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Next-generation regenerative therapy for ischemic stroke using peripheral blood mononuclear cells

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Neural Regeneration Research 2024年第11期19卷 2341-2342页

作者： Masato Kanazawa Itaru Ninomiya Yutaka Otsu Masahiro Hatakeyama Department of Neurology Brain Research InstituteNiigata UniversityNiigataJapan

Stroke is the second leading cause of death and the third leading cause of disability worldwide after heart *** predict that stroke deaths and permanent disabilities will increase worldwide by the year ***-target therapies may be insufficient,because ischemic cerebral injury involves several ***-mediated therapies are ideal,because they target multiple cell types to enhance protection and recovery.

关键词： ischemic death cerebral

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电子非厄米系统中的拓扑自旋图样

Science Bulletin 2024年第9期69卷 325-333页

作者：张骁骁 Naoto Nagaosa RIKEN Center for Emergent Matter Science(CEMS) WakoSaitama 351-0198Japan Department of Applied Physics University of TokyoTokyo 113-8656Japan

Non-Hermitian systems have been discussed mostly in the context of open systems and *** experimental progress is much from optical,cold-atomic,and classical platforms due to the vast tunability and clear identification of ***,their counterpart in solid-state electronic systems in equilibrium remains unmasked although highly desired,where a variety of materials are available,calculations are solidly founded,and accurate spectroscopic techniques can be *** demonstrate that,in the surface state of a topological insulator with spin-dependent relaxation due to magnetic impurities,highly nontrivial topological soliton spin textures appear in momentum *** spin-channel phenomena are delicately related to the type of non-Hermiticity and correctly reveal the most robust non-Hermitian features detectable ***,the distinct topological soliton objects can be deformed to each other,mediated by topological transitions driven by tuning across a critical direction of doped *** results not only open a solid-state avenue to exotic spin patterns via spin-and angle-resolved photoemission spectroscopy,but also inspire non-Hermitian dissipation engineering of spins in solids.

关键词： Non-Hermitian system Topological spin texture Magnetic impurity Surface state ARPES

Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki Watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

Coated boron layers by boronization and a real-time boron coating using an impurity powder dropper in the LHD

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Plasma Science and Technology 2024年第8期26卷 25-31页

作者： Naoko ASHIKAWA Robert LUNSFORD Federico NESPOLI Erik GILSON Yaowei YU Jiansheng HU Shinichiro KADO National Institute for Fusion Science Toki 509-5292Japan Princeton Plasma Physics Laboratory Princeton NJ 08540United States of America Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China Institute of Advanced Energy Kyoto UniversityKyoto 611-0011Japan

In the Large Helical Device(LHD),diborane(B2H6)is used as a standard boron source for boronization,which is assisted by helium glow *** 2019,a new Impurity Powder Dropper(IPD)system was installed and is under evaluation as a real-time wall conditioning *** the LHD,which is a large-sized heliotron device,an additional helium(He)glow discharge cleaning(GDC)after boronization was operated for a reduction in hydrogen recycling from the coated boron *** operational time of 3 h was determined by spectroscopic data during glow discharges.A flat hydrogen profile is obtained on the top surface of the coated boron on the specimen exposed to *** results suggest a reduction in hydrogen at the top surface by *** oxygen in coated boron was obtained by boronization,and the coated boron,which has boron-oxide,on the first wall by B-IPD was also *** the difference in coating areas between B2H6 boronization and B-IPD operation,it would be most effective to use the IPD and B2H6 boronization coating together for optimized wall conditioning.

关键词： boron layer oxygen impurity hydrogen recycling impurity powder dropper LHD EAST

An Adaptive Strategy-incorporated Integer Genetic Algorithm for Wind Farm Layout Optimization

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Journal of Bionic Engineering 2024年第3期21卷 1522-1540页

作者： Tao Zheng Haotian Li Houtian He Zhenyu Lei Shangce Gao Faculty of Engineering University of ToyamaToyama9300887Japan

Energy issues have always been one of the most significant concerns for scientists *** the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of *** energy is a readily available and sustainable energy *** farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind ***-heuristic algorithms have been widely employed in wind farm layout *** paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout *** adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind *** this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind *** results demonstrate a notable advantage of AIGA.

关键词： Wind farm layout optimization problem Meta-heuristic algorithms Adaptive Integer genetic algorithm

Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku Asano Shinji Kudo Taisuke Maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

Dendritic Deep Learning for Medical Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 803-805页

作者： Zhipeng Liu Zhiming Zhang Zhenyu Lei Masaaki Omura Rong-Long Wang Shangce Gao the Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan the Faculty of Engineering University of FukuiFukui-shi 910-8507Japan IEEE

Dear Editor,This letter presents a novel segmentation approach that leverages dendritic neurons to tackle the challenges of medical imaging *** this study,we enhance the segmentation accuracy based on a SegNet variant including an encoder-decoder structure,an upsampling index,and a deep supervision ***,we introduce a dendritic neuron-based convolutional block to enable nonlinear feature mapping,thereby further improving the effectiveness of our approach.

关键词： thereby Deep enable

Dendritic Learning-Incorporated Vision Transformer for Image Recognition

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 539-541页

作者： Zhiming Zhang Zhenyu Lei Masaaki Omura Hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor,This letter proposes to integrate dendritic learnable network architecture with Vision Transformer to improve the accuracy of image *** this study,based on the theory of dendritic neurons in neuroscience,we design a network that is more practical for engineering to classify visual *** on this,we propose a dendritic learning-incorporated vision Transformer(DVT),which out-performs other state-of-the-art methods on three image recognition benchmarks.

关键词： Image network image

Three-dimensional crystal defect imaging by STEM depth sectioning

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Chinese Physics B 2024年第8期33卷 2-7页

作者： Ryo Ishikawa Naoya Shibata and Yuichi Ikuhara Institute of Engineering Innovation The University of TokyoBunkyoTokyo 113-8656Japan

One of the major innovations awaiting in electron microscopy is full three-dimensional imaging at atomic *** the success of aberration correction to deep sub-angstrom lateral resolution,spatial resolution in depth is still far from atomic *** scanning transmission electron microscopy(STEM),this poor depth resolution is due to the limitation of the illumination *** overcome this physical limitation,it is essential to implement a next-generation aberration corrector in STEM that can significantly improve the depth *** review discusses the capability of depth sectioning for three-dimensional imaging combined with large-angle illumination ***,the statistical analysis approach remarkably improves the depth resolution,making it possible to achieve three-dimensional atomic resolution imaging at oxide *** will also discuss the future prospects of three-dimensional imaging at atomic resolution by STEM depth sectioning.

关键词： atomic-resolution STEM STEM depth sectioning depth resolution dopants surface topography