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Ethanol extract of Oenanthe javanica increases cell proliferation and neuroblast differentiation in the adolescent rat dentate gyrus

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Neural Regeneration Research 2015年第2期10卷 271-276页

作者： Bai Hui Chen Joon Ha Park Jeong Hwi Cho In Hye Kim Bich Na Shin Ji Hyeon Ahn Seok Joon Hwang Bing Chun Yan Hyun Jin Tae Jae Chul Lee Eun Joo Bae Yun Lyul Lee Jong Dai Kim Moo-Ho Won Il Jun Kang Department of Physiology College of Medicine and Institute of Neurodegeneration and Neuroregeneration Hallym University Department of Neurobiology School of Medicine Kangwon National University Department of Food Science and Biotechnology College of Agriculture and Life Sciences Kangwon National University Department of Integrative Traditional & Western Medicine Medical College Yangzhou University Department of Biomedical Science and Research Institute for Bioscience and Biotechnology Hallym University Department of Pediatrics Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Food Science and Nutrition Hallym University

Oenanthe javanica is an aquatic perennial herb that belongs to theOenanthe genus in Apiaceae family, and it displays well-known medicinal properties such as protective effects against glu-tamate-induced neurotoxicity. However, few studies regarding effects ofOenanthe javanica on neurogenesis in the brain have been reported. In this study, we examined the effects of a normal diet and a diet containing ethanol extract ofOenanthe javanica on cell proliferation and neu-roblast differentiation in the subgranular zone of the hippocampal dentate gyrus of adolescent rats using Ki-67 （an endogenous marker for cell proliferation） and doublecortin （a marker for neuroblast）. Our results showed thatOenanthe javanica extract signiifcantly increased the number of Ki-67-immunoreactive cells and doublecortin-immunoreactive neuroblasts in the subgranular zone of the dentate gyrus in the adolescent rats. In addition, the immunoreactivity of brain-derived neurotrophic factor was signiifcantly increased in the dentate gyrus of the Oenanthe javanica extract-treated group compared with the control group. However, we did not ifnd that vascular endothelial growth factor expression was increased in theOenanthe javanica extract-treated group compared with the control group. These results indicate thatOenanthe javanica extract improves cell proliferation and neuroblast differentiation by increasing brain-de-rived neurotrophic factor immunoreactivity in the rat dentate gyrus.

关键词： nerve regeneration Oenanthe javanica extract cell proliferation neuroblast differentiation brain-derived neurotrophic factor vascular endothelial growth factor rat neural regeneration

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Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils

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Neural Regeneration Research 2016年第2期11卷 270-277页

作者： Ki-YeonYoo In Hye Kim Jeong-Hwi Cho li Hyeon Ahn Joon Ha Park Jae-Chul Lee Hyun-Jin Tae Dae Won Kim Jong-Dai Kim Seongkweon Hong Moo-Ho Won il Jun Kang Department of Oral Anatomy College of Dentistry and Research Institute of Oral Science Gangneung-Wonju National University GangneungRepublic of Korea Department of Neurobiology School of Medicine Kangwon National University Chuncheon Republic of Korea Department of Biomedical Science Research Institute of Bioscience and Biotechnology Hallym University Chuncheon Republic of Korea Department of Biochemistry and Molecular Biology College of Dentistry and Research Institute of Oral Science Gangneung-Wonju NationalUniversity Gangneung Republic of Korea Division of Food Biotechnology School of Biotechnology Kangwon National University Chuncheon Republic of Korea Department of Surgery School of Medicine Kangwon National University Chuncheon Republic of Korea Department of Food Science and Nutrition Hallym University Chuncheon Republic of Korea

In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne（CIL） extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region（CA1） from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach.

关键词： nerve regeneration transient cerebral ischemia delayed neuronal death pyramidal neurons inflammatory cytokines neural regeneration

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