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Increased expression of regulatory T cell-associated markers in recent-onset diabetic children

Open Journal of Immunology 2011年第3期1卷 57-64页

作者： Mikael Pihl Mikael Chéramy Jenny Mjosberg Johnny Ludvigsson Rosaura Casas Division of Pediatrics and diabetes Research Center Department of Clinical and Experimental MedicineLinkoping UniversityLinkopingSweden Division of Clinical Immunology Department of Clinical and Experimental MedicineLinkoping UniversityLinkopingSweden

CD4+CD25hi T cells are thought to be crucial for the maintenance of immunological tolerance to self antigens. In this study, we investigated the frequencies of these cells in the early stage of type 1 diabetes, as well as in a setting of possible pre-diabetic autoimmunity. Hence, the expression of FOXP3, CTLA-4, and CD27 in CD4+ CD25hi T cells was analyzed using flow cytometry in 14 patients with recent onset type 1 diabetes, in 9 at-risk individuals, and 9 healthy individuals with no known risk for type 1 diabetes. Our results show there were no differences in the frequency of CD4+CD25hi cells between groups. However, compared to controls, recent-onset type 1 diabetic patients had higher expression of FOXP3, CTLA-4, and CD27 in CD4+ CD25hi cells from peripheral blood. The median fluorescence intensity of FOXP3 was significantly higher in CD4+CD25hi cells from patients with type 1 diabetes than from controls. Furthermore, a positive correlation between the frequency of FOXP3+ cells and the median fluorescence intensity of FOXP3 was observed among patients with type 1 diabetes. These data suggest that the frequency of CD4+CD25hi FOXP3+ T cells in the periphery is not decreased but rather increased at onset of type 1 diabetes. Thus, functional deficiencies rather than reduced numbers of CD4+CD25hi cells could contribute to the development of type 1 diabetes.

关键词： Regulatory T cells Type 1 diabetes Autoantibodies

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