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A pilot study of radiologic measures of abdominal adiposity:weighty contributors to early pancreatic carcinogenesis worth evaluating?

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Cancer Biology & Medicine 2017年第1期14卷 66-73页

作者： Jennifer B.Permuth Jung W.Choi Dung-Tsa Chen Kun Jiang Gina DeNicola Jian-Nong Li Domenico Coppola Barbara A.Centeno Anthony Magliocco Yoganand Balagurunathan Nipun Merchant Jose G.Trevino Daniel Jeong Departments of Cancer Epidemiology Gastrointestinal Oncology Diagnostic Imaging and Interventional Radiology Biostatistics and Bioinformatics Anatomic Pathology Cancer Imaging and Metabolism Moffitt Cancer Center and Research InstituteTamPa 33612FLUSA Department of Surgery Sylvester Comprehensive Cancer Center at the University of Miami Miller School of MedicineMiami 33136FLUSA Department of Surgery Division of General SurgeryUniversity of Florida Health Sciences CenterGainesville 32611FLUSA

Objective:Intra-abdominal fat is a risk factor for pancreatic cancer(PC),but little is known about its contribution to PC precursors known as intraductal papillary mucinous neoplasms(IPMNs).Our goal was to evaluate quantitative radiologic measures of abdominal/visceral obesity as possible diagnostic markers of IPMN severity/***:In a cohort of 34 surgically-resected,pathologically-confirmed IPMNs(17 benign;17 malignant) with preoperative abdominal computed tomography(CT) images,we calculated body mass index(BMI) and four radiologic measures of obesity:total abdominal fat(TAF) area,visceral fat area(VFA),subcutaneous fat area(SFA),and visceral to subcutaneous fat ratio(V/S).Measures were compared between groups using Wilcoxon two-sample exact tests and other ***:Mean BMI for individuals with malignant IPMNs(28.9 kg/m^2) was higher than mean BMI for those with benign IPMNs(25.8 kg/m^2)(P=0.045).Mean VFA was higher for patients with malignant IPMNs(199.3 cm^2) compared to benign IPMNs(120.4cm^2),P=0.092.V/S was significantly higher(P=0.013) for patients with malignant versus benign IPMNs(1.25 vs.0.69 cm^2),especially among *** accuracy,sensitivity,specificity,and positive and negative predictive value of V/S in predicting malignant IPMN pathology were 74%,71%,76%,75%,and 72%,***:Preliminary findings suggest measures of visceral fat from routine medical images may help predict IPMN pathology,acting as potential noninvasive diagnostic adjuncts for management and targets for intervention that may be more biologically-relevant than *** investigation of gender-specific associations in larger,prospective IPMN cohorts is warranted to validate and expand upon these observations.

关键词： Abdominal obesity pre-malignant lesions pancreatic cancer computed tomography

Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis

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World Journal of Gastroenterology 2016年第17期22卷 4403-4410页

作者： Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of Medicine Suita Osaka 565-0871 Japan Department of Surgery Osaka University Graduate School of Medicine Suita Suita Osaka 565-0871 Japan aMs New Otani Clinic Osaka Osaka 540-8570 Japan Department of Gastroenterology Ogaki Municipal Hospital Ogaki Gifu 503-8502 Japan Department of Gastroenterology and Hepatology Japan Community Health Care Organization Osaka Hospital Osaka Osaka 540-8570 Japan Department of Surgery Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan

AIM: To determine the efficacy of Mac-2 binding protein (Mac-2bp) for diagnosis of chronic ***: Fifty-nine healthy volunteers (HV), 162 patients with chronic pancreatitis (CP), and 94 patients with pancreatic ductal adenocarcinoma (PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer (including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay (carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic (ROC) ***: Serum Mac-2bp levels were significantly increased in CP patients compared to HV (P < 0.0001) and PDAC patients (P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces ***: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population.

关键词： Pancreatic ductal adenocarcinoma Chronic pancreatitis Biomarker Steatopancreatitis Mac-2 binding protein (LGALS3BP)

A Floating Island Treatment System for the Removal of Phosphorus from Surface Waters

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Engineering 2018年第5期4卷 597-609页

作者： Mark T. Brown Treavor Boyer R.J. Sindelar Sam Arden Amar Persaud Sherry Brandt-Williams Department of Environmental Engineering Sciences University of Florida Gainesville FL 32611 USA St. Johns River Water Management District Palatka FL 32177 USA

The goal of this project was to design, build, and test a pilot-scale floating modular treatment system for total phosphorus （TP） removal from nutrient-impaired lakes in central Florida, USA. The treatment sys-tem consisted of biological and physical-chemical treatment modules. First, investigations of prospective biological and physical-chemical treatment processes in mesocosms and in bench-scale experiments were conducted. Thirteen different mesocosms were constructed with a variety of substrates and combi-nations of macrophytes and tested for TP and orthophosphate （PO4-^3） removal efficiencies and potential areal removal rates. Bench-scale jar tests and column tests of seven types of absorptive media in addition to three commercial resins were conducted in order to test absorptive capacity. Once isolated process testing was complete, a floating island treatment system （FITS） was designed and deployed for eight months in a lake in central Florida. Phosphorus removal efficiencies of the mesocosm systems averaged about 40%-50%, providing an average uptake of 5.0 g.m ^2.a ^1 across all mesocosms. The best-performing mesocosms were a submerged aquatic vegetation （SAV） mesocosm and an algae scrubber （AGS）, which removed 20 and 50 mg.m ^2.d ^1, respectively, for an average removal of 5.5 and 12.0 g.m ^2.a ^1 for the SAV and AGS systems, Of the absorptive media, the best performance was alum residual （AR）, which reduced PO4-^3 concentrations by about 75% after 5 min of contact time. Of the commercial resins tested, the PhosX resin was superior to the others, removing about 40% of phosphorus after 30 rain and 60% after 60min. Under baseline operation conditions during deployment, the FITS exhibited mean PO4-^3 removal efficiencies of 53%; using the 50th and 90th percentile of PO4-^3 removal during deployment, and the footprint of the FITS system, yielded efficiencies for the combined FITS system of 56% and 86%, respectively, and areal phosphorus removal rates between 8.9

关键词： Phosphorus removal Lake ecosystem Floating island treatment

Effect of naringenin in Qianggu capsule on population pharmacokinetics in Chinese women with primary osteoporosis

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Journal of Traditional Chinese Medicine 2015年第2期35卷 141-153页

作者： Wang Jiannong Jiang Junjie Xie Yanming Wei Xu Li Jianpeng Duan Jingli Xiong Xin Institute of Basic Medical Sciences Xi Yuan HospitalChina Academy of Chinese Medical Sciences Chinese Clinical Basic Institute China Academy of Chinese Medical Sciences Department of Pharmaceutics Third Hospital Affiliated Peking University

OBJECTIVE:To characterize naringenin(NAR) population pharmacokinetics(PPK) in Chinese women with primary ***:Ninety-eight female patients with primary osteoporosis from the Jingshan,Beixinqiao,Jiaodaokou,Chaoyangmen,and Donghuamen communities in Beijing,China,aged 40 to 80 years,received oral Qianggu capsules(250 mg).Blood samples were collected before and at 0.5,1,2,3,4,6,8,10,12,and 24 h after *** concentration of NAR in the blood samples was measured using high performance liquid chromatography-tandem mass *** analyses were performed with nonlinear mixed-effect modeling software(version 7.1.2,PsN3.2.12).The clearance(C1),central distribution volume(V),absorption rate constant(Ka1),peripheral distribution volume(VII),and inter-compartmental clearance(CLII) were set as parameters and estimated by the base model,covariate model,and final ***-Yang deficiency[Shenyangxu(SYAX)]and liver-kidney-Yin deficiency(Ganshenyinxu) are patterns of symptoms in Traditional Chinese Medicine that were set as covariates,along with age,height,blood urea nitrogen,serum creatinine,alanine transaminase,aspartate transaminase,and *** stepwise forward and backward procedures were accomplished to build *** final model was evaluated by internal and external validation,visual predictive check,bootstrap,and leverage ***:A one compartment open model with first order degradation was the best fitted to the concentration-time profiles following oral administration of *** mean of population parameters of the final model,C1,SYAX on C1,V,Ka1,CLII,and VII,were measured to be 37.6 L/h,0.427 L,123 L/h,0.12/h,0.3056,and 1.446,***-individual variability was estimated and SYAX was identified as a significant ***:The population pharmacokinetic model described in this study could effectively characterize the pharmacokinetic profile of NAR following administration of a single dose of o

关键词： Naringenin Pharmacokinetics Medicine Chinese traditional Qianggu capsule total flavonoids of Drynaria fortunei

Metamaterial-enhanced near-field readout platform for passive microsensor tags

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Microsystems & Nanoengineering 2022年第2期8卷 203-215页

作者： Ke Wu Guangwu Duan Xiaoguang Zhao Chunxu Chen Stephan William Anderson Xin Zhang Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Photonics Center Boston UniversityBostonMA 02215USA Department of Radiology Boston University Medical CampusBostonMA 02118USA

Radiofrequency identification(RFID),particularly passive RFID,is extensively employed in industrial applications to track and trace products,assets,and material *** ongoing trend toward increasingly miniaturized RFID sensor tags is likely to continue as technology advances,although miniaturization presents a challenge with regard to the communication coverage ***,efforts in applying metamaterials in RFID technology to increase power transfer efficiency through their unique capacity for electromagnetic wave manipulation have been *** particular,metamaterials are being increasingly applied in far-field RFID system ***,we report the development of a magnetic metamaterial and local field enhancement package enabling a marked boost in near-field magnetic strength,ultimately yielding a dramatic increase in the power transfer efficiency between reader and tag *** application of the proposed magnetic metamaterial and local field enhancement package to near-field RFID technology,by offering high power transfer efficiency and a larger communication coverage area,yields new opportunities in the rapidly emerging Internet of Things(loT)era.

关键词： passive offering yielding

Co-promoted Mo-carbide catalytic system for sustainable manufacturing of chemicals via co-processing of CO_(2) with ethane

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Green Carbon 2023年第1期1卷 94-103页

作者： Vera Bikbaeva Nikolay Nesterenko Nuria García-Moncada Valentin Valtchev Laboratoire Catalyse et Spectrochimie ENSICAENUniversitéde CaenCNRS6 Boulevard Maréchal Juin14050 CaenFrance Servicios Generales de Investigación XPSCentro de InvestigaciónTecnología e Innovación de la Universidad de Sevilla(CITIUS)Av.Reina Mercedes 4B41012SevillaSpain

The study reports progress in developing a molybdenum carbide-based catalyst for co-processing ethane and CO_(2).The cobalt promoting of molybdenum carbide improved the activity and stability of ethane transformation in the presence of CO_(2) substantially without any impact on ethylene *** Mo-Co supported catalyst also showed interesting performance in catalyzing ethane dry reforming and that application could be a perspective further use for this *** addition,the comprehensive analysis of mono-and bi-metallic catalysts revealed that Co-promoting prevented rapid Mo-carbide ***,tuning operation conditions allowed to control catalyst’s selectivity and maximize CO_(2) utilization or ethylene formation.

关键词： CO_(2)utilization Oxidative dehydrogenation CO_(2)negative ethylene production Cobalt-molybdenum synergy Embryonic zeolite

Extracellular RNAs as potential biomarkers for cancer

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 364-381页

作者： Christine Happel Aniruddha Ganguly Danilo A.Tagle National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Cancer Diagnosis Program Division of Cancer Treatment and DiagnosisNational Cancer Institute at the National Institutes of HealthBethesdaMD 20892USA

The discovery that all cells secrete extracellular vesicles(EVs)to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular *** are widely distributed in many body fluids,including blood,cerebrospinal fluid,urine and *** are nano-sized EVs of endosomal origin that regulate many pathophysiological processes including immune responses,inflammation,tumour growth,and *** individuals release exosomes with a cargo of different RNA,DNA,and protein contents into the circulation,which can be measured non-invasively as biomarkers of healthy and diseased ***-derived exosomes carry a unique set of DNA,RNA,protein and lipid reflecting the stage of tumour progression,and may serve as diagnostic and prognostic biomarkers for various ***,many gaps in knowledge and technical challenges in EVs and extracellular RNA(exRNA)biology,such as mechanisms of EV biogenesis and uptake,exRNA cargo selection,and exRNA detection *** NIH Common Fund-supported exRNA Communication Consortium was launched in 2013 to address major scientific challenges in this *** review focuses on scientific highlights in biomarker discovery of exosome-based exRNA in cancer and its possible clinical application as cancer biomarkers.

关键词： Extracellular vesicles exosomes extracellular RNA cancer biomarker liquid biopsy

A parametric study of the hydrodynamic roughness produced by a wall coating layer of heavy oil

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Petroleum Science 2017年第1期14卷 155-166页

作者： S. Rushd R. S. Sanders Department of Chemical and Materials Engineering University of Alberta Edmonton AB Canada

In water-lubricated pipeline transportation of heavy oil and bitumen, a thin oil film typically coats the pipe wall. A detailed study of the hydrodynamic effects of this fouling layer is critical to the design and operation of oil-water pipelines, as it can increase the pipeline pressure loss （and pumping power requirements） by 15 times or more. In this study, a parametric investigation of the hydrodynamic effects caused by the wall coating of viscous oil was conducted. A custom-built rectangular flow cell was used. A validated CFD-based procedure was used to determine the hydrodynamic roughness from the measured pressure losses. A similar procedure was followed for a set of pipe loop tests. The effects of the thickness of the oil coating layer, the oil viscosity, and water flow rate on the hydrodynamic roughness were evaluated. Oil viscosities from 3 to 21300 Pa s were tested. The results show that the equivalent hydrodynamic roughness produced by a wall coating layer of viscous oil is dependent on the coating thickness but essentially independent of oil viscosity. A new correlation was developed using these data to predict the hydrodynamic roughness for flow conditions in which a viscous oil coating is produced on the pipe wall.

关键词： Pipeline transportation - Heavy oil Wallfouling Lubricated pipe flow CFD simulation

Yielding behavior of triplex medium Mn steel alternated with cooling strategies altering martensite/ferrite interfacial feature

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Journal of Materials Science & Technology 2022年第31期126卷 60-70页

作者： Bin Hu Xiao Shen Qinyi Guo Qinghua Wen Xin Tu Cancan Ding Fanglin Ding Wenwen Song Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Steel Institute RWTH Aachen UniversityIntzestraße 152072 AachenGermany

In this paper, we report the influence of cooling processes on the yielding behavior of a medium Mn steel(MMS) with triplex microstructure, i.e. austenite(γ), ferrite(α) and as-quenched martensite(α’). After the intercritical annealing(IA) at both 725℃ and 750℃, the steel was subjected to the two cooling processes, i.e. air cooling(AC) and water quenching(WQ). It exhibits the discontinuous yielding after the AC following the IA at 750℃ while the continuous yielding after the WQ. Compared with WQ process,both the dilatometry and the microstructural examinations show that the AC process leads to lower Ms temperature, larger retained austenite(RA) fraction and less martensite, the latter is always companied with geometry necessary dislocations(GNDs) generated near the α/α’ interfaces. Considering the complexity of nanosized tri-phases in this steel, the presence of martensite with key features in the resultant specimens was systematically examined by atom probe tomography(APT) on the samples prepared by the specific target lift-out method. The APT results directly revealed the C/Mn co-segregation at the α’/αinterfaces in the AC samples but not in WQ samples. The numerical simulation results further suggest that the segregation of C and Mn at the α’/α interfaces may be due to different mechanisms. We conclude that the yielding of triplex MMS is determined by both the quantity of GNDs generated near theα/α’ interfaces, which increases with martensite fraction, and the extent of their immobilization resulting from the interfacial segregation of solute atoms when the presence of martensite is sufficient. WQ tends to suppress the discontinuous yielding of MMS since the rapid cooling may promote more martensite formed with the increasing quantity of GNDs and prevent the interfacial segregation of both C and Mn.

关键词： Triplex medium Mn steel Phase boundary Segregation Discontinuous yielding