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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors

Cellular & Molecular Immunology 2024年第10期21卷 1089-1108页

作者： Lei Peng Giacomo Sferruzza Luojia Yang Liqun Zhou Sidi Chen Department of Genetics Yale University School of MedicineNew HavenCTUSA System Biology Institute Yale UniversityWest HavenCTUSA Combined Program in the Biological and Biomedical Sciences Yale UniversityNew HavenCTUSA Molecular Cell Biology Geneticsand Development ProgramYale UniversityNew HavenCTUSA Immunobiology Program Yale UniversityNew HavenCTUSA Yale Comprehensive cancer Center Yale University School of MedicineNew HavenCTUSA Department of Neurosurgery Yale University School of MedicineNew HavenCTUSA Yale Stem Cell Center Yale University School of MedicineNew HavenCTUSA Yale Liver Center Yale University School of MedicineNew HavenCTUSA Yale Center for Biomedical Data Science Yale University School of MedicineNew HavenCTUSA Yale Center for RNA Science and Medicine Yale University School of MedicineNew HavenCTUSA

In the past decade,chimeric antigen receptor(CAR)-T cell therapy has emerged as a promising immunotherapeutic approach for combating cancers,demonstrating remarkable efficacy in relapsed/refractory hematological malignancies in both pediatric and adult ***-natural killer(CAR-NK)cell complements CAR-T cell therapy by offering several distinct ***-NK cells do not require HLA compatibility and exhibit low safety ***,CAR-NK cells are conducive to“off-the-shelf”therapeutics,providing significant logistic advantages over CAR-T *** CAR-T and CAR-NK cells have shown consistent and promising results in hematological ***,their efficacy against solid tumors remains limited due to various obstacles including limited tumor trafficking and infiltration,as well as an immuno-suppressive tumor *** this review,we discuss the recent advances and current challenges of CAR-T and CAR-NK cell immunotherapies,with a specific focus on the obstacles to their application in solid *** also analyze in depth the advantages and drawbacks of CAR-NK cells compared to CAR-T cells and highlight CAR-NK CAR ***,we explore future perspectives of these adoptive immunotherapies,highlighting the increasing contribution of cutting-edge biotechnological tools in shaping the next generation of cellular immunotherapy.

关键词： CAR-T CAR-NK Cell therapy cancer immunotherapy Solid tumor

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Non-enzymatic covalent modifications:a new link between metabolism and epigenetics

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Protein & Cell 2020年第6期11卷 401-416页

作者： Qingfei Zheng Igor Maksimovic Akhil Upad Yael David Chemical Biology Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Tri-Institutional PhD Program in Chemical Biology New YorkNY 10065USA Department of Pharmacology Weill Cornell MedicineNew YorkNY 10065USA Department of Physiology Biophysics and Systems BiologyWeill Cornell MedicineNew YorkNY 10065USA

Epigenetic modifications,including those on DNA and histones,have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic *** turn,metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin ***,non-enzymatic covalent modifications(NECMs)by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple ***,we summarize these recent advances in the identification and characterization of NECMs on nucleic acids,histones,and transcription factors,providing an additional mechanistic link between metabolism and epigenetics.

关键词： epigenetics metabolism non-enzymatic modification chromatin human disease

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Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

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Bone research 2024年第3期12卷 675-688页

作者： Na Li Baohong Shi Zan Li Jie Han Jun Sun Haitao Huang Alisha R.Yallowitz Seoyeon Bok Shuang Xiao Zuoxing Wu Yu Chen Yan Xu Tian Qin Rui Huang Haiping Zheng Rong Shen Lin Meng Matthew B.Greenblatt Ren Xu State Key Laboratory of Cellular Stress Biology Cancer Research CenterSchool of MedicineFaculty of Medicine and Life SciencesXiamen UniversityXiamen 361102China Fujian Provincial Key Laboratory of Organ and Tissue Regeneration School of MedicineXiamen UniversityXiamen 361102China Department of Sports Medicine Xiangya HospitalCentral South UniversityChangsha 410000China research Division Hospital for Special SurgeryNew YorkNY 10065USA Department of Pathology and Laboratory Medicine Weill Cornell Medical CollegeNew YorkNY 10065USA Department of Electronic and Computer Engineering Ritsumeikan UniversityKusatsuShiga 525-8577Japan

Osteogenesis imperfecta(OI)is a disorder of low bone mass and increased fracture risk due to a range of genetic variants that prominently include mutations in genes encoding typeⅠ*** it is well known that OI reflects defects in the activity of bone-forming osteoblasts,it is currently unclear whether OI also reflects defects in the many other cell types comprising bone,including defects in skeletal vascular endothelium or the skeletal stem cell populations that give rise to osteoblasts and whether correcting these broader defects could have therapeutic utility.

关键词： skeletal imperfect endothelium

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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Translating current biomedical therapies for long duration,deep space missions

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Precision Clinical Medicine 2019年第4期2卷 259-269页

作者： Sonia Iosim Matthew MacKay Craig Westover Christopher E.Mason Department of Physiology and Biophysics Weill Cornell MedicineNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA The Feil Family Brain and Mind research Institute Weill Cornell MedicineNew YorkNY 10021USA The WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

It is been shown that spaceflight-induced molecular,cellular,and physiologic changes cause alterations across many modalities of the human body,including cardiovascular,musculoskeletal,hematological,immunological,ocular,and neurological *** Twin Study,a multi-year,multi-omic study of human response to spaceflight,provided detailed and comprehensive molecular and cellular maps of the human response to radiation,microgravity,isolation,and *** rich data identified epigenetic,gene expression,inflammatory,and metabolic responses to spaceflight,facilitating a better biomedical roadmap of features that should be monitored and safe-guarded in upcoming ***,by exploring new developments in pre-clinical models and clinical trials,we can begin to design potential cellular interventions for exploration-class missions to Mars and potentially *** paper will discuss the overall risks astronauts face during spaceflight,what is currently known about human response to these risks,what pharmaceutical interventions exist for use in space,and which tools of precision medicine and cellular engineering could be applied to aerospace and astronaut medicine.

关键词： NASA spaceflight International Space Station NASA Twin Study multi-scale omics

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