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Plasma metabolomics combined with mass spectrometry imaging reveals crosstalk between tumor and plasma in gastric cancer genesis and metastasis

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Chinese Chemical Letters 2025年第1期36卷 506-512页

作者： Yanhua Chen Xian Ding Jun Zhou Zhaoying Wang Yunhai Bo Ying Hu Qingce Zang Jing Xu Ruiping Zhang Jiuming He Fen Yang Zeper Abliz Key Laboratory of Mass Spectrometry Imaging and Metabolomics(State Ethnic Affairs Commission) Center for Imaging and Systems BiologyCollege of Life and Environmental SciencesMinzu University of ChinaBeijing 100081China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Center of Drug Clinical TrialPeking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Food Environment and Public Health Minzu University of ChinaBeijing 100081China Key laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing 100081China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of BioBankPeking University Cancer Hospital and InstituteBeijing 100142China Pharmacy Department of Beijing Chao–Yang Hospital Capital Medical UniversityBeijing 100020China

Gastric Carcinoma(GC)is a highly fatal malignant tumor with a poor *** elevated mortality rates are primarily due to its proclivity for late-stage *** the metabolic interactions between tumor microenvironment and the systemic bloodstream could help to clearly understand the mechanisms and identify precise biomarkers of tumor growth,proliferation,and *** this study,an integrative approach that combines plasma metabolomics with mass spectrometry imaging of tumor tissue was developed to investigate the global metabolic landscape of GC tumorigenesis and *** results showed that the oxidized glutathione to glutathione ratio(GSSH/GSH)became increased in non-distal metastatic GC(M0),which means an accumulation of oxidative stress in tumor ***,it was found that the peroxidation of polyunsaturated fatty acids,such as 9,10-EpOMe,9-HOTrE,etc.,were accelerated in both plasma and tumor tissues of distal metastatic GC(M1).These changes were further confirmed the potential effect of CYP2E1 and GGT1 in metastatic potential of GC by mass spectrometry imaging(MSI)and immunohistochemistry(IHC).Collectively,our findings reveal the integrated multidimensional metabolomics approach is a clinical useful method to unravel the bloodtumor metabolic crosstalk,illuminate reprogrammed metabolic networks,and provide reliable circulating biomarkers.

关键词： Metabolomics Spatial-resolved metabolomics Gastric cancer Blood-tumor metabolic crosstalk Lipid peroxidation

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Effective stress dissipation by multi-dimensional architecture engineering for ultrafast and ultralong sodium storage

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Journal of Energy Chemistry 2025年第2期101卷 619-629页

作者： Man Zhang Jing Zhu Qianqian Li Fenghua Zheng Sijiang Hu Youguo Huang Hongqiang Wang Xing Ou Qichang Pan Qingyu Li Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical Sciences Guangxi Normal University School of Metallurgy and Environment Central South University

Stress accumulation is a key factor leading to sodium storage performance deterioration for NiSe2-based ***,inhibiting the concentrated local stress during the sodiataion/desodiation process is crucial for acquiring stable NiSe2-based materials for sodium-ion batteries（SIBs）,Herein,a stress dissipation strategy driven by architecture engineering is proposed,which can achieve ultrafast and ultralong sodium storage *** from the conventional sphere-like or rod-like architecture,the three-dimensional（3D） flower-like NiSe2@C composite is delicately designed and assembled with onedimensional nanorods and carbon *** importantly,the fundamental mechanism of improved structure stability is unveiled by simulations and experimental results *** demonstrates that this designed multidimensional flower-like architecture with dispersed nanorods can balance the structural mismatch,avoid concentrated local strain,and relax the internal stress,mainly induced by the unavoidable volume variation during the repeated conversion ***,it can provide more Na+-storage sites and multi-directional migration pathways,leading to a fast Na+-migration channel with boosted reaction *** expected,it delivers superior rate performance(441 mA h g-1at 5.0 A g-1) and long cycling stability(563 mA h g-1at 1.0 A g-1over 1000 cycles) for *** work provides useful insights for designing high-performance conversion-based anode materials for SIBs.

关键词： Conversion-based anodes Multi-dimensional architecture Sodium-ion batteries Stress dissipation Structure engineering

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A composite hydrogel with porous and homogeneous structure for efficient osmotic energy conversion

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Chinese Chemical Letters 2025年第2期36卷 234-238页

作者： Guilong Li Wenbo Ma Jialing Zhou Caiqin Wu Chenling Yao Huan Zeng Jian Wang College of Materials and Chemistry & Chemical Engineering Chengdu University of Technology

With the impact of energy crisis and environmental problems, it is urgent to develop green sustainable energy. Osmotic energy stored in the salinity difference between seawater and river water is one of the sustainable, abundant, and renewable energy. However, the membranes used to capture osmotic energy by reverse electrodialysis （RED） always suffer from low ion selectivity, low stability and low *** with three-dimensional （3D） networks have shown great potential for ion transportation and energy conversion. In this work, based on the homogeneity and porosity characteristics of acrylamide（AM） hydrogel, as well as the remarkable stability and abundant negative charge of 3-sulfopropyl acrylate potassium salt （SPAK）, a high-performance AM/SPAK cation-selective hydrogel membrane was successfully developed for harvesting osmotic energy. Compared to AM hydrogels, utilizing AM/SPAK as a monomer mixture greatly facilitated the preparation of homogeneous polymers, exhibiting a porous structure, exceptional ion selectivity, and remarkable stability. A maximum output power density of 13.73 W/m2was achieved at a 50-fold NaCl concentration gradient, exceeding the commercial requirement of 5 W/m2. This work broadens the idea for the construction and application of composite hydrogel in high efficiency osmotic energy conversion.

关键词： Cation-selective membrane Osmotic energy Porous structure Power density Stability

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Catalytic detoxification of mitoxantrone by graphitic carbon nitride(g-C_(3)N_(4))supported Fe/Pd bimetallic nanoparticles

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Journal of Environmental sciences 2025年第2期148卷 614-624页

作者： Qianyu Xu Haoyang Fu Jiyuan Gu Liyu Lei Lan Ling State Key Laboratory for Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China

The overuse of antibiotics and antitumor drugs has resulted in more and more extensive pollution of water bodies with organic drugs,causing detrimental ecological effects,which have attracted attention towards effective and sustainable methods for antibiotics and antitumor drug ***,the hybrid nanomaterial(g-C_(3)N_(4)@Fe/Pd)was synthesized and used to remove a kind of both an antibiotic and antitumor drug named mitoxantrone(MTX)with 92.0%removal efficiency,and the MTX removal capacity is 450 mg/*** exposing to the hybrid material the MTX aqueous solution changed color from dark blue to lighter progressively,and LC-UV results of residual solutions showthat a newpeak at 3.0min(MTX:13.2min)after removal by g-C_(3)N_(4)@Fe/Pd appears,with the simultaneous detection of intermediate products indicating that g-C_(3)N_(4)@Fe/Pd indeed degrades *** mass spectrometric analysis suggests that the nuclear mass ratio decreased from 445.2(M+1H)to 126.0(M+1H),169.1(M+1H),239.2(M+1H),267.3(M+1H),285.2(M+1H),371.4(M+1H)and 415.2(M+1H),and the maximum proportion(5.63%)substance of all degradation products(126.0(M+1H))is 40-100 times less toxic than MTX.A mechanism for the removal and degradation of mitoxantrone was ***,actual water experiments confirmed that the maximum removal capacity of MTX by g-C_(3)N_(4)@Fe/Pd is up to 492.4 mg/g(0.02 g/L,10 ppm).

关键词： Degradation LC-QTOF-MS Nanoparticles Mitoxantrone Aqueous solution

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Stress anisotropy regulated wrinkling pattern evolution on a core-shell soft cylinder

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science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 132-144页

作者： Yan Zhao Zhipan Jie Yilong Zhang Guo-Yang Li Yanping Cao Chao Jiang State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Department of Mechanics and Engineering science College of EngineeringPeking UniversityBeijing 100871China Institute of Biomechanics and Medical Engineering AMLDepartment of Engineering MechanicsTsinghua UniversityBeijing100084China

Diverse wrinkling patterns can occur on curved bilayer systems under differential growth or *** such systems,stress anisotropy is frequently encountered,and the coupling effect of curvature and stress anisotropy on the pattern evolution remains largely *** this study,we investigate the evolution of wrinkling patterns on a cylinder core-shell system with stress anisotropy leveraging both theoretical analysis and finite element *** buckling analysis has identified three distinct critical buckling modes regulated by the stress anisotropy,i.e.,axial sinusoidal mode,checkerboard mode,and circumferential sinusoidal *** finite element simulations,along with post-buckling analysis,reveal seven distinct evolutionary paths stemming from the three critical buckling *** present phase diagrams for both the critical buckling modes and their evolutionary paths,which are determined by dimensionless curvature and stress *** results not only expand the theoretical research on surface wrinkling of a core-shell soft cylinder but also introduce stress anisotropy as a significant parameter for regulating the wrinkling patterns and their evolutionary paths in curved bilayer *** revelation of a multitude of wrinkling patterns and their evolutionary pathways holds great potential for advancing applications that leverage tunable wrinkle surfaces.

关键词： wrinkling pattern evolutionary path stress anisotropy dimensionless curvature core-shell soft cylinder

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Research on the hazards of gas leakage and explosion in a full-scale residential building

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Defence Technology(防务技术) 2025年第1期43卷 168-181页

作者： Chengjun Yue Li Chen Zhan Li Bin Feng Ruizhi Xu Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing 211189China

The gas explosion in residential building has always been a highly concerned *** in homogeneous mixtures have been extensively ***,mixtures are often inhomogeneous in the practical scenarios due to the differences in the densities of methane and *** order to investigate the effects of gas explosions in inhomogeneous mixtures,experimental studies involving gas leakage and explosion are conducted in a full-scale residential building to reproduce the process of gas *** fitting the dimensionless buoyancy as a function of dimensionless height and dimensionless time,a distribution model of gas in large-scale spaces is established,and the mechanism of inhomogeneous distribution of methane is also be ***,the stratified reconstruction method(SRM)is introduced for efficiently setting up inhomogeneous concentration fields in *** simulation results highlight that for the internal overpressure,the distribution of methane has no effect on the first overpressure peak(ΔP1),while it significantly influences the subsequent overpressure peak(ΔP2),and the maximum difference between the overpressure of homogeneous and inhomogeneous distribution is174.3%.Moreover,the initial concentration distribution also has a certain impact on the external overpressure.

关键词： Methane distribution Inhomogeneous mixture Gradient layer Gas explosion Explosive simulation

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi Li Yabo Xie Qiancheng Chen Xin Zhang Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

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Experiments and modeling of microstructural and mechanical behaviors of laser-welded Ni-based superalloy at high temperatures

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Chinese Journal of Aeronautics 2025年第1期38卷 99-114页

作者： Ting HOU Yong LI Degang WANG Yuelin WANG Marko VILOTIC School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Department of Structure Shenyang Aircraft Designand Research InstituteShenyang 110000China Engineering Center Shenyang Aircraft CorporationShenyang 110000China Faculty of Technical science University of Novi SadNovi Sad 21102Serbia

The performance of welded Ni-based superalloys at high temperatures is essential to be evaluated due to their particular service environment for aero-engines and high-speed *** tensile properties and related microstructural evolutions such as the carbide precipitate and grain of a laser-welded Ni-based alloy were experimentally and numerically investigated at different temperatures(20,300,500,800℃).The results show that at room temperature,the strength of the Base Material(BM)was slightly smaller,with a difference of less than 1%,than the Welded Material(WM),which can be attributed to the more uniformly distributed needle-shaped carbide precipitates in the WM than those nonuniformly coarser spherical ones in the *** at 300℃ and 500℃,the strength of WM decreased more obviously compared with that of BM due to the more apparent growth of grain:13.52%loss in yield strength in WM alloys as compared with BM alloys at 300℃,and 16.57% at 500℃.At 800℃,the strength of BM and WM both decreased to a similar level due to Dynamic Recrystallization(DRX).However,a much higher elongation was observed for the BM than WM(less than 50%of BM),which can be attributed to the enhanced dislocation accumulation capability of the large spherical carbides along grain boundaries on the fracture surface in ***,a unified model considering the welding effects on both microstructures(dislocation,carbides,and grain)and mechanical properties evolutions at different temperatures was developed and *** on this model,the key temperature ranges(20–600℃)where apparent weakening of strength and uniform plasticity occurs for welded structures were identified,providing a direct guidance for potential structure and process design.

关键词： Ni-based superalloy Microstructure Mechanical properties Constitutive model High temperature

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Review of precipitation strengthening in ultrahigh-strength martensitic steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 256-269页

作者： Zhihao Tian Chunlei Shang Chaolei Zhang Xiaoye Zhou Honghui Wu Shuize Wang Guilin Wu Junheng Gao Jiaming Zhu Xinping Mao Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China School of Civil Engineering Shandong UniversityJinan 250061China

Martensite is an important microstructure in ultrahigh-strength steels,and enhancing the strength of martensitic steels often involves the introduction of precipitated phases within the martensitic *** considerable research efforts devoted to this area,a systematic summary of these advancements is *** review focuses on the precipitates prevalent in ultrahigh-strength martensitic steel,primarily carbides(e.g.,MC,M_(2)C,and M_(3)C)and intermetallic compounds(e.g.,Ni Al,Ni_(3)X,and Fe_(2)Mo).The precipitation-strengthening effect of these precipitates on ultrahigh-strength martensitic steel is discussed from the aspects of heat treatment processes,microstructure of precipitate-strengthened martensite matrix,and mechanical ***,a perspective on the development of precipitation-strengthened martensitic steel is presented to contribute to the advancement of ultrahigh-strength martensitic *** review highlights significant findings,ongoing challenges,and opportunities in the development of ultrahigh-strength martensitic steel.

关键词： ultrahigh-strength martensitic steel precipitation strengthening mechanical property carbide intermetallic compound

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Significant reduction of anisotropy in stress relaxation aging and mechanical properties improvement for 2195 Al-Cu-Li alloy subjected to plastic loading

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Chinese Journal of Aeronautics 2025年第1期38卷 217-234页

作者： Liwen ZHANG Heng LI Tianjun BIAN Changhui WU Yanfeng YANG State Key Lab of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Aeronautical Polytechnic Institute Xi’an 710089China Shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Although the plastic loading can enhance creep deformation and yield strength,the anisotropic Stress Relaxation Aging(SRA)behavior and mechanism under plastic loading remain unclear,which presents a significant challenge in accurately shaping aluminum alloy *** this study,the SRA behavior of 2195-T4 Al-Cu-Li alloys were thoroughly studied under initial loading stresses within the elastic(210/250 MPa)and plastic(380/420 MPa)ranges at 180℃by stress relaxation and tensile tests as well as microstructure *** findings reveal that compared with those under elastic loadings,in-plane anisotropy(IPA)values of the stress relaxation amount,yield strength and fracture elongation under plastic loadings are reduced by 60%–80%,70%–90% and 72%–89%,***,IPA values of precipitate size in grains and PrecipitationFree Zones(PFZ)width at grain boundaries under plastic loading decrease by 31.4%and 94.4%*** results indicate plastic loading significantly weakens the anisotropic SRA behavior,owing to numerous uniformly distributed fine T1phases and small IPA values of both T1precipitates size and PFZ width in various loading *** with those of elastic loadingaged alloys,yield strength of plastic loading-aged alloys shows high strength-ductility because of the combined effect of closely dispersed fine T1precipitates,narrowed PFZ and numerous sheared and rotated T1phases at different locations during tensile *** uniformly distributed larger Kernel Average Misorientation(KAM)and Schmidt factor values of the plastic loading-aged alloy,as well as the cross-slip generated,also help to enhance the strength and ductility of the alloy.

关键词： Aluminum-lithium alloy Stress relaxation aging Precipitation-free zones In-plane anisotropy Stress relaxation

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