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Science China(Life sciences) 2017年第8期60卷 797-805页

作者： Lifan Sun Jun Qin Kailun Wang Jie Zhang State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Pathogen/microbe-associated molecular patterns(PAMPs/MAMPs) are recognized by plant pattern recognition receptors(PRRs)localized on the cell surface to activate immune *** PAMP-triggered immunity(PTI) confers resistance to a broad range of pathogenic microbes and,therefore,has a great potential for genetically engineering broad-spectrum resistance by transferring PRRs across plant *** effectors secreted by phytopathogens often directly target and inhibit key components of PTI signaling pathways via diverse biochemical *** some cases,plants have evolved to produce decoy proteins that mimic the direct virulence target,which senses the biochemical activities of pathogenic *** kind of perception traps the effectors of erroneous targeting and results in the activation of effector-triggered immunity(ETI) instead of suppressing *** mechanism suggests that artificially designed decoy proteins could be used to generate new recognition specificities in a particular *** this review,we summarize recent advances in research investigating PAMP recognition by PRRs and virulence effector surveillance by decoy *** expansion of recognition specificities,conferred by the transgenic expression of EF-Tu receptor(EFR) and AvrPphB susceptible 1(PBS1) decoys,has highlighted the considerable potential of PRRs and artificially designed decoys to expand plant resistance spectra and the need to further identify novel PRRs and decoys.

关键词： pattern recognition receptor effector decoy PAMP-triggered immunity resistance

Non-Markovian Effect on Gene Transcriptional Systems

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chinese Physics Letters 2016年第10期33卷 163-166页

作者：冯燕陵董建敏汤旭磊 The First Hospital of Lanzhou University Institute of Modern Physics Chinese Academy of Sciences

The time delays in both synthesis and degradation reactions, reflecting the non-Markovian behavior, are intro- duced in the stochastic gene transcriptional dynamics. The effects of the time delays on the stationary proba- bility distribution, mean first passage time and stochastic resonance are discussed in detail based on the delayed stochastic differential equation and the corresponding delay Fokker-Planck equation. The time delays in synthesis reactions and in degradation reactions play a completely opposite role. The time delay in synthesis （degradation） reaction enhances （reduces） the mean first passage time, and tends to reduce （enhance） the signal-to-noise ratio. Finally, the effect of Causs-distributed time delays on the transcriptional system is explored to test whether the previous approximation of employing a certain delay time works well or not.

关键词： in is of on

Real-space observation of individual skyrmions in helimagnetic nanostripes

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chinese Physics B 2015年第12期24卷 186-197页

作者：金驰名杜海峰 High Magnetic Field Laboratory Chinese Academy of Sciences(CAS) Collaborative innovation Center of Advanced Microstructures Nanjing University School of Physical Science University of Science and Technology of China

Controllable formation and manipulation of domain walls in one-dimensional（1D） nanostripes underpins a promising type of emergent spintronic device. Magnetic skyrmion is topologically stable whirlpool-like spin texture and is expected to replace familiar domain wall phenomena to build such devices, owing to its prominent features including small size,topological stability and the small critical current required to move it. It is thus essential to understand skyrmions＇ properties in such a nanostructured element. In this paper, we mainly give fundamental insight into this issue. Experimental achievements in the formation and stability of individual skyrmions in the nanostripe are outlined in detail.

关键词： magnetic devices magnetic nanostructures

In-situ formation of layer-like Ag_(2)MoO_(4)induced by high-temperature oxidation and its effect on the self-lubricating properties of NiCoCrAlYTa/Ag/Mo coatings

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Journal of Materials Science & Technology 2021年第16期75卷 164-173页

作者： Enkang Hao Yulong An Jie Chen Xiaoqin Zhao Guoliang Hou Jianmin Chen Meizhen Gao Fengyuan Yan State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China China academy of Ordnance Science Ningbo Branch Ningbo 315103China Key Lab for Magnetism and Magnetic Materials of MOE School of Physical Science and TechnologyLanzhou UniversityLanzhou 730000China

Ag-Mo-O ternary oxide has attracted growing attention because of its potential as a solid lubricant at high *** work designs and prepares NiCoCrAlYTa/Ag/Mo composite coating,performed using high velocity oxy-fuel(HVOF)spraying *** environment temperature plays an important role in the microstructure and phases as well as lubricant properties of NiCoCrAlYTa/Ag/Mo *** the environment temperature is above 600℃,the outer diffusion and oxidation of Ag and Mo lead to the formation of Ag2 MoO4 on the coating ***-like Ag2 MoO4 could form a continuous lubricant film at 800℃and consequently let the composite coating present the best tribological ***,a small number of hard particles could play a good bearing role during friction and improve the tribological properties of the composite coating.

关键词： Microstructure evolution In-situ formation Ag_(2)MoO_(4) Layer-like structure High-temperature friction

Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer

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Science Bulletin 2019年第2期64卷 91-100页

作者： Tianqun Lang Xinyue Dong Zhong Zheng Yiran Liu Guanru Wang Qi Yin Yaping Li State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences Nano Science and Technology Institute University of Science and Technology of China College of Life sciences Jilin University School of Pharmacy Yantai University

Efficient tumor-targeting drug delivery systems are urgently needed for treating metastatic breast *** this work, a docetaxel(DTX)-loaded micelle(pDM) as the tumor-microenvironment-responsive delivery platform is developed. The micelle is composed of a pH-sensitive amphiphilic copolymer,poly((1,4-butanediol)-diacrylate-b-N,N-diisopropylethylenediamine)-polyethyleneimine(BD-PEI), and a matrix metalloproteinase(MMP)-responsive polymer, poly((1,4-butanediol)-diacrylate-b-N,N-diisopropy lethylenediamine)-peptide-polyethylene glycol(PEG)(BD-peptide-PEG). The PEG block of BD-peptidePEG will be split by MMPs at the tumor microenvironment, which leads to the change of the surface charge and particle size of the micelle to more positive and smaller one. Owing to this transformation and enhanced permeability and retention(EPR) effect, pDM delivers more DTX into tumor tissues and is internalized more efficiently by tumor cells than the non-MMP-sensitive micelles in the 4 T1 tumorbearing mice model. In addition, DTX is released in acidic endo/lysosomes due to the dissociation of the micelle, triggered by the protonation of the hydrophobic block of BD-PEI. As a result, the DTX-loaded micelle inhibits primary tumor growth and pulmonary metastasis effectively. Thus, this pH/MMP-dual-sensitive drug delivery system, which simultaneously attains three keypoints: prolonged circulation time, directional and efficient uptake into tumor cells, and speedy intracellular drug release, is a promising strategy for metastatic breast cancer therapy.

关键词： Breast cancer Dual-sensitive micelle Metastasis Tumor-targeting

Synergistic modulation of spin and fluorescence signals in a nano-Saturn assembled by a metallofullerene and cycloparaphenylene nanohoop

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Nano Research 2023年第2期16卷 3372-3378页

作者： Jie Zhang Zhenlin Qiu Chong Zhao Yuxi Lu Wang Li Linshan Liu Chunru Wang Yuanzhi Tan Taishan Wang Beijing National Laboratory for Molecular sciences Key Laboratory of Molecular Nanostructure and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materialsand Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China University of chinese academy of sciences Beijing 100049China School of Pharmacy Guizhou Medical UniversityGuiyang 550025China

Spin-based interdisciplinary research has attracted considerable attention,and various applications in magnetic memory,quantum science,and precision measuring technology have been *** this study,we induced a fluorescence property in a spin-active molecule by supramolecular assembly and realized a synergistic modulation of its spin and fluorescence properties.A Saturn-shaped supramolecular complex was synthesized using a spin-active metallofullerene Sc_(3)C_(2)@C80 with a fluorescent nanohoop of tetra-benzothiadiazole-based[12]cycloparaphenylene(TB[12]CPP),and its spin and fluorescence properties were comprehensively ***-dependent electron paramagnetic resonance(EPR)spectroscopy and fluorescence analyses were *** changes in the EPR signals and fluorescence peaks were discovered in the temperature range of 170–290 *** on nuclear magnetic resonance observations and theoretical calculations,a temperature-dependent host–guest interaction between Sc_(3)C_(2)@C_(80)and a nanohoop was demonstrated,which explained the synchronous changes in the EPR signals and fluorescence peaks for Sc_(3)C_(2)@C_(80)⊂TB[12]*** application of Sc_(3)C_(2)@C_(80)as a molecular spin system to probe the host–guest interaction was also *** results show that the supramolecular assembly can be used to design advanced spin systems coupled with optical and magnetic behaviors based on paramagnetic and luminescent molecules.

关键词： metallofullerene nanohoop electron spin fluorescence host–guest interaction

Carbonaceous aerogel and CoNiAl-LDH@CA nanocomposites derived from biomass for high performance pseudo-supercapacitor

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Science Bulletin 2017年第12期62卷 841-845页

作者： Sidi Zhang Jian Liu Peipei Huang Hao Wang Changyan Cao Weiguo Song Beijing National Laboratory for Molecular sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of chinese academy of sciences Beijing 100049China The academy of Military Economics Student Brigade Wuhan 430035China

Conversion of waste biomass to valuable carbonaceous material is a sustainable and environmental benign method for energy and reduction of greenhouse gas emission. Herein, a two-step hydrothermal method was developed to fabricate high performance electrode material from pomelo peels. In the first step, the pomelo peels were transformed to carbonaceous aerogel （CA）, which constructed of three- dimensional, sponge-like brown monolith with hierarchical pores, low-density （0.032 g]cm3） and excel- lent mechanical flexibility. Then, the cobalt nickel aluminum layered double hydroxide （CoNiAI-LDH） was in situ loaded on the surface of CA to form exquisite core-shell structure （CoNiAI-LDH@CA） through the second hydrothermal step. When used as an electrode material for supercapacitor, CoNiA1-LDHOCA exhibited high specific capacitances of 1,134F/g at 1A/g and 902Fig at 10A/g, respectively. Furthermore, they displayed an excellent cycling stability without an obvious capacitance decrease after 4,000 cycles.

关键词： BiomassCarbonaceous aerogelLayered double hydroxideSupercapacitor

Review on synergistic damage effect of irradiation and corrosion on reactor structural alloys

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Nuclear Science and Techniques 2024年第3期35卷 109-141页

作者： Hui Liu Guan-Hong Lei He-Fei Huang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The synergistic damage effect of irradiation and corrosion of reactor structural materials has been a prominent research *** paper provides a comprehensive review of the synergistic effects on the third-and fourth-generation fission nuclear energy structural materials used in pressurized water reactors and molten salt *** competitive mechanisms of multiple influencing factors,such as the irradiation dose,corrosion type,and environmental temperature,are summarized in this *** approaches are proposed to alleviate the synergistic damage caused by irradiation and corrosion,thereby promoting in-depth research in the future and solving this key challenge for the structural materials used in reactors.

关键词： Irradiation and corrosion Synergistic effect Austenitic stainless steels Nickel-based alloys Reactors

The endo-beta mannase MAN7 contributes to cadmium tolerance by modulating root cell wall binding capacity in Arabidopsis thaliana

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Journal of Integrative Plant Biology 2023年第7期65卷 1670-1686页

作者： Qi Wu Yu Ting Meng Zhi Hang Feng Ren Fang Shen Xiao Fang Zhu State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese academy of sciences Beijing 100049China College of Environmental and Resource sciences Zhejiang UniversityHangzhou 310058China

The heavy metal cadmium(Cd) is detrimental to crop growth and threatens human health through the food chain. To cope with Cd toxicity,plants employ multiple strategies to decrease Cd uptake and its root-to-shoot translocation. However, genes that participate in the Cd-induced transcriptional regulatory network, including those encoding transcription factors, remain largely unidentified. In this study, we demonstrate that ENDO-BETA-MANNASE 7(MAN7) is necessary for the response of Arabidopsis thaliana to toxic Cd levels. We show that MAN7 is responsible for mannase activity and modulates mannose content in the cell wall, which plays a role in Cd compartmentalization in the cell wall under Cd toxicity conditions. Additionally,the repression of root growth by Cd was partially reversed via exogenous application of mannose,suggesting that MAN7-mediated cell wall Cd redistribution depends on the mannose ***, we identified a basic leucine zipper(bZIP) transcription factor, bZIP44, that acts upstream of MAN7 in response to Cd *** dual-luciferase assays indicated that bZIP44 directly binds to the MAN7 promoter region and activates its transcription. Loss of bZIP44 function was associated with greater sensitivity to Cd treatment and higher accumulation of the heavy metal in roots and ***, MAN7 overexpression relieved the inhibition of root elongation seen in the bzip44mutant under Cd toxicity conditions. This study thus reveals a pathway showing that MAN7-associated Cd tolerance in Arabidopsis is controlled by bZIP44 upon Cd exposure.

关键词： Arabidopsis thaliana bZIP44 cadmium cell wall MAN7 mannose

Microstructure characteristics of segregation zone in 17-4PH stainless steel piston rod

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Journal of Iron and Steel Research International 2017年第7期24卷 718-723页

作者： Jia-long Tian Wei Wang Wei Yan Zhou-hua Jiang Yi-yin Shan Ke Yang School of Materials and Metallurgy Northeastern University Institute of Metal Research Chinese Academy of Sciences Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of Sciences

The segregation of Cu and Ni in a 17-4PH stainless steel piston rod has been confirmed to be responsible for the cracking after heat *** investigation showed that the segregation zone was composed of three layers,namely the fine grain martensitic layer,the coarse grain martensitic layer and the coarse grain austenitic layer from the matrix to the crack *** button ingots with the same chemical compositions as those three layers have been prepared to evaluate the grain size distribution,microstructure and mechanical *** effects of Cu and Ni segregation on the microstructures of those three layers have been explored by thermodynamic *** on the microstructure and mechanical properties results,an intensive understanding of the cracking in the segregation zone was therefore reached.

关键词： 17-4PH stainless steel Piston rod Segregation Thermodynamic calculation Crack