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Asian Journal of Andrology 2019年第3期21卷 300-303页

作者： Chao-Xu Wang Wei-Ping Zhang Hong-Cheng Song Department of Urology Beijing Children's Hospital Affiliated to Capital Medical University Beijing 100045 China

There is still debate regarding the optimal surgical approach for proximal hypospadias. This retrospective study aims to evaluate the long-term outcomes using transverse preputial island flap urethroplasty. A total of 320 patients were included, with a mean follow-up of 40.2 months (range: 1–156 months). Complications were encountered in 125 patients (39.1%), including fistulas in 53 (16.6%), urethral strictures in 31 (9.7%), and diverticula in 41 (12.8%). The mean timing of presentation with a complication was 15.8 months (median: 1.7, range: 1–145), of which 79.2% were early complications and 20.8% were late complications. In all, 20.8% of the patients with complications presented after ≥1 year, and 12.8% presented after ≥5 years. Univariate analysis revealed that age at the time of surgery, flap length, and location of the urethral meatus were not correlated with complications. A stricture was present in 31.7%(13/41) of those with diverticula (P < 0.001), while late urethral diverticula were accompanied by urethral strictures in 11.1%(1/9) of cases (P = 0.213). These results indicate that transverse preputial island flap urethroplasty still has a high incidence of complications, even when performed by highly experienced physicians. Most complications of hypospadias are diagnosed within 1 year postoperatively, while fistulas and urinary strictures generally occur within 2 months and diverticula tend to be present by 1 year.

关键词： diverticulum fistula follow-up hypospadias late complications urethral stricture

A new three-step procedure for pancreatic head carcinoma with invasion of superior mesenteric artery

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 286-289页

作者： Rui Tang Jia-Hong Dong Department of Hepatopancreatobiliary Surgery Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua University

Pancreatic head carcinoma is characterized by high malignancy and a low survival rate and its mortality ranks fourth for malignant tumors with a 5-year survival rate of only 5%[1].Treatment of this cancer relies on surgical ***,the resection rate is only about 20%,because majority of the patients are classified as unresectable when diagnosed due to distant metastasis or

关键词： SMA A new three-step procedure for pancreatic head carcinoma with invasion of superior mesenteric artery

Intracardiac echocardiography in the diagnosis and closure of patent foramen ovale

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Journal of Geriatric Cardiology 2021年第9期18卷 697-701页

作者： Kang-Ning HAN Xiao-Teng MA Shi-Wei YANG Yu-Jie ZHOU beijing Anzhen Hospital Capital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseaseThe Key Laboratory of Remodeling-related Cardiovascular DiseaseMinistry of EducationBeijingChina

Patent foramen ovale(PFO)which is caused by failed fusion of septum primum and septum secundum,is the first leading congenital heart abnormality,affecting about 25%of the general population.

关键词： population. closure diagnosis

Augmented reality technology for preoperative planning and intraoperative navigation during hepatobiliary surgery: A review of current methods

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 101-112页

作者： Rui Tang Long-Fei Ma Zhi-Xia Rong Mo-Dan Li Jian-Ping Zeng Xue-Dong Wang Hong-En Liao Jia-Hong Dong Department of Hepatopancreatobiliary Surgery Beijing Tsinghua Changgung Hospital School of Clinical Medicine No.168 Litang Road Changping DistrictTsinghua University Department of Biomedical Engineering School of Medicine Tsinghua University Service de Chirurgie Hépatobiliaire Pancréatique et de Transplantation Hépatique Centre Hospitalier de l'Université de Montréal(CHUM) Université de Montréal

Background: Augmented reality(AR) technology is used to reconstruct three-dimensional(3D) images of hepatic and biliary structures from computed tomography and magnetic resonance imaging data, and to superimpose the virtual images onto a view of the surgical field. In liver surgery, these superimposed virtual images help the surgeon to visualize intrahepatic structures and therefore, to operate precisely and to improve clinical *** Sources: The keywords "augmented reality", "liver", "laparoscopic" and "hepatectomy" were used for searching publications in the Pub Med database. The primary source of literatures was from peer-reviewed journals up to December 2016. Additional articles were identified by manual search of references found in the key ***: In general, AR technology mainly includes 3D reconstruction, display, registration as well as tracking techniques and has recently been adopted gradually for liver surgeries including laparoscopy and laparotomy with video-based AR assisted laparoscopic resection as the main technical application. By applying AR technology, blood vessels and tumor structures in the liver can be displayed during surgery,which permits precise navigation during complex surgical procedures. Liver transformation and registration errors during surgery were the main factors that limit the application of AR ***: With recent advances, AR technologies have the potential to improve hepatobiliary surgical procedures. However, additional clinical studies will be required to evaluate AR as a tool for reducing postoperative morbidity and mortality and for the improvement of long-term clinical outcomes. Future research is needed in the fusion of multiple imaging modalities, improving biomechanical liver modeling,and enhancing image data processing and tracking technologies to increase the accuracy of current AR methods.

关键词： Augmented reality Image-guided surgery Liver surgery 3D technology

Low LDL-C level and intracranial haemorrhage risk after ischaemic stroke:a prospective cohort study

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Stroke & Vascular Neurology 2023年第2期8卷 127-133页

作者： Jie Xu Zimo Chen Meng Wang Jinglin Mo Jing Jing Gulbahram Yalkun Liye Dai Xia Meng Hao Li Zixiao Li Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingFengtaiChina China National Clinical Research Center for Neurological Diseases BeijingChina

Background and purpose The Treat Stroke to Target trial has confirmed the benefit of targeting low-density lipoprotein cholesterol(LDL-C)of<1.8 mmol/L in patients who had an ischaemic stroke(IS).However,haemorrhagic r... 详细信息

Background and purpose The Treat Stroke to Target trial has confirmed the benefit of targeting low-density lipoprotein cholesterol(LDL-C)offrom China Stroke Center Alliance programme with complete baseline information were prospectively enrolled.793572 patients who had an IS were categorised into 6 groups according to LDL-C level(from the increased intracranial haemorrhage risk related to low LDL-C *** Among patients who had an IS,the low LDL-C level(<1.4 mmol/L or<1.8 mmol/L)at baseline is associated with increased risk of intracranial haemorrhage during acute *** actively lowering LDL-C level for patients who had an IS,clinicians should also concern about the haemorrhagic risk associated with low LDL-C level.

关键词： intracranial prospective cholesterol

Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics

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Stroke & Vascular Neurology 2021年第2期6卷 291-297页

作者： Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina Department of Neurology The First people's Hospital of TaizhouTaizhouChina Department of Neurology Wuhan First HospitalWuhanChina Department of Neurology The First People's Hospital of Xi'anXi'anChina Department of Neurology The Second People’s Hospital of JinzhongJinzhongChina Department of Neurology WuYuan County People’s HospitalBayannurChina Department of Neurology Qiqihar City Rongjian Stroke Prevention and Treatment InstituteQiqiharChina Department of Neurology Peking University Shenzhen HospitalShenzhenChina Department of Neurology Luoyang Central HospitalLuoyangChina Department of Neurology Qinghai Provincial People's HospitalXiningChina Department of Neurology Tianjin Huanhu HospitalTianjinChina Department of Neurology Pingdingshan First People's HospitalPingdingshanChina Department of Neurology Changzhi People's HospitalChangzhiChina Department of Neurology Zhejiang Provincial People's HospitalHangzhouChina Department of Neurology Xinjiang Uygur Autonomous Region People's HospitalUrumqiChina

Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively *** here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were *** was extracted from white blood cells of *** are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 *** average depth is intended to be greater than 30×for each ***,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and *** each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same *** copy number variations and structural variations are also called for each *** of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public *** The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were *** of the baseline clinical characteristics of the 10914 and the excluded patients were *** The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke.

关键词： patients transient characteristics

Rationale and design of Patient-centered Retrospective Observation of Guideline-Recommended Execution for Stroke Sufferers in China: China PROGRESS

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Stroke & Vascular Neurology 2019年第3期4卷 165-170页

作者： Zixiao Li Chunjuan Wang Yong Jiang Xinmiao Zhang Ying Xian Liping Liu Xingquan Zhao Hongqiu Gu Xia Meng Hao Li Yilong Wang Yongjun Wang Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Center of Stroke Beijing Institute for BrainDisordersBeijingChina beijing Key Laboratory of Translational Medicine forCerebrovascular Disease BeijingChina Duke Clinical Research Institute North CarolinaUSA Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background In 2009,China launched ambitious healthcare reform plans to provide affordable and equitable basic healthcare for all patients,including the substantial number of patients who had a ***,little is known about the pattern of evidence-based stroke care and outcomes across hospitals,regions and time during the last *** The Patient-centered Retrospective Observation of Guideline-Recommended Execution for Stroke Sufferers in China(China PROGRESS)Study aims to use findings from a representative sample of Chinese hospitals over the last decade to improve future stroke care for patients hospitalised with ischaemic stroke(IS)or transient ischaemic attack(TIA).Design The China PROGRESS Study will use a two-stage cluster sampling method to identify over 32000 patient records from 208 hospitals across the Eastern,Central and Western geographical regions in *** assess the temporal trends in patient characteristics,treatment and outcomes,study investigators will select records from 2005,2010 and 2015.A double data reading/entry system will be developed to conduct this assessment.A central coordinating centre will monitor case ascertainment,data abstraction and data *** will examine patient characteristics,testing patterns,in-hospital treatment and outcomes,and variations across regions and across *** The China PROGRESS Study is the first nationally representative study that aims to better understand care quality and outcomes for patients with IS or TIA before and after the national healthcare reform in *** initiative will translate findings into clinical practices that improve care quality for patients who had a stroke and policy recommendations that allow these changes to be implemented *** approval This study has also been approved by the central institutional review board(IRB)at beijing Tiantan Hospital.

关键词： PROGRESS Observation centered

Performance of Xpert MTB/RIF Ultra and Xpert MTB/RIF for the Diagnosis of Tuberculosis through Testing of Formalin-fixed Paraffin-embedded Tissues

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Biomedical and Environmental Sciences 2019年第12期32卷 922-925页

作者： DU Wei Li SONG Jing WANG Jian Guo LIU Zi Chen LI Kun WANG Yu Xuan DONG Yu Jie CHE Nan Ying Department of Pathology Beijing Key Laboratory for Drug Resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Department of Medical Engineering Beijing Chest HospitalCapital Medical UniversityBeijing 101149China

Tuberculosis(TB)is a significant infectious disease caused by Mycobacterium tuberculosis(MTB).In 2017,10.0 million new TB cases and 1.3 million deaths were reported globally,according to World Health Organization(WHO)[1].The Mycobacterial culture test is the gold standard for diagnosis but the positive rate is only about 30%[1],and it is eve n lower with extrapulm onary *** sputum-negative pulmonary and extrapulm on ary TB,pathological exami nation playsan importa nt role in diag no *** detecti on of MTB in forma I i fixed pa raff i n-embedded(FFPE)tissues iscritical for the definite pathological diagnosis of culture-negative *** diagnosis is essentialin reducing TB-related morbidity and mortality[2].Molecular pathological tests detecting MTB DNA have shown advantages in improving diagnostic sen sitivity.

关键词： diagnosis Xpert Tuberculosis

Comparative profiling of immune genes improves the prognoses of lower grade gliomas

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Cancer Biology & Medicine 2022年第4期19卷 533-550页

作者： Zhiliang Wang Wen Cheng Zheng Zhao Zheng Wang Chuanbao Zhang Guanzhang Li Anhua Wu Tao Jiang Department of Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100050China Department of Neurosurgery The First Hospital of China Medical UniversityShenyang 110001China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Objective:Lower grade gliomas(LGGs),classified as World Health Organization(WHO)grade II and grade III gliomas,comprise a heterogeneous group with a median survival time ranging from 4–13 *** prediction of the survival times of LGGs remains a major challenge in clinical ***:We reviewed the expression data of 865 LGG patients from 5 transcriptomics *** comparative profile of immune genes was analyzed for signature identification and ***-house RNAseq and microarray data from the Chinese Glioma Genome Atlas(CGGA)dataset were used as training and internal validation cohorts,*** samples from The Cancer Genome Atlas(TCGA)and GSE16011 cohorts were used as external validation cohorts,and the real-time PCR of frozen LGG tissue samples(n=36)were used for clinical ***:A total of 2,214 immune genes were subjected to pairwise comparison to generate 2,449,791 immune-related gene pairs(IGPs).A total of 402 IGPs were identified with prognostic values for *** HOXA9-related and CRH-related scores facilitated identification of patients with different *** immune signature based on 10 IGPs was constructed to stratify patients into low and high risk groups,exhibiting different clinical outcomes.A nomogram,combining immune signature,1p/19q status,and tumor grade,was able to predict the overall survival(OS)with c-indices of 0.85,0.80,0.80,0.79,and 0.75 in the training,internal validation,external validation,and tissue sample cohorts,***:This study was the first to report a comparative profiling of immune genes in large LGG cohorts.A promising individualized immune signature was developed to estimate the survival time for LGG patients.

关键词： Lower grade glioma immune gene pairs signature prognosis

Comparision between portosystemic shunts and endoscopic therapy for prevention of variceal re-bleeding:a systematic review and meta-analysis

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Chinese Medical Journal 2019年第9期132卷 1087-1099页

作者： Guang-Peng Zhou Li-Ying Sun Lin Wei Wei Qu Zhi-Gui Zeng Ying Liu Yi-Zhou Jiang Zhi-Jun Zhu Liver Transplantation Center Beijing Friendship HospitalCapital Medical UniversityBeijing 100005China Clinical Center for Pediatric Liver Transplantation Capital Medical UniversityBeijing 100005China National Clinical Research Center for Digestive Diseases Beijing 100005China Intensive Care Unit Beijing Friendship HospitalCapital Medical UniversityBeijing 100005China

Background:Portosystemic shunts,including surgical portosystemic shunts and transjugular intra-hepatic portosystemic shunt (TIPS),may have benefit over endoscopic therapy (ET) for treatment of variceal bleeding in patients with cirrhotic portal hypertension;however,whether there being a survival benefit among them remains *** study was to compare the effect of three above-mentioned therapies on the short-term and long-term survival in patient with ***:Using the terms "variceal hemorrhage or variceal bleeding or variceal re-bleeding" OR "esophageal and gastric varices" OR "portal hypertension" and "liver cirrhosis," the Cochrane Central Register of Controlled Trials,PubMed,Embase,and the references of identified trials were searched for human randomized controlled trials (RCTs) published in any language with full texts or abstracts (last search June 2017).Risk ratio (RR) estimates with 95% confidence interval (CI) were calculated using random effects model by Review *** quality of the included studies was evaluated using the Cochrane Collaboration’s tool for the assessment of the risk of ***:Twenty-six publications comprising 28 RCTs were included in this *** studies included a total of 2845 patients:496 (4 RCTs) underwent either surgical portosystemic shunts or TIPS,1244 (9 RCTs) underwent either surgical portosystemic shunts or ET,and 1105 (15 RCTs) underwent either TIPS or *** was no significant difference in overall mortality and 30-day or 6-week survival among three *** with TIPS and ET,separately,surgical portosystemic shunts were both associated with a lower bleeding-related mortality (RR = 0.07,95% CI = 0.01–0.32;P<0.001;RR = 0.17,95% CI = 0.06–0.51,P<0.005) and rate of variceal re-bleeding (RR = 0.23,95% CI = 0.10–0.51,P<0.001;RR = 0.10,95% CI = 0.04–0.24,P<0.001),without a significant difference in the rate of postoperative hepatic encephalopathy (RR = 0.52,95% CI = 0.25–1.00,P = 0.1

关键词： Portosystemic shunts Endoscopic therapy Variceal rebleeding Cirrhosis Meta-analysis