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Injury and protection of spiral ganglion neurons

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Chinese Medical Journal 2024年第6期137卷 651-656页

作者： Beilei Duan Kevin A.Peng Line Wang Department of Otorhinolaryngology Head and Neck SurgeryBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Neurotology House ClinicLos AngelesCA 90017USA

Cochlear spiral ganglion neurons(SGNs)are bipolar ganglion cells and are the first neurons in the auditory transduction *** transmit complex acoustic information from hair cells to second-order sensory neurons in the cochlear nucleus for sound *** to SGNs causes largely irreversible hearing impairment because these neurons are highly differentiated cells and cannot regenerate,making treatment of sensorineural hearing loss(SNHL)arising from SGN injury *** exposed to ototoxic drugs or damaging levels of noise or when there is loss of neurotrophic factors(NTFs),aging,and presence of other factors,SGNs can be irreversibly damaged,resulting in *** has been found that NTFs and stem cells can induce regeneration among dead spiral ganglion *** this paper,we summarized the present knowledge regarding injury,protection,and regeneration of SGNs.

关键词： Spiral ganglion Injury Protection Auditory hair cell Ototoxic drugs Aminoglycosides Presbycusis

Refractive index sensing based on a twisted nano-kirigami metasurface

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Photonics Research 2024年第2期12卷 218-225页

作者： SHUQI QIAO XIAOCHEN ZHANG QINGHUA LIANG YANG WANG CHANG-YIN JI XIAOWEI LI LAN JIANG SHUAI FENG HONGLIAN GUO JIAFANG LI School of science Minzu University of ChinaBeijing 100081China Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Plasmonic sensing technology has attracted considerable attention for high sensitivity due to the ability to effectively localize and manipulate *** this study,we demonstrate a refractive index(RI)sensing scheme based on open-loop twisted meta-molecule arrays using the versatile nano-kirigami *** sensing has the features of a small footprint,flexible control,and simple *** engineering the morphology of meta-molecules or the RI of the ambient medium,the chiral surface lattice resonances can be significantly enhanced,and the wavelength,intensity,and sign of circular dichroism(CD)can be flexibly *** the relation between the wavelength of the CD peak and the RI of the superstrate,the RI sensor achieves a sensitivity of 1133 nm/***,we analyze these chiroptical responses by performing electromagnetic multipolar decomposition and electric field *** study may serve as an ideal platform for applications of RI measurement and provide new insights into the manipulation of chiral light–matter interactions.

关键词： twisted chiral index

Accurate estimation of Li/Ni mixing degree of lithium nickel oxide cathode materials

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Chinese Physics B 2024年第5期33卷 631-635页

作者：陈鹏浩徐磊禹习谦李泓 Institute of Physics Chinese Academy of SciencesBeijing 100190China Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China beijing Frontier Research Center on Clean Energy Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijing 101400China

Li/Ni mixing negatively influences the discharge capacity of lithium nickel oxide and high-nickel ternary cathode ***,accurately measuring the Li/Ni mixing degree is difficult due to the preferred orientation of labbased XRD measurements using Bragg–Brentano ***,we find that employing spherical harmonics in Rietveld refinement to eliminate the preferred orientation can significantly decrease the measurement error of the Li/Ni mixing *** Li/Ni mixing ratio obtained from Rietveld refinement with spherical harmonics shows a strong correlation with discharge capacity,which means the electrochemical capacity of lithium nickel oxide and high-nickel ternary cathode can be estimated by the Li/Ni mixing *** findings provide a simple and accurate method to estimate the Li/Ni mixing degree,which is valuable to the structural analysis and screening of the synthesis conditions of lithium nickel oxide and high-nickel ternary cathode materials.

关键词： lithium nickel oxide high-nickel ternary cathode Li/Ni mixing spherical harmonics function discharge capacity

Alignment error modeling and control of a double-sided microlens array during precision glass molding

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Microsystems & Nanoengineering 2024年第2期10卷 311-322页

作者： Zihao Zeng Tianfeng Zhou Qian Yu Jia Zhou Gang Wang Qiuchen Xie Zifan Wang Xiaoqiang Yao Yubing Guo School of Medical technology Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China School of Mechanical Engineering Beijing Institute of TechnologyNo.5 Zhongguancun South StreetHaidian DistrictBeijing100081China

Double-sided microlens arrays(DSMLAs)include combinations of two single-sided MLAs to overcome positioning errors and greatly improve light transmissivity compared to other types of *** glass molding(PGM)is used to fabricate DSMLAs,but controlling alignment errors during this process is *** this paper,a mold assembly was manufactured with a novel combination of materials to improve the alignment accuracy of mold cores during PGM by using the nonlinear thermal expansion characteristics of the various materials to improve the DSMLA alignment *** establishing a mathematical model of the DSMLA alignment error and a thermal expansion model of the mold-sleeve pair,the relationship between the maximum alignment error of the DSMLA and the mold-sleeve gap was *** research provides a method to optimize the mold-sleeve gap and minimize the alignment error of the *** measured DSMLA alignment error was 10.56μm,which is similar to the predicted maximum alignment *** measurements showed that the uniformity of the homogenized beam spot was 97.81%,and the effective homogeneous area accounted for 91.66%of the total *** proposed method provides a novel strategy to improve the performance of DSMLAs.

关键词： sided alignment error

3D reconstruction and defect pattern recognition of bonding wire based on stereo vision

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CAAI Transactions on Intelligence technology 2024年第2期9卷 348-364页

作者： Naigong Yu Hongzheng Li Qiao Xu Ouattara Sie Essaf Firdaous Faculty of Information technology Beijing University of TechnologyBeijingChina beijing Key Laboratory of Computing Intelligence and Intelligent System Beijing University of TechnologyBeijingChina Engineering Research Center of Digital Community Ministry of EducationBeijingChina College of Robotic UniversitéFélix Houphouët‐BoignyAbidjanCôte d’Ivoire

Non-destructive detection of wire bonding defects in integrated circuits(IC)is critical for ensuring product quality after ***-processing-based methods do not provide a detailed evaluation of the three-dimensional defects of the bonding ***,a method of 3D reconstruction and pattern recognition of wire defects based on stereo vision,which can achieve non-destructive detection of bonding wire defects is *** contour features of bonding wires and other electronic components in the depth image is analysed to complete the 3D reconstruction of the bonding *** to filter the noisy point cloud and obtain an accurate point cloud of the bonding wire surface,a point cloud segmentation method based on spatial surface feature detection(SFD)was *** can extract more distinct features from the bonding wire surface during the point cloud segmentation ***,in the defect detection process,a directional discretisation descriptor with multiple local normal vectors is designed for defect pattern recognition of bonding *** descriptor combines local and global features of wire and can describe the spatial variation trends and structural features of *** experimental results show that the method can complete the 3D reconstruction and defect pattern recognition of bonding wires,and the average accuracy of defect recognition is 96.47%,which meets the production requirements of bonding wire defect detection.

关键词： bonding wire defect detection point cloud point cloud segmentation

Establishment of Constraint Relation of Robot Dynamics Equation Based on Kinematic Influence Coefficients Method

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Journal of Shanghai Jiaotong university(science) 2024年第3期29卷 450-456页

作者：徐亚茹李克鸿商新娜金晓明刘荣张建成 beijing Engineering Research Center of Smart Mechanical Innovation Design Service Beijing Union UniversityBeijing 100027China College of Robotics Beijing Union UniversityBeijing 100020China Robotics Institute Beihang UniversityBeijing 100191China

Due to the diversity of work requirements and environment,the number of degrees of freedom(DOFs)and the complexity of structure of industrial robots are constantly *** is difficult to establish the accurate dynamical model of industrial robots,which greatly hinders the realization of a stable,fast and accurate trajectory tracking ***,the general expression of the constraint relation in the explicit dynamic equation of the multi-DOF industrial robot is derived on the basis of solving the Jacobian matrix and Hessian matrix by using the kinematic influence coefficients ***,an explicit dynamic equation with general constraint relation expression is established based on the Udwadia-Kalaba *** problem of increasing the time of establishing constraint relationship when the multi-DOF industrial robots complete complex task constraints is *** the SCARA robot as the research object,the simulation results show that the proposed method can provide a new idea for industrial robot system modeling with complex constraints.

关键词： industrial robot constraint relationship kinematic influence coefficients method Jacobian matrix Hessian matrix

Natural Disaster Risk Monitoring for Immovable Cultural Relics Based on Digital Twin

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Journal of Geodesy and Geoinformation science 2024年第1期7卷 90-104页

作者： LI Bolun DONG Youqiang QIAO Yunfei HOU Miaole WEN Caihuan The International Joint Laboratory of Safety and Energy Conservation for Ancient Buildings Beijing University of Civil Engineering and ArchitectureBeijing 102616China China Cultural Heritage Information and Consulting Center Beijing 100029China Hebei Institute of Geological Surveying and Mapping Langfang 065000China

Natural disaster risk monitoring is an important task for disaster prevention and *** the case of immovable cultural relics,however,the feedback mechanism,risk factors,monitoring logic,and monitoring indicators of natural disaster risk monitoring are *** to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for *** on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics,this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital *** framework focuses on risk monitoring,including the physical entities of natural disaster risk for immovable cultural relics,monitoring indicators,and virtual entity construction.A platform for monitoring the natural disaster risk of immovable cultural relics is *** the Puzhou Ancient City Site as a test bed,the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales.

关键词： immovable cultural relics natural disaster risk digital twin risk monitoring

Determination of the critical rainfall of runoff-initiated debris flows by the perspective of physical mechanics and Shields stress

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Journal of Mountain science 2024年第4期21卷 1160-1173页

作者： MA Chao ZHU Yongtai LU Lu DU Cui LYU Liqun DONG Jie School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China beijing Institute of Geological Hazard Prevention Beijing 100120China School of Software Engineering Chengdu University of Information TechnologyChengdu610225China Civil and Environmental Engineering Department Clarkson UniversityNY 13699USA

The critical rainfall of runoff-initiated debris flows is utmost importance for local early hazard *** paper presents research on the critical rainfall of runoff-initiated debris flows through comparisons between slope gradients and three key factors,including topographic contributing area,dimensionless discharge,and Shields *** rainfall amount was estimated by utilizing in-situ rainfall records and a slope-dependent Shields stress model was *** created model can predict critical Shields stress more accurately than the other two ***,a new dimensionless discharge equation was proposed based on the corresponding discharge-gradient *** new equation,along with factors such as contributing area above bed failure sites,channel width,and mean diameter of debris flow deposits,predicts a smaller rainfall amount than the in-situ measured *** the slope-dependent Shields stress model performs well and the estimated rainfall amount is lower than the in-situ records,the sediment initiation in the experiments falls within sheet flow regime due to a large Shields ***,further sediment initiation experiments at a steeper slope range are expected in the future to ensure that the sediment transport belongs to mass failure regime characterized by a low level of Shields ***,a more accurate hazard forecast on the runoff-initiated debris flow holds promise when the corresponding critical slope-dependent dimensionless discharge of no motion,fluvial sediment transport,mass flow regime,and sheet flow regime are considered.

关键词： Infinite slope stability Shields stress Contributing area-slope gradient Rainfall back estimation

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU Rui ZHANG Sheng YUAN Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction