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Distinct gut microbiomes in Thai patients with colorectal polyps

World Journal of Gastroenterology 2024年第27期30卷 3336-3355页

作者： Thoranin Intarajak Ahmad Nuruddin Khoiri Kanthida Kusonmano Weerayuth Kittichotirat Sawannee Sutheeworapong Supapon Cheevadhanarak Wandee Udomchaiprasertkul Chinae Thammarongtham Bioinformatics Unit Chulabhorn Royal AcademyLak Si 10210BangkokThailand Bioinformatics and Systems Biology Program School of Bioresources and Technologyand School of Information TechnologyKing Mongkut’s University of Technology ThonburiBang Khun Thian 10150BangkokThailand Bioinformatics and Systems Biology ProgramSchool of Bioresources and Technologyand School of Information TechnologyKing Mongkut’s University of Technology ThonburiBang Khun Thian 10150BangkokThailand Systems Biology and Bioinformatics Unit Pilot Plant Development and Training InstituteKing Mongkut’s University of Technology ThonburiBang Khun Thian 10150BangkokThailand Molecular Genomic Research Laboratory Chulabhorn Royal AcademyLak Si 10210BangkokThailand National Center for Genetic Engineering and Biotechnology King Mongkut's University of Technology ThonburiBang Khun Thian 10150BangkokThailand School of Bioresources and Technology King Mongkut’s University of Technology ThonburiBank Khun Thian 10150BangkokThailand Fungal Biotechnology Unit Pilot Plant Development and Training InstituteKing Mongkut’s University of Technology ThonburiBang Khun Thian 10150BangkokThailand

BACKGROUND Colorectal polyps that develop via the conventional adenoma-carcinoma sequence[e.g.,tubular adenoma(TA)]often progress to malignancy and are closely associated with changes in the composition of the gut *** is limited research concerning the microbial functions and gut microbiomes associated with colorectal polyps that arise through the serrated polyp pathway,such as hyperplastic polyps(HP).Exploration of microbiome alterations asso-ciated with HP and TA would improve the understanding of mechanisms by which specific microbes and their metabolic pathways contribute to colorectal *** To investigate gut microbiome signatures,microbial associations,and microbial functions in HP and TA *** Full-length 16S rRNA sequencing was used to characterize the gut microbiome in stool samples from control participants without polyps[control group(CT),n=40],patients with HP(n=52),and patients with TA(n=60).Significant differences in gut microbiome composition and functional mechanisms were identified between the CT group and patients with HP or *** techniques in this study included differential abundance analysis,co-occurrence network analysis,and differential pathway *** Colorectal cancer(CRC)-associated bacteria,including Streptococcus gallolyticus(***),Bacteroides fragilis,and Clostridium symbiosum,were identified as characteristic microbial species in TA *** gnavus,associated with dysbiosis and gastrointestinal diseases,was significantly differentially abundant in the HP and TA *** pathway analysis revealed that HP patients exhibited enrichment in the sulfur oxidation pathway exclusively,whereas TA patients showed dominance in pathways related to secondary metabolite biosynthesis(e.g.,mevalonate);*** was a major ***-occurrence network and dynamic network analyses revealed co-occurrence of dysbiosis-associated bacteria in HP patients,wh

关键词： Gut microbiome Colorectal adenoma Hyperplastic polyp Full-length 16s rRNA Microbial correlation networks Predicted functional mechanisms

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Maslinic acid supplementation prevents di(2-ethylhexyl)phthalate-induced apoptosis via PRDX6 in peritubular myoid cells of Chinese forest musk deer

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Journal of Environmental Sciences 2024年第9期143卷 47-59页

作者： Heran Cao Zhenpeng Li Tianqi Jin Shuyang He Shujuan Liu Long Li Yang Wang Ye Gong Gang Wang Fangxia Yang Wuzi Dong College of Animal Science and Technology Northwest A&F UniversityShaanxi 712100China College of Forestry Northwest A&F UniversityShaanxi 712100China Biology Research Centre of Qin-Mountains Wildlife Northwest A&F UniversityShaanxi 712100China Shaanxi Qiyuan-Times Agri-Tech Development Co.Ltd. Shaanxi 725000China

Chinese forest musk deer(FMD),an endangered species,have exhibited low reproductive rates even in captivity due to stress *** revealed the presence of di(2-ethylhexyl)phthalate(DEHP),an environmental endocrine disruptor,in the serum and skin of captive *** FMDs with maslinic acid(MA)has been observed to alleviate the stress response and improve reproductive rates,although the precise molecular mechanisms remain ***,this study aims to investigate the molecular mechanisms underlying the alleviation of DEHP-induced oxidative stress and cell apoptosis in primary peritubular myoid cells(PMCs)through MA *** PMCs were isolated and exposed to DEHP in *** results demonstrated that DEHP significantly suppressed antioxidant levels and promoted cell apoptosis in primary ***,interfering with the expression of PRDX6 was found to induce excessive reactive oxygen species(ROS)production and cell apoptosis in primary *** with MA significantly upregulated the expression of PRDX6,thereby attenuating DEHP-induced oxidative stress and cell apoptosis in primary *** findings provide a theoretical foundation for mitigating stress levels and enhancing reproductive capacity of in captive FMDs.

关键词： Maslinic acid Forest musk deer Di(2-ethylhexyl)phthalate Peritubular myoid cells PRDX6

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Effect of chemical regulators on the recovery of leaf physiology,dry matter accumulation and translocation,and yield-related characteristics in winter wheat following dry-hot wind

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Journal of Integrative Agriculture 2024年第1期23卷 108-121页

作者： Yanan Xu Yue Wu Yan Han Jiqing Song Wenying Zhang Wei Han Binhui Liu Wenbo Bai Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Dryland Farming Research Hebei Academy of Agriculture and Forestry SciencesHengshui 053000China Shandong General Station of Agricultural Technology Extension Jinan 250100China

Dry-hot wind stress causes losses in wheat productivity in major growing regions worldwide,especially winter wheat in the Huang-Huai-Hai Plain of China,and both the occurrence and severity of such events are likely to increase with global climate *** investigate the recovery of physiological functions and yield formation using a new noncommercial chemical regulator(NCR)following dry-hot wind stress,we conducted a three-year field experiment(2018-2021)with sprayed treatments of tap water(control),monopotassium phosphate(CKP),NCR at both the jointing and flowering stages(CFS),and NCR only at the jointing stage(FSJ)or flowering stage(FSF).The leaf physiology,biomass accumulation and translocation,grain-filling process,and yield components in winter wheat were *** the single spraying treatments,the FSJ treatment was beneficial for the accumulation of dry matter before anthesis,as well as larger increases in the maximum grain-filling rate and mean grain-filling *** FSF treatment performed better in maintaining a high relative chlorophyll content as indicated by the SPAD value,and a low rate of excised leaf water loss in flag leaves,promoting dry matter accumulation and the contribution to grain after anthesis,prolonging the duration of grain filling,and causing the period until the maximum grain-filling rate reached *** CFS treatment was better than any other treatments in relieving the effects of dry-hot *** exogenous NCR treatments significantly increased grain yields by 12.45-18.20% in 2018-2019,8.89-13.82% in 2019-2020,and 8.10-9.00% in *** conventional measure of the CKP treatment only increased grain yield by 6.69% in *** CFS treatment had the greatest mitigating effect on yield loss under dry-hot wind stress,followed by the FSF and FSJ treatments,and the CKP treatment only had a minimal *** summary,the CFS treatment could be used as the main chemical control measure for wheat stress resistance and yield

关键词： preparation stress foliar spraying grain-filling remobilization

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Coherent optical frequency transfer via 972-km fiber link

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Chinese Physics B 2024年第2期33卷 277-282页

作者：邓雪张翔臧琦焦东东王丹刘杰高静许冠军董瑞芳刘涛张首刚 National Time Service Centre Chinese Academy of SciencesXi’an 710600China Key Laboratory of Time Reference and Application Chinese Academy of SciencesXi’an 710600China School of Communications and Information Engineering and School of Artificial Intelligence Xi’an University of Posts and TelecommunicationsXi’an 710121Chin

We demonstrate coherent optical frequency dissemination over a distance of 972 km by cascading two spans where the phase noise is passively compensated *** of employing a phase discriminator and a phase locking loop in the conventional active phase control scheme,the passive phase noise cancellation is realized by feeding double-trip beat-note frequency to the driver of the acoustic optical modulator at the local *** passive scheme exhibits fine robustness and reliability,making it suitable for long-distance and noisy fiber *** optical regeneration station is used in the link for signal amplification and cascaded *** phase noise cancellation and transfer instability of the 972-km link is investigated,and transfer instability of 1.1×10^(-19)at 10^(4)s is *** work provides a promising method for realizing optical frequency distribution over thousands of kilometers by using fiber links.

关键词： optical frequency transfer fiber link phase noise cancellation

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Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1/GSDMD Pathway

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Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao YOU Yue XU Shu-juan ZHANG Ye-hao CHEN Yuan-yuan XIN Gao-jie LIU Zi-xin REN Jun-guo CAO Ce LI Ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing Key Laboratory of Chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–160 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-18, IL-1β, monocyte chemotactic protein 1(MCP-1), tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1(Caspase-1), GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-18,IL-1β, MCP-1, TNF-α and IL-6(P<0.01 or P<0.05). At the same time, by inhibiting NLRP3/Caspase-1/GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1, GSDMD and GSDMD-N proteins(P<0.01). Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： Chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

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Reaction Kinetics and Secondary Organic Aerosol Composition Analysis of 2-Cyclohexen-1-one with NO_(3) Radicals

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Chemical Research in Chinese Universities 2024年第4期40卷 730-736页

作者： HU Lin TONG Shengrui XU Yanyong ZHANG Hailiang YU Shanshan CHEN Meifang GE Maofa Structural Chemistry of Unstable and Stable Species Chinese Academy of Sciences Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing100190P.R.China College of Ecology and Environment Xinjiang UniversityUrumqi830017P.R.China University of Chinese academy of Sciences Beijing100049P.R.China

Unsaturated ketones are typical oxygenated volatile organic compounds(OVOCs)with high reactivity,and are important precursors in air *** sources of OVOCs are complex and include direct emissions and secondary oxidation formation of VOCs in the atmosphere.2-Cyclohexen-1-one is a widespread substance,and is derived from the industrial catalytic oxidation of *** this paper,we investigated the rate constants of the chemical reactions of 2-cyclohexen-1-one with NO_(3) radicals,which is(7.25±0.29)×10^(-15) cm^(3)·molecule^(-1)·s^(-1) at 298 K and under 1 atm(1 atm=101325Pa).It supplemented the kinetics of NO_(3) radicals database,and revealed its effects in the nighttime *** addition,the reaction products of 2-cyclohexen-1-one with NO_(3) radicals were detected by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS),which revealed a series of nitrate esters in the composition of the secondary organic aerosol(SOA),which may reduce atmospheric ***,the possible pathways for the generation of the products were developed.

关键词： Kinetics Unsaturated ketone Nitrate radical Secondary organic aerosol

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A Tutorial Review of the Solar Power Curve: Regressions, Model Chains, and Their Hybridization and Probabilistic Extensions

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Advances in Atmospheric Sciences 2024年第6期41卷 1023-1067页

作者： Dazhi YANG Xiang’ao XIA Martin János MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory for Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3Budapest H-1111Hungary

Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly *** numerous trending topics,energy meteorology has been attracting the most attention *** essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical *** this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power *** power curves can be modeled in two primary ways,one of regression and the other of model *** classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.

关键词： review energy meteorology solar power curve model chain solar power prediction

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Transcriptomic and metabolomic analysis provides insights into lignin biosynthesis and accumulation and differences in lodging resistance in hybrid wheat

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Journal of Integrative Agriculture 2024年第4期23卷 1105-1117页

作者： Weibing Yang Shengquan Zhang Qiling Hou Jiangang Gao Hanxia Wang Xianchao Chen Xiangzheng Liao Fengting Zhang Changping Zhao Zhilie Qin Institute of Hybrid Wheat Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Beijing Municipal Key Laboratory of Molecular Genetics of Hybrid Wheat Beijing 100097China

The use of hybrid wheat is one way to improve the yield in the ***,greater plant heights increase lodging risk to some *** this study,two hybrid combinations with differences in lodging resistance were used to analyze the stem-related traits during the filling stage,and to investigate the mechanism of the difference in lodging resistance by analyzing lignin synthesis of the basal second internode(BSI).The stem-related traits such as the breaking strength,stem pole substantial degree(SPSD),and rind penetration strength(RPS),as well as the lignin content of the lodging-resistant combination(LRC),were significantly higher than those of the lodgingsensitive combination(LSC).The phenylpropanoid biosynthesis pathway was significantly and simultaneously enriched according to the transcriptomics and metabolomics analysis at the later filling stage.A total of 35 critical regulatory genes involved in the phenylpropanoid pathway were ***,42%of the identified genes were significantly and differentially expressed at the later grain-filling stage between the two combinations,among which more than 80%were strongly up-regulated at that stage in the LRC compared with *** the contrary,the LRC displayed lower contents of lignin intermediate metabolites than the *** results suggested that the key to the lodging resistance formation of LRC is largely the higher lignin synthesis at the later grain-filling ***,breeding strategies for synergistically improving plant height and lodging resistance of hybrid wheat were put forward by comparing the LRC with the conventional wheat applied in large areas.

关键词： gene expression lignin synthesis lodging-resistance hybrid wheat

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BaTiO_(3)/p-GaN/Au self-driven UV photodetector with bipolar photocurrent controlled by ferroelectric polarization

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Chinese Physics B 2024年第4期33卷 202-207页

作者：韩无双刘可为杨佳霖朱勇学程祯陈星李炳辉刘雷申德振 State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Ferroelectric materials are promising candidates for ultraviolet photodetectors due to their ferroelectric *** this work,a BaTiO_(3)/p-GaN/Au hybrid heterojunction-Schottky self-driven ultraviolet photodetector was fabricated with excellent bipolar photoresponse *** 0 V bias,the direction of the photocurrent can be switched by flipping the depolarization field of BaTiO_(3),which allows the performance of photodetectors to be controlled by the ferroelectric ***,a relatively large responsivity and a fast response speed can be also *** particular,when the depolarization field of BaTiO_(3) is in the same direction of the built-in electric field of the Au/p-GaN Schottky junction(up polarized state),the photodetector exhibits a high responsivity of 18 mA/W at 360 nm,and a fast response speed of<40 ms at 0 *** findings pave a new way for the preparation of high-performance photodetectors with bipolar photocurrents.

关键词： ferroelectric effect bipolar self-driven photodetector

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Cancer statistics for young adults aged 20 to 49 years in China from 2000 to 2017:a population-based registry study

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Science China(Life Sciences) 2024年第4期67卷 711-719页

作者： Yi Teng Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Siyi He Mengdi Cao Shaoli Zhang Qianru Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

An increasing cancer incidence among adults younger than 50 years has been reported for several types of cancer in multiple *** aimed to report cancer profiles and trends among young adults in *** from the China Cancer Registry Annual Report were used to estimate incidence and mortality among young adults(ages 20–49 years)in China in 2017,and an age-period-cohort model was employed to estimate the average annual percent change(AAPC)in incidence and mortality from 2000 to *** 25 cancer types were grouped into obesity-or overweight-associated cancers(12 cancer types)and additional cancers(13 cancer types).In 2017,there were 681,178new cases and 214,591 cancer deaths among young adults in *** young adults,the most common cancers were thyroid,breast,cervical,liver,lung,and colorectal cancer,and the leading causes of cancer deaths were liver,lung,cervical,stomach,breast,and colorectal *** 2000 to 2017,the cancer incidence increased for all cancers combined among young adults,with the highest AAPC(1.46%)for adults aged 20–24 years,while cancer mortality decreased,with the highest AAPC(-1.63%)for those aged 35–39 *** conclusion,the cancer incidence in China has increased among young adults,while cancer mortality has decreased for nearly all *** control measures,such as obesity control and appropriate screening,may contribute to reducing the increasing cancer burden among young adults.

关键词： young adults incidence mortality trends China

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