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Responses of soil microbial communities to manure and biochar in wheat cultivation of a rice-wheat rotation agroecosystem in East China

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Pedosphere 2023年第6期33卷 893-904页

作者： Jun MENG Wenjin LI Yingbo QIU Zhangtao LI Linze LI Yu LUO Haipeng GUO Yijun YU Shengdao SHAN Huaihai CHEN Zhejiang Province Key Laboratory of Recycling and Ecological Treatment of Waste Biomass School of Environmental and Natural ResourcesZhejiang University of Science and TechnologyHangzhou 310023China State Key Laboratory of Biocontrol School of EcologyShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment College of Environmental&Natural Resource SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products Ningbo UniversityNingbo 315211China Arable Soil Quality and Fertilizer Administration Bureau of Zhejiang Province Hangzhou 310020China

Soil contamination in agroecosystems remains a global environmental problem. Biochar has been suggested as an organic amendment to alleviate soil pollution, sequester carbon(C), and improve soil fertility. However, information on how bacterial and fungal communities in acidic bulk and rhizosphere soils respond to swine manure and its biochar is still lacking. In this study, biochar and swine manure were applied at two rates of 1.5 and 3 t ha-1in a rice-wheat rotation field to assess how soil characteristics, especially p H and chemical element availability, correlate to compositional variations of bacteria and fungi in bulk and rhizosphere soils. Our results showed that high rates of biochar and manure promoted the bacterial richness in bulk and rhizosphere soils by increasing soil pH and reducing soil arsenic(As) and copper(Cu) availability. Compared with soil As and Cu availability, soil p H had opposite effects on beta diversity of both the bacterial and fungal communities. Specifically, biochar and swine manure applications stimulated the bacterial classes Gemmatimonadetes, Deltaproteobacteria, and Gammaproteobacteria by increasing soil pH and decreasing soil available chemical elements. Opposite trends were observed in fungal communities responding to biochar and manure. For example, biochar restrained the fungal class Eurotiomycetes by decreasing soil As and Cu availability, but manure inhibited Leotiomycetes mainly because of an increase in soil pH and a decrease in soil dissolved organic C. These suggest that both bacterial and fungal communities respond significantly to biochar and manure amendments in both bulk and rhizosphere soils, possibly because of their sensitive adaptation to variations in soil environmental factors, such as pH level and chemical element availability.

关键词： bacteria chemical element element availability fungi rhizosphere soil dissolved organic C soil pH

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Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma

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Cancer Communications 2019年第1期39卷 634-644页

作者： You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Imaging and Interventional Radiology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nuclear Medicine Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Clinical Trials Center Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the *** nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical *** this study,we examined whether ENPG could be an effective treatment for localized stage I ***:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in sun yat-sen university Cancer ***,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference *** survival outcomes,quality of life(QOL),and medical costs between two groups were ***:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with *** 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused ***,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results.

关键词： Nasopharyngeal carcinoma Localized Early stage Endoscopic nasopharyngectomy Intensity-modulated radiotherapy Survival Medical cost Quality of life

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MicroRNA-34c-5p provokes isoprenaline-induced cardiac hypertrophy by modulating autophagy via targeting ATG4B

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2374-2390页

作者： Yuhong Zhang Yanqing Ding Min Li Jing Yuan Youhui Yu Xueying Bi Huiqi Hong Jiantao Ye Peiqing Liu Department of Pharmacology and Toxicology School of Pharmaceutical SciencesNational and Local United Engineering Lab of Druggability and New Drugs EvaluationSun Yat-sen UniversityGuangzhou 510006China State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510006China

Pathological cardiac hypertrophy serves as a significant foundation for cardiac dysfunction and heart failure. Recently, growing evidence has revealed that microRNAs(miRNAs) play multiple roles in biological processes and participate in cardiovascular diseases. In the present research, we investigate the impact of miRNA-34 c-5 p on cardiac hypertrophy and the mechanism involved. The expression of miR-34 c-5 p was proved to be elevated in heart tissues from isoprenaline(ISO)-infused mice. ISO also promoted miR-34 c-5 p level in primary cultures of neonatal rat cardiomyocytes(NRCMs). Transfection with miR-34 c-5 p mimic enhanced cell surface area and expression levels of foetal-type genes atrial natriuretic factor(Anf) and β-myosin heavy chain(β-Mhc) in NRCMs. In contrast, treatment with miR-34 c-5 p inhibitor attenuated ISO-induced hypertrophic responses. Enforced expression of miR-34 c-5 p by tail intravenous injection of its agomir led to cardiac dysfunction and hypertrophy in mice, whereas inhibiting miR-34 c-5 p by specific antagomir could protect the animals against ISO-triggered hypertrophic abnormalities. Mechanistically, miR-34 c-5 p suppressed autophagic flux in cardiomyocytes, which contributed to the development of hypertrophy. Furthermore, the autophagy-related gene 4 B(ATG4 B) was identified as a direct target of miR-34 c-5 p, and miR-34 c-5 p was certified to interact with 3’untranslated region of Atg4 b mRNA by dual-luciferase reporter assay. miR-34 c-5 p reduced the expression of ATG4 B, thereby resulting in decreased autophagy activity and induction of hypertrophy. Inhibition of miR-34 c-5 p abolished the detrimental effects of ISO by restoring ATG4 B and increasing autophagy. In conclusion, our findings illuminate that miR-34 c-5 p participates in ISO-induced cardiac hypertrophy, at least partly through suppressing ATG4 B and autophagy. It suggests that regulation of miR-34 c-5 p may offer a new way for handling hypertrophy-related cardiac dysfuncti

关键词： Pathological cardiac hypertrophy Isoprenaline miR-34c-5p ATG4B LC3 Autophagy Autophagic flux Neonatal rat cardiomyocytes Mice

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Alpha-2-macroglobulin as a radioprotective agent: a review

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Chinese Journal of Cancer Research 2014年第5期26卷 611-621页

作者： Xueying Chen Xiangbo Kong Zhaoqiang Zhang Wei Chen Jieyu Chen Huanyang Li Wanting Cao Yaping Ge Silian Fang Department of Oral and Maxillofacial Surgery The Sixth Affiliated Hospital of Sun Yat-Sen University Department of Periodontology Sun Yat-Sen Memorial HospitalSun Yat-Sen University Department of Stomatology Zhuhai HospitalGuangdong Provincial Hospital of Traditional Chinese Medical

Radiation is an important modality in cancer treatment, and eighty percent of cancer patients need radiotherapy at some point during their clinical management. However, radiation-induced damage to normal tissues restricts the therapeutic doses of radiation that can be delivered to tumours and thereby limits the effectiveness of the treatment. The use of radioprotectors represents an obvious strategy to obtain better tumour control using a higher dose in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical efficacy owing to their inherent toxicity and high cost. Hence, the development of radioprotective agents with lower toxicity and an extended window of protection has attracted a great deal of attention, and the identification of alternative agents that are less toxic and highly effective is an absolute necessity. Recent studies have shown that alpha-2-macroglobulin（α2M） possesses radioprotective effects. α2M is a tetrameric, disulfide-rich plasma glycoprotein that functions as a nonselective inhibitor of different types of non-specific proteases and as a carrier of cytokines, growth factors, and hormones. α2M induces protein factors whose interplay underlies radioprotection, which supports the idea that α2M is the central effector of natural radioprotection in the rat. Pretreatment with α2M has also induced a significant reduction of irradiation-induced DNA damage and the complete restoration of liver and body weight. Mihailovi？ et al. concluded that the radioprotection provided by α2M was in part mediated through cytoprotection of new blood cells produced in the bone marrow; these authors also indicated that an important aspect of the radioprotective effect of amifostine was the result of the induction of the endogenous cytoprotective capability of α2M. The radioprotective effects of α2M are possibly due to antioxidant, antifibrosis, and anti-inflammatory functions, as well as the maintenance of homeostasis

关键词： Alpha-2-macroglobulin(α 2 M) ionising radiation radioprotection radiation-induced fibrosis mechanism

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Cardiomyocyte electrical-mechanical synchronized model for high-content, dose-quantitative and time-dependent drug assessment

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Microsystems & Nanoengineering 2021年第2期7卷 131-142页

作者： Jiaru Fang Xinwei Wei Hongbo Li Ning Hu Xingxing Liu Dongxin Xu Tao Zhang Hao Wan Ping Wang Xi Xie The First Affiliated Hospital of sun yat-sen university School of Electronics and Information TechnologyGuangdong Province Key Laboratory of Display Material and TechnologySun Yat-sen UniversityGuangzhou510006China Biosensor National Special Laboratory Key Laboratory of Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou310027China State Key Laboratory of Transducer Technology Chinese Academy of SciencesShanghai200050China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou510006China

Cardiovascular diseases have emerged as a significant threat to human ***,drug development is a time-consuming and costly process,and few drugs pass the preclinical assessment of safety and *** existing patch-clamp,Ca2+imaging,and microelectrode array technologies in cardiomyocyte models for drug preclinical screening have suffered from issues of low throughput,limited long-term assessment,or inability to synchronously and correlatively analyze electrical and mechanical ***,we develop a high-content,dose-quantitative and time-dependent drug assessment platform based on an electrical-mechanical synchronized(EMS)biosensing *** microfabricated EMS can record both firing potential(FP)and mechanical beating(MB)signals from cardiomyocytes and extract a variety of characteristic parameters from these two signals(FP–MB)for further *** system was applied to test typical ion channel drugs(lidocaine and isradipine),and the dynamic responses of cardiomyocytes to the tested drugs were recorded and *** high-throughput characteristics of the system can facilitate simultaneous experiments on a large number of ***,a database of various cardiac drugs can be established by heat map analysis for rapid and effective screening of *** EMS biosensing system is highly promising as a powerful tool for the preclinical development of new medicines.

关键词： electrical consuming patch

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High-efciency improved symmetric successive over-relaxation preconditioned conjugate gradient method for solving large-scale finite element linear equations

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Applied Mathematics and Mechanics(English Edition) 2013年第10期34卷 1225-1236页

作者：李根唐春安李连崇 Department of Applied Mechanics and Engineering School of EngineeringSun Yat-sen University Institute for Rock Instability and Seismicity Research School of Civil EngineeringDalian University of Technology

Fast solving large-scale linear equations in the finite element analysis is a classical subject in computational mechanics. It is a key technique in computer aided engineering （CAE） and computer aided manufacturing （CAM）. This paper presents a high-efficiency improved symmetric successive over-relaxation （ISSOR） preconditioned conjugate gradient （PCG） method, which maintains lelism consistent with the original form. Ideally, the by 50% as compared with the original algorithm. the convergence and inherent paralcomputation can It is suitable for be reduced nearly high-performance computing with its inherent basic high-efficiency operations. By comparing with the numerical results, it is shown that the proposed method has the best performance.

关键词： improved preconditioned conjugate gradient (PCG) method conjugate gradient method large-scale linear equation finite element method

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A 2D NiFe Bimetallic Metal–Organic Frameworks for Efficient Oxygen Evolution Electrocatalysis

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Energy & Environmental Materials 2019年第1期2卷 18-21页

作者： Yongchao Hao Qinglin Liu Ying Zhou Zeqian Yuan Yanan Fan Zhuofeng Ke Cheng-Yong Su Guangqin Li MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-Sen UniversityNo.135Xingang Xi RoadGuangzhou 510275China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Materials Science and EngineeringSun Yat-Sen UniversityGuangzhou 510275China

The oxygen evolution reaction(OER) is the cornerstone for many important energy conversion devices, including metal–air battery and water ***, an optimized NiFe-based metal–organic framework is developed as highly efficient active material for OER. It just needs a low overpotential of 0.31 V to deliver a current density of 10 mA cm-2 with a favorable Tafel slope of 43.7 mV dec-1 in 0.1 M KOH electrolyte for the as-prepared Ni0.75Fe0.25 BDC, which is superior to RuO2. This efficient catalytic performance is due to the introduction of Fe in Ni-based MOFs could benefit the kinetics and charge transfer efficiency, resulting in the optimal activity toward OER. Besides, the obtained active material demonstrates good stability, suggesting the great potential value in sustainable electrochemical energy storage and conversion devices.

关键词： iron-doping metal-organic frameworks oxygen evolution reaction two-dimension

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Exploiting the point spread function for optical imaging through a scattering medium based on deconvolution method

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Journal of Innovative Optical Health Sciences 2019年第4期12卷 21-31页

作者： Hexiang He Xiangsheng Xie Yikun Liu Haowen Liang Jianying Zhou School of Physics and Optoelectronic Engineering Foshan university Foshan 528000 P.R.China Department of Physics College of Science Shantou University Shantou 515063P.R.China School of Physics sun yat-sen university Guangzhou 510275 P.R.China

Visual perception of humans penetrating turbid medium is hampered by *** techniques have been prompted recently to recover optical imaging through turbid *** them,speckle correlation based on deconvolution is one of the most attractive methods taking advantage of high imaging quality,robustness,eas-of-use,and *** exploiting the point spread function(PSF)of the scattering system,large Field-of-View,extended Depth-of-Field,noninvasiveness and spectral resoluation are now available as successful solutions for high quality and multifunctional image *** this paper,we review the progress of imaging through a scattering medium based on deconvolution method,including the principle,the breakthrough of the limitation of the optical memory ffect,the improvement of the deconvolution algorithm and innovative applications.

关键词： Speckle correlation deconvolution scattering medium imaging through turbid media

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Visualization of the Oncolytic Alphavirus M1 Life Cycle in Cancer Cells

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Virologica Sinica 2021年第4期36卷 655-666页

作者： Jia Dan Lin Nie Xudong Jia Cuiying Xu Jing Cai Yuan Lin Jun Hu Wenbo Zhu Yinyin Li Dong Chen Ying Liu Cheng Hu Guangmei Yan Jiankai Liang Qinfen Zhang Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China State Key Lab for Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275China Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China Department of Urology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China

Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells,but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain ***,we study the key stages of M1 virus infection and replication in the M1 virus-sensitive HepG2 liver cancer cell line by transmission electron microscopy,specifically examining viral entry,assembly,maturation and *** found that M1 virus induces vacuolization of cancer cells during infection and ultimately nuclear marginalization,a typical indicator of ***,our results suggest that the endoplasmic reticulum participates in the assembly of *** the early and late stage of infection,three kinds of special cytopathic vacuoles are formed and appear to be involved in the replication,maturation and release of the *** together,our data displayed the process of M1 virus infection of tumor cells and provide the structural basis for the study of M1 virus-host interactions.

关键词： Oncolytic virus M1 Alphavirus Electron microscopy Life cycle of virus

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Electrochemical Synthesis and Magnetic Studies of Ni-Fe-Co-Mn-Bi-Tm High Entropy Alloy Film

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Chemical Research in Chinese Universities 2010年第4期26卷 640-644页

作者： YAO Chen-zhong ZHANG Peng TONG Ye-xiang XIA Dao-cheng MA Hui-xuan Key Laboratory of Bioinorganic and Synthetic Chemistry Ministry of Education School of Chemistry and Chemical Engineering Institute of Optoelectronic and Functional Composite Materials Sun Yat-Sen University Guangzhou 510275 P. R. China Department of Applied Chemistry Yuncheng University Yuncheng 041000 P. R. China

Amorphous Ni-Fe-Co-Mn-Bi-Tm high entropy alloy films were firstly prepared by potentiostatic electro- deposition. The results indicate that the six elements can be co-deposited in an organic system of DMF （N,N-dimethylformamide）-CH3CN. The surface of the film is composed of compact and uniform particles with triangular cone shape and a particle size of 100-200 nm. A simple face-centered-cubic structure is identified by XRD patterns after the films were annealed under Ar atmosphere. The annealed alloy film shows soft magnetic properties and the magnetization decreases with Fe content decreasing.

关键词： High entropy alloy Electrodeposition Magnetic property Heat treatment

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