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Signal Transduction and Targeted Therapy 2020年第1期5卷 2465-2467页

作者： Huan-Xin Chen Ming-Yang Li Yi-Yao Jiang Hai-Tao Hou Jun Wang Xiao-Cheng Liu Qin Yang Guo-Wei He Center for Basic Medical Research&Department of Cardiovascular Surgery TEDA International Cardiovascular HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Graduate School Peking Union Medical CollegeBeijingChina The First Affiliated Hospital of Zhejiang University Hangzhouand School of PharmacyWannan Medical CollegeWuhuChina Department of Surgery Oregon Health and Science UniversityPortlandORUSA

Dear Editor,Atrial fibrillation(AF)is one of the most common cardiac *** prevalence increases significantly with *** is well known that patients with AF are associated with an increased risk of stroke,1 and AF is a great economic burden on the worldwide socioeconomic *** studies have shown that electrical,contractile,and structural remodeling play key roles in the onset and maintenance of AF.2 Other possible pathogenesis mechanisms include calcium handling abnormalities,autonomic imbalance,and genetic factors.3 However,the exact molecular mechanism associated with AF remains unknown.

关键词： fibrillation atrial cardiac

Change of Th1/Th2 Cytokine Equilibrium in Rats with Severe Sepsis and Therapeutic Effect of Recombinant Interleukin-12 and Shenmai Injection (参麦注射液)

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Chinese Journal of Integrated Traditional and Western Medicine 2005年第2期11卷 136-141页

作者：于泳浩崔乃强傅强李君 General Hospital of tianjin Medical University Tianjin (300052) Nankai Hospital

Objective: To evaluate the dynamic change of Th1/Th2 cytokines in serum, peritoneal lavage fluid (PLF) and splenic macrophages (SM) in rats with severe peritonitis, and to observe the therapeutic effects of recombinant interleukin-12 (rIL-2) and Shenmai injection (SMI, 参麦注射液), a Chinese medicinal ***: Severe peritonitis (SP) model was induced by intraperitoneal injection of E. coli and B. frag, and mild peritonitis (MP) model was induced by cecal ligation and punching. Then the following experiments were done: (1) Survival rates of animals after every 6 hrs in the 72 hrs after modeling were recorded, serum and PLF levels of cytokines, including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), and interleukin-10 (IL-10), 6 hrs, 12 hrs, 24 hrs and 48 hrs after modeling were measured. (2) Model rats were treated with rIL-12 or SMI, the survival rate was recorded and serum levels of TNF-α, INF-γ, and IL-10 before and after treatment were measured, and (3) amount of these cytokines produced by SM were determined 6 hrs, 12 hrs and 24 hrs after treatment. The survival rates and levels of cytokines were then compared between the groups (model group treated with rIL-12 or SMI, untreated model group, and blank group).Results: Serum and PLF levels of IFN-γ, TNF-α at all the time points in SP rats were significantly lower than those in MP rats while those of IL-10 6 hrs and 12 hrs after modeling were significantly higher in the former than that in the latter (P<0.05). IFN-γ secretion of SM in SP rats was significantly higher than that in MP rats 6 hrs after modeling (P<0.05). Administration of rlL-12 or SMI given before modeling could improve the survival rate of the model rats (P<0.05) and cause significant increase of the serum level and SM secretion of IFN-γ. Conclusion: Imbalance in promoting/antagonizing inflammatory cytokines and Th2 response dominance appear in SP rats early at the initiating stage, and SM secretion of inflammation promoting factor

关键词： sepsis immuno-modulatory cytokine interleukin tumor necrosis factor interferon splenic macrophage Shenmai injection rat

Effect of extracellular adenosine triphosphate hydrolysis by apyrase on bleomycin-induced circulating and alveolar mononuclear phagocyte activation and lung inflammation

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Chinese Medical Journal 2023年第4期136卷 494-496页

作者： Chengcheng Su Shengkun Lang Yongqiang Ma Luqing Wei Bin Liu Hongyan Yang Wenjie Ji Department of Respiratory and Critical Care Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Department of Radiology Characteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Department of Cardiac Intensive Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Institute of Occupational Medicine Beijing Center for Disease Prevention and ControlBeijing 100020China

To the Editor:Lung fibrosis is characterized by extracellular matrix accumulation and remodeling of the lung *** lung fibrosis has been extensively studied,there is still a lack of effective anti-pulmonary fibrosis drugs at *** pathogenesis of lung fibrosis involves many aspects in which the lung macrophages play a particularly important role.[1]It has been reported that the manipulation of the monocyte/macrophage phenotype switch might be a potential target for many macrophagemediated inflammatory *** our previous study,mice that were exposed to bleomycin(BLM)showed a dynamic change of mononuclear phagocytes in the circulating system,lung alveoli,and interstitial *** rapid increase of the number of circulating Ly6Chi monocytes after BLM stimulation,followed by the expansion of M2-like alveolar macrophages(AMf)numbers,is closely associated with lung inflammatory response and fibrosis.[2,3]

关键词： lung alveolar inflammation

非阿基米德模糊赋2-范空间上的Mazur-Ulam定理（英文）

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应用数学 2014年第2期27卷 355-359页

作者：常丽芳宋眉眉天津理工大学理学院天津300384

本文给出非阿基米德模糊赋2-范空间的概念,并且证明在一定条件下Mazur-Ulam定理在此空间上成立.

关键词： Mazur-Ulam定理非阿基米德模糊赋2-范空间模糊等距

Tropism mechanism of stem cells targeting injured brain tissues by stromal cell-derived factor-1

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Chinese Journal of Traumatology 2009年第5期12卷 -页

作者： ZHANG Sai LIU Xiao-zhi LIU Zhen-lin SHANG Chong-zhi HU Qun-liang Department of Neurosurgery Affiliated Hospital of Medical College of Chinese People's Armed Police ForceTianjin 300162 China

Objective: To explore the role and function of stromal cell-derived factor- 1 (SDF- 1) in stem cells migrating into injured brain ***: Rat-derived nerve stem cells (NSCs) were isolated and cultured routinely. Transwell system was used to observe the migration ability of NSCs into injured nerve cells. Immunocytochemistry was used to explore the expression of chemotactic factor receptor-4 (CXCR-4) in NSCs. In vivo, we applied immunofluorescence technique to observe the migration of NSCs into injured brain area. Immunofluorescence technique and Western blotting were used to test expression level of SDF- 1. After AMD3100 (a special chemical blocker) blocking CXCR-4, the migration ability of NSCs was tested in vivo and in vitro, ***: NSCs displayed specific tropism for injured nerve cells or traumatic brain area in vivo and in vitro. The expression level of SDF-1 in traumatic brain area increased remarkably and the expression level of CXCR-4 in the NSCs increased simultaneously. After AMD3100 blocking the expression of CXCR-4, the migration ability of NSCs decreased significantly both in vivo and in ***: SDF-1 may play a key role in stem cells migrating into injured brain area through specially combining with CXCR-4.

关键词： Stromal cell-derived factor Stem cells Chemotactic factor Traumatic brain injury

Effects of Nephritis No.3 Recipe on Nitric Oxide,Nitric Oxide Synthase Secreted by Cultured Mesangial Cells in Rats and the Gene Expression of Inducible Nitric Oxide Synthase

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Chinese Journal of Integrated Traditional and Western Medicine 2003年第3期9卷 210-214页

作者：陈志强黄怀鹏黄文政朱小棣林清棋 Institute of Integrative Chinese and Western Medicine Hebei Medical UniversityShijiazhuang 050017 Nanjing University of TCM The Affiliated Hospital of tianjin College of TCM The Affilated Hospital of tianjin College of TCM

Objective:To explore the effect of the Nephritis No. 3 (N-3) recipe on nitric oxide (NO), nitric oxide synthase (NOS) secreted by cultured mesangial cells (MC) and its gene expression of the in-ducible nitric oxide synthase (iNOS). Methods:The drug (nephritis No. 3)-containing serum was prepared with serum pharmacological technique, and then was applied to react on mesangial cells cultured in fetal calf serum (FCS) and cells cultured in FCS plus lipopolysaccharide. To observe the secretion of NO and NOS and the gene expression of iNOS by means of RT-PCR. Results:Under the two kinds of culture conditions, the content of NO and NOS in the groups with drug-containing serum were higher than those without drug-containing serum (P<0. 05, P<0. 01), and the expression of iNOS mRNA was up-regulated too. Conclusion: The N-3 could significantly promote the secretion of NO and NOS and the mRNA expression of iNOS in rats.

关键词： Nephritis No. 3 recipe mesangial cell nitric oxide nitric oxide synthase

Polyethylene glycol radical-initiated aerobic propargylic oxidation in dense carbon dioxide

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Journal of Energy Chemistry 2013年第3期22卷 363-367页

作者： Zhenfeng Diao Bin Li Bing Yu Anhua Liu Liangnian He State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University

The selective aerobic oxidation of alkynes to corresponding α,β-acetylenic ketones was achieved in polyethylene glycol/dense CO2/O2 biphasic system without any catalyst or additive. The effects of reaction parameters, e.g. temperature, CO2 pressure, PEG molecular weight and loading on the reaction were carefully examined. Moreover, various substrates worked well in the presence of PEG 1000 under 5 MPa of CO2 and 2 MPa of O2 at 100 ℃ for 12 to 24 h and acceptable yield and selectivity could be obtained in most cases. Preliminary mechanistic investigations were also discussed.

关键词： carbon dioxide polyethylene glycol selective oxidation alkynes β-acetylenic ketones

Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

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Neural Regeneration Research 2017年第12期12卷 2084-2091页

作者： Bin Pan Zhong-ju Shi Jia-yin Yan Jia-he Li Shi-qing Feng Department of Orthopedics Tianjin Medical University General Hospital Tianjin China

Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after peripheral nerve injury, as bioinformatic analysis revealed that the target gene of NONMMUG014387 was collagen triple helix repeat containing 1（Cthrc1）. Cthrc1 may promote cell proliferation in a variety of cells by activating Wnt/PCP signaling. Nonetheless, bioinformatic analysis still needs to be verified by biological experiment. In this study, the candidate long non-coding RNA, NONMMUG014387, was overexpressed in mouse Schwann cells by recombinant adenovirus transfection. Plasmid p HBAd-MCMV-GFP-NONMMUG014387 and p HBAd-MCMV-GFP were transfected into Schwann cells. Schwann cells were divided into three groups： control（Schwann cells without intervention）, Ad-GFP（Schwann cells with GFP overexpression）, and Ad-NONMMUGO148387（Schwann cells with GFP and NONMMUGO148387 overexpression）. Cell Counting Kit-8 assay was used to evaluate proliferative capability of mouse Schwann cells after NONMMUG014387 overexpression. Polymerase chain reaction and western blot assay were performed to investigate target genes and downstream pathways of NONMMUG014387. Cell proliferation was significantly increased in Schwann cells overexpressing lnc RNA NONMMUG014387 compared with the other two groups. Further, compared with the control group, m RNA and protein levels of Cthrc1, Wnt5 a, ROR2, Rho A, Rac1, JNK, and ROCK were visibly up-regulated in the Ad-NONMMUGO148387 group. Our findings confirm that long non-coding RNA NONMMUG014387 can promote proliferation of Schwann cells surrounding the injury site through targeting Cthrc1 and activating the Wnt/PCP pathway.

关键词： nerve regeneration peripheral nerve injury Schwann cells long non-coding RNAs proliferation Wnt/PCP pathway Cell CountingKit-8 assay adenovirus overexpression sciatic nerve Cthrcl neural regeneration

A Wavelet-Based Method to Predict Muscle Forces From Surface Electromyography Signals in Weightlifting

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Journal of Bionic Engineering 2012年第1期9卷 48-58页

作者： Gaofeng Wei Feng Tian Gang Tang Chengtao Wang Institute of Medical Equipment China Academy of Military Medical Science Tianjin 300161 P. R. China Logistics Engineering College Shanghai Maritime University Shanghai 200135 P. R. China Department of Mechanical Engineering Shanghai Jiaotong University Shanghai 200240 P. R. China

The purpose of this study was to develop a wavelet-based method to predict muscle forces from surface electromyography （EMG） signals in vivo. The weightlifting motor task was implemented as the case study. EMG signals of biceps brachii, triceps brachii and deltoid muscles were recorded when the subject carried out a standard weightlifting motor task. The wavelet-based algorithm was used to process raw EMG signals and extract features which could be input to the Hill-type muscle force models to predict muscle forces. At the same time, the musculoskeletal model of subject＇s weightlifting motor task was built and simulated using the Computed Muscle Control （CMC） method via a motion capture experiment. The results of CMC were compared with the muscle force predictions by the proposed method. The correlation coefficient between two results was 0.99 （p〈0.01）. However, the proposed method was easier and more efficiency than the CMC method. It has potential to be used clinically to predict muscle forces in vivo.

关键词： wavelet EMG muscle force weightlifting musculoskeletal motion

Exosome Is an Important Novel Way of Acupuncture Information Transmission

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 377-383页

作者： Ning-Cen Li Ming-Yue Li Zhong-Xi Lu Mu-Yang Li Xue-Mao Zhuo Yong Chen Ting-Ting Wang Li-Ying Xing Mei-Juan Wang Kai Shan Ze-Lin Chen Calista Hui-Min Lim Bo Chen Yi Guo Research Center of Experimental Acupuncture science Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 300381China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Novahealth TCM Clinic Pte Ltd. Singapore

As a physical stimulation of the body surface,the process of transmitting acupuncture information from acupoints to target organs through meridians and collaterals is complex,and network regulation is the most basic mode of *** are membrane vesicles formed by various types of cells and secreted to the extracellular matrix through a series of *** speculate that exosomes and their carriers,as important carriers of communication among neurons,endocrine cells,and immune cells,may play an important role in the process of acupuncture information *** in the acupoint area is an important interactive form of transformation from physical information to chemical *** exosome is an important means of delivery for acupuncture to play an important role in the network *** structure and information molecules of exosomes are the important material bases for acupuncture *** experimental research,it was found that acupuncture can regulate the release of exosome and may have a certain relationship with acupuncture ***,exosome may play an important role in the process of acupuncture information transmission,which is an important new way of acupuncture information transmission.

关键词： Acupuncture exosome information transmission network regulation