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Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： Wen-Jing Wang Xiang-Min Dong Guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

Li-Zn alloy patch for defect-free polymer interface film enables excellent protection effect towards stable Li metal anode

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Chinese Chemical Letters 2024年第10期35卷 447-451页

作者： Zihao Wang Jing Xue Zhicui Song Jianxiong Xing Aijun Zhou Jianmin Ma Jingze Li School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China School of Mathematics and Physics Weinan Normal UniversityWeinan 714099China School of Chemistry TiangongUniversityTianjin 300387China Huzhou Key Laboratory of Smart and Clean Energy Yangtze Delta Region Institute(Huzhou)University of Electronic Science and Technology of ChinaHuzhou313001China

Constructing a smart polymer film with favorable lithium(Li)transport capability and mechanical flexibility for suppressing Li dendrite growth is an effective ***,the porosity and the swelling of the polymer membrane cannot completely prevent liquid electrolyte from sweeping through the artificial protection film,severely deteriorating the cyclic ***,we propose a defectfree hybrid film that consists of Li+conductive lithium polyacrylate(LiPAA)polymer interface layer and Li-Zn alloy patch to tackle the critical problems of traditional polymer composite passivation *** pinhole leaks of the polymer matrix are self-filled by Li-Zn alloy patches,enhancing the integrity of LiPAA ***,a defect-free hybrid film is nailed flat against the Li metal anode,exhibiting extraordinary stability in the liquid electrolyte and enabling perfect protection *** facile strategy produces a promising anode for next generation Li batteries.

关键词： Limetal anode Patch Li-Zn alloy LiPAA Hybrid film

Economic forecasting with big data:A literature review

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Journal of Management Science and Engineering 2024年第2期9卷 254-270页

作者： Wencan Lin Yunjie Wei Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing100190China Center for Forecasting Science Chinese Academy of SciencesBeijing100190China

Big data technology has revolutionized the research paradigm of economic forecasting regardless of the data source,forecasting method,or forecasting *** study evaluates the current literature on economic forecasting using big data and employs bibliometric approaches to offer a comprehensive ***,utilizing the advanced structural variation analysis technique,we can identify papers with transformative potential in this *** study provides valuable suggestions for enhancing scholars'understanding of significant research,novel breakthroughs,and emerging trends in the role of big data in economic forecasting.

关键词： Big data Economic forecasting Bibliometric analysis Structural variation analysis

New quantification of symmetry energy from neutron skin thicknesses of 48Ca and 208Pb

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Nuclear Science and Techniques 2024年第10期35卷 217-225页

作者： Rong An Shuai Sun Li-Gang Cao Feng-Shou Zhang School of Physics Ningxia University Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal University Key Laboratory of Beam Technology of the Ministry of Education Institute of Radiation TechnologyBeijing Academy of Science and Technology Center of Theoretical Nuclear Physics National Laboratory of the Heavy Ion Accelerator of Lanzhou

Precise knowledge of the nuclear symmetry energy can be tentatively calibrated using multimessenger *** neutron skin thickness of a heavy nucleus is one of the most sensitive indicators for probing the isovector components of effective interactions in asymmetric nuclear *** studies have suggested that the experimental data from the CREX and PREX2 collaborations are not mutually compatible with existing nuclear *** this study,we review the quantification of the slope parameter of the symmetry energy L from the neutron skin thicknesses of48Ca *** energy density functionals classified by various isoscalar incompressibility coefficients K were employed to evaluate the bulk properties of finite *** calculated results suggest that the slope parameter L deduced from208Pb is sensitive to the compression modulus of symmetric nuclear matter,but not that *** effective parameter sets classified by K=220 MeV can provide an almost overlapping range of L from48Ca and208Pb.

关键词： Energy density functional Neutron skin thickness Nuclear symmetry energy

Relative difficulty distillation for semantic segmentation

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Science china(Information Sciences) 2024年第9期67卷 126-145页

作者： Dong LIANG Yue SUN Yun DU Songcan CHEN Sheng-Jun HUANG MIIT Key Laboratory of Pattern Analysis and Machine Intelligence College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Shenzhen Research Institute Nanjing University of Aeronautics and Astronautics

Current knowledge distillation(KD) methods primarily focus on transferring various structured knowledge and designing corresponding optimization goals to encourage the student network to imitate the output of the teacher network. However, introducing too many additional optimization objectives may lead to unstable training, such as gradient conflicts. Moreover, these methods ignored the guidelines of relative learning difficulty between the teacher and student networks. Inspired by human cognitive science, in this paper, we redefine knowledge from a new perspective — the student and teacher networks' relative difficulty of samples, and propose a pixel-level KD paradigm for semantic segmentation named relative difficulty distillation(RDD). We propose a two-stage RDD framework: teacher-full evaluated RDD(TFE-RDD) and teacher-student evaluated RDD(TSE-RDD). RDD allows the teacher network to provide effective guidance on learning focus without additional optimization goals, thus avoiding adjusting learning weights for multiple losses. Extensive experimental evaluations using a general distillation loss function on popular datasets such as Cityscapes, Cam Vid, Pascal VOC, and ADE20k demonstrate the effectiveness of RDD against state-ofthe-art KD methods. Additionally, our research showcases that RDD can integrate with existing KD methods to improve their upper performance bound. Codes are available at https://***/sunyueue/***.

关键词： knowledge distillation semantic segmentation relative difficulty sample weighting prediction discrepancy

Multi-timescale Modeling and Dynamic Stability Analysis for Sustainable Microgrids:State-of-the-art and Perspectives

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Protection and Control of Modern Power Systems 2024年第3期9卷 1-35页

作者： Mingyue Zhang Yang Han Yuxiang Liu Amr S.Zalhaf Ensheng Zhao Karar Mahmoud Mohamed M.F.Darwish Frede Blaabjerg the School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China IEEE 不详 the University of Electronic Science and Technology of china(UESTC) ChengduChina Aswan University the School of Electrical Engineering Aalto UniversityFinland the Department of Electrical Engineering Faculty of Engineering at ShoubraBenha University the Department of EEA School of Electrical EngineeringAalto University

The increasing trend for integrating renewable energy sources into the grid to achieve a cleaner energy system is one of the main reasons for the development of sustainable microgrid(MG)*** typical power-electronized power systems,MGs make extensive use of power electronics converters,which are highly controllable and flexible but lead to a profound impact on the dynamic performance of the whole *** with traditional large-capacity power systems,MGs are less resistant to perturbations,and various dynamic variables are coupled with each other on multiple timescales,resulting in a more complex system instability *** meet the technical and economic challenges,such as active and reactive power-sharing,voltage,and frequency deviations,and imbalances between power supply and demand,the concept of hierarchical control has been introduced into MGs,allowing systems to control and manage the high capacity of renewable energy sources and ***,as the capacity and scale of the MG system increase,along with a multi-timescale control loop design,the multi-timescale interactions in the system may become more significant,posing a serious threat to its safe and stable *** investigate the multi-timescale behaviors and instability mechanisms under dynamic inter-actions for AC MGs,existing coordinated control strategies are discussed,and the dynamic stability of the system is defined and classified in this ***,the modeling and assessment methods for the stability analysis of multi-timescale systems are also ***,an outlook and discussion of future research directions for AC MGs are also presented.

关键词： Sustainable microgrid hierarchical control modeling model simplification multi-timescale dynamic stability analysis timescale decomposition.

AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken

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Science china(Life Sciences) 2024年第7期67卷 1468-1478页

作者： Jiang Deng Jia-Cheng Yang Yue Feng Ze-Jing Xu Kamil Kuča Meng Liu Lv-Hui Sun State Key Laboratory of Agricultural Microbiology Hubei Hongshan LaboratoryFrontiers Science Center for Animal Breeding and Sustainable ProductionCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic

Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic *** hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1to the highly toxic exo-AFB1-8,9-epoxide(AFBO)in ***,the transcriptional regulation mechanism of these CYP genes in the liver of chicks in AFB1metabolism remains ***-luciferase reporter assay,bioinformatics and site-directed mutation results indicated that specificity protein 1(SP1)and activator protein-1(AP-1)motifs were located in the core region-1,063/-948,-606/-541 of the CYP1A1 promoter as well as-636/-595,-503/-462,-147/-1 of the CYP2A6 ***,overexpression and decoy oligodeoxynucleotide technologies demonstrated that SP1 and AP-1 were pivotal transcriptional activators regulating the promoter activity of CYP1A1 and ***,bioactivation of AFB1to AFBO could be increased by upregulation of CYP1A1 and CYP2A6 expression,which was trans-activated owing to the upregulation of AP-1,rather than SP1,stimulated by AFB1-induced reactive oxygen ***,nano-selenium could reduce ROS,downregulate AP-1 expression and then decrease the expression of CYP1A1 and CYP2A6,thus alleviating the toxicity of *** conclusion,AP-1 and SP1 played important roles in the transactivation of CYP1A1 and CYP2A6 expression and further bioactivated AFB1to AFBO in chicken liver,which could provide novel targets for the remediation of aflatoxicosis in chicks.

关键词： aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation

Development of a Front End Array for Broadband Phased Array Receiver

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Research in Astronomy and Astrophysics 2024年第4期24卷 60-70页

作者： Kai Wang Liang Cao Jun Ma Xue-Feng Duan Hao Yan Mao-Zheng Chen Yun-Wei Ning Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 8300lChina University of the Chinese Academy of Sciences Beijing 100049China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China

The receiver is a signal receiving device placed at the focus of the *** order to improve the observation efficiency,the concept of phased array receiver has been proposed in recent years,which places a small phased array at the focal plane of the reflector,and flexible pattern and beam scanning functions can be achieved through a beamforming *** combined with the element multiplexing,all beams within the entire field of view can be observed simultaneously to achieve continuous sky *** article focuses on the front-end array of phased array receiver at 0.7-1.8 GHz for QiTai Telescope,and designs a Vivaldi antenna array of PCB structure with dual line *** polarization antenna is designed to arrange in a rectangle manner by 11×*** on the simulation results of the focal field,32,18,and eight elements were selected to form one beam at 0.7,1.25,and1.8 *** analog beamforming network was constructed,and the measured gains of axial beam under uniform weighting were 19.32,13.72,and 15.22 *** the beam scanning method of reflector antenna,the pattern test of different position element sets required for PAF beam scanning was carried out under independent *** pattern optimization at 1.25 GHz was carried out by weighting method of conjugate field *** with uniform weighting,the gain,sidelobe level,and main beam direction under conjugate field matching have been *** the above test and simulation results are slightly different,which is related to the passive array and laboratory testing condition,the relevant work has accumulated experience in the development of the front-end array for the phased array receiver,and has good guiding significance for future performance verification after the array is installed on the telescope.

关键词： telescopes instrumentation:detectors techniques:radar astronomy

Quantum Voting Machine Encoded with Microwave Photons

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Chinese Physics Letters 2024年第7期41卷 12-17页

作者：张钰杨垂平苏奇平康逸豪郑文李邵雄于扬 national Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China Shishan Laboratory Nanjing UniversitySuzhou 215163China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Department of Physics Hangzhou Normal UniversityHangzhou 310036China Hefei national Laboratory Hefei 230088China

We propose a simple quantum voting machine using microwave photon qubit encoding, based on a setup comprising multiple microwave cavities and a coupled superconducting flux qutrit. This approach primarily relies on a multi-control single-target quantum phase gate. The scheme offers operational simplicity, requiring only a single step, while ensuring verifiability through the measurement of a single qubit phase information to obtain the voting results. It provides voter anonymity, as the voting outcome is solely tied to the total number of affirmative votes. Our quantum voting machine also has scalability in terms of the number of ***, the physical realization of the quantum voting machine is general and not limited to circuit quantum electrodynamics. Quantum voting machine can be implemented as long as the multi-control single-phase quantum phase gate is realized in other physical systems. Numerical simulations indicate the feasibility of this quantum voting machine within the current quantum technology.

关键词： quantum microwave simplicity