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Increased presence of effector lymphocytes during Helicobacter hepaticus-induced colitis

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World Journal of Gastroenterology 2012年第13期18卷 1459-1469页

作者： Sarah J McCaskey Elizabeth A Rondini Jonathan F Clinthorne Ingeborg M Langohr Elizabeth M Gardner Jenifer I Fenton Department of Food Science and Human Nutrition College of Osteopathic MedicineMichigan State UniversityEast LansingMI 48824United States Department of Food Science Human Nutrition Michigan State UniversityEast LansingMI 48824United States Department of Pathobiology and Diagnostic Investigation Michigan State UniversityEast Lansing MI 48824United States

AIM： To identify and characterize drosophila mothers against decapentaplegic （SMAD）3-dependent changes in immune cell populations following infection with He- Iicobacter hepaticus （H. hepaticus）. METHODS： SMAD3/ （n = L9） and colitis-resistant SMAD3＋/ （n = 24） mice （8-10 wk of age） were in- fected with/-/, hepaticus and changes in immune cell populations [T lymphocytes, natural killer （NK） cells, T regulatory cells] were measured in the spleen and mesenteric lymph nodes （MsLNs） at 0 d, 3 d, 7 d and 28 d post-infection using flow cytometry. Genotype-dependent changes in T lymphocytes and granzyme B＋ cells were also assessed after 28 d in proximal colon tissue using immunohistochemistry. RESULTS： As previously observed, SMAD3＋, but not SMAD3＋/- mice, developed colitis, peaking at 4 wk post-infection. No significant changes in T cell subsets were observed in the spleen or in the MsLNs between genotypes at any time point. However, CD4＋ and CD8＋/ CD62L＋＋ cells, an effector T lymphocyte population, as well as NK cells （NKp46/DX5＋） were significantly higher in the MsLNs of SMAD3/ mice at 7 d and 28 d post-in- fection. In the colon, a higher number of CD3＋ cells were present in SMAD3＋ compared to SMAD3＋/- mice at base- line, which did not significantly change during infection. However, the number of granzyme B＋ cells, a marker of cytolytic lymphoo/tes, significantly increased in SMAD3＋ mice 28 d post-infection compared to both SMAD3＋/- mice and to baseline values. This was consistent with more severe colitis development in these animals. CONCLUSION： Data suggest that defects in SMAD3 signaling increase susceptibility to H. hepaticus-induced colitis through aberrant activation and/or dysregulation of effector lymphoo/tes.

关键词： Transforming growth factor-J3 Colitis Dro-sophila mothers against decapentaplegic Colon cancer T lymphocytes

Long term periodicity analysis of the spectral index of 2251+158

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Research in Astronomy and Astrophysics 2011年第3期11卷 286-292页

作者： Yu-Hai Yuan Jun-Hui Fan Center for Astrophysics Guangzhou University Guangzhou 510006 China Center for Astrophysics University of Science and Technology of China Hefei 230026 China

We analyze the radio spectral index of blazars from the university of michigan Radio Astronomy Observatory database,and find that there exists quasiperiodic activity in 2251＋*** long-term periodicity analysis is accomplished by three methods,which are the Jurkevich method（Jurkevich）,the discrete correlation function（DCF）,and the Periodogram method（P）.The results show that 2251＋158 has two strong periodicities,which are P1=6.3±1.1 yr and P2=3.8±1.2 yr.

关键词： blazars:data analysis:individual:2251+158

Peroxidase-like properties of Ruthenium nanoframes

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Science Bulletin 2016年第22期61卷 1739-1745页

作者： Haihang Ye Jacob Mohar Qingxiao Wang Massimo Catalano Moon J.Kim Xiaohu Xia Department of Chemistry Michigan Technological University Department of Materials Science and Engineering University of Texas at Dallas

This work reports the inherent peroxidase-like properties of Ruthenium （Ru） nanoframes. After templating with Palladium （Pd） seeds, Ru nanoframes with an octa- hedral shape, average edge length of 6.2 nm, and thickness of 1.8 nm were synthesized in high purity （〉95 %） and good uniformity. Using the oxidation of 3,3t,5,5＇-tetram- ethylbenzidine （TMB） by H202 as a model catalytic reac- tion, the Ru frames were demonstrated to be approximately three times more active than natural peroxidases in cat- alyzing the formation of colored products. As compared to their natural counterparts, Ru frames have a stronger binding affinity to TMB as well as a weaker binding affinity to hydrogen peroxide during the catalysis. The Ru frames as peroxidase mimics proved to be chemically and thermally stable. This work represents the first demonstration of Ru nanostructure-based peroxidase mimics and is therefore expected to inspire future research on bio-applications of Ru nanomaterials.

关键词： Ruthenium Nanoframes Peroxidase Enzyme mimic Catalysis

Visualizing hypoxic modulation of beta cell secretions via a sensor augmented oxygen gradient

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Microsystems & Nanoengineering 2023年第1期9卷 191-202页

作者： Kai Duan Mengyang Zhou Yong Wang Jose Oberholzer Joe F.Lo Department of Mechanical Engineering Bioengineering ProgramUniversity of Michigan at DearbornDearbornMI48128USA Department of Surgery/Transplant University of VirginiaCharlottesvilleVA22908USA

One distinct advantage of microfluidic-based cell assays is their scalability for multiple concentrations or *** scaling can be extremely powerful when combining multiple parameters and ***,in situ stimulation and detection eliminates variability between individual ***,conventional microfluidics must combat diffusion,which limits the spatial distance and time for molecules traveling through ***,we leveraged a multilayered microfluidic approach to integrate a novel oxygen gradient(0–20%)with an enhanced hydrogel sensor to study pancreatic beta *** enabled our microfluidics to achieve spatiotemporal detection that is difficult to achieve with traditional *** this device,we demonstrated the in situ detection of calcium,insulin,and ATP(adenosine triphosphate)in response to glucose and oxygen ***,insulin was quantified at levels as low as 25 pg/mL using our imaging ***,by analyzing the spatial detection data dynamically over time,we uncovered a new relationship between oxygen and beta cell *** observed an optimum oxygen level between 10 and 12%,which is neither hypoxic nor normoxic in the conventional cell culture *** results provide evidence to support the current islet oscillator *** future applications,this spatial microfluidic technique can be adapted for discrete protein detection in a robust platform to study numerous oxygen-dependent tissue dysfunctions.

关键词： hypoxic stimulation gradient

Impact of pediatric traumatic brain injury on hippocampal neurogenesis

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Neural Regeneration Research 2021年第5期16卷 926-933页

作者： Mariam Rizk Justin Vu Zhi Zhang Department of Natural Sciences University of Michigan-DearbornDearbornMIUSA

Traumatic brain injury(TBI)is a major cause of mortality and morbidity in the pediatric *** advances in medical care,the mortality rate of pediatric TBI has ***,more children and adolescents are living with TBI-related cognitive and emotional impairments,which negatively affects the quality of their *** hippocampal neurogenesis plays an important role in cognition and mood *** in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases,including *** endogenous hippocampal neurogenesis after TBI merits significant ***,TBI affects the function of neural stem/progenitor cells in the dentate gyrus of hippocampus,which results in aberrant migration and impaired dendrite development of adult-born ***,a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature *** injuries,such as neuroinflammation and oxidative stress,exert a significant impact on hippocampal ***,a variety of therapeutic approaches have been proposed for ameliorating secondary TBI *** this review,we discuss the uniqueness of pediatric TBI,adult hippocampal neurogenesis after pediatric TBI,and current efforts that promote neuroprotection to the developing brains,which can be leveraged to facilitate neuroregeneration.

关键词： adult hippocampal neurogenesis astrocytes development microglia neuroinflammation neuroregeneration oxidative stress pediatric traumatic brain injury plasticity stem cell

Sequence Stratigraphy and Rudist Facies Development of the Upper Barremian-Lower Cenomanian Platform, Northern Sinai, Egypt

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Acta Geologica Sinica(English Edition) 2018年第1期92卷 286-310页

作者： Yasser SALAMA Michael GRAMMER Shaban SABER Soheir EL-SHAZLY Gouda ABDEL-GAWAD Beni-Suef university Faculty of SciencesGeology Department Boone Pickens School of Geology Oklahoma State University

The Lower Cretaceous sections in northern Sinai are composed of the Risan Aneiza(upper Barremian-middle Albian) and the Halal(middle Albian-lower Cenomanian) formations. The facies reflect subtle paleobathymetry from inner to outer ramp facies. The inner ramp facies are peritidal, protected to open marine lagoons, shoals and rudist biostrome facies. The inner ramp facies grade northward into outer ramp deposits. The upper Barremian-lower Cenomanian succession is subdivided into nine depositional sequences correlated with those recognized in the neighbouring Tethyan areas. These sequences are subdivided into 19 medium-scale sequences based on the facies evolution, the recorded hardgrounds and flooding surfaces, interpreted as the result of eustatic sea level changes and local tectonic activities of the early Syrian Arc rifting stage. Each sequence contains a lower retrogradational parasequence set that constituted the transgressive systems tracts and an upper progradational parasequence set that formed the highstand systems tracts. Nine rudist levels are recorded in the upper Barremian through lower Cenomanian succession at Gabal Raghawi. At Gabal Yelleg two rudist levels are found in the Albian. The rudist levels are associated with the highstand systems tract deposits because of the suitability of the trophic conditions in the rudist-dominated ramp.

关键词： Cretaceous sequence stratigraphy rudists Sinai Egypt

Multi-frequency VLBI Observations of NRAO 150

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Chinese Journal of Astronomy and Astrophysics 2001年第6期1卷 507-513页

作者： Yong-JunChen Dong-RongJiang Fu-JunZhang ShanghaiAstronomicalObservatory ChineseAcademyofSciencesShanghai200030 NationalAstronomicalObservatories ChineseAcademyofSciencesBeijing100012

We present multi-frequency, high resolution, radio structures of NRAO 150 with VLBA and EVN array respectively, both of which show a very collimated one-sided jet structure beyond an angular distance of 80 mas. Model fitting is performed for observations at 2.3 GHz and 8.4 GHz which reveal the source to be consisting of several components at position angle -30°. According to the light curves at 4.8 GHz, 8.0 GHz and 14.5 GHz an outburst is currently occurring in its rising stage, which suggests that a new component is probably in the course of forming. Spectral analysis reveals that the new component probably has a higher spectral index. The maximum proper motion of -0.46 mas yr-1 is expected if we suppose that the new component is moving away from core at the beginning of the flaring.

关键词： galaxies: active - galaxies: radio source: individual: NRAO 150 -radio structure: galaxies

Effects of protein and lignin on cellulose and xylan anaylses of lignocellulosic biomass

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Journal of Integrative Agriculture 2017年第6期16卷 1268-1275页

作者： James MacLellan Rui Chen Zhengbo Yue Robert Kraemer Yan Liu Wei Liao Department of Biosystems and Agricultural Engineering Michigan State University School of Resources and Environmental Engineering Hefei University of Technology

Interactions of lignocellulosic components during fiber analysis were investigated using the highly adopted compositional analysis procedure from the National Renewable Energy Laboratory（NREL）,*** feedstock samples were used to study the effects of lignin/protein,cellulose/protein,and xylan/protein interaction on carbohydrate *** structural influence in the synthetic samples,lignin and protein components were the most significant（P〈0.05）factors on cellulose *** xylan was consistent and unaffected by content variation throughout the synthetic *** of the observed relationships from synthetic feedstocks was fulfilled using real lignocellulosic feedstocks：corn stover,poplar,and alfalfa,in which similar results have been obtained,excluding cellulose analysis of poplar under higher protein content and xylan analysis of alfalfa under higher protein *** results elucidated that according to their protein and lignin contents of different lignocellulosic materials,accuracy of the NREL method on cellulose and xylan analyses could be improved by applying a stronger extraction step to replace water/ethanol extraction.

关键词： lignocellulosic biomass cellulose xylan lignin protein

Inductively coupled, mm-sized, singlechannel optical neuro-stimulator withintensity enhancer

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Microsystems & Nanoengineering 2019年第1期5卷 454-465页

作者： Wasif Khan Yaoyao Jia Fatma Madi Arthur Weber Maysam Ghovanloo Wen Li Department of Electrical and Computer Engineering Michigan State UniversityEast LansingMIUSA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGAUSA Department of Physiology Michigan State UniversityEast LansingMIUSA

We introduce a single channel neuro-stimulator consisting of a reflector-coupled microscale light emitting diode(μLED)with an integrated mm-sized wireless receiver(Rx)coil for free-floating,battery-free,untethered optogenetics *** system utilizes a two-coil inductive link to deliver instantaneous power at a low operating frequency(<100 MHz)for continuous optical stimulation with minimized invasiveness and tissue exposure to electromagnetic *** a microscale reflector to theμLED provides significant light intensity enhancement compared to a bareμ*** activated stimulators have an operational temperature increase of<1℃,well below the safety limit of biomedical *** vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the primary visual cortex of rats,using c-Fos biomarker as a reporter of light-evoked neuronal activity.

关键词： sized channel utilize