检索结果-南通市图书馆

Oligomerization between BSU1 Family Members Potentiates Brassinosteroid Signaling in Arabidopsis

Molecular Plant 2016年第1期9卷 178-181页

作者： Eun-Ji Kim Ji-Hyun youn Chan-Ho Park Tae-woo Kim Shenheng Guan Shouling Xu AlmaL. Burlingame young-Pil Kim Seong-Ki Kim zhi-yong wang Tae-wuk Kim Research Institute for Natural Sciences Hanyang University Seoul 133-791 Korea

Brassinosteroid （BR） regulates diverse physiological and devel- opmental processes in plants （Choudhary et al., 2012）. BR binds to the receptor kinase BRI1 to trigger a phosphorylation/ dephosphorylation cascade, which includes phosphorylation of Brassinosteroid Signaling Kinase 1 （BSK1） and Constitutive Differential Growth 1 （CDG1） by BRI1, phosphorylation of BSU1 by CDG1, and dephosphorylation of BIN2 （a GSK3-1ike kinase） by BSU1 （Kim et al., 2009, 2011; wang et al., 2014）. Almost all the downstream components of BR signaling are encoded by multiple genes of a family.

关键词： RESEARCH Oligomerization Brassinosteroids Arabidopsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect

引用

Signal Transduction and Targeted Therapy 2022年第8期7卷 2701-2703页

作者： Mingyue Liu Xu wang Xuexiang Du yan zhang Chunxia Ai Siwen Hu-Lieskovan Tianhong Li Martin Devenport yang Liu Pan zheng Division of Immunotherapy Institute of Human Virology and Department of SurgeryUniversity of Maryland School of MedicineBaltimoreMD 21202USA Key Laboratory of Infection and Immunity of Shandong Province&Department of Immunology School of Basic Medical SciencesShandong UniversityJinan 250012China Shanghai Institute of Immunology Department of Immunology and MicrobiologyState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of MedicineShanghai 200025China Division of Oncology Huntsman Cancer InstituteUniversity of Utah School of MedicineSalt Lake CityUT 84112USA Division of Hematology/Oncology Department of Internal MedicineUniversity of California Davis School of MedicineUniversity of California Davis Comprehensive Cancer CenterSacramentoCA 95817USA OncoC4 IncRockvilleMD 20805USA

Dear Editor,In combination,anti-CTLA-4 and anti-PD-1 mAb provide the most effective immunotherapy,although severe immune-related adverse events(irAEs)also occur at high frequency.1 It is urgent to develop strategies t... 详细信息

关键词： preserving CD24 urgent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structure of unliganded membrane-proxima domains FN4-FN5-FN6 of DCC

引用

Protein & Cell 2017年第9期8卷 701-705页

作者： Lorenzo I. Finci Jie zhang Xiaqin Sun Robert G. Smock Rob Meijers yan zhang Junyu Xiao Jia-huai wang State Key Laboratory of Biomembrane and Membrane Biotechnology College of Life Sciences Peking University Dana-Farber Cancer Institute Harvard Medical School Boston MA 02215 USA European Molecular Biology Laboratory (EMBL) Hamburg Out-station Hamburg Germany PKU-IDG/McGovern Institute for Brain Research Peking University Beijing 100871 China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences and Peking-Tsinghua Center for Life Sciences Peking University Beijing 100871 China Beijing Advanced Innovation Center for Struc tural Biology Tsinghua-Peking Center for Life Sciences School of Life Sciences and School of Medicine Tsinghua University Beijing 100084 China The Francis Crick Institute London NW12BE UK

Dear Editor, Deleted in colorectal cancer （DCC） is a single pass transmembrane glycoprotein that was originally identified in humans as a candidate tumor suppressor （Fearon et al., 1990）. DCC belongs to the immunoglobulin superfamily, and the extracellular fragment is composed of four immunoglobu- lin-like （Ig-like） domains followed by six fibronectin type III （FN） domains. DCC plays a pivotal role in axon guidance by mediating a combination of attractive and repulsive effects through interactions with the diffusible guidance cue,

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

引用

Genes & Diseases 2019年第4期6卷 419-430页

作者： wei wang Bo Hu Jiang-Jiang Qin Jian-wen Cheng Xin Li Mehrdad Rajaei Jia Fan Xin-Rong yang Ruiwen zhang Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX77204USA Drug Discovery Institute University of HoustonHoustonTX77204USA Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai200032China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Fudan UniversityShanghai200032China

Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma(HCC)and are associated with increased mortality due to this *** MDM2 has been demonstrated to be a valid approach for the treatment of ***,most of the MDM2 inhibitors evaluated to date have been designed to block the MDM2 and p53 binding,and have limited efficacy against tumors with mutant or deficient *** the present study,we developed a novel MDM2 inhibitor(termed SP141)that has direct effects on MDM2 and exerts anti-HCC activity independent of the p53 status of the cancer *** demonstrate that SP141 inhibits cell growth and prevents cell migration and invasion,independent of ***,SP141 directly binds the MDM2 protein and promotes MDM2 *** inhibition of MDM2 by SP141 also increases the sensitivity of HCC cells to *** addition,in orthotopic and patient-derived xenograft models,SP141 inhibits MDM2 expression and suppresses tumor growth and metastasis,without any host ***,the inhibition of MDM2 by SP141 is essential for its anti-HCC *** results provide support for the further development of SP141 as a lead candidate for the treatment of HCC.

关键词： CRISPR/Cas9 Hepatocellular carcinoma MDM2 p53-independent Patient-derived xenograft

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mass spectrometry based proteomics profiling of human monocytes

引用

Protein & Cell 2017年第2期8卷 123-133页

作者： yong zeng Fei-yan Deng wei zhu Lan zhang Hao He Chao Xu Qing Tian Ji-Gang zhang Li-Shu zhang Hong-Gang Hu Hong-wen Deng College of Life Sciences and Bioengineering Beijing Jiaotong University Beijing 100044 China Center of Bioinformatics and Genomics Tulane University School of Public Health and Tropical Medicine New Orleans LA 70112 USA College of Life Sciences Hunan Normal University Changsha 410081 China Laboratory of Proteins and Proteomics Department of Epidemiology Soochow University School of Public Health Suzhou 205123 China

Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehensive proteome knowledge base specifically for human monocytes by integrating both in vivo and in vitro datasets. The top 2000 expressed genes from in vitro datasets and 779 genes from in vivo experiments were integrated into this study. Altogether, a total of 2237 unique monocyte-expressed genes were cataloged. Biological functions of these monocyte-expressed genes were annotated and classified via Gene Ontology （GO） analysis. Furthermore, by extracting the overlapped genes from in vivo and in vitro datasets, a core gene list including 541 unique genes was generated. Based on the core gene list, further gene-disease associations, pathway and network analyses were performed. Data analyses based on multiple bioinformatics tools produced a large body of biologically meaningful information, and revealed a number of genes such as SAMHDI, G6PD, GPD2 and EN01, which have been reported to be related to immune response, blood biology, bone remodeling, and cancer respectively. As a unique resource, this study can serve as a reference map for future in-depth research on monocytes biology and monocyte-involved human diseases.

关键词： human monocytes proteomics knowledgebase gene ontology gene-disease association network analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

锰和热处理工艺对硅锰双相钢显微组织的影响

引用

金属热处理 1992年第9期17卷 13-16页

作者：周子军田琮宋沂生北京科技大学 100083

研究了三种低碳硅锰钢顶端淬火后的显微组织。试验结果表明,锰含量高于1.6%的低碳硅锰钢,在(α+γ)两相区(780℃或850℃)加热25min后,端淬试样上J=5～85mm范围内(J:距水冷端的距离)均可得到铁素体加马氏体的双相组织,而且J在30～85mm范... 详细信息

研究了三种低碳硅锰钢顶端淬火后的显微组织。试验结果表明,锰含量高于1.6%的低碳硅锰钢,在(α+γ)两相区(780℃或850℃)加热25min后,端淬试样上J=5～85mm范围内(J:距水冷端的距离)均可得到铁素体加马氏体的双相组织,而且J在30～85mm范围内,马氏体体积百分数变化很小(试验用B或C钢)。

关键词：双相钢锰端淬试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：