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“Mutation blacklist”and “mutation whitelist”of SARS-CoV-2

Journal of Biosafety and Biosecurity 2022年第2期4卷 114-120页

作者： Yamin Sun Min Wang Wenchao Lin Wei Dong Jianguo Xu Research Institute of Public Health Nankai UniversityTianjinPR China Research Center for Functional Genomics and Biochip TianjinPR China State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 202206PR China TEDA Institute of Biological sciences and Biotechnology Nankai UniversityPR China Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730PR China

Over the past two years,scientists throughout the world have completed more than 6 million SARS-CoV-2 genome ***,the number of SARS-CoV-2 genomes exceeds the total number of all other viral *** genomes are a record of the evolution of SARS-CoV-2 in the human host,and provide information on the emergence of *** this study,analysis of these sequenced genomes identified 296,728 de novo mutations(DNMs),and found that six types of base substitutions reached saturation in the sequenced genome *** on this analysis,a“mutation blacklist”of SARS-CoV-2 was *** loci on the“mutation blacklist”are highly conserved,and these mutations likely have detrimental effects on virus survival,replication,and *** information is valuable for SARS-CoV-2 research on gene function,vaccine design,and drug *** association analysis of DNMs and viral transmission rates,we identified 185 DNMs that positively correlated with the SARS-CoV-2 transmission rate,and these DNMs where classified as the“mutation whitelist”of *** mutations on the“mutation whitelist”are beneficial for SARS-CoV-2 transmission and could therefore be used to evaluate the transmissibility of new *** occurrence of mutations and the evolution of viruses are dynamic *** more effectively monitor the mutations and variants of SARS-CoV-2,we built a SARS-CoV-2 mutation and variant monitoring and pre-warning system(MVMPS),which can monitor the occurrence and development of mutations and variants of SARSCoV-2,as well as provide pre-warning for the prevention and control of SARS-CoV-2(https://***/).Additionally,this system could be used in real-time to update the“mutation whitelist”and“mutation blacklist”of SARS-CoV-2.

关键词： SARS-CoV-2 Mutation saturation De novo mutations Transmission

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Massive‐scale genomic analysis reveals SARS‐CoV‐2 mutation characteristics and evolutionary trends

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mLife 2022年第3期1卷 311-322页

作者： Yamin Sun Min Wang Wenchao Lin Wei Dong Jianguo Xu Research Institute of Public Health Nankai UniversityTianjinChina TEDA Institute of Biological sciences and Biotechnology Nankai UniversityTianjinChina Engineering and Research Center for Microbial Functional Genomics and Detection Ministry of EducationNankai UniversityTianjinChina State Key Laboratory for Infectious Disease Prevention and Control Chinese Center for Disease Control and PreventionNational Institute for Communicable Disease Control and PreventionBeijingChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijingChina

The severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)pandemic resulted in significant societal ***,an in‐depth understanding of SARS‐CoV‐2 virus mutation and its evolution will help determine the direction of the COVID‐19 *** this study,we identified 296,728 de novo mutations in more than 2,800,000 high‐quality SARS‐CoV‐2 *** possible factors affecting the mutation frequency of SARS‐CoV‐2 in human hosts were analyzed,including zinc finger antiviral proteins,sequence context,amino acid change,and translation *** a result,we proposed that when adenine(A)and tyrosine(T)bases are in the context of AM(M stands for adenine or cytosine)or TA motif,A or T base has lower mutation ***,we hypothesized that translation efficiency can affect the mutation frequency of the third position of the codon by the selection,which explains why SARS‐CoV‐2 prefers AT3 codons *** addition,we found a host‐specific asymmetric dinucleotide mutation frequency in the SARS‐CoV‐2 genome,which provides a new basis for determining the origin of the SARS‐CoV‐***,we summarize all possible factors affecting mutation frequency and provide insights into the mutation characteristics and evolutionary trends of SARS‐CoV‐2.

关键词： de novo mutation evolutionary trends mutation characteristics mutation frequency SARS‐CoV‐2

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基于实时自适应控制的大动态范围CIS(英文)

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天津大学学报 2006年第B6期39卷 232-237页

作者：胡燕翔姚素英徐江涛天津大学专用集成电路设计中心天津300072

多次采样组合是扩大CIS动态范围的有效方法,但实时实现尚未达到使用的程度．针对实时在片控制提出一种多次采样组合的VLSI实现方法．通过获取加权像素光强平均值以及饱和像素数目和严重欠曝光像素的数目来确定CIS的采样方式．采样多帧... 详细信息

多次采样组合是扩大CIS动态范围的有效方法,但实时实现尚未达到使用的程度．针对实时在片控制提出一种多次采样组合的VLSI实现方法．通过获取加权像素光强平均值以及饱和像素数目和严重欠曝光像素的数目来确定CIS的采样方式．采样多帧组合模式时,实时对曝光次数和曝光时间点进行调度,依据积分时间将多次采样组合为大动态范围的输出图像．使用FPGA平台对该方法进行模拟,模拟结果证明了该方法的有效性和实时性,能够显著扩展CIS的动态范围．

关键词： CIS 动态范围积分时间多次采样组合饱和

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Phytochemical and pharmacological studies on Solanum lyratum:a review

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Natural Products and Bioprospecting 2022年第1期12卷 600-634页

作者： Yue Zhao Wen-Ke Gao Xiang-Dong Wang Li-Hua Zhang Hai-Yang Yu Hong-Hua Wu State Key Laboratory of Component-Based Chinese Medicine Institute of Traditional Chinese MedicineTianjin University of Traditional Chinese Medicine10 Poyanghu RoadWest AreaTuanbo New TownJinghai DistrictTianjin 301617People’s Republic of China

Solanum lyratum is one of the temperate plants,broadly distributed in Korea,China,Japan,India,and South-East Asia and well-documented in those oriental ethnic medicine systems for curing cancers,jaundice,edema,gonorrhea,cholecystitis,phlogosis,rheumatoid arthritis,*** review systematically summarized the research progress on *** respecting the botany,traditional uses,phytochemistry,pharmacology,and toxicology to increase people’s in-depth understanding of this plant,by data retrieval in a series of online or off-line electronic databases as far as we can *** saponins and alkaloids,terpenoids,nitrogenous compounds,and flavonoid compounds are the main chemical constituents in *** them,steroidal alkaloids and saponins are the major active ingredi-ents ever found in ***,exerting activities of anti-cancer,anti-inflammation,anti-microbial,anti-allergy,and anti-oxidation in vivo or in *** a result,*** has been frequently prescribed for the abovementioned therapeutic purposes,and there are substantial traditional and modern shreds of evidence of its use.

关键词： Solanum lyratum Thunb. Steroidal saponins Steroidal alkaloids Anti-cancer Toxicity

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Hydrogenation of Alkenes Catalyzed by Rare-Earth Metal Phosphinophosphinidene Complexes:1,2-Addition/Elimination Versusσ-Bond Metathesis Mechanism

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CCS Chemistry 2022年第10期4卷 3309-3318页

作者： Bin Feng Hao-Yu Zhang Hongling Qin Qian Peng Xuebing Leng Yaofeng Chen State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032 State Key Laboratory of Elemento-Organic Chemistry and Frontiers science Center for New Organic Matter College of ChemistryNankai UniversityTianjin 300071

Rare-earth metal complexes have been used as catalysts for many types of ***,the mechanistic studies showed that basically,these various reactions proceeded withσ-bond metathesis of RE–E bond(RE:rare-earth metals;E:main group elements)or RE ions acting as Lewis acid centers to activate the polar functional groups of the *** this article,a lutetium phosphinophosphinidene complex,with Lu=P double-bond character,was synthesized and structurally characterized.

关键词： rare-earthmetal phosphinidene alkene hydrogenation reaction mechanism density functional theory calculations

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Research on Chaotic Time Series Prediction Based on K-entropy and RBF Neural Networks

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Journal of Systems science and Information 2006年第4期4卷 741-748页

作者： Xiu Yan Junhai Ma Management School Tianjin University Tianjin 300072 China Department of Foundation Tianjin Urban Construction Institute Tianjin 300384 China

In this paper, a method of direct multi-step prediction of chaotic time series is proposed, which is based on Kolmogorov entropy and radial basis functions neural networks. This is done first by reconstructing a phase space using chaotic time series, then using K-entropy as a quantitative parameter to obtain the maximum predictability time of chaotic time series, finally the predicted chaotic time series data can be acquired by using RBFNN. The application considered is Lorenz system. Simulation results for direct multi-step prediction method are compared with recurrence multi-step prediction method. The results indicate that the direct multi-step prediction is more accurate and rapid than the recurrence multi-step prediction within the maximum predictability time of chaotic time series. So, it is convenient to forecast and control with real time using the method of direct multi-step prediction.

关键词： Kolmogorov entropy chaotic time series RBF neural networks multi-step prediction

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Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

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Congenital Heart Disease 2023年第1期18卷 7-21页

作者： Ji-Yang Zuo Huan-Xin Chen Zhi-Gang Liu Qin Yang Guo-Wei He Clinical School of Cardiovascular Disease Department of Cardiovascular SurgeryTEDA International Cardiovascular HospitalTianjin Medical UniversityTianjin300457China The Institute of Cardiovascular Diseases&Department of Cardiovascular Surgery TEDA International Cardiovascular HospitalTianjin University&Chinese Academy of Medical SciencesTianjin300457China

Background:Atrial septal defect(ASD)is one of the common congenital heart *** MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been ***:In 613 subjects including 320 ASD patients,we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics ***:Eleven variants were identified in the MYH6 gene promoter,of which four variants were found only in ASD patients,and two variants(g.3434G>C and g.4524C>T)were identified for the first *** functional experiments indicated that all four variants reduced the transcriptional activity of the MYH6 gene promoter(p<0.05).Subsequent analysis through the JASPAR(A database of transcription factor binding profiles)suggests that these variants may alter transcription factor binding sites,which may in turn lead to changes in myocardin subunit expression and ASD ***:Our study for the first time focuses on variants in the promoter region of the MYH6 gene in Chinese patients with ASD and the discovered variants have functional *** study provides new insights in the role of the MYH6 gene promoter region to better understand the genetic basis of ASD formation and facilitates clinical diagnosis.

关键词： Atrial septal defect MYH6 genetic variants congenital heart disease

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Inertial Viscosity Iterative Method for Solving Pseudo-monotone Variational Inequality Problems and Fixed Point Problems

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Acta Mathematica Sinica,English Series 2022年第5期38卷 937-952页

作者： Gang CAI Qiao Li DONG Yu PENG School of Mathematics science Chongqing Normal UniversityChongqing 401331P.R.China College of science Civil Aviation University of ChinaTianjin 300300P.R.China

In this paper,we investigate a new inertial viscosity extragradient algorithm for solving variational inequality problems for pseudo-monotone and Lipschitz continuous operator and fixed point problems for quasi-nonexpansive mappings in real Hilbert *** convergence theorems are obtained under some appropriate conditions on the ***,we give some numerical experiments to show the advantages of our proposed *** results obtained in this paper extend and improve some recent works in the literature.

关键词： Extragradient method variational inequality fixed point strong convergence quasi-nonexpansive mapping

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Synergistical heterointerface engineering of Fe-Se nanocomposite for high-performance sodium-ion hybrid capacitors

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Rare Metals 2022年第7期41卷 2470-2480页

作者： Pu-Guang Ji Ying Liu Shuang-Bin Han Yu-Fu Yan Oleg Victorovich Tolochko Eugene Strativnov Mirtemir Shodievich Kurbanov Hua Wang Cheng-Wei Zhang Gong-Kai Wang School of Materials science&Engineering and tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control technology Hebei University of TechnologyTianjin 300130China Institute of Machinery Materialsand TransportPeter the Great St.Petersburg Polytechnic UniversitySaint Petersburg 195251Russian Federation The Gas Institute of the National Academy of sciences of Ukraine Kyiv 03113Ukraine Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of UzbekistanTashkent 100125Uzbekistan School of Chemistry Beijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China

As environmentally benign and high-efficiency energy storage devices,sodium-ion capacitors(SICs),which combine the merits of batteries and supercapacitors,are considered to have potentially high energy/power densities and long ***,the lack of high-rate anodes that can match the high-power-density cathode hinders the commercial application of *** this work,heterostructured Fe/FeSe_(2)/Fe_(3)Se_(4)nanocomposite is pre-pared by chemical vapor deposition(CVD)method and investigated as the anode for *** heterointerface manipulation,Fe/FeSe_(2)/Fe_(3)Se_(4)demonstrates better sodium ion storage performances than the pure FeSe_(2)and FeSe_(2)/Fe_(3)Se_(4).It can deliver a specific capacity of 484.8 mAh·g^(-1)after 100 cycles at 0.5 A·g^(-1),as well as a good capacity *** excellent performance of Fe/FeSe_(2)/Fe_(3)Se_(4)nanocomposite can be ascribed to the synergistic effect of the heterointerface engineered components,where FeSe_(2)and Fe_(3)Se_(4) are responsible for offering a high capacity and metallic Fe can server as mini-current collectors,effec-tively accelerating the electron and charge transfer ***,the heterointerface significantly facilitates the sodium ion fast transport,and retards the structural variation during ***-1000//activated carbon(AC)SIC affords a high energy density of 112 Wh·kg^(-1)at 107.5 W·kg^(-1),its power density can achieve 10,750 W·kg^(-1)with remained energy density of 44.2 Wh·kg^(-1),as well as an outstanding cycling stability,demonstrating this effective heterointerface engineered anode strategy for high-performance SICs.

关键词： Sodium-ion hybrid capacitors Anode Heterostructure Fe/FeSe2/Fe3Se4 nanocomposite

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Comment on“Breviscapine alleviates nonalcoholic steatohepatitis by inhibiting TGF-β-activated kinase 1-dependent signaling”

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Traditional Medicine Research 2022年第2期7卷 67-69页

作者： Ya-Ru Li Yuan Yao Long Ma State Key Laboratory of Food Nutrition and Safety Key Laboratory of Industrial MicrobiologyMinistry of EducationTianjin Key Laboratory of Industry MicrobiologyChina International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal ChemistryCollege of BiotechnologyTianjin University of Science&TechnologyTianjin 300457China.

The article by Lan et al.[1],published on 30 October 2021 in Hepatology,showed the relationship between the natural flavonoid compound breviscapine and nonalcoholic steatohepatitis(NASH).The researchers demonstrated that breviscapine might be a novel therapeutic candidate for the treatment of *** can be proven that breviscapine prevents metabolic stress-induced NASH progression through direct inhibition of the TGF-β-activated Kinase 1(TAK1)signaling pathway.

关键词： inhibiting al. hepatitis

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