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Exertional heat illness risk factors and physiological responses of youth football players

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Journal of Sport and Health Science 2021年第1期10卷 91-98页

作者： Susan W.Yeargin John J.Dickinson Dawn M.Emerson Jessica Koller Toni M.Torres-McGehee Zachary Y.Kerr Department of Exercise Science University of South CarolinaColumbiaSC 29208USA Palmetto Health/USC Orthopedic Center Keenan High SchoolColumbiaSC 29203USA Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKS 66045USA Surgi-Care Inc. BostonMA 02115USA Department of Exercise and Sport Science University of North CarolinaChapel HillNC 27599-8700USA

Objective:To determine which intrinsic and extrinsic exertional heat illness(EHI)risk factors exist in youth American football players and observe perceptual and physiological responses of players during events(games and practices).Methods:Cross-sectional cohort study observing 63 youth football players,varying in *** variables were league(weightrestricted(WR,n=27)and age-restricted(AR,n=36))and event *** variables were anthropometrics,work-to-rest ratio,and wet bulb globe *** variables included preparticipation examination and uniform configuration.A subset of 16 players participated in physiological variables(heart rate and gastrointestinal temperature).Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the ***:Mean values for anthropometric variables were higher(p<0.05)in the AR league than the WR *** time(χ^2(1,111)=4.232;p=0.039)and rest time(χ^2(1,111)=43.41;p<0.001)were significantly greater for games,but ratios were significantly higher for practices(χ^2(1,111)=40.62;p<0.001).The majority of events(77%)observed were in black and red flag wet bulb globe temperature risk categories.A total of 57%of the players had a preparticipation examination,and up to 82%of events observed were in full *** gastrointestinal temperature and heart rate responses ranged widely and no players reached critical ***:Extrinsic(disproportionate work ratios,environmental conditions)and intrinsic(higher body mass index)EHI risk factors exist in youth *** risk factors may be influenced by event and league *** youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt.

关键词： Adolescents Anthropometrics Core temperature Heat exchange Pediatric Wet bulb globe temperature

Lessons learned from the Youngstown, Ohio induced earthquake sequence from January 2011 to January 2012

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第5期9卷 783-796页

作者： A.P.Morris D.A.Ferrill G.R.Walter A.M.Price K.J.Smart R.J.Skoumal M.R.Brudzinski B.S.Currie Southwest research Institute Culebra Road 6220 San Antonio TX 78238-5166 USA United States Geological Survey Earthquake Science Center 345 Middlefield Rd Building 3A RM 113 Menlo Park CA 94025 USA Department of Geology and Environmental Earth Science Miami University Oxford OH 45056 USA

The Youngstown earthquake sequence of 2011 is one of the clearest examples of inadvertently induced seismicity for which detailed documentation is *** this paper,we investigate(i) likely stress states in the vicinity of the injection well,(ii) a range of likely permeability scenarios,and(iii) relatively simple methods by which induced seismicity can be evaluated and *** use relocated hypocenters from the seismic sequence to construct a basement fault structure,which is then used to serve as a reference surface within the basement,and on which we calculate the effects of pore pressure changes induced by the injection activities of the Northstar #1 injection *** also deduce an in situ(preinjection) strike-slip stress regime,where ρ2≈ρ3,and it is consistent with both recent earthquake data and published stress estimates for the *** the reactivation characteristics of the basement are known or assumed,a critical or threshold slip tendency can be determined and the basement faults can be analyzed for the likelihood of reactivation in a perturbed pore pressure *** of well injection pressures and simulated pore pressure perturbations within the basement below the injection well indicates that permeability anisotropy is necessary to generate sufficient pore pressure perturbation to induce fault *** of the well’s injection history show that our estimate of in situ stress state,coupled with a highly anisotropic permeability structure,can generate sufficient pore pressure perturbation on the inferred basement structure to cause reactivation,potentially slipping an area of approximately 4×10~5 m~2.

关键词： Induced seismicity Wastewater injection Slip tendency

Prevalence of multi-drug resistant uropathogenic Escherichia coli in Potohar region of Pakistan

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 60-66页

作者： Ihsan Ali Zara Rafaque Safia Ahmed Sajid Malik Javid Iqbal Dasti Department of Microbiology Qauid-i-Azam University Department of Animal Sciences Qauid-i-Azam University

Objective:To scrutinize patterns of multi-drug-resistant uropathogenic Escherichia coli(UPEC) strains and particularly of fluoroquinolone-resistance this is an alternative choice for the treatment of urinary tract ***:Bacterial samples(n = 250) were collected from out-patients from August 2012 to August 2014 *** susceptibility profiling and determination of minimum inhibitory concentrations(MICs) and minimum bactericidal concentrations were performed according to the guidelines of Clinical and Laboratory Standards Institute(CLSI,2012).Genes,qnrA,qnrB and qnrS were identified by DNA amplification and ***:The highest percentage of UPEC isolates were resistant to co-trimoxazole(82%) followed by cephalothin(80%),2nd Gen,3rd Gen and 4th Gen cephalosporins,*** against gentamicin,amikacin remained 29% and 4%.For other drugs including nitrofurantoin,tetracycline,carbapenem and beta-lactam inhibitors remained below 10%.Altogether,59% of the isolates were resistant to at least three antibiotics including one ***,MICs for ciprofloxacin remained(MIC≥256 μg/mL) and for levofloxacin(MIC≥16 μg/mL and 32 μg/mL).No significant differences were observed regarding MIC values of extended spectrumβ-lactamase(ESBL) and non-ESBL *** qnrS and qnrB positive isolates MICs remained above 32 μg/*** of UPEC was significantly higher among females and 40% of the isolates were ESBL ***:Higher percentages of ESBL producing UPEC were associated with urinary tract ***,the majority of these isolates were multi-drug resistant and fluoroquinolone-resistant.

关键词： Fluoroquinolone-resistant Uropathogenic E.coli Multi-drug resistant Extended spectrum beta-lactamase

Helicobacter pylori and cytokine gene variants as predictors of premalignant gastric lesions

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World Journal of Gastroenterology 2019年第30期25卷 4105-4124页

作者： Anca Negovan Mihaela Iancu Emoke Fulop Claudia Banescu Department of Clinical Science-internal Medicine University of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania Department of Medical Informatics and Biostatistics “Iuliu Ha.ieganu”University of Medicine and PharmacyCluj-NapocaCluj 400349Romania Department of Morphological Sciences HistologyUniversity of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania Genetics Laboratory Center for Advanced Medical and Pharmaceutical ResearchUniversity of MedicinePharmacySciences and Technology of Targu Mure.Mure.540139Romania

Gastric cancer remains the third leading cause of mortality from cancer worldwide and carries a poor prognosis,due largely to late *** importance of the interaction between Helicobacter pylori(***)infection,the main risk factor,and host-related genetic factors has been studied intensively in recent *** genetic predisposition for non-hereditary gastric cancer is difficult to assess,as neither the real prevalence of premalignant gastric lesions in various populations nor the environmental risk factors for cancer progression are clearly *** non-cardiac intestinal-type cancer,identifying the factors that modulate the progression from inflammation toward cancer is crucial in order to develop preventive *** role of cytokines and their gene variants has been questioned in regard to non-self-limiting *** gastritis and its evolution to gastric atrophy and intestinal metaplasia;the literature now includes various and non-conclusive results on this *** influence of the majority of cytokine single nucleotide polymorphisms has been investigated for gastric cancer but not for preneoplastic gastric *** the investigated gene variants onlyIL10T-819C,IL-8-251,IL-18RAP917997,IL-22 rs1179251,IL1-B-511,IL1-B-3954,IL4R-398 and IL1RN were identified as predictors for premalignant gastric lesions *** of the most important limiting factors is the inhomogeneity of the studies(e.g.,the lack of data on concomitant *** infection,methods used to assess preneoplastic lesions,and source population).Testing the modifying effect of *** infection upon the relationship between cytokine gene variants and premalignant gastric lesions,or even testing the interaction between *** and cytokine gene variants in multivariable models adjusted for potential covariates,could increase generalizability of results.

关键词： Helicobacter pylori Gastritis Premalignant Glandular atrophy Intestinal metaplasia Single-nuclear polymorphism Gene variants Interleukins

Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole Ludwig Tobias Fehlmann Fabian Kern Manfred Gogol Walter Maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-Katharina von Thaler Christian Deuschle Florian Metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart Meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of Medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(Mini-Mental State Examination;MMSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted Presearch for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

The Shifting Landscape of Latent Print Testimony:An American Perspective

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Journal of Forensic Science and Medicine 2017年第2期3卷 72-81页

作者： Heidi Eldridge RTI International Research Triangle ParkNCUSA School of Criminal Justice University of LausanneLausanneSwitzeriand

Friction ridge comparison testimony in the United States has long been characterized by speaking in absolutes:fingerprints are unique,the Analysis,Comparison,Evaluation,and Verification methodology has a zero-error rate,and the testimony presented by the expert should be regarded as an incontrovertible *** the National research Council released their watershed report in 2009,questioning and criticizing these clear overstatements of the strength of the evidence,many commentators and professional organizations recommended that the friction ridge community rethink the way their evidence was presented in reports and in ***,change has been slow to *** some agencies have begun a shift in the way they present their findings,many others still testify the same way they always *** paper presents the historical context of where American friction ridge testimony has been,lays out the arguments for why it needs to change,describes some recent efforts to improve,and highlights some likely directions for the future of friction ridge reporting and testimony in the United States.

关键词： Friction ridge latent prints testimony

Ontology-based Access Control for FAIR Data

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Data Intelligence 2020年第1期2卷 66-77,304,305页

作者： Christopher Brewster Barry Nouwt Stephan Raaijmakers Jack Verhoosel Data Science Department at TNO Kampweg 55Soesterberg 3769 DEThe Netherlands Institute of Data Science Maastricht UniversityMaastricht 6229 ERThe Netherlands

This paper focuses on fine-grained,secure access to FAIR data,for which we propose ontology-based data access *** policies take into account both the FAIR aspects of the data relevant to access(such as provenance and licence),expressed as metadata,and additional metadata describing *** this tripartite approach(data,associated metadata expressing FAIR information,and additional metadata about users),secure and controlled access to object data can be *** yields a security dimension to the“A”(accessible)in FAIR,which is clearly needed in domains like security and *** domains need data to be shared under tight controls,with widely varying individual access *** this paper,we propose an approach called Ontology-Based Access Control(OBAC),which utilizes concepts and relations from a data set's domain *** argue that ontology-based access policies contribute to data reusability and can be reconciled with privacy-aware data access *** illustrate our OBAC approach through a proof-of-concept and propose that OBAC to be adopted as a best practice for access management of FAIR data.

关键词： Access control Semantic technology Ontology Security FAIR

A photometric study of two neglected eclipsing binaries

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research in Astronomy and Astrophysics 2021年第7期21卷 192-198页

作者： V.Kudak M.Fedurco V.Perig S.Parimucha Laboratory of Space researches Uzhhorod National UniversityUzhhorodDaleka Str.2A88000Ukraine Institute of Physics Faculty of ScienceUniversity of P.J.SafarikKosicePark Angelinum 904001Slovakia

We present the first BVR photometry,period variation and photometric light curve analysis of two poorly studied eclipsing binaries,V1321 Cyg and CR *** were carried out from November 2017 to January 2020 at the observatory of Uzhhorod National *** variations were studied using all available early published as well as our minima *** used the newly developed ELIS a code for the light curve analysis and determination of photometric parameters for both *** found that V1321 Cyg is a close detached eclipsing system with a low photometric mass ratio of q=0.28 which suggests that the binary is a post-mass transfer *** significant period changes in this system are *** Tau is,on the other hand,a semi-detached system where the secondary component almost fills its Roche *** detected a long-term period increase at a rate of 1.49 × 10^(-7) d yr^(-1),which supports mass transfer from the lower mass secondary component to the more massive primary.

关键词： binaries:close binaries:eclipsing stars:individual(V1321 Cyg CR Tau)

Improved image resolution on thoracic carcinomas by quantitative 18F-FDG coincidence SPECT/CT in comparison to 18F-FDG PET/CT

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The Journal of Biomedical research 2020年第4期34卷 309-317页

作者： Yuming Zheng Chaoling Jin Huijuan Cui Haojie Dai Jue Yan Pingping Han Bailing Hsu Nuclear Medicine Department China-Japan Friendship HospitalBeijing 100029China Oncology of Integrative Medicine Department China-Japan Friendship HospitalBeijing 100029China Nuclear Medicine Department Danli HospitalBeijing 100073China Nuclear Science and Engineering Institute University of Missouri-ColumbiaColumbiaMO 65201USA.

Currently,18F-FDG coincidence SPECT(Co-SPECT)/CT scan still serves as an important tool for diagnosis,staging,and evaluation of cancer treatment in developing *** implemented full physical corrections(FPC) to Co-SPECT(quantitative Co-SPECT) to improve the image resolution and contrast along with the capability for image *** included attenuation,scatter,resolution recovery,and noise reduction.A standard NEMA phantom filled with 10:1 F-18 activity concentration ratio in spheres and background was utilized to evaluate image ***,15 patients with histologically confirmed thoracic carcinomas were included to undergo a 18 F-FDG Co-SPECT/CT scan followed by a 18 F-FDG PET/CT *** parameters as SUVmax,SUVmean,SULpeak,and MTV from both quantitative Co-SPECT and PET were *** resolution of Co-SPECT for NEMA phantom was improved to reveal the smallest sphere from a diameter of 28 mm to 22 mm(17 mm for PET).The image contrast was enhanced from 1.7 to 6.32(6.69 for PET) with slightly degraded uniformity in background(3.1% vs.6.7%)(5.6% for PET).Patients’ SUVmax,SUVmean,SULpeak,and MTV measured from quantitative Co-SPECT were overall highly correlated with those from PET(r=0.82-0.88).Adjustment of the threshold of SUVmax and SUV to determine SUVmean and MTV did not further change the correlations with PET(r=0.81-0.88).Adding full physical corrections to Co-SPECT images can significantly improve image resolution and contrast to reveal smaller tumor lesions along with the capability to quantify functional parameters like PET/CT.

关键词： 18F-FDG coincidence SPECT/CT full physical corrections thoracic carcinomas image quantitation