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Protective Effect of Holothurian Intestine Against Indomethacin Induced Gastric Muco.al Damage in Rats

Journal of Ocean University of China 2017年第3期16卷 547-554页

作者： LI Xiaoyu QIAO Xuejing ZHANG Cuiping GAO Hua NIU Qinghui WU Tong ZHANG Qi TIAN Zibin Department of Gastroenterology the Affiliated Hospital of Qingdao University Department of Pharmacy College of Medicine of Qingdao University

Our study aimed to investigate the protective effects of Holothurian intestines(HI) on NSAIDs-induced gastric muco.al damage and the possible mechanism. At first, 60 male Wistar rats were induced of gastric lesions with indomethacin(IDM, 30 mg kg^(-1)). The rats were pretreated for 15 co.secutive days with saline, sucralfate, or HI(0.4g kg^(-1) d-1, 0.8 g kg^(-1) d^(-1) and 1.6 g kg^(-1) d^(-1)) prior to IDM treatment, followed by evaluations of macrosco.ic damage and microsco.ic features; and investigation of the levels of inflammatory cytokines, oxidative stress parameters, gastric muco.al prostaglandin E2(PGE2) and total hexosamine in tissues. The expression of co.-1 and co.-2 m RNA in the gastric tissue were determined by quantitative polymerase chain reaction(q PCR). Pathological gastric ulcer indexes, levels of pro-inflammatory cytokines(IL-1β, IL-17, TNF-α) and lipid peroxidation were significantly decreased in HI-treated groups, whereas the levels of protective factors(TGF-β, GSH, SOD activity and PGE2) were significantly elevated especially in the group with HI 1.61 g kg^(-1) d^(-1)(P co.-2 mRNA decreased significantly in HI groups(P co.ld be a dietary preventive agent for the prevention of gastric damage.

关键词： holothurian intestine NSAID indomethacin gastric ulcer sucralfate

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Protective Effect of Holothurian Intestine Against Indomethacin Induced Gastric Muco.al Damage in Rats

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中国海洋大学学报（英文版） 2017年第3期 547-554页

作者： LI Xiaoyu QIAO Xuejing ZHANG Cuiping GAO Hua NIU Qinghui WU Tong ZHANG Qi TIAN Zibin Department of Gastroenterology，the Affiliated Hospital of Qingdao University Department of Pharmacy，co.lege of Medicine of Qingdao University

Our study aimed to investigate the protective effects of Holothurian intestines（HI） on NSAIDs-induced gastric muco.al damage and the possible mechanism. At first, 60 male Wistar rats were induced of gastric lesions with indomethacin(IDM, 30 mg kg-1). The rats were pretreated for 15 co.secutive days with saline, sucralfate, or HI(0.4g kg-1 d-1, 0.8 g kg-1 d-1 and 1.6 g kg-1 d-1) prior to IDM treatment, followed by evaluations of macrosco.ic damage and microsco.ic features; and investigation of the levels of inflammatory cytokines, oxidative stress parameters, gastric muco.al prostaglandin E2（PGE2） and total hexosamine in tissues. The expression of co.-1 and co.-2 m RNA in the gastric tissue were determined by quantitative polymerase chain reaction（q PCR）. Pathological gastric ulcer indexes, levels of pro-inflammatory cytokines（IL-1β, IL-17, TNF-α） and lipid peroxidation were significantly decreased in HI-treated groups, whereas the levels of protective factors（TGF-β, GSH, SOD activity and PGE2） were significantly elevated especially in the group with HI 1.61 g kg-1 d-1（P co.-2 mRNA decreased significantly in HI groups（P co.ld be a dietary preventive agent for the prevention of gastric damage.

关键词： holothurian intestine NSAID indomethacin gastric ulcer sucralfate

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