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Evaluation of intratesticular chlorhexidine gluconate for chemical contraception in dogs

Asian pacific Journal of Reproduction 2022年第5期11卷 231-235页

作者： Aeknath Virendra Om Prakash Shrivastava Satya Nidhi Shukla Manish Kumar Shukla Nitin Kumar Bajaj Afroza Khanam Firdous Ahmad Khan Department of Animal Reproduction Gynecology and ObstetricsNanaji Deshmukh Veterinary Science UniversityJabalpur482001Madhya PradeshIndia Department of Animal Reproduction Gynecology and ObstetricsSardar Vallabhbhai Patel UniversityMeerut250110Uttar PradeshIndia Department of Large Animal Medicine and Surgery School of Veterinary MedicineSt.George’s UniversityTrue BlueGrenadaWest Indies

Objective:To investigate the contraceptive effect of intratesticular injection of chlorhexidine gluconate in dogs and compare it with that of zinc gluconate neutralized with ***:Twenty-four sexually mature male mongrel dogs were randomly divided by replicate into four groups(n=6 per group).GroupⅡreceived intra-testicular injection of 2 mL zinc gluconate(10 mg/mL)neutralized with ***Ⅱreceived intratesticular injection of 2 mL chlorhexidine gluconate(5%w/v).GroupⅢreceived intratesticular injection of 2 mL chlorhexidine gluconate(4%w/v).GroupⅣdid not receive any treatment and served as the control *** morphometry was conducted on day 0,7,15 and 30 after *** was collected and evaluated on day 0 and *** were analyzed using repeated measures analysis of ***:There was no difference in the mean values of various parameters between dogs treated with zinc gluconate and those treated with chlorhexidine gluconate at any of the time *** dogs treated with zinc gluconate or chlorhexidine gluconate,there was a significant increase in the testicular morphometric parameters on day 7 followed by a significant reduction thereafter(day 15 and 30).In contrast,there was no change in any of the parameters in the control untreated dogs during the course of the *** to the pre-treatment values,the mean scrotal circumference and the mean paired testicular volume and testicular weight on day 30 were significantly lower in the treated *** samples collected on day 30 from treated dogs were found to be azoospermic,whereas no change in semen quality was observed in the control untreated ***:Intratesticular injection of chlorhexidine gluconate(5%w/v and 4%w/v)is equally as effective as zinc gluconate neutralized with arginine for chemical contraception in dogs.

关键词： Canine Contraception Zinc gluconate Chlorhexidine gluconate Morphometry

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