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Three-dimensional modeling with national coverage:case of The Netherlands

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Geo-Spatial Information Science 2013年第4期16卷 267-276页

作者： Jantien STOTER Linda van den BRINK Jakob BEETZ Hugo LEDOUX Marcel REUVERS Paul JANSSEN Friso PENNING George VOSSELMAN Sander OUDE ELBERINK Kadaster Hofstraat 1107311ApeldoornThe Netherlands OTB-Section GIS technology)Delft University of technology Jaffalaan 92600 AADelftKZThe Netherlands Geonovum Barchman Wuytierslaan 103818 LH AmersfoortThe Netherlands Department of the Built Environment Eindhoven University of TechnologyVRT 9.08Postbus 5135600 MBEindhovenThe Netherlands Department GeoInformation City of The HagueThe Netherlands Faculty of Geo-Information Science and Earth Observation–ITC University of TwenteHengelosestraat 997514 AEEnschedeThe Netherlands

Three-dimensional technologies have matured over the *** the same time,3D information is becoming increasingly important in many *** it is not straightforward to apply the solutions that work on prototypes,small areas or for specific projects to 3D modeling of a whole *** the Netherlands,two initiatives are ongoing to address the issues of nation-wide 3D ***,the initiative that aims at establishing and implementing a national 3D standard for large-scale topography with support of all *** and maintaining the large-scale data are the responsibility of local governments(mainly municipalities).The second initiative is led by the Kadaster(the organization responsible for topographic mapping in the Netherlands)and aims at automatically generating a 3D version of the 1:10 k object-oriented data-set based on a smart combination of the two-dimensional data with high-resolution laser *** initiatives are presented in this paper including results,open issues,and future plans.

关键词： 3D modeling 3D standard country wide 3D mapping

A star-based data structure to store efficiently 3D topography in a database

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Geo-Spatial Information Science 2013年第4期16卷 256-266页

作者： Hugo LEDOUX Martijn MEIJERS Faculty of Architecture and the Built Environment OTBGIS technologyDelft University of TechnologyJaffalaan 92628 BXDelftThe Netherlands

For storing and modeling three-dimensional(3D)topographic objects(***,roads,dykes,and the terrain),tetrahedralizations have been proposed as an alternative to boundary *** in theory they have several advantages,current implementations are either not space efficient or do not store topological relationships(which makes spatial analysis and updating slow,or require the use of an expensive 3D spatial index).We discuss in this paper an alternative data structure for storing tetrahedralizations in a database management system(DBMS).It is based on the idea of storing only the vertices and stars of edges;triangles and tetrahedra are represented *** has been used previously in main memory,but not in a *** describe how to modify it to obtain an efficient implementation in a DBMS,and we describe how it can be used for modeling 3D *** we demonstrate with different real-world examples,the structure is compacter than known alternatives,it permits us to store attributes for any primitives,and has the added benefit of being topological,which permits us to query it *** structure can be easily implemented in most DBMS(we describe our implementation in PostgreSQL),and we present some of the engineering choices we made for the implementation.

关键词： 3D GIS tetrahedralization database management system(DBMS) data structures

Multimodal probe for optical coherence tomography epidetection and micron-scale indentation

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 64-72页

作者： L.Bartolini F.Feroldi J.J.A.Weda M.Slaman J.F.de Boer D.Iannuzzi Department of Physics and Astronomy Vrije Universiteit Amsterdam and LaserLab Amsterdam de Boelelaan 1081 1081HV AmsterdamThe Netherlands

We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical *** scarning a sample under the probe,we can obtain structural crosse soction images and identify a region of interest in a nonhomogencous ***,with the same probe and setup,we can immediately target that area with a series of spherical indentation measurements,in which the applied load is known with aμN precision,the indentation depth with sub-/m precision and a maximum contact radius of 100 *** to the visualization of the internal structure of the sample,we can gain a better insi ght into the observed mechanical *** ability to impart a small,confined load,and perfomn OCT A scans at the same time,could lead to an altemative,high transverse resolution,Optical Coherence Elastography(OCE)sensor.

关键词： Optomechanical microindentation optical coherence tomography indentation multimodal sensor,epidetection

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij Wouter N.Leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.Veraar Johannes G.Dauwerse Gerard J.P.van Westen Bob van de Water Leo S.Price Dorien j.M.Peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present address:NEXUS Personalized Health Technologies ETH ZurichSwitzerland Department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.V. LeidenThe Netherlands Division of Medicinal Chemistry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycystic kidney disease(PKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative *** signalling rewiring in PKD that drives cyst formation is highly complex and not fully *** a consequence,the effects of drugs are sometimes difficult to *** previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst ***,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved *** identified 81 active molecules that inhibit cyst ***-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in *** an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celastrol inhibited the growth of renal cysts and maintained kidney function.

关键词： PKD celastrol pyrvinium pamoate high-content screening 3D

The effect of particle size and amount of inoculum on fungal treatment of wheat straw and wood chips

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Journal of Animal Science and Biotechnology 2017年第1期8卷 217-225页

作者： Sandra J. A. van Kuijk Anton S. M. Sonnenberg Johan J. P. Baars Wouter H. Hendriks John W. Cone Animal Nutrition Group Wageningen University De Elst 1 6708WD Wageningen The Netherlands Plant Breeding Wageningen University Droevendaalsesteeg 1 6708PB Wageningen The Netherlands

Background： The aim of this study was to optimize the fungal treatment of lignocellulosic biomass by stimulating the colonization. Wheat straw and wood chips were treated with Ceriporiopsis subvermispora and Lentinula edodes with various amounts of colonized millet grains（0.5, 1.5 or 3.0 % per g of wet weight of substrate） added to the substrates. Also, wheat straw and wood chips were chopped to either 0.5 or 2 *** of the fungal treatment after 0, 2, 4, 6, or 8 wk of incubation was determined by changes in chemical composition, in vitro gas production（IVGP） as a measure for rumen degradability, and ergosterol content as a measure of fungal ***： Incomplete colonization was observed for C. subvermispora treated wheat straw and L. edodes treated wood chips. The different particle sizes and amounts of inoculum tested, had no significant effects on the chemical composition and the IVGP of C. subvermispora treated wood chips. Particle size did influence *** treatment of wheat straw. The L. edodes treatment of 2 cm wheat straw resulted in a more selective delignification and a higher IVGP than the smaller particles. Addition of 1.5 % or 3 % L. edodes inoculum to wheat straw resulted in more selective delignification and a higher IVGP than addition of 0.5 % ***： Particle size and amount of inoculum did not have an effect on C. subvermispora treatment of wood chips. At least 1.5 % L. edodes colonized millet grains should be added to 2 cm wheat straw to result in an increased IVGP and acid detergent lignin（ADL） degradation.

关键词： Amount of inoculum Fungal treatment In vitro rumen degradability Lignin degradation Lignocellulosic biomass Particle size

A DNA-Binding Bromodomain-Containing Protein Interacts with and Reduces Rx1-Mediated Immune Response to Potato Virus X

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Plant Communications 2020年第4期1卷 101-114页

作者： Octavina C.A.Sukarta Philip D.Townsend Alexander Llewelyn Christopher H.Dixon Erik J.Slootweg Lars-Olof Pålsson Frank L.W.Takken Aska Goverse Martin J.Cann Laboratory of Nematology Department of Plant SciencesWageningen University6708 PB WageningenThe Netherlands Department of Biosciences Durham UniversitySouth RoadDurham DH13LEUK Biophysical Sciences Institute Durham UniversitySouth RoadDurham DH13LEUK Department of Chemistry Durham UniversitySouth RoadDurham DH13LEUK Molecular Plant Pathology Swammerdam Institute for Life SciencesUniversity of AmsterdamScience Park 9041098 XH AmsterdamThe Netherlands

Plant NLR proteins enable the immune systemto recognize and respond to pathogen *** early consequence of immune activation is transcriptional *** have been shownto act in the nucleus and interact with transcription *** Rx1 NLR protein of potato binds and distorts doublestranded ***,the components of the chromatin-localized Rx1 complex are largely ***,we report a physical and functional interaction between Rx1 and NbDBCP,a bromodomaincontaining chromatin-interacting *** accumulates in the nucleoplasmand nucleolus,interacts with chromatin,and redistributes Rx1 tothe nucleolus in a subpopulation of imaged ***1 overexpression reduces the interaction between NbDBCP and *** is a negative regulator of Rx1-mediated immune responses to potato virus X(PVX),and this activity requires an intact ***,Rx1 has been shown to regulate the DNA-binding activity of a Golden2-like transcription factor,***1 and NbDBCP act synergistically to reduce NbGlk1 DNA binding,suggesting a mode of action for NbDBCP’s inhibitory effect on *** study provides new mechanistic insight into the mechanism by which a chromatin-localized NLR complex co-ordinates immune signaling after pathogen perception.

关键词： cellular immune response DNA-binding protein host-pathogen interaction plant biochemistry plant defense plant virus

Metallic nanostructures for efficient LED lighting

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Light(Science & Applications) 2016年第1期5卷 778-787页

作者： Gabriel Lozano Said RK Rodriguez Marc A Verschuuren Jaime Gómez Rivas Instituto de Ciencia de Materiales de Sevilla Consejo Superior de Investigaciones Científicas-Universidad de Sevilla(CSIC-US)41092 SevillaSpain Laboratoire de Photonique et de Nanostructures(LPN) Centre National de la Recherche Scientifique(CNRS)91460 MarcoussisFrance Philips research Laboratories 5656AE EindhovenThe Netherlands Dutch Institute for Fundamental Energy research 5600 HH EindhovenThe Netherlands COBRA research Institute Technical University of EindhovenEindhovenThe Netherlands

Light-emitting diodes(LEDs)are driving a shift toward energy-efficient ***,modifying the emission intensities,colors and directionalities of LEDs in specific ways remains a challenge often tackled by incorporating secondary optical *** nanostructures supporting plasmonic resonances are an interesting alternative to this approach due to their strong light–matter interaction,which facilitates control over light emission without requiring external secondary optical *** review discusses new methods that enhance the efficiencies of LEDs using nanostructured *** is an emerging field that incorporates physics,materials science,device technology and ***,we provide a general overview of state-of-the-art LED lighting,discussing the main characteristics required of both quantum wells and color converters to efficiently generate white ***,we discuss the main challenges in this field as well as the potential of metallic nanostructures to circumvent *** review several of the most relevant demonstrations of LEDs in combination with metallic nanostructures,which have resulted in light-emitting devices with improved *** also highlight a few recent studies in applied plasmonics that,although exploratory and eminently fundamental,may lead to new solutions in illumination.

关键词： light-emitting diodes nanophotonics plasmonics solid-state lighting

Thermally stimulated exciton emission in Si nanocrystals

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Light(Science & Applications) 2017年第1期6卷 228-234页

作者： Elinore MLD de Jong Huub Rutjes Jan Valenta M Tuan Trinh Alexander N Poddubny Irina N Yassievich Antonio Capretti Tom Gregorkiewicz Van der Waals-Zeeman Institute University of AmsterdamScience Park 9041098 XHAmsterdamThe Netherlands Department of Chemical Physics and Optics Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 312116 Prague 2Czech Republic Department of Electrical Engineering and Computer Science University of Michigan2200 Bonisteel BlvdAnn ArborMI 48109USA Ioffe Institute Russian Academy of Sciences26 Polytechnicheskaya194021 St PetersburgRussia

Increasing temperature is known to quench the excitonic emission of bulk silicon,which is due to thermally induced dissociation of ***,we demonstrate that the effect of temperature on the excitonic emission is reversed for quantumconfined silicon *** laser-induced heating of silicon nanocrystals embedded in SiO2,we achieved a more than threefold(4300%)increase in the radiative(photon)emission *** theoretically modeled the observed enhancement in terms of the thermally stimulated effect,taking into account the massive phonon production under intense *** results elucidate one more important advantage of silicon nanostructures,illustrating that their optical properties can be influenced by *** also provide an important insight into the mechanisms of energy conversion and dissipation in ensembles of silicon nanocrystals in solid *** practice,the radiative rate enhancement under strong continuous wave optical pumping is relevant for the possible application of silicon nanocrystals for spectral conversion layers in concentrator photovoltaics.

关键词： micro-photoluminescence nanocrystal optical spectroscopy silicon thermal

Modified snowdrift games for multi-robot water polo matches

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Modified snowdrift games for multi-robot water polo matches