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Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer

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Food Science and Human Wellness 2024年第4期13卷 2221-2233页

作者： Ruijie Xu Zhijie Yao Hao Zhang Haitao Li Wei Chen State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China

Loss of susceptibility to anoikis signals is a crucial step in *** resistance therefore represents a promising adjuvant therapeutic target for cancer *** this study,we have conducted a rationalized screening to search for novel leading anoikis sensitizer from daily *** 19 tested dietary phytochemicals,the best results were obtained with apigenin,a natural component of ***,apigenin sensitized breast cancer cells to anoikis,lowered the number of circulating tumor cells,and protected against breast cancer metastasis to lung in ***,we demonstrated that the thromboxane A_(2)(TXA_(2))-TXA_(2)receptor(TP)axis has a critical role in acquired anoikis resistance by activating PI3K-Akt signaling *** of TXA_(2)signaling up-regulated p53 as well as its target gene p21,caused a G1 phase arrest,and finally led to apoptosis in breast cancer ***_(2)level was positively correlated with breast cancer cell anoikis rate,and apigenin significantly inhibited TXA_(2)biosynthesis in vitro and in ***,we identified apigenin as a potent anoikis sensitizer with anti-metastatic properties in a mouse model of breast cancer,and these findings might provide a rationale for introducing apigenin supplementation to breast cancer patients.

关键词： Apigenin Anoikis Breast cancer metastasis Thromboxane A2

Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022

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Journal of Environmental Sciences 2024年第2期136卷 172-188页

作者： Yaping Jiang Shaocai Yu Xue Chen Yibo Zhang Mengying Li Zhen Li Zhe Song Pengfei Li Xiaoye Zhang Eric Lichtfouse Daniel Rosenfeld Key Laboratory of Environmental Remediation and Ecological Health Ministry of EducationResearch Center for Air Pollution and HealthCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Science and Technology Hebei Agricultural UniversityBaoding 071000China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Aix-Marseille Univ CNRSColl FranceCNRSIRDINRAEEuropole Mediterraneen de l’ArboisAvenue Louis Philibert13100 Aix en ProvenceFrance Xi’an Jiaotong University State Key Laboratory of Multiphase Flow in Power EngineeringXi’an 710049China Institute of Earth Sciences The Hebrew University of JerusalemJerusalemIsrael

To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control *** provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special ***,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological *** show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,*** emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in *** the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission *** the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,*** results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission ***,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost *** implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted.

关键词： PM_(2.5) WRF-CMAQ Meteorological conditions Emission reductions Winter Olympic games

Recent advances in Ni-Al bimetallic catalysis for unreactive bond transformation

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Science China Chemistry 2018年第8期61卷 1004-1013页

作者： Yin-Xia Wang Mengchun Ye State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071 China

Ni-Al bimetallic catalysis proves to be an efficient catalytic strategy for unreactive bond transformations. Recently, chiral bifunctional ligands, especially amphoteric secondary phosphine oxide(SPO) ligand, are used for a more powerful synergistic effect in the bimetal-catalyzed reactions, providing not only milder reaction conditions and higher reactivity but also excellent reaction selectivity. Herein, we give a brief review on the development of Ni-Al bimetallic catalytic system and highlight recent advances in enantioselective Ni-Al bimetallic catalysis for unreactive bond transformation.

关键词： nickel aluminum bimetallic catalysis SPO ligand unreactive bond

Reactions of Rare-Earth Metal Based Lewis Pairs with Azides

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Chinese Journal of Chemistry 2020年第6期38卷 559-564页

作者： Yifan Dong Kejian Chang Xin Xu Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

The reactivity of homoleptic rare-earth metal aryloxide based Lewis pairs toward organic azide substrates has been investigated *** of RE(OAr)3(RE=La,Sm,X and Sc,Ar=2,6-'Bu2-C6H3),PEt3 and Me3SiN3 in 2:1:1 molar ratio resulted in formation of separated ion pair complexes[Me3Si-PEt3]^+[(ArO)3RE-N=N=N-RE(OAr)3]^-under mild *** of phosphine with the nitrogen-containing Lewis base l,4-diazabicyclo[2.2.2]octane(DABCO)produced analogous rare-earth azide complexes with[Me3Si-DABCO]+*** contrast,reaction of the La(OAr)3/PEt3 Lewis pair with 1-adamantyl azide(AdN3)afforded the typical frustrated Lewis pair-type 1,1-addition product.A tetrahydrofuran ring-opening reaction was also observed for the resulting rare-earth azide complex with the[Me3Si-PEt3]+cation,with cleavage of the C—0 bond by Si/P cooperation.

关键词： azide rare complexes

Isospecific Polymerization of Methyl Methacrylate by Intramolecular Rare-Earth Metal Based Lewis Pairs

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Chinese Journal of Chemistry 2021年第1期39卷 149-156页

作者： Yiqun Zhou Shengjie Jiang Xin Xu Key Loborotory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

A series of cationic rare-earth aryloxide complexes,ie,,[LREOAr^(1)]^(+)[B(C_(6)F_(5))_(4)]^(-)(L=CH_(3)C(NAr)CHC(CH_(3))(NCH(R)CH_(2)PPh_(2));RE=Y,Lu;Ar'=2,6-tBU_(2)-C_(6)H_(3),2,6-(PhCMe_(2))_(2)-4-Me-C_(6)H_(2);Ar=2,6-iPr_(2)-C_(6)H_(3),2,6-(Ph_(2)CH)_(2)-4-iPr-C_(6)H_(2);R=H,CH_(3),iPr,Ph),were prepared and ap-plied to the Lewis pair polymerization of methyl methacrylate(MMA).The stereoregularity of the resulting PMMA was significantly affected by the R substituent on the pendant arm of the tridentate NNP ligand,and was found to increase with increase in the steric hindrance of R.

关键词： Rare-earth Lewis pair Tridentate ligand Polymerization Tacticity

A Mild, General, Metal-Free Method for Desulfurization of Thiols and Disulfides Induced by Visible-Light

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Chinese Journal of Chemistry 2021年第5期39卷 1255-1258页

作者： Wenting Qiu Shuai Shi Ruining Li Xianfeng Lin Liangming Rao Zhankui Sun Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of PharmacyShanghai Jiao Tong UniversityNo.800 Dongchuan Rd.Shanghai 200240China Huzhou Research and Industrialization Center for Technology Chinese Academy of Sciences1366 Hongfeng RoadHuzhouZhejiang 313000China Shanghai Institute of Nutrition and Health Chinese Academy of SciencesShanghai 200031China

A visible-light-induced metal-free desulfurization method for thiols and disulfides has been *** radical desulfurization features mild conditions,robustness,and excellent functionality *** was successfully applied not... 详细信息

关键词： Desulfurization Photochemistry Radical reactions Thiol Visible-light

Recent Advances in Transition Metal-Catalyzed Asymmetric Radical Reactions

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Chinese Journal of Chemistry 2018年第3期36卷 247-256页

作者： Kuai Wang Wangqing Kong Institute for Advanced Studies Wuhan University 299 Bayi Road Wuchang District Wuhan Hubei 430072 China

Control of enantioselectivity in radical reactions was a formidable challenge for organic chemists for decades. Thanks to the key role of transition metal complexes both in promoting and highly enantioselectively controlling sophisticated synthetic routes, great improvements in this filed have been achieved by merging transition-metal asymmetric catalysis with radical chemistry. Herein we provide a perspective of some of the most significant contributions in the field during the past decades. Accordingly, the major advances are classified based on different strategies for controlling stereoselectivity including：（1） chiral metal complex chelation, （2） chiral metal complex combined with radical species and reductive elimination, （3） chiral metal complex outer-sphere substitution by radical intermediate. Brief discussion of mechanism is presented whenever relevant.

关键词： transition metal-catalyzed enantioselectivity radical reactions asymmetric catalysis

Recent Advances in Organic Electrochemical C-H Functionalization

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Chinese Journal of Chemistry 2018年第4期36卷 338-352页

作者： qi-Liang Yang Ping Fan Tian-Sheng Mei State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry & Molecular Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 China

Organic electrochemistry has a rich history in organic synthesis and has been considered as a promising alternative to traditional chemical oxidants and reductants because it obviates the use of stoichiometric amount of dangerous and toxic reagents. In particular, the electrochemical C-H bonds functionalization is one of the most desirable approaches for the construction of carbon-carbon （C-C） and carbon-heteroatom （C-X） bonds. This review summarizes the substantial progress made in the last few years in C-H functionalization via organic electrochemistry. It is divided into sections on C-C, C-N, C-O, C-S, C-Halogen and C-P bond formation.

关键词： organic electrochemistry C-H functionalization carbon-carbon bond formation carbon-heteroatom bond formation

Synthetic[FeFe]-H_2ase models bearing phosphino thioether chelating ligands

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Chinese Chemical Letters 2018年第11期29卷 1651-1655页

作者： Yingjie Zhao Xin Yu Huilan Hu Xinlong Hu Sakthi Raje Raja Angamuthu Chen-Ho Tung Wenguang Wang School of Chemistry and Chemical Engineering Shandong University Laboratory of Inorganic Synthesis and Bioinspired Catalysis (LISBIC) Department of ChemistryIndian Institute of Technology Kanpur

A series of {2Fe3S} complexes bearing phosphino thioether chelating ligand were synthesized on the basis of Fe2（Me2pdt）（1,2-Cy2PC6H4SMe）（CO）4 （Me2pdt= Me2C（CH2S ）2, 1）. The disubstituted Fe（1）Fe（1） compound 1 exhibits a reversible one-electron redox even for [Fe（Ⅰ）Fe（Ⅱ）]＋/0 couple. Based on the oxidation of I to [1]＋, the tri-substituted [Fe（Ⅰ）Fe（Ⅱ）]＋ cationic complex [Fe2/Me2pdt）/1,2-Cy2PC6H4SMe）（PPh3）（CO）3]＋（[2]＋） was synthesized. Reduction of [2]＋ provided the neutral tri-substituted Fe（l）Fe（1） compound 2. The substitution of the CO in I ligand by PPh3 results in an anodic shift of the Fe11Fe＋/Fe1Fe1 couple of470 mV. Most importantly, this substitution also leads to the Fe-Fe bonds in 1 and 2 with large Lewis basicity difference, i.e. △pKaMeCN ～ 10.

关键词： [FeFe]-H2ases models Mixed-valence Fe(Ⅰ)Fe(Ⅱ) Phosphino thioether ligand Diiron bridging hydride Lewis-acid basicity