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Antitumor effects of different Ganoderma lucidum spore powder in cell-and zebrafish-based bioassays

Journal of Integrative Medicine 2021年第2期19卷 177-184页

作者： Yue-jiao Shi Hua-xian Zheng Zhu-ping Hong Han-bo Wang Ying Wang Ming-yan Li Zhen-hao Li zhejiang Shouxiangu Pharmaceutical Co. LtdWuyi 321200Zhejiang ProvinceChina zhejiang Shouxiangu Botanical Drug institute Co. LtdHangzhou 310012Zhejiang ProvinceChina zhejiang Engineering Research Center of Rare Medicinal Plants Wuyi 321200Zhejiang ProvinceChina Pharmaceutical Informatics institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310012Zhejiang ProvinceChina

Objective:Ganoderma lucidum spore(GLS)is gaining recognition as a medicinal part of *** and has been reported to possess various pharmacological properties,such as antitumor *** this work,wall-broken GLS powder(BGLSP)and wall-removed GLS powder(RGLSP),two kinds of GLS powder with different manufacturing techniques,were compared in terms of contents of active constituents and in vivo and in vitro antitumor ***:The ultraviolet and visible spectrophotometry method was used to determine the contents of polysaccharides and total triterpenoids in BGLSP and *** individual triterpenoids were further quantified using ultra-high-performance liquid chromatography and quantitative analysis of multicomponents by single *** antitumor effects of BGLSP and RGLSP were evaluated using in vitro cell viability assay against human gastric carcinoma SGC-7901,lung carcinoma A549 and lymphoma Ramos and further validated by in vivo zebrafish xenograft models with transplanted SGC-7901,A549 and Ramos,Results:The results showed that the contents of polysaccharides,total triterpenoids and individual triterpenoids of RGLSP were significantly higher than those of *** both BGLSP and RGLSP inhibited the three tumor cell lines in vitro in a dose-dependent manner,the inhibitory effects of RGLSP were much better than those of *** the in vivo zebra fish assay,RGLSP exhibited more potent inhibitory activities against tumors transpla nted into the zebra fish compared with BGLSP,and the inhibition rates of RGLSP reached approximately 78%,31%and 83%on SGC-7901,A549 and Ramos,***:The results indicated that the antitumor effects of GLS were positively correlated with the contents of the polysaccha rides and triterpenoids and demonstrated that the wall-removing manufacturing technique could significantly improve the levels of active constituents,and thereby enhance the antitumor activity.

关键词： Ganoderma lucidum Tumor Cancer cell Zebrafish Wall-broken Ganoderma lucidum spore powder Wall-removed Ganoderma lucidum spore powder

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Germplasm resources and secondary metabolism regulation in Reishi mushroom(Ganoderma lucidum)

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Chinese Herbal Medicines 2023年第3期15卷 376-382页

作者： Xinyu He Yiwen Chen Zhenhao Li Ling Fang Haimin Chen Zongsuo Liang Ann Abozeid Zongqi Yang Dongfeng Yang key Laboratory of Plant Secondary Metabolism and Regulation of zhejiang Province College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018China zhejiang Shouxiangu Botanical Drug institute Co. Ltd.Hangzhou 310018China Shaoxing Academy of Biomedicine Co. Ltd.of Zhejiang Sci-Tech UniversityZhejiang Engineering Research Center for Development Technology of Medicinal and Edible Health FoodShaoxing 312000China Botany and Microbiology Department Faculty of ScienceMenoufia UniversityShebin Elkoom 32511Egypt

Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites,in which triterpenoids are the major *** paper introduced the germplasm resources of genus Ganoderma from textual research,its distribution and identification at the molecular *** we overviewed *** in the components,the biological activities and biosynthetic pathways of ganoderic acid,aiming to provide scientific evidence for the development and utilization of *** germplasm resources and the biosynthesis of ganoderic acid.

关键词： chemical constituents Ganoderma lucidum(Leyss.ex Fr.)Karst. ganoderic acid germplasm resources pharmacological activities secondary metabolism regulation

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