuzhou University Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences

A new water-stable metal-organic framework,[Cu_2（bdc）_2（tpt）_3]·2H_2O（1,H_2 bdc = terephthalic acid,tpt = 2,4,6-tri（4-pyridinyl）-1,3,5-triazine）,has been synthesized and characterized by elemental analysis,infrared（IR） spectrum,thermogravimetric analysis（TGA）,powder X-ray diffraction（PXRD） and single-crystal X-ray diffraction. Compund 1 crystalizes in monoclinic,space group C2/c with a = 30.147（5）,b = 11.0548（17）,c = 20.867（4）？,β = 115.035（2）o,C_（70）H_（48）Cu_2N_（18）O_（10）,Mr = 1428.34,V = 6301.0（18）？~3,Z = 8,D_c = 1.506 g/cm^3,μ = 0.754 mm^（–1）,F（000） = 2928,GOOF = 1.058,λ（MoK α） = 0.71073 ？,the final R = 0.0387 and wR = 0.1091 for 6230 observed reflections with I 〉 2σ（I）. In compound 1,the half metallacycles [Cu_2（tpt）_3] are linked by the bdc2-ligands to form a 1D bent ladder-like chain featured with a nano-sized channel,and these chains link each other via intermolecular hydrogen bonds and π-π stacking interactions to form a 3D supramolecular architecture with the voids filled with free water molecules. In addition,the water stability of 1 was investigated by PXRD patterns,which indicate that compound 1 keeps its structural integrity in boiling water for at least three days.

关键词： crystal structure metal-organic framework mixed ligands water-stable

Stomatal Density and Bio-water Saving

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Journal of Integrative Plant Biology 2007年第10期49卷 1435-1444页

作者： Yao Wang Xi Chen Cheng-Bin Xiang School of Life Sciences University of Science and Technology of China Hefei China230027

Bio-water saving is to increase water use efficiency of crops or crop yield per unit of water input. Plant water use efficiency is determined by photosynthesis and transpiration, for both of which stomata are crucial. Stomata are pores on leaf epidermis for both water and carbon dioxide fluxes that are controlled by two major factors： stomatal behavior and density. Stomatal behavior has been the focus of intensive research, while less attention has been paid to stomatal density. Recently, a number of genes controlling stomatal development have been identified. This review summarizes the recent progress on the genes regulating stomatal density, and discusses the role of stomatal density in plant water use efficiency and the possibility to increase plant water use efficiency, hence bio-water saving by genetically manipulating stomatal density.

关键词： Arabidopsis photosynthesis stomata stomatal density stomatal formation transpiration water use efficiency.