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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of Sport and Health Science 2024年第4期13卷 521-536页

作者： Helder S.Lopes Marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani Fabio M.Azevedo School of Science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA School of Exercise and Rehabilitation Sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:Five databases(MEDLINE,Embase,CINAHL,SPORTDiscus,and Web of Science)were searched from inception to September *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:Seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PFP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(SMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(SMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PFP presented with reduced hamstring strength compared to painfree controls during isometric(SMD=-0.48,95%CI:-0.82 to-0.14),concentric(SMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(SMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PFP presented with reduced hamstring flexibility when compared to pain-free controls(SMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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Structural and functional differences in the brains of patients with MCI with and without depressive symptoms and their relations with Alzheimer's disease:an MRI study

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Psychoradiology 2023年第1期3卷 182-192页

作者： Rodolfo Dias Chiari-Correia Vitor Tumas Antonio Carlos Santos Carlos Emesto G Salmon Department of Neurosciences and Behavioral Sciences Ribeirao Preto Medical SchoolUniversity of Sao Paulo3900 Bandeirantes AvenueRibeirao Preto SP14040-900Brazil Department of Medical Imaging Hematology and Clinical OncologyRibeirao Preto Medical SchoolUniversity of Sao Paulo3900 Bandeirantes AvenueRibeirao Preto SP14040-900Brazil Department of Physics Faculty of PhilosophySciences and LettersUniversity of Sao Paulo3900 Bandeirantes AvenueRibeirao Preto SP14040-900Brazil

Background:The mild cognitive impairment(MCI)stage among elderly individuals is very complex,and the level of diagnostic accu-racy is far from *** studies have tried to improve the’MCI due to Alzheimer’s disease(AD)’classification by further stratifying these patients into ***-related symptoms may play an important role in helping to better define the MCI stage in elderly ***:In this work,we explored functional and structural differences in the brains of patients with nondepressed MCI(nDMCI)and patients with MCI with depressive symptoms(DMCI),and we examined how these groups relate to AD atrophy patterns and cognitive ***:Sixty-five participants underwent MRI exams and were divided into four groups:cognitively normal,nDMCI,DMCI,and *** compared the regional brain volumes,cortical thickness,and white matter microstructure measures using diffusion tensor imaging among ***,we evaluated changes in functional connectivity using fMRI ***:In comparison to the nDMCI group,the DMCI patients had more pronounced atrophy in the hippocampus and ***,DMCI patients had asymmetric damage in the limbic-frontal white matter ***,two medial pos-terior regions,the isthmus of cingulate gyrus and especially the lingual gyrus,had high importance in the structural and functional differentiation between the two ***:It is possible to differentiate nDMCI from DMCI patients using MRI techniques,which may contribute to a better charac-terization of subtypes of the MCI stage.

关键词： mild cognitive impairment depressive disorders Alzheimer’s Disease neuroimaging

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Prototyping low-cost automatic weather stations for natural disaster monitoring

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数字通信与网络:英文版 2023年第4期9卷 941-956页

作者： Gabriel F.L.R.Bernardes Rogerio Ishibashi Andre A.S.Ivo Valerio Rosset Bruno Y.L.Kimura Institute of Science and Technology Federal University of Sao Paulo(ICT/UNIFESP)Sao Jose dos CamposSPBrazil Brazilian National Center for Monitoring and Early Warnings of Natural Disasters(Cemaden) Sao Jose dos CamposSPBrazil

Weather events put human lives at risk mostly when people might occupy areas susceptible to natural *** Professional Weather Stations(PWS)in vulnerable areas is key for monitoring weather with reliable ***,such professional instrumentation is notably expensive while remote sensing from a number of stations is *** imposes challenges on the large-scale weather station deployment for broad monitoring from large observation networks such as in Cemaden—The Brazilian National Center for Monitoring and Early Warning of Natural *** this context,in this paper,we propose a Low-Cost Automatic Weather Station(LCAWS)system developed from Commercial Off-The-Shelf(COTS)and open-source Internet of Things(IoT)technologies,which provides measurements as reliable as a reference PWS for natural disaster *** being automatic,LCAWS is a stand-alone photovoltaic system connected wirelessly to the Internet in order to provide real-time reliable end-to-end weather *** achieve data reliability,we propose an intelligent sensor calibration method to correct *** a 30-day uninterrupted observation with sampling in minute resolution,we show that the calibrated LCAWS sensors have no statistically significant differences from the PWS *** such,LCAWS has opened opportunities for reducing maintenance costs in Cemaden's observational network.

关键词： Wireless automatic weather station Low-cost weather instrumentation Natural disaster monitoring Intelligent sensor calibration Internet of things

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How do greenhouse gas emissions vary with biofertilizer type and soil temperature and moisture in a tropical grassland?

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Pedosphere 2020年第5期30卷 607-617页

作者： Abmael da Silva CARDOSO Juliana Bega JUNQUEIRA Ricardo Andrade REIS Ana Claudia RUGGIERIAnimal Science Departament College of Agricultural and Veterinarian SciencesSao Paulo State UniversityJaboticabal 14884-900(Brazil) Kenji Agricultural and Environmental Consultancy Ribeirdo Preto 14010-079(Brazil)

Greenhouse gases are known to play an important role in global *** this study,we determined the effects of selected soil and climate variables on nitrous oxide(N2O),methane(CH4),and carbon dioxide(CO2)emissions from a tropical grassland fertilized with chicken slurry,swine slurry,cattle slurry,and cattle *** N2O emissions did not differ between treatments and varied from 29.26 to 32.85 mg N m^-***,cumulative CH4 emissions were not significantly different among the treatments and ranged from 6.34 to 57.73 mg CH4 m^-*** and compost application induced CO2 emissions that were significantly different from those in the control *** CH4 conversion factors measured were 0.21%,1.39%,4.39%,and 5.07%for cattle compost,chicken slurry,swine slurry,and cattle slurry,respectively,differing from the recommendations of the Intergovernmental Panel on Climate Change(IPCC).The fraction of added Nemitted as N2O was 0.39%,which was lower than the IPCC default value of 2%.Our findings suggest that N2O emissions could be mitigated by replacing synthetic fertilizer sources with either biofertilizer or *** results indicate the following:N2O emission was mainly controlled by soil temperature,followed by soil moisture and then soil NH^"content;CH4 fluxes were mainly controlled by soil moisture and chamber headspace temperature;and CO2 fluxes were mainly controlled by chamber headspace temperature and soil moisture.

关键词： emission factor methane conversion factor methane oxidation methane production capacity slurry fertilizer soil moisture

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Autonomous machine learning for early bot detection in the internet of things

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Digital Communications and Networks 2023年第6期9卷 1301-1309页

作者： Alex Medeiros Araujo Anderson Bergamini de Neira Michele Nogueira Department of Informatics Federal University of Parana(UFPR)CuritibaBrazil Department of Computer Science Federal University of Minas Gerais(UFMG)Belo HorizonteBrazil

The high costs incurred due to attacks and the increasing number of different devices in the Internet of Things(IoT)highlight the necessity of the early detection of botnets(i.e.,a network of infected devices)to gain an advantage against ***,early botnet detection is challenging because of continuous malware mutations,the adoption of sophisticated obfuscation techniques,and the massive volume of *** literature addresses botnet detection by modeling the behavior of malware spread,the classification of malicious traffic,and the analysis of traffic *** article details ANTE,a system for ANTicipating botnEt signals based on machine learning *** system adapts itself to different scenarios and detects different types of *** autonomously selects the most appropriate Machine Learning(ML)pipeline for each botnet and improves the classification before an attack effectively *** system evaluation follows trace-driven experiments and compares ANTE results to other relevant results from the literature over four representative datasets:ISOT HTTP Botnet,CTU-13,CICDDoS2019,and *** show an average detection accuracy of 99.06%and an average bot detection precision of 100%.

关键词： Network security Bot early detection Autonomous machine learning Network traffic analysis

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Taenidium barretti ichnofabric and rainfall seasonality:Insights into dryland suites of Scoyenia ichnofacies

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Journal of Palaeogeography 2023年第1期12卷 28-49页

作者： Diego Luciano Nascimento Renata Guimaraes Netto Alessandro Batezelli Francisco Sergio Bernardes Ladeira Daniel Sedorko ICHNOS research Group Geology Graduate ProgramUnisinos UniversityAv.Unisinos95010 Sao LeopoldoRS93022-750Brazil Campinas State University Geology and Natural Resources DepartmentZeferino Vaz University CityBarao GeraldoCampinasSP13083-970Brazil Laboratory of Pedology(LABPED) Department of GeographyGeosciences InstituteGeosciencesState University of CampinasCampinasSP13083-855Brazil Museu Nacional Departamento de Geologia e PaleontologiaUniversidade Federal do Rio de Janeiro.Horto BotanicoParque Quinta da Boa VistaR.Gen.Herculano Gomes1340Sao CristovaoRio de JaneiroRJ20940-040Brazil

The present work analyzes the monotypic Taenidium barretti ichnofabric developed in abandoned channels and floodplains to understand its paleoecological significance in highly seasonal fluvial *** data come from the Cretaceous paleosols of the Marília Formation(Bauru Basin,SE Brazil),in which the *** ichnofabric and rhizoliths represent the biotic *** larvae are considered to be the most likely *** tracemakers in these *** intensity and recurrence of bioturbation suggest that the windows of opportunity for beetle population growth were very short and controlled by the progressive substrate desiccation after flood *** characteristics of the trace fossil assemblage suggest soil colonization by r-strategic organisms triggered by flooding events that provided the resource inputs necessary for their living during rainy *** results also show that in fluvial systems with high discharge variations,the boundaries between a“pre-desiccation suite”and a“desiccation suite”in the Scoyenia ichnofacies can be diffuse due to the short duration of colonization windows and progressive terrestrialization of floodplains and ***,the frequency of flooding events,the lowered water table,and the rapidity of substrate desiccation constrained colonization by other burrowers and may be considered as firstorder factors controlling the generation of a monotypic *** ***,the monotypic Taenidium ichnofabric in the Scoyenia ichnofacies context is an ichnomarker of brief windows for colonization in highly seasonal environments.

关键词： Ichnology Paleopedology Continental ichnofacies Meniscate burrows Ichnofabric

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The ultra-sonication of minerals in swine feed

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Journal of Animal Science and Biotechnology 2015年第4期6卷 416-423页

作者： Mayra A.D.Saleh Pedro M.Padilha Lucelia Hauptli Dirlei A.Berto Department of Animal Production Lageado FarmFaculty of Animal Science and Veterinary MedicineUNESP-Sao Paulo State UniversityBotucatu Campus Department of Chemistry and Biochemistry Institute of BiosciencesUNESP-Sao Paulo State UniversityBotucatu CampusRubiao Junior District UFSC-Federal University of Santa Catarina Center for Agricultural Sciences

A sample preparation method based on ultrasound assisted-extraction （UAE） of Ca, Mg and P from swine feed has been described. The experiment was performed to cover the variables influencing the sonication process and, the method validation using standard reference material. Final solutions obtained upon sonication were analyzed by flame atomic absorption spectrometry （for Ca and Mg） and by UV-vis spectrophotometry （for P）. The best conditions for metal extraction were as follows： sample mass： 100 mg in 20 mL 0.10 mol/L HCI, a particle size：〈60 lam, sonication time： 5 cycles of 10 s and ultrasound power： 102 W. The UAE method was applied in digestibility assays in different piglet feeds and their results showed that it is highly comparable （P 〉 0.05） to the other methods used for such purposes, as block digestion, and offered a Ca, Mg and P method of quantification limit of 10.6, 12.4 and 14 mg/kg, respectively. The major advantages of the UAE method compared to other methods are the high treatment rate, low reagent usage in the extracts and, it does not generate toxic residues that might negatively affect human health and the environment, accompanied by good precision and accuracy.

关键词： Digestibility assay Green analytical chemistry Macronutrients Piglet Ultrasound-assisted extraction

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Ammonium Improves Corn Phosphorus Acquisition Through Changes in the Rhizosphere Processes and Root Morphology

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Pedosphere 2019年第4期29卷 534-539页

作者： Elialdo Alves DE SOUZA Natália Rodrigues FERREIRA-ELOY Camila da Silva GRASSMANN Ciro Antonio ROSOLEM Philip J.WHITE School of Agronomic Sciences Sao Paulo State University The James Hutton Institute

Dear Editor, Phosphorus (P) deficiency is the most limiting factor in tropical agriculture since most soils in this region are predominantly acids with high-energy P-binding compounds. Therefore, up to 90% of the P applied becomes fixed in soils, which raises environmental concerns and production costs (Syers et al., 2008). Thus, developing strategies to imptove P use efficiency (PUE) is essential to mitigate environmental problems and improve profits. These strategies should consider the soil-root-rhizosphere system because it is the most biochemical active site where nutrient uptake occurs (Hinsinger, 2011).

关键词： Root Morphology Rhizosphere Processes Dear Editor

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Exosomes:Small vesicles with big roles in cancer,vaccine development,and therapeutics

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Bioactive Materials 2022年第4期7卷 281-294页

作者： Abhimanyu Thakur Diana Carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen Pritzker School of Molecular Engineering The University of ChicagoUnited States Ben May Department for Cancer research The University of ChicagoUnited States Tropical Disease Laboratory Department of GeneticsEvolutionMicrobiology and ImmunologyInstitute of BiologyUniversity of Campinas(UNICAMP)S˜ao PauloBrazil

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every *** the availability of chemotherapy,radiotherapy,immunotherapy,and surgery,a cure for cancer has not been ***,exosomes have gained significant attention due to the therapeutic potential of their various components including proteins,lipids,nucleic acids,miRNAs,and *** constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 *** are released from different cells and are present in biofluids including blood,cerebrospinal fluid(CSF),and *** perform crucial multifaceted functions in the malignant progression of cancer via autocrine,paracrine,and endocrine *** ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer *** this review,we discuss the major components of exosomes and their role in cancer *** also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.

关键词： Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system

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Increased branching independent of strigolactone in cytokinin oxidase 2-overexpressing tomato is mediated by reduced auxin transport

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Molecular Horticulture 2022年第1期2卷 153-171页

作者： Lilian Ellen Pino Joni E.Lima Mateus H.Vicente Ariadne F.L.de Sá Francisco Pérez-Alfocea Alfonso Albacete Juliana L.Costa TomášWerner Thomas Schmülling Luciano Freschi Antonio Figueira Agustin Zsögön Lázaro E.P.Peres Laboratory of Plant Breeding Centro de Energia Nuclear na AgriculturaUniversity of Sao PauloSão PauloBrazil Laboratory of Hormonal Control of Plant Development Department of Biological SciencesEscola Superior de Agricultura‘Luiz de Queiroz’University of Sao PauloPiracicabaBrazil Botany Department ICBFederal University of Minas GeraisBelo HorizonteBrazil Department of Plant Nutrition CEBAS-CSICCampus Univ.EspinardoMurciaSpain Institute of Biology/Applied Genetics Freie Universität BerlinBerlinGermany Institute of Biology University of GrazSchubertstraße 518010 GrazAustria Biosciences Institute University of Sao PauloSão PauloBrazil Plant Sciences Department Federal University of ViçosaViçosaBrazil

Tomato production is influenced by shoot branching,which is controlled by different *** we produced tomato plants overexpressing the cytokinin-deactivating gene CYTOKININ OXYDASE 2(CKX2).CKX2-overexpressing(CKX2-OE)plants showed an excessive growth of axillary shoots,the opposite phenotype expected for plants with reduced cytokinin content,as evidenced by LC-MS analysis and ARR5-GUS *** TCP transcription factor SlBRC1b was downregulated in the axillary buds of CKX2-OE and its excessive branching was dependent on a functional version of the GRAS-family gene LATERAL SUPPRESSOR(LS).Grafting experiments indicated that increased branching in CKX2-OE plants is unlikely to be mediated by root-derived *** CKX2-OE plants with transgenic antisense plants for the strigolactone biosynthesis gene CAROTENOID CLEAVAGE DIOXYGENASE(CCD7-AS)produced an additive phenotype,indicating independent effects of cytokinin and strigolactones on increased *** the other hand,CKX2-OE plants showed reduced polar auxin transport and their bud outgrowth was reduced when combined with auxin ***,CKX2-OE basal buds did not respond to auxin applied in the decapitated *** results suggest that tomato shoot branching depends on a fine-tuning of different hormonal balances and that perturbations in the auxin status could compensate for the reduced cytokinin levels in CKX2-OE plants.

关键词： CKX2 Hormones Plant development Solanum

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