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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 142-148页

作者： Zengfu Ou Jun Wang Jihai Zhang Yukang Ding Shenwei Chen Wenya Zhai Jingcheng Li Dingyong Zhong Donghui Guo School of Physics Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of PhysicsSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China

Open-shell graphene nanostructures(GNs)are promising candidates for future spintronics and quantum *** progress based on on-surface synthetic approach has successfully created such GNs on metallic ***,the doping effect of metallic surfaces is inevitably present and can significantly tune their electronic and magnetic ***,we investigate the zigzag end states of open-shell 7-armchair graphene nanoribbons(7-AGNRs)on Au(111),Au(100)and Ag(111)*** with the manipulation of a scanning tunneling microscope,we demonstrate that the end states can be tuned from empty states to singly occupied states and to doubly occupied states by substrate ***,the singly occupied states can be finely tuned,with the occupancy number of the states and related magnetic behaviors uncovered by experiments at different temperatures and magnetic *** results provide a comprehensive study of the magnetic response of open-shell GNs on metallic surfaces at different doping levels.

关键词： open-shell graphene nanostructures magnetic response metallic substrate doping Kondo resonance scanning tunneling microscopy/spectroscopy

A new autophagy-related nomogram and mechanism in multiple myeloma

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Genes & Diseases 2024年第5期11卷 29-32页

作者： Hanying Huang Yang Li Ziang Zhu Yang Liu Weida Wang Shuzhao Chen Xiaoping Wu Yun Wang Yanzhou Chen Huanxin Lin Yang Liang Lingling Shu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Hematologic Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Key Laboratory of Neurosurgery in Guangdong Province Southern Medical UniversityGuangzhouGuangdong 510060China Department of Neurosurgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510060China State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong Kong 999077China

Multiple myeloma(MM)is the second most common hematological *** is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains *** models or scoring modalities can be used to predict the survival prognosis of MM patients;however,these predictions are still not accurate *** have previously found that scorings related to bone marrow microenvironment metabolism can improve predictive efficacy.

关键词： metabolism prognosis myeloma

BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong Bao Lin Tang Chaoye Wang Chunlei Liu Yukai Wang Yuyan Teng Mohan Zheng Weiping Mu Zhixiang Zuo Yubin Xie Xiaotong Luo Jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

整合素α6靶向自组装促凋亡纳米多肽对中枢神经系统急性淋巴细胞白血病的靶向治疗

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Engineering 2024年第4期35卷 226-240页

作者： Jia-Cong Ye Wan-Qiong Li Mei-Ling Chen Qian-Kun Shi Hua Wang Xin-Ling Li Ying-He Li Jie Yang Qiao-Li Wang Fang Hu Yan-Feng Gao Shu-Wen Liu Mu-Sheng Zeng Guo-Kai Feng Guangdong Provincial Key Laboratory of New Drug Screening&NMPA Key Laboratory of Drug Metabolism Research and Evaluation School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Oncology in South China&Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Biomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of NephrologySouthern Medical UniversityGuangzhou 510515China

There is currently no effective targeted therapeutic strategy for the treatment of central nervous system acute lymphoblastic leukemia(CNS-ALL).Integrinα6 is considered a potential target for CNS-ALL diagnosis and therapy because of its role in promoting CNS-ALL disease *** targeted peptide D(RWYD)(abbreviated RD),with nanomolar affinity to integrinα6 was identified by peptide scanning techniques such as alanine scanning,truncation,and ***,we developed a therapeutic nanoparticle based on the integrinα6-targeted peptide for treating *** self-assembled proapoptotic nanopeptide_(D)(RWYD)-_(D)(KLAKLAK)_(2)-G_(D)(FFY)(abbreviated RD-KLA-Gffy)contains the integrinα6-targeted peptide RD,the well-known proapoptotic peptide_(D)(KLAKLAK)_(2)(abbreviated KLA),and the self-assembling tetrapeptide GD(FFY)(abbreviated Gffy).The functional mechanism of RD-KLA-Gffy is clarified using different *** results demonstrate that RD-KLA-Gffy is highly enriched in CNS-ALL lesions and induces tumor cell apoptosis,thus reducing CNS-ALL disease burden and prolonging the survival of CNS-ALL mice without obvious ***,the combined use of RD-KLA-Gffy and methotrexate(MTX)shows a potent antitumor effect in treating CNS-ALL,indicating that RD-KLA-Gffy plays an important role in suppressing CNS-ALL progression either as a single agent or in combination with MTX,which shows promise for application in CNS-ALL therapy.

关键词： Central nervous system acute lymphoblastic leukemia Integrinα6 Targeted peptide Proapoptotic Nanopeptide

Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 463-471页

作者： Yu Nie Jin-Bo Huang Shu-Jiao He Hua-Di Chen Jun-Jun Jia Jing-Jing Li Xiao-Shun He Qiang Zhao General Surgery Center Department of Hepatobiliary Surgery IIResearch Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China Organ Transplant Center the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology Guangzhou 510080China Guangdong Provincial International Cooperation Base of Science and Technology Guangzhou 510080China Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Primary non-function(PNF) and early allograft failure(EAF) after liver transplantation(LT) seriously affect patient outcomes. In clinical practice, effective prognostic tools for early identifying recipients at high risk of PNF and EAF were urgently needed. Recently, the Model for Early Allograft Function(MEAF), PNF score by King's College(King-PNF) and Balance-and-Risk-Lactate(BAR-Lac) score were developed to assess the risks of PNF and EAF. This study aimed to externally validate and compare the prognostic performance of these three scores for predicting PNF and EAF. Methods: A retrospective study included 720 patients with primary LT between January 2015 and December 2020. MEAF, King-PNF and BAR-Lac scores were compared using receiver operating characteristic(ROC) and the net reclassification improvement(NRI) and integrated discrimination improvement(IDI) analyses. Results: Of all 720 patients, 28(3.9%) developed PNF and 67(9.3%) developed EAF in 3 months. The overall early allograft dysfunction(EAD) rate was 39.0%. The 3-month patient mortality was 8.6% while 1-year graft-failure-free survival was 89.2%. The median MEAF, King-PNF and BAR-Lac scores were 5.0(3.5–6.3),-2.1(-2.6 to-1.2), and 5.0(2.0–11.0), respectively. For predicting PNF, MEAF and King-PNF scores had excellent area under curves(AUCs) of 0.872 and 0.891, superior to BAR-Lac(AUC = 0.830). The NRI and IDI analyses confirmed that King-PNF score had the best performance in predicting PNF while MEAF served as a better predictor of EAD. The EAF risk curve and 1-year graft-failure-free survival curve showed that King-PNF was superior to MEAF and BAR-Lac scores for stratifying the risk of EAF. Conclusions: MEAF, King-PNF and BAR-Lac were validated as practical and effective risk assessment tools of PNF. King-PNF score outperformed MEAF and BAR-Lac in predicting PNF and EAF within 6 months. BAR-Lac score had a huge advantage in the prediction for PNF without post-transplant variables. Proper use

关键词： Primary non-function Early allograft failure Risk predicting model Liver transplantation

PM_(1)颗粒物长期暴露与高血压住院:一项基于中国南方大型社区队列的因果推断研究

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Science Bulletin 2024年第9期69卷 1313-1322页

作者：张昱勤陈世瑞韦晶姜杰林晓王莹郝春吴文静袁柱培孙洁王涵杜志成张王剑郝元涛 Department of Medical Statistics School of Public Health&Center for Health Information Research&Sun Yat-sen Global Health InstituteSun Yat-sen UniversityGuangzhou 510080China Department of Atmospheric and Oceanic Science Earth System Science Interdisciplinary CenterUniversity of MarylandCollege Park 20742USA Department of Epidemiology&Biostatistics School of Public HealthPeking UniversityBeijing 100191China Peking university Center for Public Health and Epidemic Preparedness&Response Peking UniversityBeijing 100191China Key Laboratory of Epidemiology of Major Diseases(Peking university) Ministry of EducationBeijing 100191China

Limited evidence exists on the effect of submicronic particulate matter(PM_(1)) on hypertension hospitalization. Evidence based on causal inference and large cohorts is even more scarce. In 2015, 36,271 participants were enrolled in South China and followed up through 2020. Each participant was assigned single-year, lag0–1, and lag0–2 moving average concentration of PM_(1)and fine inhalable particulate matter(PM2.5) simulated based on satellite data at a 1-km resolution. We used an inverse probability weighting approach to balance confounders and utilized a marginal structural Cox model to evaluate the underlying causal links between PM_(1)exposure and hypertension hospitalization, with PM2.5-hypertension association for comparison. Several sensitivity studies and the analyses of effect modification were also conducted. We found that a higher hospitalization risk from both overall(HR: 1.13, 95% CI:1.05–1.22) and essential hypertension(HR: 1.15, 95% CI: 1.06–1.25) was linked to each 1 μg/m3increase in the yearly average PM_(1)concentration. At lag0–1 and lag0–2, we observed a 17%–21% higher risk of hypertension associated with PM_(1). The effect of PM_(1)was 6%–11% higher compared with PM2.5. Linear concentration-exposure associations between PM_(1)exposure and hypertension were identified, without safety thresholds. Women and participants that engaged in physical exercise exhibited higher susceptibility, with 4%–22% greater risk than their counterparts. This large cohort study identified a detrimental relationship between chronic PM_(1)exposure and hypertension hospitalization, which was more pronounced compared with PM2.5and among certain groups.

关键词： PM_(1) Hypertension Causal inference Large cohort

用于紫外线成像和无线报警的水凝胶基可伸缩、高稳定性和高性能的光电传感器

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Science China Materials 2024年第6期67卷 1926-1937页

作者：洪杰钊姚帝杰王浩丁琼玲罗艺冰于家豪张鹤曾令兴杨柏儒王冰陶凯吴进 State Key Laboratory of Optoelectronic Materials and Technologies and Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical university in Shenzhen Northwestern Polytechnical UniversityShenzhen 518063China State Key Laboratory of Transducer Technology Shanghai 200050China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing National Engineering Research Center of Novel Equipment for Polymer ProcessingKey Laboratory of Polymer Processing Engineering(SCUT)Ministry of EducationSouth China University of TechnologyGuangzhou 510641China Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Environment and ResourcesFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化... 详细信息

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化铜/碳-水凝胶-氧化锌/碳的新型应变隔离异质结构的本征可拉伸(拉伸应变或弯曲高达150%)紫外线探测器,该探测器具有高灵敏度(开/关比为2100%)、高稳定性(大于4000次循环),以及快速响应和恢复时间(分别为1.5和4 s).值得注意的是,该探测器通过水凝胶桥在氧化铜/碳和氧化锌/碳电极之间引入的p-n结能带结构,以及离子导电水凝胶中I^(-)/I_(3)^(-)的电化学反应机制,显著提高了其载流子效率和紫外线响应强度.本文通过集成传感器与所设计的电路板,进一步开发了一种无线紫外线报警系统,用于紫外线强度超标警报.此外,本文还设计了一种光电传感器阵列,并将其用作视网膜假体,以实现对环境紫外线强度的实时监测和成像.本文基于水凝胶基异质结构为开发可穿戴、可拉伸的光电紫外线传感器单元和成像阵列提供了一种新的可行方法.

关键词： flexible hydrogel sensors stretchable UV sensors UV imaging array optoelectronic sensors wireless alarm

揭示配体拓扑结构对Fe-Nx-C单原子催化剂表面氧还原反应中间体吸附的影响（英文）

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Chinese Journal of Catalysis 2024年第4期59卷 214-224页

作者：吴德贵熊孝根赵中栋宋树芹丁朝斌中山大学化学工程与技术学院中山大学中法核工程与技术学院中山大学材料科学与技术学院

过渡金属单原子氮掺杂碳催化剂（TM-N-CSAC）因其更高的金属原子效率而被认为是提升氧还原反应（ORR）效率的重要途径.TM-N-CSAC反应中心的活性与配体结构密切相关,构建基于配体结构的ORR活性描述符是高效设计高催化活性单原子催化剂的... 详细信息

过渡金属单原子氮掺杂碳催化剂（TM-N-CSAC）因其更高的金属原子效率而被认为是提升氧还原反应（ORR）效率的重要途径.TM-N-CSAC反应中心的活性与配体结构密切相关,构建基于配体结构的ORR活性描述符是高效设计高催化活性单原子催化剂的关键.然而目前大多配体描述符基于催化剂的综合表观性质,如OH吸附能和金属中心d带中心等,其获取仍需进行额外计算,不利于通过配体结构快速推测反应活性;而目前基于配体结构拓扑参数,如金属中心原子及其配位原子属性、数量等设计的描述符存在对催化活性的描述较差或仅适用于特定配体等问题.解决该难题的关键在于理清OH与TM-N-C SAC成键的微观机制.本文全面考察了ORR中间体OH在21种具有不同氮原子数量、位置以及不同配体尺寸的卟啉型FeNxC SAC表面上的吸附机制.对有限尺寸卟啉型Fe-Nx-C （x=0-4）SAC模型上OH吸附的密度泛函理论计算结果表明, OH吸附能与SAC的配位氮原子的数量并不线性相关,且受氮原子排布方式的影响.利用能量分解分析（EDA）将OH与SAC的成键作用分解,重点讨论氮的掺入对静电作用、泡利排斥作用和轨道作用的影响.针对静电作用, Bader分析与电荷密度差值分析结果表明,氮的掺入一方面将电荷向配位原子上聚集,且配位原子上电荷数随氮原子数量增加而线性增加;另一方面大幅增强铁-配体键（Fe-L）的离子性,减少铁与配体间的电子密度,提高铁中心电子能量,并从而改变静电作用能量.对于泡利排斥作用,其影响因素与静电作用类似,因而作用强度与静电作用强度呈较好线性关系.对于轨道作用,结合扩展过渡态-化学价的自然轨道（ETS-NOCV）和电子定域化（LOL-π）等综合分析发现,氮原子的掺入破坏了配体的离域π键,从而影响OH与配体的轨道在成键时的相互作用.此外,对配体大小影响的研究表明,配体边缘原子仅当出现在包含配位原子的环上时才对OH与SAC成键有较大影响,这充分证明了OH吸附这一过程的局域性.综上,本文提供了Fe-N-C型SAC上完整的OH吸附键形成机制,强调了配位原子及其近邻原子对吸附活性的影响,为构建基于SAC拓扑特征的ORR活性描述符,实现SAC配体的快速筛选提供参考.

关键词：单原子催化剂氧还原反应配体拓扑结构能量分解分析密度泛函理论

用于紫外线成像和无线报警的水凝胶基可伸缩、高稳定性和高性能的光电传感器（英文）

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Science China Materials 2024年

作者：洪杰钊姚帝杰王浩丁琼玲罗艺冰于家豪张鹤曾令兴杨柏儒王冰陶凯吴进 State Key Laboratory of Optoelectronic Materials and Technologies and Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat-sen University State Key Laboratory of Optoelectronic Materials and Technologies and Guangdong Province Key Laboratory of Display Material and Technology School ofElectronics and Information Technology Sun Yat-sen University Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical University Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Environment and Resources Fujian Normal University State Key Laboratory of Transducer Technology Shanghai State Key Laboratory of Polymer Materials Engineering Sichuan University Research & Development Institute of Northwestern Polytechnical university in Shenzhen Northwestern Polytechnical University Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing National Engineering Research Center ofNovel Equipment for Polymer Processing Key Laboratory of Polymer Processing Engineering (SCUT) Ministry of Education South China University of Technology Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing Engineering (SCUT) Ministry of Education South China University ofTechnology

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化...

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化铜/碳-水凝胶-氧化锌/碳的新型应变隔离异质结构的本征可拉伸(拉伸应变或弯曲高达150%)紫外线探测器,该探测器具有高灵敏度(开/关比为2100%)、高稳定性(大于4000次循环),以及快速响应和恢复时间(分别为1.5和4 s).值得注意的是,该探测器通过水凝胶桥在氧化铜/碳和氧化锌/碳电极之间引入的p-n结能带结构,以及离子导电水凝胶中I-/I3-的电化学反应机制,显著提高了其载流子效率和紫外线响应强度.本文通过集成传感器与所设计的电路板,进一步开发了一种无线紫外线报警系统,用于紫外线强度超标警报.此外,本文还设计了一种光电传感器阵列,并将其用作视网膜假体,以实现对环境紫外线强度的实时监测和成像.本文基于水凝胶基异质结构为开发可穿戴、可拉伸的光电紫外线传感器单元和成像阵列提供了一种新的可行方法.

关键词：

Highly efficient and non-doped red conjugated polymer dot for photostable cell imaging

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Chinese Chemical Letters 2023年第6期34卷 387-390页

作者： Mengqi Wu Qidong Wei Caihong Xian Chunlei Dai Xuehan He Changfeng Wu Guoming sun Lei Chen School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Teaching and Experiment Centre Sun Yat-sen UniversityShenzhen 518107China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China College of Chemistry and Environmental Science Hebei UniversityAffiliated Hospital of Hebei UniversityBaoding 071002China

By introducing a naphthothiadiazole(NT)unit as the main building block,a non-doped and red emissive conjugated polymer poly(9,9-dihexylfluorene-alt-naphthothiadiazole)(PFNT)is readily obtained through a two-step *** the NT unit has a large twist angle with its neighboring segment,the aggregation-induced quenching(AIQ)effect of PFNT can be effectively suppressed in the condensed *** a result,the corresponding PFNT polymer dot(Pdot)exhibits a high fluorescence quantum yield of53.2%with peak emission at 616 nm,which is one of the most efficient red Pdots *** Pdot shows good biocompatibility and can be employed for living cell fluorescent imaging with high *** also can be used for specific subcellular organelle imaging through immunofluorescence ***,the PFNT Pdot demonstrates much better photostability for long-time cell fluorescence imaging than commercial red *** high performances of PFNT Pdot make it a promising fluorescent probe for practical bioapplications.

关键词： Conjugated polymer dot Cell imaging Naphthothiadiazole Photostability Non-doped