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Journal of Energy Chemistry 2021年第10期30卷 304-318,I0009页

作者： Lijuan Niu Li An Xiayan Wang Zaicheng Sun beijing Key Laboratory for Green Catalysis and Separation Center of Excellence for Environmental Safety and Biological EffectsFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The nitrogen cycle plays an important role in nature,but N-containing products cannot meet human *** electrochemical synthesis of ammonia under ambient conditions has attracted the interest of many researchers because it provides a clean and pollution-free synthesis method;however,it has certain difficulties,including a high activation energy,multiple electron transfer,and *** factors limit the selectivity and activity of ammonia synthesis *** review summarizes progress in the electrochemical synthesis of ammonia from theory and ***,the reduction of nitrogen molecules is analyzed using orbit theory and the thermodynamic reaction ***,we first discuss the effect of the experimental setup on the nitrogen reduction reaction,and then the four critical of catalysts,including size,electronic,coordination,and orientation *** issues must be considered to produce highly-efficient catalysts for electrochemical nitrogen reduction(eNRR).This review provides an overview of the eNRR to enable future researchers to design rational catalysts.

关键词： Nitrogen reduction reaction NRR Electrocatalyst Nitrogen-fixing

Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

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Bioactive Materials 2024年第3期33卷 497-505页

作者： Zihao Liu Yu Wang Yuhan Zhang Liufu Hu Bozhi Chen Yang Li Xindong Guo Bingran Yu Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)and Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029China

High levels of cell-free DNA(cfDNA)induce ***,the treatment of psoriasis has the disadvantages of penetration difficulty,suppression of normal immunity,and skin *** this study,biguanide chitosan microneedles(BGC-MNs)were prepared to treat psoriasis by removing cfDNA from the dermis through the skin *** effects of chitosan with different bisguanidine contents on DNA-binding capacity,biocompatibility,and inflammation inhibition were compared,revealing that chitosan containing 20%bisguanidine(BGC2)was found to have the best overall *** vitro,BGC2 effectively cleared cfDNA and inhibited the production of inflammatory ***-MN made from BGC2 had good mechanical and solubility *** vivo,BGC-MNs cleared cfDNA,reduced the level of inflammatory factors in the dermis,and exerted a good therapeutic effect on mice with *** results suggested that BGC-MNs provided a new approach to treating psoriasis in terms of scavenging cfDNA and exerting anti-inflammatory effects.

关键词： Biguanide chitosan cfDNA Microneedles Psoriasis

Testing the polar auxin transport model with a selective plasma membrane H^(+)-ATPase inhibitor

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Journal of Integrative Plant Biology 2022年第6期64卷 1229-1245页

作者： Yongqing Yang Xiaohui Liu Wei Guo Wei Liu Wei Shao Jun Zhao Junhong Li Qing Dong Liang Ma Qun He Yingzhang Li Jianyong Han Xiaoguang Lei State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular EngineeringSynthetic and Functional Biomolecules Centerand Peking‐Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Institute of Food Science and Technology Chinese Academy of Agricultural SciencesBeijing 100193China Department of Dermatology Peking University First HospitalBeijing 100034China Iomics Biosciences Inc. Beijing 100102China College of Biological Sciences China Agricultural UniversityBeijing 100193China

Auxin is unique among plant hormones in that its function requires polarized transport across plant cells.A chemiosmotic model was proposed to explain how polar auxin transport is derived by the H^(+)gradient across the plasma membrane(PM)established by PM H^(+)-adenosine triphosphatases(ATPases).However,a classical genetic approach by mutations in PM H^(+)-ATPase members did not result in the ablation of polar auxin distribution,possibly due to functional redundancy in this gene *** confirm the crucial role of PM H^(+)-ATPases in the polar auxin transport model,we employed a chemical genetic *** a chemical screen,we identified protonstatin-1(PS-1),a selective small-molecule inhibitor of PM H^(+)-ATPase activity that inhibits auxin *** with transgenic plants and yeast strains showed that the activity of PM H^(+)-ATPases affects auxin uptake as well as acropetal and basipetal polar auxin *** propose that PS-1 can be used as a tool to interrogate the function of PM H^(+)-*** results support the chemiosmotic model in which PM H^(+)-ATPase itself plays a fundamental role in polar auxin transport.

关键词： Arabidopsis auxin transport inhibitor plasma membrane H^(+)-ATPase

Rationale and design of a randomised double-blind 2×2 factorial trial comparing the effect of a 3-month intensive statin and antiplatelet therapy for patients with acute mild ischaemic stroke or high-risk TIA with intracranial or extracranial atherosclerosis(INSPIRES)

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Stroke & Vascular Neurology 2023年第3期8卷 249-258,I0096-I0110页

作者： Ying Gao Yuesong Pan Shangrong Han Weiqi Chen Jing Jing Chunjuan Wang Yingying Yang Tingting Wang Xia Meng Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Pierre Amarenco Philip M Bath Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Dean's Office Dell Medical SchoolUniversity of Texas at AustinAustinTexasUSA Department of Neurology and Stroke Center Assistance Publique-Hôpitaux de Paris(APHP)Bichat HospitalINSERM LVTS-U1148University of ParisParisFrance Population Health Research Institute McMaster UniversityHamiltonOntarioCanada Stroke Trials Unit Mental Health&Clinical NeuroscienceUniversity of NottinghamNottinghamUK Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina National Center for Neurological Diseases BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Institute for Brain Research BeijingChina

Background It remains unclear if intensive antiplatelet and statin treatments begun within 24-72 hours of cerebral ischaemic events from intracranial or extracranial atherosclerosis is effective or *** The Intensive Statin and Antiplatelet Therapy for High-risk Intracranial or Extracranial Atherosclerosis(INSPIRES)trial is a randomised,double-blind,placebo-controlled,multicentre and 2×2 factorial trial.6100 individuals between the ages of 35 and 80 who have experienced a mild ischaemic stroke or high-risk transient ischaemic attack(TIA)within the previous 72 hours that is attributed to≥50%atherosclerotic stenosis of a major intracranial or extracranial artery or multiple infarctions of atherosclerotic origin will be enrolled in the *** subjects will be randomised 1:1:1:1 to one of four groups:(1)intensive antiplatelet therapy(combined clopidogrel and aspirin for days 1-21,then aspirin placebo and clopidogrel for days 22-90)plus immediate intensive statin therapy(atorvastatin at a dose of 80 mg daily for the first 21 days,then 40 mg daily for days 22-90);(2)intensive antiplatelet therapy plus delayed intensive statin therapy(atorvastatin placebo for days 1-3,followed by 40 mg per day of atorvastatin for days 4-90);(3)standard antiplatelet therapy(combination of clopidogrel placebo with aspirin for 90 days)plus immediate intensive statin therapy and(4)standard antiplatelet therapy plus delayed intensive statin *** primary efficacy endpoint is any new stroke(ischaemic or haemorrhagic)within 90 days after *** primary safety endpoint is moderate to severe bleeding at 90 *** The INSPIRES trial will assess the efficacy and safety of intensive antiplatelet therapy and immediate intensive statin therapy begun within 72 hours of onset in decreasing the recurrent stroke at 90 days in patients with acute mild ischaemic stroke or high-risk TIA of intracranial or extracranial atherosclerosis origin.

关键词： intracranial atherosclerosis random

Single cell transcriptomic analysis identifies novel vascular smooth muscle subsets under high hydrostatic pressure

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Science China(Life Sciences) 2021年第10期64卷 1677-1690页

作者： Zhenzhen Chen Haizeng Zhang Yingnan Bai Changting Cui Shuangyue Li Wenjie Wang Yue Deng Qiannan Gao Lu Wang Wei Qi Lijun Zhang Yan Yang Bin Geng Jun Cai Hypertension Center Department of Cardiac SurgeryFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeState Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesBeijing 100191China Novogene Bioinformatics Technology Co. Ltd.Beijing 100015China

Although some co-risk factors and hemodynamic alterations are involved in hypertension progression,their direct biomechanical effects are ***,we constructed a high-hydrostatic-pressure cell-culture system to imitate constant hypertension and identified novel molecular classifications of human aortic smooth muscle cells(HASMCs)by single-cell transcriptome *** 100-mmHg(analogous to healthy human blood pressure)or 200-mmHg(analogous to hypertension)hydrostatic pressure for 48 h,HASMCs showed six distinct vascular SMC(VSMC)clusters according to differential gene expression and gene ontology enrichment ***,two novel HASMC subsets were identified,named the inflammatory subset,with CXCL2,CXCL3 and CCL2 as markers,and the endothelial-function inhibitory subset,with AKR1C2,AKR1C3,SERPINF1 as *** inflammatory subset promoted CXCL2&3 and CCL2 chemokine expression and secretion,triggering monocyte migration;the endothelial-function inhibitory subset secreted SERPINF1 and accelerated prostaglandin F2αgeneration to inhibit *** expression of the two VSMC subsets was greatly increased in arterial media from patients with hypertension and experimental animal models of ***,we identified high hydrostatic pressure directly driving VSMCs into two new subsets,promoting or exacerbating endothelial dysfunction,thereby contributing to the pathogenesis of cardiovascular diseases.

关键词： single cell RNA-seq hypertension VSMCs hydrostatic pressure

Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma

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Bioactive Materials 2023年第10期28卷 376-385页

作者： Dafu Chen Chengyue Lei Weifeng Liu Meiyu Shao Meizhou Sun Jianxun Guo Jingjing Cao Jing-Jun Nie Peng Luo Yuwen Luo Bingran Yu Renxian Wang Shun Duan Fu-Jian Xu Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsNational Center for OrthopaedicsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology)Ministry of EducationBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Orthopaedic Oncology Surgery Beijing Jishuitan HospitalPeking UniversityBeijing100035China JST Sarcopenia Research Centre Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China

miRNAs are important regulators of gene expression and play key roles in the development of cancer, including osteosarcoma. During the development of osteosarcoma, the expression of miR-22 is significantly downregulated, making miR-22 as a promising therapeutic target against osteosarcoma. To design and fabricate efficient delivery carriers of miR-22 into osteosarcoma cells, a hydroxyl-rich reduction-responsive cationic polymeric nanoparticle, TGIC-CA (TC), was developed in this work, which also enhanced the therapeutic effects of Volasertib on osteosarcoma. TC was prepared by the ring-opening reaction between amino and epoxy groups by one-pot method, which had the good complexing ability with nucleic acids, reduction-responsive degradability and gene transfection performance. TC/miR-22 combined with volasertib could inhibit proliferation, migration and promote apoptosis of osteosarcoma cells in vitro. The anti-tumor mechanisms were revealed as TC/ miR-22 and volasertib could inhibit the PI3K/Akt signaling pathway synergistically. Furthermore, this strategy showed outstanding tumor suppression performance in animal models of orthotopic osteosarcoma, especially in patient-derived chemo-resistant and chemo-intolerant patient-derived xenograft (PDX) models, which reduced the risk of tumor lung metastasis and overcame drug resistance. Therefore, it has great potential for efficient treatment of metastasis and drug resistance of osteosarcoma by the strategy of localized, sustained delivery of miR-22 using the cationic nanocarriers combined with non-traditional chemotherapy drugs.

关键词： Nucleic acid delivery Nanoparticle Gene therapy Osteosarcoma Responsive Patient-Derived Xenograft(PDX)

In situ atomic-scale observation of dislocation behaviors in twin-structured Pt nanocrystals

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Science China(Technological Sciences) 2021年第3期64卷 599-604页

作者： GUO YiZhong SUN Tao FU LiBo HAO LongHu HUANG Ming WEI RuJian LUO JunFeng HE Xin WANG XingQuan XIONG XiaoDong WANG LiHua HAN XiaoDong beijing Key Lab of Microstructure and Property of Advanced Materials Institute of Microstructure and Properties of Advanced MaterialsBeijing University of TechnologyBeijing 100124China Grikin Advanced Materials CO. LTD.Beijing 102200China

The deformation mechanisms of twin-structured metallic materials have attracted great *** previous theoretical predictions have suggested that the repulsive force of the twin boundary(TB)can significantly affect the deformation of twinstructured metals,it remains unclear whether this prediction applies to experimental *** this paper,the atomic-scaled deformation process of twin-structured Pt nanocrystals was in situ observed using our home-made device in a high-resolution transmission electron *** have shown that the plastic deformation of the twin-structured Pt nanocrystals was governed by full dislocation generation as well as Lomer dislocation(LD)lock formation and *** LD locks were destructed,these full dislocations tended to move towards the surface of the *** findings revealed that due to the ultra-high repulsive force of TB on dislocation,there was no dislocation-TB reaction during the *** findings can enrich our understanding of the dislocation behaviors of twin-structured nanocrystals.

关键词： deformation mechanism repulsive force twin boundary dislocations in situ

Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1204-1215页

作者： Ling-Ling Wu Qinxin Zhao Qinghua Wang Qingyang Zhang Feiya Yang Bo Zheng Hai-Yu Hu Nianzeng Xing State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Urology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Fluorescence-guided surgery(FGS)with tumor-targeted imaging agents,particularly those using the near-infrared wavelength,has emerged as a real-time technique to highlight the tumor location and margins during a surgical *** accurate visualization of prostate cancer(PCa)boundary and lymphatic metastasis,we developed a new approach involving an efficient self-quenched near-infrared fluorescence probe,Cy-KUE-OA,with dual PCa-membrane ***-KUE-OA specifically targeted the prostate-specific membrane antigen(PSMA),anchored into the phospholipids of the cell membrane of PCa cells and consequently showed a strong Cy7-de-quenching *** dual–membrane-targeting probe allowed us to detect PSMA-expressing PCa cells both in vitro and in vivo and enabled clear visualization of the tumor boundary during fluorescence-guided laparoscopic surgery in PCa mouse ***,the high PCa preference of Cy-KUE-OA was confirmed on surgically resected patient specimens of healthy tissues,PCa,and lymph node *** together,our results serve as a bridge between preclinical and clinical research in FGS of PCa and lay a solid foundation for further clinical research.

关键词： Activated probe Small molecule nanoparticle Self-assembly Dual-targeting Near-infrared Prostate cancer Fluorescence-guided surgery Metastases

Examining the Impacts of Land Supply on Housing Price in Chinese Mega Cities: An Analysis of Prefecture-Level Cities in China from 2009 to 2016

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China City Planning Review 2021年第3期30卷 73-84页

作者： Wu Yaxin Tian Li Ling Yingkai Liu Jinxin(译) Mao Qizhi(校) Guangzhou Urban Planning and Design Survey Research Institute GuangzhouP.R.China Department of Urban Planning School of ArchitectureTsinghua UniversityBeijingP.R.China School of Government Administration Peking UniversityBeijingP.R.China 不详

Residential land supply is considered a powerful tool for intervening in the housing market in China. There has been continuous debate on the correlation between residential land supply and housing prices. Based on 35 Chinese prefecture-level cities’ panel data from 2009 to 2016, this study investigates the spatio-temporal characteristics of residential land supply and housing prices, and explores their relationship applying Generalized Moment Models(GMM). The results show that(1) there is an overall downward trend in residential land supply and a significant rise in housing prices in most Chinese mega cities from 2009 to 2016, and the extent varies in four economic-geographical regions;(2) the decrease in the quantity of residential land supply contributes to the rise in housing prices to some degree, but there is no significant correlation between the land supply structure and housing prices. With the integration of socio-economic factors, the quantitative results validate the previous theoretical models of the casual correlation between residential land supply and housing prices. It further depicts the constraint of insufficient residential land supply in Chinese mega cities and claims it to be a contributor of rising housing prices. The paper concludes with implications for housing strategies and future studies.

关键词： residential land supply housing prices China

Mechanism of principal stress rotation and deformation failure behavior induced by excavation in roadways

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第11期16卷 4605-4624页

作者： Jianping Zuo Zongyu Ma Chengyi Xu Shuaifei Zhan Haiyan Liu School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing100083China International Innovation Center for Mining Rock Mechanics China University of Mining and Technology(Beijing)Beijing100083China

The failure modes of rock after roadway excavation are diverse and complex.A comprehensive investigation of the internal stress field and the rotation behavior of the stress axis in roadways is essential for elucidating the mechanism of roadway *** study aimed to examine the spatial relationship between roadways and stress *** law of stress axis rotation under three-dimensional(3D)stress has been extensively studied.A stress model of roadways in the spatial stress field was established,and the far-field stress state at different spatial positions of the roadways was analyzed.A mechanical model of roadways under a 3D stress state was established using far-field stress solutions as boundary *** distribution of principal stressesσ1,σ2 andσ3 around the roadways and the variation of the stress principal axis were *** was found that the stability boundary of the stress principal axis exhibits hysteresis when compared with that of the principal stress magnitudes.A numerical analysis model for spatial roadways was established to validate the distribution of principal stress and the mechanism of principal axis *** has demonstrated that the stress axis undergoes varying degrees of spatial rotation in different orientations and radial *** on the distribution of principal stress and the rotation law of the stress principal axis,the entire evolution mechanism of the two stress adjustments to form the final failure form after roadway excavation has been *** on-site detection results also corroborate the findings presented in this *** results provide a basis for the analysis of the failure mechanism under a 3D stress state.

关键词： Roadway stress field Principal stress rotation Roadway failure mechanism Failure characteristics