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Differential Proteomic Analysis of Neonatal Cardiomyocytes in Response to β-Adrenergic Receptor Stimulation

Chemical Research in Chinese Universities 2006年第3期22卷 319-323页

作者： LI Zi-jian LIU Ning LIU Zhi-qiang LIU Shu-ying HAN Qi-de ZHANG You-yi Institute of Vascular Medicine Peking University Third Hospital and Key Laboratory ofMolecular Cardiovascular Sciences Ministry of Education Beijing 100083 P. R. China Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

β-Adrenoceptors（β-ARs） play a critical role in regulating cardiac functions under both physiological and pathological conditions. To further explore the mechanisms through which β-ARs perform its actions, proteomic approaches were adopted to study the global protein patterns in cultured neonatal rat cardiomyocytes exposed to iseproterenol （ISO）. A modified method, ＂Mirror Images in One Gel＂, was used to improve the reproducibility and resolution power of two-dimensional electrophoresis. A 2-DE map with a good reproducibility was obtained in which 1281 ± 70 spots were detected and about 1191± 54 spots were matched, with an average matching rate of 92. 9%. Nine proteins with significant changes were identified by using peptide mass fingerprinting（PMF） data obtained vht MALDI-MS.

关键词： Proteome Two-dimensional electrophoresis(2-DE) MALDI-MS β-Adrenoceptor Cardiomyocyte

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Robust Threshold Guillou-Quisquater Signature Scheme

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Wuhan University Journal of Natural Sciences 2005年第1期10卷 207-210页

作者： WANGHong ZHANGZhen-feng FENGdeng-guo StateKeyLaboratoryofInformationSecurity（GraduateSchoolofChineseAcademyofSciences） Beijing100039 StateKeyLaboratoryofInformationSecurity（InstituteofSoftwareofChineseAcademyofSciences） Beijing100080China

The deficiencies of the first threshold Guilbu-Quisquater signature schemepresented by Li-San Liu, Cheng-Kang Chu and Wen-Guey Tzeng arc analysiscd at first, and then a newthreshold Guillou-Quisquater signature scheme is presented. The new scheme isunforgeable and robustagainst any adaptive adversary if the base Guillou-Quisquater signature scheme is unforgeable underthe chosen message attack and computing the discrete logarithm modulo a prime is hard This schemecan also achieve optimal resilience. However, the new scheme does not need the assumption that N isthe product of two safe primes. The basie signature scheme underlying the new scheme is exactlyGuillou-Quisqualtr signature scheme, and the additional strong computation assumption introduced bythe first threshold Guillou-Quisquater scheme is weaken.

关键词： vcriablc secret sharing threshold cryptography digital signature scheme robust secure multiparty computation

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Optimization of grinding in reverse flotation for bauxite

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中国有色金属学会会刊：英文版 2001年第3期11卷 444-446页

作者：骆兆军王毓华胡岳华邱冠周中南大学矿物系湖南长沙 410083 中南大学湖南长沙 410083

The reverse flotation for desiliconization form bauxite is better than direct flotation, and the grinding before flotation affects the flotation indexes to some extend. The grinding dynamic equation of bauxite based on the data of grinding experiment of diasporic bauxite was derived. The calculated value of the equation is identical with the experiment value. Further the grinding dynamic equation of intermediate grain size range suitable for reversal flotation has also been derived. The grinding time required could be calculated when the mass fraction of intermediate size grain is maximum. The formulation of grinding dynamic equation considerably simplified the grinding experiment, optimized the grinding process. [

关键词： bauxite grinding dynamics optimization

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