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Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer

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Nano Research 2016年第8期9卷 2424-2432页

作者： Linlin Zhang Yang Liu Gan Liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang Department of Nuclear Medicine Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University Shanghai 200092 China Department of Chemical and Biomolecular Engineering University of California Los Angeles California 90095 USA The Shenzhen Key Laboratory of Gene and Antibody Therapy Center for Biotechnology and Biomedicine and Division of Life and Health Sciences Tsinghua University Shenzhen 518055 China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Key Laboratory of Functional Polymer Materials Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071 China

Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a two-step encapsulation process exhibited significantly prolonged plasma half-life. Furthermore, by constructing nanocapsules with similar sizes but different surface charges and chemistry, we demonstrated a generic strategy for prolonging the plasma half-life of therapeutic proteins. In an in vitro experiment, four types of bovine serum albumin （BSA） nanocapsules were incubated with fetal bovine serum （FBS） in phosphate buffer saline （PBS）; the cell uptake by HeLa cells was monitored to systematically evaluate the characteristics of the surface chemistry during drculation. Single positron emission tomography-computed tomography （SPECT） was employed to allow real-time observation of the BSA nanoparticle distribution in vivo, as well as quantification of the plasma concentration after intravenous administration. This study offers a practical method for translating a broad range of proteins for clinical use.

关键词： phosphorylcholine-basedpolymer nano-encapsulation function protein delivery protein therapy long-circulation

Ultra-low thermal conductivity of two-dimensional phononic crystals in the incoherent regime

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npj Computational Materials 2018年第1期4卷 478-484页

作者： Guofeng Xie Zhifang Ju Kuikui Zhou Xiaolin Wei Zhixin Guo Yongqing Cai Gang Zhang School of Materials Science and Engineering Hunan University of Science and Technology411201 XiangtanChina Hunan Key Laboratory of Micro-Nano Energy Materials and Devices School of Physics and OptoelectronicsXiangtan University411105 HunanChina Institute of High Performance Computing Singapore 138632Singapore

Two-dimensional silicon phononic crystals have attracted extensive research interest for thermoelectric applications due to their reproducible low thermal conductivity and sufficiently good electrical *** thermoelectric devices in high-temperature environment,the coherent phonon interference is strongly suppressed;therefore phonon transport in the incoherent regime is critically important for manipulating their thermal *** the basis of perturbation theory,we present herein a novel phonon scattering process from the perspective of bond order imperfections in the surface skin of *** incorporate this strongly frequency-dependent scattering rate into the phonon Boltzmann transport equation and reproduce the ultra low thermal conductivity of holey silicon *** reveal that the remarkable reduction of thermal conductivity originates not only from the impediment of low-frequency phonons by normal boundary scattering,but also from the severe suppression of high-frequency phonons by surface bond order imperfections *** theory not only reveals the role of the holey surface on the phonon transport,but also provide a computation tool for thermal conductivity modification in nanostructures through surface engineering.

关键词： conductivity thermal regime

PRELIMINARY INVESTIGATION ON THE MISCIBILITY OF ISOTACTIC POLYPROPYLENE (iPP) AND SYNDIOTACTIC POLYPROPYLENE (sPP) BLENDS

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Chinese Journal of Polymer Science 2006年第6期24卷 569-573页

作者： Chun-xiao Zheng Xiu-qin Zhang Joerg Rottstegge Xia Dong Ying Zhao Du-jin Wang Shan-nong Zhu Zhi-gang Wang Charles C. Han Duan-fu Xu Key Laboratory of Engineering Plastics Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China State Key Laboratory of Polymer Physics and Chemistry Joint Laboratory of Polymer Science and Materials Institute of Chemistry Chinese Academy of Sciences Beo＇ing 100080 China Graduate School of Chinese Academy of Sciences Beijing 100080 China

Experimental miscibility studies were performed on different compositions of iPP/sPP blends, where sPP has a low syndiotacticity （[rrrr] = 81%）. Combining optical microscopy, rheology, and solid state NMR spectroscopy, the miscibility of the blends was investigated at different scales in the traditionally thought to be ＂immiscible＂ iPP/sPP blends. For the composition of iPP/sPP （90/10） blend, it shows to be miscible in the melt, and furthermore, the existence of intermolecular chain interactions between sPP and iPP components was detected in the solid state.

关键词： iPP/sPP blends Miscibility Optical microscopy Rheology Solid state NMR spectroscopy.

On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis

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Microsystems & Nanoengineering 2020年第1期6卷 880-893页

作者： Liang Huang Fei Liang Yongxiang Feng Peng Zhao Wenhui Wang Department of Precision Instrument State Key Laboratory of Precision Measurement Technology and InstrumentTsinghua UniversityBeijingChina School of Instrument Science and Opto-Electronics Engineering Hefei University of TechnologyHefeiChina

Cells have different intrinsic markers such as mechanical and electrical properties,which may be used as specific ***,we present a microfluidic chip configured with two opposing optical fibers and four 3D electrodes for multiphysical parameter *** chip leverages optical fibers to capture and stretch a single cell and uses 3D electrodes to achieve rotation of the single *** to the stretching deformation and rotation spectrum,the mechanical and dielectric properties can be *** provided proof of concept by testing five types of cells(HeLa,A549,HepaRG,MCF7 and MCF10A)and determined five biophysical parameters,namely,shear modulus,steady-state viscosity,and relaxation time from the stretching deformation and area-specific membrane capacitance and cytoplasm conductivity from the rotation *** showed the potential of the chip in cancer research by observing subtle changes in the cellular properties of transforming growth factor beta 1(TGF-β1)-induced epithelial–mesenchymal transition(EMT)A549 *** new chip provides a microfluidic platform capable of multiparameter characterization of single cells,which can play an important role in the field of single-cell research.

关键词： rotation stretching fibers

Shell-thickness dependent optical properties of CdSe/ CdS core/shell nanocrystals coated with thiol ligands

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Nano Research 2016年第1期9卷 260-271页

作者： Wanzhen Lin Yuan Niu Renyang Meng Lin Huang Hujia Cao Zhenxing Zhang Haiyan Qin Xiaogang Peng Center for Chemistry of Novel & High-Performance Materials Department of Chemistry Zhejiang University Hangzhou 310027 China

Using CdSe/CdS core/shell nanocrystals with 1-10 monolayers of CdS shell as the model system, we studied effects of thiol ligands on optical properties of the nanocrystals. The core/shell nanocrystals with original ligands possessed near unity photoluminescence （PL） quantum yield and single-exponential PL decay dynamics. The effects of thiol ligands on optical properties were found to depend on the shell thickness, environment （with/without oxygen）, and excitation power （single- or multi-exciton）. Systematic and quantitative results reported in this work should provide necessary information for fundamental understanding and technical applications of quantum dots （QDs） coated with thiol ligands.

关键词： colloidal semiconductor nanocrystals thiol ligands photoluminescencequantum yield single-dot spectroscopy

SYNTHESIS AND BIOTECHNOLOGICAL APPLICATIONS OF VINYL POLYMERINORGANIC HYBRID AND MESOPOROUS MATERIALS

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Chinese Journal of Polymer Science 2000年第1期18卷 1-7页

作者： Yen Wei Kun-yuan Qiu Department of Chemistry, Drexel University, Philadelphia, Pennsylvania 19104, USA Department of Polymer Science and Engineering, Peking University, Beijing 100871, China Drexel University 美国北京大学高分子科学与工程系北京

We describe the sol-gel synthesis of a new family of organic-inorganic hybrid materials, in which various vinyl polymers are covalently bonded to and uniformly distributed in inorganic oxide matrices. The materials can be tailored to have both good toughness and hardness while maintaining excellent optical transparency. Doping the sol-gel metal oxides with optically active compounds such as D-glucose results in new optical rotatory composite materials. Removal of the dopant compounds from the composites affords mesoporous oxide materials; which represents a new, nonsurfactant-templated route to mesoporous molecular sieves. We have successfully immobilized a series of enzymes and other bioactive agents in mesoporous materials. Catalytical activities of the enzyme encapsulated in mesoporous materials were found to be much higher than those encapsulated in microporous materials.

关键词： vinyl polymer-inorganic hybrid materials mesoporous materials sol-gel process biotech-nological applications

Single small molecule-assembled nanoparticles mediate efficient oral drug delivery

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Nano Research 2019年第10期12卷 2468-2476页

作者： Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150090China College of Biological Sciences and Biotechnology Beijing Forestry UniversityBeijing 100083China Department of Neurosurgery Yale UniversityNew HavenCT 06510USA Department of Chemistry Beijing Normal UniversityBeijing 100875China Department of Biomedical Engineering Yale UniversityNew HavenCT 06510USA Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicoChinese Academy cf Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pathology Yale UniversityNew HavenCT 06510USA

Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral ***,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio *** hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming *** screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl *** show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease *** determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran *** study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery.

关键词： natural material oral drug delivery nano particle dehydrotrametenolic acid(DTA)

Contracted product of hypermatrices via STP of matrices

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Control Theory and Technology 2023年第3期21卷 265-280页

作者： Daizhan Cheng Min Meng Xiao Zhang Zhengping Ji Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Department of Control Science and Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201210China National Center for Mathematics and Interdisciplinary Sciences Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100149China

An equivalent definition of hypermatrices is *** matrix expression of hypermatrices is *** permu-tation matrices,the conversion between different matrix expressions is *** various kinds of contracted products of hyper... 详细信息

关键词： d-hypermatrix Matrix expression Permutation matrices-Contracted product Semi-tensor product(STP)

Exchange-coupled nanocomposites with novel microstructure and enhanced remanence by a new approach

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Journal of Materials Science & Technology 2021年第20期79卷 118-122页

作者： Baoru Bian Li Jin Qiang Zheng Fang Wang Xiaohong Xu Juan Du CAS Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of Sciences(CAS)Ningbo 315201China Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghai 200444China School of Chemistry and Materials Science Shanxi Normal UniversityLinfen 041004China

Exchange-coupled nanocomposites with hard/soft magnetic phases are promising for the next generation of permanent *** methods have an advantage in controlling the nanoscale size of both *** nanocomposites obtained by the chemical method generally consist of a hard phase core and a soft phase ***,the soft-phase shell is easily oxidized leading to small enhancement of ***,a novel microstructure of Fe@FePt nanocomposites with Fe soft phase core and FePt hard phase shell has been synthesized by replacement reaction,in which the size of core and shell can be controlled below 10 nm by adjusting the ratio of Fe nanoparticles to PtCl *** exchange-coupling(single-phase-like demagnetization curves)between soft-hard phases was observed due to the precise size control of both phases,and substantial enhancements both in remanence(32%)and saturation magnetization(81%)were obtained in optimal *** work provides an alternative routine to prepare heterostructure materials with various applications.

关键词： Magnetic materials Nanocomposites Core-shell microstructure Exchange-coupling interactions