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Impact of Cold Spells on Ischemic Stroke Severity and Clinical Outcomes in tianjin, China

Journal of Meteorological Research 2023年第4期37卷 564-572页

作者： Juanjuan XUE Chanjuan WEI Xiaoshuang XIA Xuemei QI Yumeng GU Zhongyan WANG Suqin HAN Lin WANG Xin LI Department of Neurology The Second Hospital of Tianjin Medical UniversityTianjin 300200 Department of Geriatrics The Second Hospital of Tianjin Medical UniversityTianjin 300200 tianjin Environmental Meteorology Center Tianjin 300200

There are several studies on the impact of extreme weather on the incidence and mortality of stroke, but the research on the effect of extreme weather events on severity and outcome of ischemic stroke is scarce. This study aimed to evaluate the impact of cold spells on the severity and clinical outcomes of patients with initial acute ischemic stroke in a hospital-based study. We enrolled 553 patients with initial ischemic stroke during the cold seasons between 2016 and 2019. Patients were separated into the mild stroke group and moderate-to-severe stroke group according to the National Institutes of Health Stroke Scale(NIHSS) of the U.S., and good outcome group and poor outcome group according to modified Rankin Scale(mRS) scores. There are nine different definitions of cold spells according to intensities and duration time. After adjustment for climate factors, air quality index, and common risk factors, it is found that cold spells were associated with moderate-to-severe neurological deficits and clinical outcomes in overall ischemic stroke patients. Furthermore, the delay effect for stroke severity started at the beginning of the cold wave(Lag 0) and lasted up to 14 days(Lags 0–14). In addition, when a cold spell was set as a daily mean temperature < 3rd or 5th percentile and with a duration ≥ 2 or 3 consecutive days, cold spells had a significant impact on clinical outcomes, and there was a definite delay effect of at least 7 days(Lags 0–7) and it lasted up to 14days(Lags 0–14). At last, we concluded that cold spells may be a contributory factor for more severe neurological deficits and worse outcomes in patients with initial ischemic stroke.

关键词： cold spell meteorological data ischemic stroke severity treatment outcome

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p53 positively regulates the proliferation of hepatic progenitor cells promoted by laminin-521

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3592-3608页

作者： Mingyang Ma Shuyao Hua Xiangde Min Liang Wang Jun Li Ping Wu Huifang Liang Bixiang Zhang Xiaoping Chen Shuai Xiang Department of General Surgery Tianjin Medical University General HospitalTianjinChina Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Clinical Nutrition Shanghai Jiao Tong University Affliated Sixth People's HospitalShanghaiChina Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Wuhan Pulmonary Hospital Wuhan Institute for Tuberculosis ControlWuhanChina Department of Pathophysiology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei key Laboratory of Hepato-Pancreato-Biliary Disease WuhanChina key Laboratory of Organ Transplantation Ministry of EducationWuhanChina key Laboratory of Organ Transplantation National Health CommissionWuhanChina key Laboratory of Organ Transplantation Chinese Academy of Medical SciencesWuhanChina

Hepatic progenitor cells(HPCs)hold tremendous potential for liver regeneration,but their well-known limitation of proliferation hampers their broader *** is evidence that laminin is required for the proliferation of HPCs,but the laminin isoform that plays the dominant role and the key intracellular downstream targets that mediate the regulation of HPC proliferation have yet to be *** we showed that p53 expression increased gradually and reached maximal levels around 8 days when lamininα4,α5,β2,β1,andγ1 subunit levels also reached a maximum during HPC activation and ***-521(LN-521)promoted greater proliferation of HPCs than do laminin,matrigel or other laminin *** of p53 by PFT-αor Ad-p53^(V143A) inhibited the promotion of proliferation by *** complementary MRI and bioluminescence imaging analysis showed that p53 inactivation decreased the proliferation of transplanted HPCs in vivo.p53 was activated by LN-521 through the Integrinα6β1/FAK-Src-Paxillin/Akt *** p53 was involved in the nuclear translocation of CDK4 and inactivation of Rb by inducing p27^(Kip1).Taken together,this study identifies LN-521 as an ideal candidate substrate for HPC culture and uncovers an unexpected positive role for p53 in regulating proliferation of HPCs,which makes it a potential target for HPC-based regenerative medicine.

关键词： laminin progenitor inhibited

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Deep learning model combined with computed tomography features to preoperatively predicting the risk stratification of gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2024年第12期16卷 4663-4674页

作者： Yi Li Yan-Bei Liu Xu-Bin Li Xiao-Nan Cui Dong-Hua Meng Cong-Cong Yuan Zhao-Xiang Ye Department of Radiology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerState Key Laboratory of Druggability Evaluation and Systematic Translational MedicineTianjin Key Laboratory of Digestive CancerTianjin 300060China School of Life Sciences Tiangong UniversityTianjin 300387China Department of Radiology Tianjin First Central HospitalTianjin 300190China

BACKGROUND Gastrointestinal stromal tumors(GIST)are prevalent neoplasm originating from the gastrointestinal *** 50%of GIST patients experience tumor recurrence within 5 ***,there is a pressing need to accurately evaluate risk stratification *** To assess the application of a deep learning model(DLM)combined with computed tomography features for predicting risk stratification of *** Preoperative contrast-enhanced computed tomography(CECT)images of 551 GIST patients were retrospectively *** image features were independently analyzed by two *** parameters were statistically analyzed to identify significant predictors of high-risk *** were randomly assigned to the training(n=386)and validation cohorts(n=165).A DLM and a combined DLM were established for predicting the GIST risk stratification using convolutional neural network and subsequently evaluated in the validation *** Among the analyzed CECT image features,tumor size,ulceration,and enlarged feeding vessels were identified as significant risk predictors(P<0.05).In DLM,the overall area under the receiver operating characteristic curve(AUROC)was 0.88,with the accuracy(ACC)and AUROCs for each stratification being 87%and 0.96 for low-risk,79%and 0.74 for intermediate-risk,and 84%and 0.90 for high-risk,*** overall ACC and AUROC were 84%and 0.94 in the combined *** ACC and AUROCs for each risk stratification were 92%and 0.97 for low-risk,87%and 0.83 for intermediate-risk,and 90%and 0.96 for high-risk,*** in AUROCs for each risk stratification between the two models were significant(P<0.05).CONCLUSION A combined DLM with satisfactory performance for preoperatively predicting GIST stratifications was developed using routine computed tomography data,demonstrating superiority compared to DLM.

关键词： Gastrointestinal stromal tumors Deep learning Risk stratification Tomography,X-ray computed Prognosis

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Electrocardiogram-based artificial intelligence for the diagnosis of heart failure:a systematic review and meta-analysis

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Journal of Geriatric Cardiology 2022年第12期19卷 970-980,1011-1015页

作者： Xin-Mu LI Xin-Yi GAO Gary Tse Shen-Da HONG Kang-Yin CHEN Guang-Ping LI Tong LIU tianjin key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina Kent and Medway medical School CanterburyUnited Kingdom National Institute of Health Data Science at Peking University Peking UniversityBeijingChina Institute of medical Technology Peking University Health Science CenterBeijingChina

BACKGROUND The electrocardiogram(ECG)is an inexpensive and easily accessible investigation for the diagnosis of cardiovascular diseases including heart failure(HF).The application of artificial intelligence(AI)has contributed to clinical practice in terms of aiding diagnosis,prognosis,risk stratification and guiding clinical *** aim of this study is to systematically review and perform a meta-analysis of published studies on the application of AI for HF detection based on the *** We searched Embase,PubMed and Web of Science databases to identify literature using AI for HF detection based on ECG *** quality of included studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2(QUADAS-2)***-effects models were used for calculating the effect estimates and hierarchical receiver operating characteristic curves were *** analysis was *** and the risk of bias were also *** A total of 11 studies including 104,737 subjects were *** area under the curve for HF diagnosis was 0.986,with a corresponding pooled sensitivity of 0.95(95%CI:0.86–0.98),specificity of 0.98(95%CI:0.95–0.99)and diagnostic odds ratio of 831.51(95%CI:127.85–5407.74).In the patient selection domain of QUADAS-2,eight studies were designated as high *** According to the available evidence,the incorporation of AI can aid the diagnosis of ***,there is heterogeneity among machine learning algorithms and improvements are required in terms of quality and study design.

关键词： diagnosis assessed specificity

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Update on diffuse large B-cell lymphoma: highlights from the 2022 ASCO Annual Meeting

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Cancer Biology & Medicine 2022年第8期19卷 1117-1120页

作者： Minghan Qiu Shan Wu Xinrui Chen Huaqing Wang Department of Oncology Tianjin Union Medical CenterNankai UniversityTianjin 300191China The Institute of Translational Medicine Tianjin Union Medical CenterNankai UniversityTianjin 300121China

Diffuse large B-cell lymphoma(DLBCL)is the most common non-Hodgkin’s lymphoma(NHL)and has high *** 30%–50%of patients develop relapsed/refractory(R/R)disease,which remains a major cause of *** recent years,a variety of novel therapies have emerged,including bispecific T-cell engagers(BiTEs),antibody–drug conjugates(ADCs),chimeric antigen receptor T cells(CAR-T),and selective BTK inhibitors,which have provided effective treatment strategies for patients with DLBCL1,***,the 58th Annual Meeting of the American Society of Clinical Oncology(ASCO)was held in Chicago,presenting cutting-edge studies in ***,we discuss a selection of interesting data on this topic.

关键词： lymphoma ASCO mortality

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Cryptococcus splenic abscess in primary biliary cholangitis: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 319-321页

作者： Yuxin Dong Qing Tang Lijun Wang Songtao Shou Department of Emergency Medicine Tianjin Medical University General HospitalTianjin 300052China

Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to *** compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are ***,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.

关键词： cholangitis impaired diseases

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Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer

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Cancer Biology & Medicine 2023年第12期20卷 903-914页

作者： Jing Qin Feng Wei Xiubao Ren National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute&HospitalTianjin 300060China tianjin’s Clinical Research Center for Cancer Tianjin 300060China key Laboratory of Cancer Prevention and Therapy Tianjin 300060China key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute&HospitalTianjin 300060China

Introduction Neutrophils,a crucial component of the innate immune system,are the most abundant bone marrow-derived eukaryotic cell in human *** functional importance of neutrophils is often overlooked because neutrophils are short-lived,terminally differentiated,and do not *** traditionally considered anti-bacterial cells,research has demonstrated the multifaceted roles of neutrophils in *** have suggested that neutrophils with normal functions co-exist with pathologically activated neutrophils that support tumorprogression and metastasis in the context of cancer.

关键词： metastasis targeted traditionally

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Treatment of hemolymphangioma by robotic surgery: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 596-600页

作者： Tian-Ning Li Yan-Hong Liu Jia Zhao Hong Mu Lei Cao Department of Clinical Lab Tianjin First Central HospitalTianjin 300000China Nankai University Tianjin Union Medical CenterTianjin 300000China tianjin medical University Tianjin First Center HospitalTianjin 300000China

BACKGROUND Hemolymphangioma of the jejunum is rare and lacks clinical specificity,and can manifest as gastrointestinal bleeding,abdominal pain,and intestinal *** tomography,magnetic resonance imaging,and other examinations show certain characteristics of the disease,but lack *** capsule endoscopy and enteroscopy make up for this deficiency,the diagnosis also still re-quires *** SUMMARY A male patient was admitted to the hospital due to abdominal distension and abdominal pain,but a specific diagnosis by computed tomography examination was not *** resection of the small intestine was performed by robotic surgery,and postoperative pathological biopsy confirmed the diagnosis of *** recurrence in the follow-up examination was *** Robotic surgery is an effective way to treat hemolymphangioma through minima-lly invasive techniques under the concept of rapid rehabilitation.

关键词： Hemolymphangioma Enteroscopy Robotic surgery Rehabilitation Case report

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m7G Methylation-Related Gene NUDT10 as novel prognostic biomarker and its ceRNA regulatory network in colorectal cancer

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medical Data Mining 2023年第2期6卷 7-20页

作者： Yu-Jian Li Xuan Kan Department of Pediatrics General Hospital of Tianjin Medical UniversityTianjin 300052China

Background:Colorectal cancer(CRC)is a life-threatening malignant disease of the digestive system,which is still a leading cause of cancer death *** methylation,a fundamental process in epigenetic regulation,also plays an important role in tumor ***,the functional mechanisms of 7-methylguanosine(m7G)methylation-related gene in CRC are ***:The differential expression of m7G methylation-related gene between CRC tissues and normal tissues in UCSC XENA,TCGA and GTEx was verified using *** regression,Nomogram were used to construct corresponding prognostic models of ***-Meier analysis,receiver operating characteristic curve analysis,clinical correlation analysis and enrichment analysis were used to further investigate the correlation and functional mechanisms of m7G methylation-related gene with ***-infiltration was used to verify the relationship between nudix hydroxylase 10(NUDT10)and immune cells,while methylation analysis was used to study the promoter methylation of *** was used to analyze the protein expression between CRC tissues and normal *** ceRNA regulatory network was used to identify the mRNA-miRNA-lncRNA regulatory ***:The m7G methylation-related gene NUDT10 was lowly expressed in *** regression,Nomogram and calibration curve finally identified NUDT10 as the novel prognostic biomarker of CRC and constructed the corresponding prognostic *** results of immunohistochemistry showed that the protein expression levels of NUDT10 differed between CRC tissues and normal *** addition,NUDT10 had predictive power for CRC and the expression of NUDT10 in CRC was closely associated with immune *** Ontology,Kyoto Encyclopedia of Genes and Genomes and Gene Set Enrichment Analysis revealed that biological functions such as the regulation of angiogenesis,muscle contraction,transporter complex and gated channel activity,pathways such as heme metabo

关键词： 7-methylguanosine methylation colorectal cancer ceRNA prognostic biomarker immune infiltration

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Role of angiotensin receptor-neprilysin inhibitor in diabetic complications

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World Journal of Diabetes 2024年第5期15卷 867-875页

作者： Ying Liu Cun-Yu Lu Yi Zheng Yu-Min Zhang Ling-Ling Qian Ku-Lin Li Gary Tse Ru-Xing Wang Tong Liu Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjin 300211China Department of Cardiology Xuzhou No.1 Peoples HospitalXuzhou 221005Jiangsu ProvinceChina Department of Cardiology Wuxi 9^(th)People’s Hospital Affiliated to Soochow UniversityWuxi 214062Jiangsu ProvinceChina Department of Cardiology Wuxi People’s Hospital Affiliated to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina School of Nursing and Health Studies Metropolitan UniversityHong Kong 999077China Kent and Medway medical School Kent CT27NTCanterburyUnited Kingdom

Diabetes mellitus is a prevalent disorder with multi-system manifestations,causing a significant burden in terms of disability and deaths ***-tensin receptor-neprilysin inhibitor(ARNI)belongs to a class of medications for treating heart failure,with the benefits of reducing hospitalization rates and *** review mainly focuses on the clinical and basic investigations related to ARNI and diabetic complications,discussing possible physiological and molecular mechanisms,with insights for future applications.

关键词： Angiotensin receptor-neprilysin inhibitor Diabetic mellitus Complication

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