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Blood-brain barrier pathology in cerebral small vessel disease

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Neural Regeneration Research 2024年第6期19卷 1233-1240页

作者： Ruxue Jia Gemma Solé-Guardia Amanda J.Kiliaan Department of Medical Imaging Anatomy Radboud University Medical Center Donders Institute for Brain Cognition & Behavior Center for Medical Neuroscience Preclinical Imaging Center PRIME Radboud Alzheimer Center

Cerebral small vessel disease is a neurological disease that affects the brain microvasculature and which is commonly observed among the elderly. Although at first it was considered innocuous, small vessel disease is nowadays regarded as one of the major vascular causes of dementia. Radiological signs of small vessel disease include small subcortical infarcts, white matter magnetic resonance imaging hyperintensities, lacunes, enlarged perivascular spaces, cerebral microbleeds, and brain atrophy; however, great heterogeneity in clinical symptoms is observed in small vessel disease patients. The pathophysiology of these lesions has been linked to multiple processes, such as hypoperfusion, defective cerebrovascular reactivity, and blood-brain barrier dysfunction. Notably, studies on small vessel disease suggest that blood-brain barrier dysfunction is among the earliest mechanisms in small vessel disease and might contribute to the development of the hallmarks of small vessel disease. Therefore, the purpose of this review is to provide a new foundation in the study of small vessel disease pathology. First, we discuss the main structural domains and functions of the blood-brain barrier. Secondly, we review the most recent evidence on blood-brain barrier dysfunction linked to small vessel disease. Finally, we conclude with a discussion on future perspectives and propose potential treatment targets and interventions.

关键词： blood-brain barrier dysfunction cerebral blood flow cerebral hypoperfusion endothelial dysfunction hypertension inflammation magnetic resonance imaging neurovascular unit oxidative stress small vessel disease tight junctions transcytosis

Shock Formation for 2D Isentropic Euler Equations with Self-similar Variables

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Chinese Annals of Mathematics,Series B 2024年第3期45卷 349-412页

作者： Wenze SU School of Mathematical Sciences Fudan UniversityShanghai 200433China

The author studies the 2D isentropic Euler equations with the ideal gas *** exhibits a set of smooth initial data that give rise to shock formation at a single point near the planar *** solutions to the 2D isentropic Euler equations are associated with non-zero vorticity at the shock and have uniform-in-time-1/3-Holder ***,these point shocks are of self-similar type and share the same profile,which is a solution to the 2D self-similar Burgers *** proof of the solutions,following the 3D construction of Buckmaster,Shkoller and Vicol(in 2023),is based on the stable 2D self-similar Burgers profile and the modulation method.

关键词： 2D isentropic Euler equations Shock formation Self-similar solution

Phase diagram of muonium hydride:the significant effect of dimensionality

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Communications in Theoretical Physics 2024年第2期76卷 182-187页

作者： Jieru Hu Massimo Boninsegni Department of Physics University of Alberta State Key Laboratory of Precision Spectroscopy East China Normal University

We carry out a theoretical investigation of the low-temperature phase diagram of muonium hydride in two dimensions,using numerical *** is shown that the phase diagram of this substance is qualitatively different in two and three ***,while in three dimensions it is essentially identical to that of parahydrogen,i.e.,only displaying a single(crystalline)*** two dimensions it is very similar to that of^(4)He,with an equilibrium liquid phase that turns superfluid at a temperature as high as~2.2 K,and crystallizes under applied *** is a well-described case of a continuous-space condensed matter system whose ground state equilibrium phase is qualitatively altered by dimensional reduction.

关键词： quantum fuids and solids quantum Monte Carlo phase diagrams

An inverse method for characterization of dynamic response of 2D structures under stochastic conditions

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Chinese Journal of Aeronautics 2024年第3期37卷 440-455页

作者： Xuefeng LI Abdelmalek ZINE Mohamed ICHCHOU Noureddine BOUHADDI Pascal FOSSAT Laboratory of Tribology and Systems Dynamic Central School of LyonEcully 69134France Institut Camille Jordan Central School of LyonEcully 69134France Department of Applied Mechanics University of Burgundy Franche-ComtéBesancon 25000France

The reliable estimation of the wavenumber space(k-space)of the plates remains a longterm concern for acoustic modeling and structural dynamic behavior *** current analyses of wavenumber identification methods are based on the deterministic *** this end,an inverse method is proposed for identifying wave propagation characteristics of twodimensional structures under stochastic conditions,such as wavenumber space,dispersion curves,and band *** proposed method is developed based on an algebraic identification scheme in the polar coordinate system framework,thus named Algebraic K-Space Identification(AKSI)***,a model order estimation strategy and a wavenumber filter are proposed to ensure that AKSI is successfully *** main benefit of AKSI is that it is a reliable and fast method under four stochastic conditions:(A)High level of signal noise;(B)Small perturbation caused by uncertainties in measurement points’coordinates;(C)Non-periodic sampling;(D)Unknown structural *** validate the proposed method,we numerically benchmark AKSI and three other inverse methods to extract dispersion curves on three plates under stochastic *** experiment is then performed on an isotropic steel *** investigations demonstrate that AKSI is a good in-situ k-space estimator under stochastic conditions.

关键词： Inverse method Dispersion relation Wavenumber space Periodic plates Stochastic conditions Wave propagation characterization

Safe Motion Planning and Control Framework for Automated Vehicles with Zonotopic TRMPC

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Engineering 2024年第2期33卷 146-159页

作者： Hao Zheng Yinong Li Ling Zheng Ehsan Hashemi State Key Laboratory of Mechanical Transmissions College of Mechanical and Vehicle EngineeringChongqing UniversityChongqing 400044China Department of Mechanical Engineering University of AlbertaEdmontonAB T6G 2H5Canada

Model mismatches can cause multi-dimensional uncertainties for the receding horizon control strategies of automated vehicles(AVs).The uncertainties may lead to potentially hazardous behaviors when the AV tracks ideal trajectories that are individually optimized by the AV's planning *** address this issue,this study proposes a safe motion planning and control(SMPAC)framework for *** the control layer,a dynamic model including multi-dimensional uncertainties is established.A zonotopic tube-based robust model predictive control scheme is proposed to constrain the uncertain system in a bounded minimum robust positive invariant set.A flexible tube with varying cross-sections is constructed to reduce the controller *** the planning layer,a concept of safety sets,representing the geometric boundaries of the ego vehicle and obstacles under uncertainties,is *** safety sets provide the basis for the subsequent evaluation and ranking of the generated *** efficient collision avoidance algorithm decides the desired trajectory through the intersection detection of the safety sets between the ego vehicle and obstacles.A numerical simulation and hardware-in-the-loop experiment validate the effectiveness and real-time performance of the *** result of two driving scenarios indicates that the SMPAC can guarantee the safety of automated driving under multi-dimensional uncertainties.

关键词： Automated vehicles Automated driving Motion planning Motion control Tube MPC Zonotope

An effective strategy of constructing multi-metallic oxides of ZnO/ CoNiO_(2)/CoO/C microflowers for improved supercapacitive performance

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Chinese Journal of Chemical Engineering 2024年第3期67卷 1-8页

作者： Wei Guo Yan Zhang Xiaxin Lei Shuang Wang College of Physics Taiyuan University of TechnologyJinzhong 030600China College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

In this work,a new ZnO/CoNiO_(2)/CoO/C metal oxides composite is prepared by cost-effective hydrothermal method coupled with annealing process under N_(2) ***,the oxidation-defect annealing environment is conducive to both morphology and component of the composite,which flower-like ZnO/CoNiO_(2)/CoO/C is *** from good chemical stability of ZnO,high energy capacity of CoNiO_(2) and CoO and good conductivity of C,the as-prepared sample shows promising electrochemical behavior,including the specific capacity of 1435 C·g^(-1) at 1 A·g^(-1),capacity retention of 87.3%at 20 A·g^(-1),and cycling stability of 90.5%for 3000 cycles at 5 A·g^(-1),***,the prepared ZnO/CoNiO_(2)/CoO/C/NF//AC aqueous hybrid supercapacitors device delivers the best specific energy of 55.9 W·h·kg^(-1) at 850 W·kg^(-1).The results reflect that the as-prepared ZnO/CoNiO_(2)/CoO/C microflowers are considered as high performance electrode materials for supercapacitor,and the strategy mentioned in this paper is benefit to prepare mixed metal oxides composite for energy conversion and storage.

关键词： Composites Electrochemistry Hydrothermal Transition metal oxides Structural control Supercapacitors

Impact of Varying Blower Opening Degrees on Indoor Environment and Thermal Comfort

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Fluid Dynamics & Materials Processing 2024年第8期20卷 1703-1716页

作者： Shengqiang Shi Abdelatif Merabtine Rachid Bennacer Julien Kauffmann UR LASMIS Universitéde Technologie de Troyes12 Rue Marie CurieTroyes10300France EPF Campus de Troyes Rosière-prés-Troyes10430France Construction Engineering Department École de Technologie Supérieure(ÉTS)University of Québec1100 Rue Notre-Dame OuestMontrealQC H3C 1K3Canada LMT/ENS-Paris-Saclay/CNRS UniversitéParis SaclayGif-sur-Yvette91190France

At present,air handling units are usually used indoors to improve the indoor environment ***,while introducing fresh air to improve air quality,air velocity has a certain impact on the occupants’thermal ***,it is necessary to explore the optimization of air-fluid-body interaction *** this study,the indoor air flow was changed by changing the opening and closing degree of the blower,and the thermal manikin is introduced to objectively evaluate the human thermal comfort under different air *** main experimental results show that the air change rate increases with the increase of the opening and closing degree of the blower considering an ACH(air changes per hour)range between 3.8 and *** a better prediction,a linear correlation with a coefficient of 0.995 is *** the blower’s opening is adjusted to 20%,25%,30%,35%,and 40%,the air velocity sensor positioned directly beneath the air inlet records average velocities of 0.19,0.20,0.21,0.28,and 0.34 m/s over four hours,*** on thermal comfort and the average sensation experienced by individuals indicate an initial increase followed by a decline when the blower’s operation begins,with optimal conditions achieved at a 35%*** findings offer valuable insights for future indoor air ventilation and heat transfer design strategies.

关键词： Air handle unit air velocity thermal comfort thermal sensation

Practical assessment of the energy density of potassium-ion batteries

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Science china Chemistry 2024年第1期67卷 4-12页

作者： Liang Sun Guanjie Li Shilin Zhang Sailin Liu Jodie Yuwono Jianfeng Mao Zaiping Guo School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaide 5000Australia

1 Introduction The evolution of modern human society closely depends on affordable,efficient,and safe energy storage ***,lithium-ion batteries(LIBs)are the dominant energy storage systems to power portable electronics... 详细信息

关键词： energy lithium smart

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

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Nano-Micro Letters 2024年第8期16卷 341-361页

作者： Xi Zhou Quan Zhou Zhaozhi He Yi Xiao Yan Liu Zhuohang Huang Yaoji Sun Jiawei Wang Zhengdong Zhao Xiaozhou Liu Bin Zhou Lei Ren Yu Sun Zhiwei Chen Xingcai Zhang The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Otorhinolaryngology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China NO.1 Middle School Affiliated to Central china Normal University Wuhan 430223People’s Republic of China

Reactive oxygen species(ROS)plays important roles in living *** ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound *** Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill ***,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) ***,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au *** two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound *** innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关键词： Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing