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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli Guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

Fluorescence quantum yield of Gd_(0.9-x)R_xEu_(0.1)OOH(R=Y, La) crystals

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Journal of Rare Earths 2015年第12期33卷 1256-1260页

作者： Hiroaki Samata Katsutoshi Kobayashi Masashi Hanioka Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University Materials Development Group Superconducting Properties Unit National Institute for Materials Science

*** （R=Y, La） crystals were synthesized by a flux method using a mixture of NaOH and KOH as the flux. X-ray diffraction data were well refined using the Rietveld method assuming that the crystals had a monoclinic structre belonging to the P21/m space group. The unit cell volumes of the Gdo.9 *** crystals increased with increasing x, whereas those of *** decreased with increasing x. The Commission Internationale de IEclairage （CIE） chromaticity coordinates of Gdo.9 *** （R=Y, La） crystals were located in the red region and were nearly constant over the range ofx values considered. The fluorescence quantum yield Dr monotonically decreased with increasing x regardless of the ionic radii of the substitute ions. The fact that the Dr value of Lao.9EuoAOOH was greater than that of *** indicated that the observed decrease in the values of the Gdo.9-,LaxEuo.1OOH crystals up to x=0.3 could not be attributed to an increase in the distance between Eu3＋ ions or to a decrease in the Gd3＋ content. The decrease might be due to an increase of killer centers introduced by elemental substitutions with the larger ion.

关键词： rare-earth oxyhydroxide phosphor elemental substitution fluorescence quantum yield

Van Vleck paramagnetism of europium oxyhydroxide

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Journal of Rare Earths 2015年第2期33卷 177-181页

作者： Hiroaki Samata Naoki Wada Tadashi C.Ozawa Graduate School of Maritime Sciences Kobe University FukaeminamiHigashinada Kobe Hyogo 658-0022 Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceNamiki Tsukuba Ibaraki 305-0044 Japan

Europium oxyhydroxide crystals were synthesized by the flux method. The as-grown crystals were transparent and had a plate-like shape with natural flat surfaces. The powder XRD data were refined by assuming a monoclinic structure of the space group P21/m and lattice parameters of a=0.4346 nm, b=0.3744 nm, c=0.6107 nm, and β=108.62°. The magnetic susceptibility of the EuOOH crystals exhibited typical Van Vleck temperature-independent paramagnetism below 120 K. The calculated susceptibility, based on Van Vleck＇s theory, agreed with the experimental data to some extent, with the coupling constant λ=458±10 K. The experimental results were in close agreement with the results calculated using a modified formula with λ=505±2 K and a constant term C=4.6×10^-4 emu/（mol·Oe）.

关键词： europium oxyhydroxide magnetic measurement Van Vleck paramagnetism rare earths

Two-parameter families of uniquely extendable Diophantine triples

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Science China Mathematics 2018年第3期61卷 421-438页

作者： Mihai Cipu Yasutsugu Fujita Maurice Mignotte Simion Stoilow Institute of Mathematics of the Romanian Academy Research unit nr. 5 P.O. Box 1-764 RO-014700 Bucharest Romania Department of Mathematics College of Industrial Technology Nihon University 2-11-1 Shin-ei Narashino Chiba 276-0028 Japan Département de Mathematique Universite de Strasbourg Strasbourg 67084 France

Let A and K be positive integers and ε∈ {-2,-1,1,2}. The main contribution of the paper is a proof that each of the D(ε~2)-triples {K, A^2 K+2εA,(A +1)~2 K + 2ε(A+1)} has uniqui extension to a D(ε~2)-quadruple. This is used to slightly strengthen the conditions required for the existencc of a D(1)-quintuple whose smallest three elements form a regular triple.

关键词： Diophantine m-tuples Pell equations hypergeometric method linear forms in logarithms

Transient receptor potential vanilloid 4-dependent calcium influx and ATP release in mouse and rat gastric epithelia

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World Journal of Gastroenterology 2016年第24期22卷 5512-5519页

作者： Hiroshi Mihara Nobuhiro Suzuki Ammar Abdullkader Boudaka Jibran Sualeh Muhammad Makoto Tominaga Yoshiaki Tabuchi Toshiro Sugiyama Department of Gastroenterology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Division of Cell Signaling Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences) National Institutes of Natural Sciences Department of Physiology College of Medicine and Health Sciences Sultan Qaboos University Life Science Research Center University of Toyama

AIM: To explore the expression of transient receptor potential vanilloid 4(TRPV4) and its physiological meaning in mouse and rat gastric epithelia. METHODS: RT-PCR and immunochemistry were used to detect TRPV4 m RNA and protein expression in mouse stomach and a rat normal gastric epithelial cell line(RGE1-01), while Ca2+-imaging and electrophysiology were used to evaluate TRPV4 channel activity. ATP release was measured by a luciferin-luciferase assay. Gastric emptying was also compared between WT and TRPV4 knockout mice. RESULTS: TRPV4 m RNA and protein were detected in mouse tissues and RGE1-01 cells. A TRPV4-specific agonist(GSK1016790A) increased intracellular Ca2+ concentrations and/or evoked TRPV4-like current activities in WT mouse gastric epithelial cells andRGE1-01 cells, but not TRPV4 KO cells. GSK1016790 A or mechanical stimuli induced ATP release from RGE1-01 cells while TRPV4 knockout mice displayed delayed gastric emptying in vivo. CONCLUSION: TRPV4 is expressed in mouse and rat gastric epithelium and contributes to ATP release and gastric emptying.

关键词： Transient receptor potential vanilloid 4 Stomach gastric emptying ATP

An association between Helicobacter pylori and upper respiratory tract disease: Fact or fiction?

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World Journal of Gastroenterology 2014年第6期20卷 1470-1484页

作者： Shin Kariya Mitsuhiro Okano Kazunori Nishizaki Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Helicobacter pylori(H. pylori) is a major cause of chronic gastritis and gastric ulcers and considerable evidence supports the notion that infection with this bacterium is also associated with gastric malignancy in addition to various other conditions including pulmonary, vascular and autoimmune disorders. Gastric juice infected with H. pylori might play an important role in upper respiratory tract infection. Although direct and/or indirect mechanisms might be involved in the association between H. pylori and upper respiratory tract diseases, the etiological role of H. pylori in upper respiratory tract disorders has not yet been fully elucidated. Although various studies over the past two decades have suggested a relationship between H. pylori and upper respiratory tract diseases, the findings are inconsistent. The present overview describes the outcomes of recent investigations into the impact of H. pylori on upper respiratory tract and adjacent lesions.

关键词： Paranasal sinus Ear Adenoid Oral cavity Pharynx Larynx Upper respiratory tract Cancer

Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential

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World Journal of Stem Cells 2017年第10期9卷 179-186页

作者： Harumichi Itoh Shimpei Nishikawa Tomoya Haraguchi Yu Arikawa Shotaro Eto Masato Hiyama Toshie Iseri Yoshiki Itoh Munekazu Nakaichi Yusuke Sakai Kenji Tani Yasuho Taura Kazuhito Itamoto Department of Small Animal Clinical Science Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Radiology Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University

AIMTo identify and characterize functionally distinct subpopulation of adipose-derived stem cells (ADSCs). METHODSADSCs cultured from mouse subcutaneous adipose tissue were sorted fluorescence-activated cell sorter based on aldehyde dehydrogenase (ALDH) activity, a widely used stem cell marker. Differentiation potentials were analyzed by utilizing immunocytofluorescece and its quantitative analysis. RESULTSApproximately 15% of bulk ADSCs showed high ALDH activity in flow cytometric analysis. Although significant difference was not seen in proliferation capacity, the adipogenic and osteogenic differentiation capacity was higher in ALDHHi subpopulations than in ALDHLo. Gene set enrichment analysis revealed that ribosome-related gene sets were enriched in the ALDHHi subpopulation. CONCLUSIONHigh ALDH activity is a useful marker for identifying functionally different subpopulations in murine ADSCs. Additionally, we suggested the importance of ribosome for differentiation of ADSCs by gene set enrichment analysis.

关键词： Adipose-derived stem/stromal cell Aldehyde dehydrogenase activity Flow cytometry Subpopulation Ribosome

Aggregation-induced emission and thermally activated delayed fluorescence of 2,6-diaminobenzophenones

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Science China Chemistry 2018年第8期61卷 925-931页

作者： Masaki Shimizu Masaki Nakatani Kenta Nishimura Faculty of Molecular Chemistry and Engineering Kyoto Institute of Technology

Exploration of novel organic luminophores that exhibit thermally activated delayed fluorescence(TADF) in the aggregated state is very crucial for advance of delayed luminescence-based applications such as time-gated bio-sensing and temperature *** report herein that synthesis, photophysical properties, molecular and crystal structures, and theoretical calculations of 2,6-bis(diarylamino)benzophenones. Absorption spectra in solution and calculations using density functional theory(DFT) method revealed that the optical excitation took place through intramolecular charge-transfer from one diarylamino moiety to an aroyl group. While the benzophenones did not luminesce in solution, the solids of the benzophenones emitted green light with moderate-to-good quantum yields. Thus, the benzophenones exhibit aggregation-induced emission. Based on the lifetime measurement, the green emission of the solids was found to include TADF. The emergence of the TADF is supported by the small energy gap between the excited singlet and triplet states, which was estimated by time-dependent DFT calculations. Thin films of poly(methyl methacrylate) doped by the benzophenones also showed green prompt and delayed fluorescence whose lifetimes were in the order of microseconds. Linear correlation between logarithm value of TADF lifetime and temperature was observed with the benzophenone in powder, suggesting that the benzophenones can serve as molecular thermometers workable under aqueous conditions.

关键词： donor-acceptor system delayed fluorescence temperature sensor

Design of Temperature-Responsive Cell Culture Surfaces for Cell Sheet Engineering

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Cyborg and Bionic Systems 2021年第1期2021卷 40-54页

作者： Y.Akiyama Institute of Advanced Biomedical Engineering and Science Tokyo Women’s Medical UniversityTWInsTokyoJapan

Temperature-responsive cell culture surfaces,which modulate cell attachment/detachment characteristics with temperature,have been used to fabricate cell *** study on fabrication of cell sheet with the temperature-responsive cell culture surface,manipulation,and transplantation of the cell sheet has established the interdisciplinary field of cell sheet engineering,in which engineering,biological,and medical fields closely *** collaboration has pioneered cell sheet engineering,making it a promising and attractive technology in tissue engineering and regenerative *** review introduces concepts of cell sheet engineering,followed by designs for the fabrication of various types of temperature-responsive cell culture surfaces and technologies for cell sheet *** development of various methods for the fabrication of temperature-responsive cell culture surfaces was also *** availability of cell sheet engineering for the treatment and regeneration of damaged human tissue has also been described,providing examples of the clinical application of cell sheet transplantation in humans.

关键词： manipulation culture attractive