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肿瘤风险与慢性疾病或疾病指标的关系：回顾性研究

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英国医学杂志中文版 2018年第9期21卷 495-506页

作者：刘斌亮马飞 Department of Epidemiology The University of Texas MD Anderson Cancer CenterHouston TX 77030 USA Institute of Population Health Sciences National Health Research Institutes ZhunanTaiwan China Graduate Institute of Biomedical Sciences College of Medicine China Medical University Taichung Taiwan China Department of Medical Research China Medical University Hospital Taichung Taiwan China

目的：评价常见慢性疾病及疾病标志指标与肿瘤风险的独立和联合关系，同时探索体力活动能否降低慢性疾病或异常疾病指标的致癌风险。研究设计：回顾性研究。研究设定：中国台湾地区人群的标准医学普查计划。纳入人群：405878人纳入研究... 详细信息

目的：评价常见慢性疾病及疾病标志指标与肿瘤风险的独立和联合关系，同时探索体力活动能否降低慢性疾病或异常疾病指标的致癌风险。研究设计：回顾性研究。研究设定：中国台湾地区人群的标准医学普查计划。纳入人群：405878人纳入研究，平均随访时间8．7年。所有参与者均测量并记录以下指标：心血管标志指标（血压、总胆固醇和心率）、糖尿病、慢性肾脏疾病指标（蛋白尿和肾小球滤过率）、肺部疾病和痛风性关节炎指标（尿酸）。主要研终点：肿瘤发病率及病死率。

关键词：疾病学习风险癌症标记

澳大利亚初级保健诊所新发腰背痛患者的预后：起始队列研究

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英国医学杂志中文版 2008年第6期11卷 339-342页

作者： Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) Musculoskeletal Division The George Institute for International Health Sydney Australia Back Pain Research Group Faculty of Health Sciences University of Sydney School of Public Health University of Sydney Department of Rheumatology Royal Prince Alfred Hospital Sydney 不详

目的估计初级保健诊所内新发腰背痛患者的1年预后，并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者（平均年龄43.3岁，男性54.8％）。该起始队列患者... 详细信息

目的估计初级保健诊所内新发腰背痛患者的1年预后，并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者（平均年龄43.3岁，男性54.8％）。该起始队列患者腰背痛时间不足两周，征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后，分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括：工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97％。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态（95％可信区间11-17天），83％在3个月内恢复。残疾（中位恢复时间31天，25-37天）和疼痛（中位58天，52-63天）则需要较长的时间才能恢复。只有72％的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列，患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。

关键词：腰背痛患者初级保健预后因素队列研究澳大利亚诊所新发评估指标

Abnormalcortical thickness in relapsing-remitting multiple sclerosis,correlations with cognition impairment,and effect of modified Bushenyisui decoction(补肾益髓汤)on cognitive function of multiple sclerosis

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Journal of Traditional Chinese Medicine 2021年第2期41卷 316-325页

作者： ZHAO Xuesong YANG Tao CHENG Fang YANG Song ZHU Wanlin LI Shaowu FAN Yongping Department of Traditional Chinese Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Anorectal Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Institute of neurosurgery Institute of NeurosurgeryTiantan HospitalCapital Medical UniversityBeijing 100070China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

OBJECTIVE:To investigate the changes of subcortical gray matter volume and cortical thickness,andexplorethe correlations between regional abnormalities of cortical thickness and cognitive impairment and the effect of modified Bushenyisui decoction(补肾益髓汤,BSYSD)on the cognitive function of multiple sclerosis(MS).METHODS:This prospective study was approved by the institutional review board.92 subjects were recruited,including 46 relapsing-remitting multiple sclerosis(RRMS)patients and 46 healthy controls(HC).Of the 46 patients,22 patients experienced the treatment of BSYSD for half a year.A conventional three-dimensional T1-weighted sequence were acquired for all participants on a 3.0 tesla magnetic resonance *** information,detailed cognitive scales Montreal Cognitive Assessment(MoCA),symbol digit modalities test(SDMT),immediate memory,delayed recall,and long-term recognition were *** gray matter volume and cortical thickness weremeasured by *** correlations between cortical thickness which MS patients showed reduced with respect to HC and cognitive scales wereanalyzed by Pearson correlation in RRMS *** influence of modified BSYSD on MS patients'cognition was analyzed by paired T ***:MoCA,immediate memory,delayed recall,and long-term delayed recognition in RRMS were significantly decreased than those of *** matter atrophy measured by FreeSurfer showed mainly in thalamus and hippocampus of RRMS *** with HC,the cortical thickness of several regions in frontal lobe,parietal lobe,temporal lobe,hippocampal,cingulate gyrus,and fusiform gyrus of RRMS patients were decreased with significant *** regions of cortical thickness thinning related to MoCA,immediate memory,delayed recall,and long-term delayed recognition were temporal lobe and fusiform *** BSYSD could improve MoCA,SDMT,immediate memory,delayed recall,and long-term delayed recognition of MS patients,and it could promote th

关键词： multiple sclerosis,relapsing-remitting cognitive dysfunction brain cortical thickness Gray matter Bushenyisui decoction

The role and regulation mechanisms of APOD in prognosis and subtyping of breast cancer

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Medical Data Mining 2023年第3期6卷 39-49页

作者： Chen-Fei Zhao Shi-Liang Chen Cong Wang Dan Hu Xiao-Xiao Yang Shi-Yuan Tong Yi-Bo He Zhe-Zhong Zhang Department of Clinical Lab The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China Department of Clinical Lab The Cixi integrated traditional Chinese and Western medicine medical and Health Group Cixi Red Cross HospitalCixi 315300China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai 200032China

Background:Breast cancer is the most common cancer,and abnormal lipid metabolism is associated with *** expression is negatively correlated with various cancers related to tumor *** methylation may affect APOD ***,this paper aims to investigate the significance of APOD expression and APOD DNA methylation in breast ***:This study utilized comprehensive bioinformatics analysis of APOD using Gene Expression database of Normal and Tumor tissues 2,UCSC Xena,*** and survival information obtained from the The Cancer Genome Atlas and Gene Expression Omnibus datasets were extracted for data ***:The correlation between APOD and breast cancer was examined,along with the connection between APOD DNA methylation and APOD *** the The Cancer Genome Atlas cohort,as well as GSE31448 and GSE65194 datasets,APOD expression decreased in breast cancer(Panalysis results showed that APOD expression was correlated with the PAM50 subtype,with the lowest expression in the Basal subtype(P<0.0001).High APOD expression is a good prognostic marker for breast cancer(HR=0.71,P=0.037).APOD methylation level was significantly negatively correlated with expression level(R=−0.4770,P<0.001),and cg15231202,cg23720929,and cg05624196 were important regulatory *** APOD expression was associated with higher metabolism and extracellular matrix ***:APOD is an independent prognostic marker for breast cancer and is regulated by DNA methylation to modulate mRNA expression.

关键词： breast cancer APOD DNA methylation bioinformatics prognosis PAM50 subtype

Impacts of ENSO on the Welfare of Rural Residents in China: A Stochastic CGE Model Assessment

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Asian Agricultural Research 2022年第11期14卷 31-40,47页

作者： Weihong HAN Xianfeng YANG Xinjiletu YANG Yuqing LIU Inner Mongolia University of Technology Hohhot 010051China

ENSO-driven extreme weather events such as droughts and floods can cause significant damage to agricultural production and different intensities of ENSO events make uncertain changes to rural residents'welfare in different *** emphasize this uncertainty,the stochastic CGE model is constructed by imbedding a stochastic parameter into the production module to analyze the impacts of ENSO on the welfare of rural residents in various regions of China and the volatility of uncertain ENSO events on the welfare of *** role of agricultural technology in improving welfare stability and transfer payments in reducing welfare losses from ENSO are also *** results show that weak ENSO events have little effect on the welfare of rural residents while strong ENSO events cause the welfare of rural residents a significant decline,and the largest decrease appears separately in the southwest region and the smallest one in the *** uncertainty of ENSO events seriously affects the stability of the welfare of the residents,with the average fluctuation level of 200%in the change of the rural residents'welfare in all regions under El Ni *** improving the anti-risk ability of agriculture can effectively reduce the fluctuation of residents'***,if the government increases the transfer payment to the rural resident for disaster relief,the welfare would increase,and the higher the payment,the greater the improvement of the welfare.

关键词： ENSO events Stochastic CGE Rural residents'welfare Uncertainty

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply

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Plant Communications 2023年第3期4卷 171-182页

作者： supply Xueni Di David Ortega-Alarcon Ramu Kakumanu Javier Iglesias-Fernandez Lucia Diaz Edward E.K.Baidoo Adrian Velazquez-Campoy Manuel Rodríguez-Concepción Jordi Perez-Gil Institute for Plant Molecular and Cell Biology(IBMCP) CSIC-Universitat Politècnica de València46022 ValenciaSpain 2Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UBCampus UAB Bellaterra08193 BarcelonaSpain 3Institute for Biocomputation and Physics of Complex Systems(BIFI)Joint Unit GBsC-CSIC-BIFIUniversidad de Zaragoza50009 ZaragozaSpain 4Departamento de Bioquímica y Biología Molecular y CelularUniversidad de Zaragoza50009 ZaragozaSpain 5Joint BioEnergy Institute5885 Hollis StreetEmeryvilleCA 94608USA 6Biological Systems and Engineering DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA 7Nostrum Biodiscovery SL08029 BarcelonaSpain 8Instituto de Investigación Sanitaria de Aragón(IIS Aragon)50009 ZaragozaSpain 9Centro de Investigación Biomédica en Red en elÁrea Temática de Enfermedades Hepáticas y Digestivas(CIBERehd)28029 MadridSpain

Isoprenoids are a very large and diverse family of metabolites required by all living *** isoprenoids derive fromthe double-bond isomers isopentenyl diphosphate(IPP)and dimethylallyl diphosphate(DMAPP),which are produced by the methylerythritol 4-phosphate(MEP)pathway in bacteria and plant *** has been reported that IPP and DMAPP feedback-regulate the activity of deoxyxylulose 5-phosphate synthase(DXS),a dimeric enzyme that catalyzes the main flux-controlling step of the MEP *** we provide experimental insights *** titration calorimetry and dynamic light scattering approaches showed that IPP and DMAPP can allosterically bind to DXS in vitro,causing a size *** silico ligand binding site analysis and docking calculations identified a potential allosteric site in the contact region between the two monomers of the active DXS *** of IPP and DMAPP contents in vivo followed by immunoblot analyses confirmed that high IPP/DMAPP levels resulted in monomerization and eventual aggregation of the enzyme in bacterial and plant *** of the enzymatically active dimeric conformation allows a fast and reversible reduction of DXS activity in response to a sudden increase or decrease in IPP/DMAPP supply,whereas aggregation and subsequent removal of monomers that would otherwise be available for dimerization appears to be a more drastic response in the case of persistent IPP/DMAPP overabundance(e.g.,by a blockage in their conversion to downstream isoprenoids).Our results represent an important step toward understanding the regulation of the MEP pathway and rational design of biotechnological endeavors aimed at increasing isoprenoid contents in microbial and plant systems.

关键词： isoprenoids DXS feedback regulation allosteric monomerization

Mechanism of the Rpn13-induced activation of Uch37

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Protein & Cell 2014年第8期5卷 616-630页

作者： Lianying Jiao Songying Ouyang Neil Shaw Gaojie Song Yingang Feng Fengfeng Niu Weicheng Qiu Hongtao Zhu Li-Wei Hung Xiaobing Zuo V. Eleonora Shtykova Ping Zhu Yu-Hui Dong Ruxiang Xu Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China iHuman Institute ShanghaiTech University Shanghai 201210 China Shandong Provincial Key Laboratory ofEnergy-Genetics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Qingdao 266101 China Physics Division 'Los Alamos National Laboratory Los Alamos NM 87545 USA X-ray Science Division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 USA Institute of Crystallography~ Russian Academy of Sciences 59 Leninsky Pr. 117333 Moscow Russian Federation Center for Multi-disciplinary Research Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China Department of Nerosurgery The Military General Hospital of Beijing PLA Beijing 100700 China

Uch37 is a de-ubiquitinating enzyme that is activated by Rpn13 and involved in the proteasomal degradation of proteins. The full-length Uch37 was shown to exhibit low iso-peptidase activity and is thought to be auto-inhibited. Structural comparisons revealed that within a homo- dimer of Uch37, each of the catalytic domains was blocking the other＇s ubiquitin （Ub）-binding site. This blockage likely prevented Ub from entering the active site of Uch37 and might form the basis of auto-inhibition. To understand the mode of auto-inhibition clearly and shed light on the activation mechanism of Uch37 by Rpn13, we investigated the Uch37-Rpn13 complex using a combi- nation of mutagenesis, biochemical, NMR, and small- angle X-ray scattering （SAXS） techniques. Our results also proved that Uch37 oligomerized in solution and had very low activity against the fluorogenic substrate ubi- quitin-7-amino-4-methylcoumarin （Ub-AMC） of de-ubiq- uitinating enzymes. Uch37AHb＇Hc＇KEKE, a truncation removal of the C-terminal extension region （residues 256- 329） converted oligomeric Uch37 into a monomeric form that exhibited iso-peptidase activity comparable to that of a truncation-containing the Uch37 catalytic domain only. We also demonstrated that Rpn13C （Rpn13 residues 270- 407） could disrupt the oligomerization of Uch37 by sequestering Uch37 and forming a Uch37-Rpn13 com- plex. Uch37 was activated in such a complex, exhibiting 12-fold-higher activity than Uch37 alone. Time-resolved SAXS （TR-SAXS） and FRET experiments supported the proposed mode of auto-inhibition and the activation mechanism of Uch37 by Rpn13. Rpn13 activated Uch37 by forming a 1：1 stoichiometric complex in which the active site of Uch37 was accessible to Ub.

关键词： Uch37-Rpn13 complex de-ubiquitination,SAXS analysis oligomerization iso-peptidase

基于装备制造业需求的国际化工科人才培养策略探究——以浙南地区为例

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大学教育 2020年第6期 151-153页

作者：陈希章张祥雷温州大学机电工程学院浙江温州325035

人才是任何领域创新发展的核心要素,通过分析浙南地区装备制造业创新发展对国际化工科人才的迫切需求,阐述了现阶段国际化工科人才培养在师资队伍、教育理念、课程体系、实践教学等方面存在的问题,提出了相应的改革措施和方案,包括培养... 详细信息

人才是任何领域创新发展的核心要素,通过分析浙南地区装备制造业创新发展对国际化工科人才的迫切需求,阐述了现阶段国际化工科人才培养在师资队伍、教育理念、课程体系、实践教学等方面存在的问题,提出了相应的改革措施和方案,包括培养具有国际化视野和教学水平的师资队伍、实施项目制人才培养模式、建设国际化实践教育基地、实施系统化的学生科研与创新计划、吸引国际优秀生源等“全方位”的人才培养策略,探索适合浙南地区高校培养国际化工科人才的建设途径。

关键词：工科国际化人才培养装备制造业浙南地区

浅谈浙南地区机电装备制造业国际化工科人才的创新能力培养

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教育教学论坛 2020年第37期 116-117页

作者：张祥雷陈希章温州大学机电工程学院浙江温州325035

浙南地区机电装备制造业对于国际化工科人才的需求呈急速增长趋势,如何培养具有国际化水平的工科创新人才已成为当地一大难题。文章提出了从企业内部挖潜、培养师资、抓好生源、开发教学资源、开展产学研合作、进行国际交流、吸引留学... 详细信息

浙南地区机电装备制造业对于国际化工科人才的需求呈急速增长趋势,如何培养具有国际化水平的工科创新人才已成为当地一大难题。文章提出了从企业内部挖潜、培养师资、抓好生源、开发教学资源、开展产学研合作、进行国际交流、吸引留学生等方面,实现国际化工科人才创新能力的培养目标。

关键词：国际化工科人才机电装备浙南地区