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Next generation of neurological therapeutics:Native and bioengineered extracellular vesicles derived from stem cells

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Asian Journal of Pharmaceutical Sciences 2022年第6期17卷 779-797页

作者： Shilin Jin Zhongyue Lv Lin Kang Jiayi Wang Chengcheng Tan Liming Shen Liang Wang Jing Liu Stem Cell Clinical Research Center National Joint Engineering LaboratoryThe First Affiliated Hospital of Dalian Medical UniversityDalian 116011China liaoning Key Laboratory of Frontier Technology of Stem Cell and Precision Medicine Dalian Engineering Research Center for Genetic Variation Detection of Infectious Pathogenic MicroorganismsDalian Innovation Institute of Stem Cell and Precision MedicineDalian 116085China

Extracellular vesicles(EVs)-based cell-free therapy,particularly stem cell-derived extracellular vesicles(SC-EVs),offers new insights into treating a series of neurological disorders and becomes a promising candidate for alternative stem cell regenerative ***,SC-EVs are considered direct therapeutic agents by themselves and/or dynamic delivery systems as they have a similar regenerative capacity of stem cells to promote neurogenesis and can easily load many functional small molecules to recipient cells in the central nervous ***,as non-living entities,SC-EVs avoid the uncontrollability and manufacturability limitations of live stem cell products in vivo(e.g.,low survival rate,immune response,and tumorigenicity)and in vitro(e.g.,restricted sources,complex preparation processes,poor quality control,low storage,shipping instability,and ethical controversy)by strict quality control ***,SC-EVs can be engineered or designed to enhance further overall yield,increase bioactivity,improve targeting,and extend their ***,this review provides an overview on the biological properties of SC-EVs,and the current progress in the strategies of native or bioengineered SC-EVs for nerve injury repairing is *** we further summarize the challenges of recent research and perspectives for successful clinical application to advance SC-EVs from bench to bedside in neurological diseases.

关键词： Extracellular vesicles Stem cells Neurological disease Exosomes Bioengineer

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Understanding the Separations of Oil/Water Mixtures from Immiscible to Emulsions on Super-wettable Surfaces

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Journal of Bionic Engineering 2016年第1期13卷 1-29页

作者： Hai Zhu Zhiguang Guo Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei University Wuhan 430062 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China

As the frequent oil spill accidents happens and large quantities of oily wastewater from all kinds of industries are being discharged, the environment has been seriously polluted and our living areas have been horribly threatened. To deal with these issues, attentions have been aroused on the treatments of the oily wastewater. Recently, numerous superwettable materials have been fabricated. In this review, we summarize the new development of the materials for the separation of oil/water mixtures, mainly including the immiscible and emulsified mixtures. For the separation of immiscible ones, special materials with fixed wettability are firstly detailed, where three types of materials can be classified based on their wettability, i.e. superhydrophobic and superoleophilic materials, superhydrophilic and underwater superoleophobic materials, and superhydrophilic and su- peroleophobic materials. Then, the smart materials with switchable wettabilities responsive to external stimulus, for instance, light, solvent, pH, temperature, and electrical potential, are presented. Meanwhile, the single, dual, and multiple stimu- lus-responsive materials are also described. As for the separation of emulsified oil/water mixtures, the materials for the sepa- ration of water-in-oil （W/O）, oil-in-water （O/W）, and both water-in-oil （W/O） and oil-in-water （O/W） emulsions are sequen- tially introduced. Finally, some challenges are discussed and the outlook in this filed is proposed.

关键词： superwettable immiscible mixtures emulsified mixtures separation materials

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Bismuth-Based Free-Standing Electrodes for Ambient-Condition Ammonia Production in Neutral Media

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Nano-Micro Letters 2020年第10期12卷 164-175页

作者： Ying Sun Zizhao Deng Xi‑Ming Song Hui Li Zihang Huang Qin Zhao Daming Feng Wei Zhang Zhaoqing Liu Tianyi Ma Institute of Clean Energy Chemistry Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced MaterialsCollege of ChemistryLiaoning UniversityShenyang 110036People’s Republic of China Discipline of Chemistry University of NewcastleCallaghanNSW 2308Australia Key Laboratory for Green Synthesis and Preparative Chemistry of Advanced Materials College of ChemistryLiaoning UniversityShenyang 110036People’s Republic of China School of Chemistry and Chemical Engineering Guangzhou Key Laboratory for Environmentally Functional Materials and TechnologyGuangzhou UniversityGuangzhou 510006People’s Republic of China

Electrocatalytic nitrogen reduction reaction is a carbon-free and energy-saving strategy for efficient synthesis of ammonia under ambient ***,we report the synthesis of nanosized Bi2O3 particles grown on functionalized exfoliated graphene(Bi2O3/FEG)via a facile electrochemical deposition *** obtained free-standing Bi2O3/FEG achieves a high Faradaic efficiency of 11.2%and a large NH3 yield of 4.21±0.14μgNH3 h^-1 cm^-2 at-0.5 V versus reversible hydrogen electrode in 0.1 M Na2SO4,better than that in the strong acidic and basic *** from its strong interaction of Bi 6p band with the N2p orbitals,binder-free characteristic,and facile electron transfer,Bi2O3/FEG achieves superior catalytic performance and excellent long-term stability as compared with most of the previous reported *** study is significant to design low-cost,high-efficient Bi-based electrocatalysts for electrochemical ammonia synthesis.

关键词： N2 reduction Bi2O3 nanoplate Electrocatalysis Free-standing

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Flexible artificial synapse based on single-crystalline BiFeO_(3) thin film

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Nano Research 2022年第3期15卷 2682-2688页

作者： Zhen Zhao Amr Abdelsamie Rui Guo Shu Shi Jianhui Zhao Weinan Lin Kaixuan Sun Jingjuan Wang Junling Wang Xiaobing Yan Jingsheng Chen Key Laboratory of Brain-like Neuromorphic Devices and Systems of Hebei province College of Electron and Information EngineeringHebei UniversityBaoding 071002China Department of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117576Singapore Department of Physics Southern University of Science and TechnologyShenzhen 518055China

Realization of functional flexible artificial synapse is a significant step toward neuromorphic ***,a flexible artificial synapse based on ferroelectric tunnel junctions(FTJs)is demonstrated,using BiFeO_(3)(BFO)thin film as the functional *** inorganic single crystalline FTJs grown on rigid perovskite substrates at high temperatures are integrated with the flexible plastic substrates,by using the water-soluble Sr_(3)Al_(2)O_(6)(SAO)as the sacrificial layer and the following *** transferred freestanding BFO thin film exhibits excellent ferroelectric ***,the memristive properties and the brain-like synaptic learning performance of the flexible FTJs are *** results show that multilevel resistance states were maintained well of the flexible artificial synapse,together with their stable synaptic learning *** work indicates the promising opportunity of ferroelectric thin film based flexible synapse used in the future neuromorphic computing system.

关键词： flexible ferroelectricity memristor artificial synapse

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Comparison of Two Methods to Assess the Size Structure of Phytoplankton Community Assemblages, in Liaodong Bay, China

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Journal of Ocean University of China 2019年第5期18卷 1207-1215页

作者： SONG Lun WU Jing DU Jing LI Nan WANG Kun WANG Peng State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHaerbin 150090China Key Laboratory of Marine Biological Resources and Ecology liaoning Ocean and Fisheries Science Research Institute Dalian 116023China

Liaodong Bay is one of the largest semi-enclosed bays located in Bohai Sea,in northeast *** is an important feeding and spawning place,even wintering and breeding migration base for many marine *** size structure of phytoplankton communities is a key feature of marine ecosystems and can be used as an indicator for algae disaster,but the methods to evalute is still ***,we compared the size-fractionated chlorophyll-a method with a high-throughout sequencing method in an evaluation of the size structure of phytoplankton assemblages in Liaodong Bay,China,in *** proportion of picophytoplankton was estimated at just 19%according to the results based on size-fractionated chlorophyll-a,which likely represents a severe *** sequencing method confirmed that many kinds of phytoplankton species appeared in more than one size-fractionated filter membrane,with some even dominating where the filter membrane pore size was greater than the individual phytoplankton *** to the sequencing method,the phytoplankton assemblages in Liaodong Bay were dominated by picophytoplankton(average proportion=44%),followed by the nanophytoplankton(average 32%),a composition that is more consistent with other *** sequencing method provides a more robust way to assess the size structure and taxonomic diversity of marine phytoplankton communities.

关键词： size structure chlorophyll-a high-throughout sequencing Liaodong Bay

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Graphene-integrated waveguides:Properties,preparation,and applications

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Nano Research 2022年第11期15卷 9704-9726页

作者： Kaili Chang Zenghui Li Yuzong Gu Kaihui Liu Ke Chen Center for the Physics of Low-Dimensional Materials School of Physics and ElectronicsHenan UniversityKaifeng 475004China State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China

Graphene-integrated waveguides(GIWGs)have shown immense potential for applications in next-generation datacom technology due to graphene’s compactness and its functional complementarity with traditional optical ***,the fabrication techniques of GIWGs lack scalability for commercial *** we discuss the recent developments of GIWGs in two-dimensional optoelectronics by focusing on their properties,wave–matter interaction mechanisms,and fabrication *** highlight representative advances on the advantages and potential applications of GIWGs in telecom ***,we outline major challenges and development trends to bridge the gap between proof-of-concept demonstrations and practical applications.

关键词： graphene waveguide integration process optoelectronics two-dimensional materials

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Interfacial Effects of Superhydrophobic Plant Surfaces： A Review

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Journal of Bionic Engineering 2014年第3期11卷 325-345页

作者： Guiyuan Wang Zhiguang Guo Weimin Liu Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials and Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials Hubei University Wuhan 430062 P. R. China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Lanzhou 730000 P. R. China

Nature is a huge gallery of art involving nearly perfect structures and properties over the millions of years of development. Many plants and animals show water-repellent properties with fine micro-structures, such as lotus leaf, water skipper and wings of butterfly. Inspired by these special surfaces, the artificial superhydrophobic surfaces have attracted wide attention in both basic research and industrial applications. The wetting properties of superhydrophobic surfaces in nature are affected by the chemical compositions and the surface topographies. So it is possible to realize the biomimetic superhydrophobic surfaces by tuning their surface roughness and surface free energy correspondingly. This review briefly introduces the physical-chemical basis of superhydrophobic plant surfaces in nature to explain how the superhydrophobicity of plant surfaces can be applied to different biomimetic functional materials with relevance to technological applications. Then, three classical effects of natural surfaces are classified： lotus effect, salvinia effect, and petal effect, and the promising strategies to fabricate biomimetic su- perhydrophobic materials are highlighted. Finally, the prospects and challenges of this area in the future are proposed.

关键词： interfacial effects superhydrophobicity plant leaves contact angle bionics

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Synthesis of CA_(6)/AlON composite with enhanced slag resistance

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 756-765页

作者： Yunsong Liu Enhui Wang Linchao Xu Tao Yang Zhijun He Tongxiang Liang Xinmei Hou Beijing Advanced Innovation Center for Materials Genome Engineering Collaborative Innovation Center of Steel TechnologyUniversity of Science and Tech-nology BeijingBeijing 10083China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Different amounts of AlON have been introduced in calcium hexaaluminate(CA_(6)) using two approaches, that is, one-step and twostep methods, to improve the slag resistance of CA_(6). A one-step method can directly sinter the mixtures combining Al_(2)O_(3), CaCO_(3), and Al in flowing nitrogen, in which AlON clusters are always formed because of the poor wettability of Al by Al_(2)O_(3), leading to the high porosity of CA_(6)/AlON composite. In a two-step method, CA_(6)and AlON are prepared separately and then mixed and sintered in flowing nitrogen. Compared with the sample prepared by the one-step method, CA_(6)and AlON in composite by the two-step method are more uniformly distributed,and the optimized amount of AlON added is 10wt%. The slag corrosion and penetration test shows that the CA_(6)/AlON composite using the two-step method exhibits superior slag corrosion protection. The promoted effect of AlON on slag penetration and corrosion resistance is also discussed.

关键词： CA_(6)/AlON composite two-step method wettability slag resistance

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Pseudo-gap phase and duality in a holographic fermionic system with dipole coupling on Q-lattice

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Chinese Physics C 2016年第4期40卷 28-33页

作者：凌意刘鹏牛超吴健聘 Institute of High Energy Physics Chinese Academy of Sciences State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Institute of Gravitation and Cosmology Department of Physics School of Mathematics and PhysicsBohai University

We classify the different phases by the “pole-zero mechanism” for a holographic fermionic system which contains a dipole coupling with strength p on a Q-lattice background. A complete phase structure in p space can be depicted in terms of Fermi liquid, non-Fermi liquid, Mott phase and pseudo-gap phase. In particular, we find that in general the region of the pseudo-gap phase in p space is suppressed when the Q-lattice background is dual to a deep insulating phase, while for an anisotropic background, we have an anisotropic region for the pseudo-gap phase in p space as well. In addition, we find that the duality between zeros and poles always exists regardless of whether or not the model is isotropic.

关键词： holographic anisotropic classify dipole duality insulating correspondence Fermi suppressed regardless

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Development and Property Tuning of Refractory High-Entropy Alloys:A Review

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Acta Metallurgica Sinica(English Letters) 2022年第8期35卷 1231-1265页

作者： Xing-Jiang Hua Ping Hu Hai-Rui Xing Jia-Yu Han Song-Wei Ge Shi-Lei Li Chao-Jun He Kuai-She Wang Chun-Juan Cui School of Metallurgy Engineering Xi'an University of Architecture and TechnologyXi'an 710055China National and Local Joint Engineering Research Center for Functional Materials Processing Xi'an University of Architecture and TechnologyXi'an 710055China

In the past decade, multi-principal element high-entropy alloys (referred to as high-entropy alloys, HEAs) are an emerging alloy material, which has been developed rapidly and has become a research hotspot in the fi eld of metal materials. It breaks the alloy design concept of one or two principal elements in traditional alloys. It is composed of five or more principal elements, and the atomic percentage (at.%) of each element is greater than 5%but not more than 35%. The high-entropy eff ect caused by the increase of alloy principal elements makes the crystals easy form body-centered cubic or face-centered cubic structures, and may be accompanied by intergranular compounds and nanocrystals, to achieve solid solution strengthening,precipitation strengthening, and dispersion strengthening. The optimized design of alloy composition can make HEAs exhibit much better than traditional alloys such as high-strength steel, stainless steel, copper-nickel alloy, and nickel-based superalloy in terms of high strength, high hardness, high-temperature oxidation resistance, and corrosion resistance. At present,refractory high-entropy alloys (RHEAs) containing high-melting refractory metal elements have excellent room temperature and high-temperature properties, and their potential high-temperature application value has attracted widespread attention in the high-temperature fi eld. This article reviews the research status and preparation methods of RHEAs and analyzes the microstructure in each system and then summarizes the various properties of RHEAs, including high strength, wear resistance, high-temperature oxidation resistance, corrosion resistance, etc., and the common property tuning methods of RHEAs are explained, and the existing main strengthening and toughening mechanisms of RHEAs are revealed. This knowledge will help the on-demand design of RHEAs, which is a crucial trend in future development. Finally, the development and application prospects of RHEAs are prospected to

关键词： Refractory high-entropy alloys Research status Microstructure Property tuning Strengthening and toughening

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